Review
Nutrition & Dietetics
Ishani Bhat, Bangera Sheshappa Mamatha
Summary: Lutein's antioxidant properties protect against oxidative stress in age-related macular degeneration and cognitive decline, but its bioavailability is influenced by genetic factors. Research into how individual genetic variability affects lutein bioavailability is crucial for optimizing dietary recommendations and adjusting medication dosages.
NUTRITION RESEARCH
(2021)
Article
Neurosciences
Julian Seelig, Raban Arved Heller, Patrick Haubruck, Qian Sun, Georg Jochen Klingenberg, Julian Hackler, Helena Lucia Crowell, Volker Daniel, Arash Moghaddam, Lutz Schomburg, Bahram Biglari
Summary: The serum levels of SELENBP1 are related to the degree of neurological impairment in patients with TSCI and offer information on remission odds. The correlation of SELENBP1 with CCL2 levels establishes a novel connection between selenium metabolism and immune cell activation, which may have implications for neurological damage and regeneration processes.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Helen Maye, Mueez Waqar, Francesca Colombo, Elvira Lekka
Summary: This study provides the first external validation of the GCS-P score for outcome prediction in TBI patients. The results show that GCS-P is a useful predictor of discharge destination and 30-day mortality, especially for patients with severe TBI.
ACTA NEUROCHIRURGICA
(2023)
Article
Biology
Ziva Pogacar, Kelvin Groot, Fleur Jochems, Matheus Dos Santos Dias, Antonio Mulero-Sanchez, Ben Morris, Mieke Roosen, Leyma Wardak, Giulia De Conti, Arno Velds, Cor Lieftink, Bram Thijssen, Roderick L. Beijersbergen, Rene Bernards, Rodrigo Leite de Oliveira
Summary: This study identifies factors that influence the sensitivity and resistance to the abandoned cancer drug indisulam, providing a theoretical basis for its rational reuse in the clinic. The study also reveals a synthetic lethal interaction between the loss of SRPK1 gene and indisulam, potentially enabling the use of SRPK1 inhibitor SPHINX31 as a therapeutic approach. Furthermore, the study identifies components of the degradation complex that mediate resistance to indisulam.
LIFE SCIENCE ALLIANCE
(2022)
Article
Neurosciences
Yujiao Lu, Abbas Jarrahi, Nicholas Moore, Manuela Bartoli, Darrell W. Brann, Babak Baban, Krishnan M. Dhandapani
Summary: Traumatic brain injury (TBI) is a leading cause of progressive neurodegeneration and is associated with mortality and morbidity worldwide. Inflammation plays a crucial role in neurodegenerative changes and cognitive dysfunction after TBI, suggesting a potential link between immune activation and age- or TBI-induced cognitive decline. This mini-review explores the association between cellular senescence and poor TBI outcomes, as well as the potential use of senotherapeutics as therapeutics for TBI.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Immunology
Yuan Liu, Rui Wang, Peizhen Wen, Wenbin An, Jinxin Zheng, Tao Zhang, Pengshan Zhang, Haoyu Wang, Fan Zou, Hui Pan, Junwei Fan, Zhihai Peng
Summary: This study investigated the genetic risk of patients with tacrolimus intolerance after liver transplantation. The results suggested that switching to cyclosporine (SFTC) may increase the risk of dyslipidemia and insulin resistance, while specific SNPs of CYP3A5 gene could be potential genetic risks for tacrolimus intolerance.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Laure-Alix Clerbaux, Maria Cristina Albertini, Nuria Amigo, Anna Beronius, Gillina F. G. Bezemer, Sandra Coecke, Evangelos P. Daskalopoulos, Giusy del Giudice, Dario Greco, Lucia Grenga, Alberto Mantovani, Amalia Munoz, Elma Omeragic, Nikolaos Parissis, Mauro Petrillo, Laura A. Saarimaki, Helena Soares, Kristie Sullivan, Brigitte Landesmann
Summary: This article utilizes the Adverse Outcome Pathway (AOP) framework to describe how eleven selected factors influence COVID-19 and its underlying mechanisms. The approach helps identify knowledge gaps for further research and proposes biomarkers for high-risk patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Nutrition & Dietetics
Filippo Vernia, Salvatore Longo, Gianpiero Stefanelli, Angelo Viscido, Giovanni Latella
Summary: Colorectal cancer is influenced by a combination of genetic and environmental factors, with diet and lifestyle modifications playing a significant role in reducing the risk and preventing tumors. The Western diet high in fat, red meat, and processed meat is associated with an increased risk of colorectal cancer, while a high intake of dietary fiber can partially counteract these negative effects.
