Article
Cell Biology
Maria Bacova, Katarina Bimbova, Alexandra Kisucka, Nadezda Lukacova, Jan Galik
Summary: This study observed that long-lasting oscillating field stimulation (OFS) applied after spinal cord injury (SCI) can promote tissue repair and regeneration, increase the number of spared axons and oligodendrocytes, and improve sensory and motor functions in rats.
NEURAL REGENERATION RESEARCH
(2022)
Article
Medicine, Research & Experimental
Chao Fang, Jian Sun, Laifu Wei, Fei Gao, Jun Qian
Summary: This study demonstrated that oscillating field stimulation (OFS) enhanced the differentiation of endogenous neural stem cells (NSCs) into neurons and oligodendrocytes, and accelerated the regeneration of myelinated axons, resulting in improved locomotion recovery in a spinal cord injury (SCI) rat model.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Medicine, General & Internal
Soshi Samejima, Claire Shackleton, Raza N. Malik, Kawami Cao, Anibal Bohorquez, Tom E. Nightingale, Rahul Sachdeva, Andrei V. Krassioukov
Summary: Spinal cord injury (SCI) leads to severe cardiovascular dysfunction, and autonomic dysreflexia (AD) is one of the causes of high blood pressure in SCI patients. Recently, spinal cord stimulation (SCS) has been considered as a potential intervention to alleviate unstable blood pressure after SCI. This case series demonstrates the real-time effect of epidural SCS (eSCS) at the lumbosacral spinal cord in mitigating AD in individuals with SCI.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Neurosciences
Giuliano Taccola, Ronaldo M. Ichiyama, V. Reggie Edgerton, Parag Gad
Summary: This review discusses the physiological states of spinal networks, highlighting the stochastic modulation by changing ensembles of proprioceptive and supraspinal input. Spinal epidural interfaces offer a platform for studying spinal network dynamics post-injury. Low-frequency epidural pulses can evoke motor responses with oscillatory patterns. The neural variability among spinal networks is seen as a fundamental mechanism of network design rather than noise interfering with movement control.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Cell Biology
Yi-Xin Wang, Jin-Zhu Bai, Zhen Lyu, Guang-Hao Zhang, Xiao-Lin Huo
Summary: Oscillating field stimulation (OFS) is a potential method for treating spinal cord injury. The study found that continuous OFS for more than 6 weeks effectively promotes the recovery of motor function, possibly by promoting axon regeneration, inhibiting astrocyte proliferation, and improving linear arrangement of astrocytes.
NEURAL REGENERATION RESEARCH
(2022)
Article
Cell Biology
Chao Fang, Jian Sun, Jun Qian, Cai-Liang Shen
Summary: A combination of oscillating field stimulation and neural stem cells transplantation can improve motor function recovery and promote neurogenesis after spinal cord injury.
NEURAL REGENERATION RESEARCH
(2023)
Article
Medicine, General & Internal
Agnieszka Wincek, Juliusz Huber, Katarzyna Leszczynska, Wojciech Fortuna, Stefan Okurowski, Krzysztof Chmielak, Pawel Tabakow
Summary: High-frequency rTMS treatment in iSCI patients led to improvements in muscle electrical activity parameters, motor unit recruitment, and transmission of neural impulses in spinal pathways.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Jaclyn R. Wecht, William M. Savage, Grace O. Famodimu, Gregory A. Mendez, Jonah M. Levine, Matthew T. Maher, Joseph P. Weir, Jill M. Wecht, Jason B. Carmel, Yu-Kuang Wu, Noam Y. Harel
Summary: The study found that subthreshold TSCS can facilitate hand muscle responses to motor cortex stimulation, especially when the TSCS arrives simultaneously or slightly after the cortical stimulation, indicating the potential for enhanced synaptic plasticity in circuits serving hand function.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Clinical Neurology
Alice Lin, Elias Shaaya, Jonathan S. Calvert, Samuel R. Parker, David A. Borton, Jared S. Fridley
Summary: This review assesses the efficacy of spinal cord stimulation for individuals with chronic spinal cord injury. The results show that spinal cord stimulation can improve sensorimotor and autonomic function. However, further research and optimization are needed before clinical translation.
Article
Engineering, Environmental
Ting Li, Zhongbing Liu, Jingxuan Wang, Haoming Ye, Yujie Wan, Xingjie Du, Xiaoduan Sun, Meiling Zhou, Yan Lin, Pei Jing, Zhirong Zhong
Summary: This study developed zein-based spherical nanoparticles for targeted delivery of metformin to spinal cord injury. The nanoparticles showed anti-inflammatory and neuroprotective activities, promoting spinal cord repair and partial recovery of motor function.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Biomedical
Fatma Inanici, Lorie N. Brighton, Soshi Samejima, Christoph P. Hofstetter, Chet T. Moritz
Summary: Upper extremity paralysis post spinal cord injury greatly impacts independence and quality of life. Non-invasive transcutaneous electrical stimulation shows promising results in rapidly and sustainably restoring hand and arm function, reducing muscle spasticity, and improving autonomic functions. Long-term neuroplasticity may play a role in maintaining functional recovery beyond the stimulation period.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Hatice Kumru, Loreto Garcia-Alen, Aina Ros-Alsina, Sergiu Albu, Margarita Valles, Joan Vidal
Summary: This study aimed to investigate whether transcutaneous spinal cord stimulation (tSCS) could improve respiratory function in individuals with cervical spinal cord injury (cSCI). The results showed that subjects who received tSCS combined with inspiratory muscle training (IMT) experienced significant improvements in breathlessness/dyspnea, hypophonia, maximum inspiratory pressure (MIP), maximum expiratory pressure (MEP), and forced vital capacity. Therefore, tSCS may serve as an effective adjunctive therapy for respiratory impairments following SCI.
Article
Engineering, Biomedical
Noah Bryson, Lorenzo Lombardi, Rachel Hawthorn, Jie Fei, Rodolfo Keesey, J. D. Peiffer, Ismael Seanez
Summary: This study investigated whether muscle recruitment selectivity of individual muscles could be enhanced by multielectrode configurations of transcutaneous spinal cord stimulation (tSCS) in neurologically intact individuals. The results showed that multielectrode configurations improved the selectivity and activation of specific muscles, potentially enhancing single-joint movements in neurorehabilitation.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Engineering, Biomedical
Bi-Qin Lai, Xiang Zeng, Wei-Tao Han, Ming