Article
Clinical Neurology
Henry Olayere Obanife, Ismail Jinjiri Nasiru, Olugbenga Olabisi Ogunleye, Misbahu Ahmad, Ega Joseph Otorkpa, Bello Bala Shehu
Summary: Motorcycle-associated head injury mainly affects young men who use motorcycles for commercial purposes. Survival is higher among patients who undergo brain CT scans, have extra-axial clots, and receive operative treatment. However, patients who cannot afford brain CT scans, have bilateral pupillary dilatation, CT findings that are not surgically treatable, and severe head injury may have a higher mortality rate.
WORLD NEUROSURGERY
(2022)
Article
Neuroimaging
Carl Trolle, Estee Goldberg, Clas Linnman
Summary: This study conducted a systematic review and meta-analysis to investigate cervical spinal cord atrophy after spinal cord injury. The results showed that the level of injury and time since injury influenced the atrophy, and more severe atrophy was observed in more rostral injuries. The study suggests the need for larger and longitudinal studies, data sharing, and standardized protocols.
NEUROIMAGE-CLINICAL
(2023)
Article
Hematology
Roland Jaeger, Heinz Gisslinger, Elisabeth Fuchs, Edith Bogner, Jelena D. Milosevic Feenstra, Jakob Weinzierl, Fiorella Schischlik, Bettina Gisslinger, Martin Schalling, Michael Zoerer, Kurt Krejcy, Christoph Klade, Robert Kralovics
Summary: This study investigated the impact of germline genetic polymorphisms on hematologic and molecular responses in polycythemia vera patients undergoing interferon treatment. While genome-wide association studies did not show significant associations, targeted analysis revealed a significant effect of the IFNL4 diplotype on molecular responses. These findings suggest the potential for personalized treatment strategies based on IFNL4 functionality in PV patients undergoing interferon therapy.
Review
Neurosciences
Roxana N. Beladi, Kyle S. Varkoly, Lauren Schutz, Liqiang Zhang, Jordan R. Yaron, Qiuyun Guo, Michelle Burgin, Ian Hogue, Wesley Tierney, Wojciech Dobrowski, Alexandra R. Lucas
Summary: Progressive neurological damage following brain or spinal cord trauma leads to motor function loss, with limited treatment options. Early clotting and hemorrhage post SCI and TBI trigger immune cell activation and neuronal damage. Thrombotic and thrombolytic proteases play a role in both healing and damaging immune cell interactions, impacting neuron and glial cell growth.
CURRENT NEUROPHARMACOLOGY
(2021)
Review
Immunology
Colleen N. Bodnar, James B. Watson, Emma K. Higgins, Ning Quan, Adam D. Bachstetter
Summary: The text discusses the importance of CNS barriers and the impact of TBI on these barriers. It addresses both primary and secondary injuries on a cellular and molecular level, as well as their effects on rebuilding and inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Neurosciences
Erskine Chu, Richelle Mychasiuk, Tabitha R. F. Green, Akram Zamani, Larissa K. Dill, Rishabh Sharma, April L. Raftery, Evelyn Tsantikos, Margaret L. Hibbs, Bridgette D. Semple
Summary: The role of SHIP-1 in brain immune responses and tissue damage after pediatric TBI in mice is not essential, but reduced SHIP-1 activity induces a greater inflammatory response in the hippocampus chronically post-TBI.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Critical Care Medicine
Cece C. C. Kooper, Carlijn W. W. van der Zee, Jaap Oosterlaan, Frans B. B. Ploetz, Marsh Koenigs
Summary: Mild traumatic brain injury (mTBI) is common in children and can lead to neurocognitive deficits. However, there are currently no clinical tools for early identification of children at risk. This systematic review examines existing literature on prediction models for neurocognitive outcomes in children with mTBI. The findings highlight the importance of early identification and targeted treatment for optimizing recovery.
JOURNAL OF NEUROTRAUMA
(2023)
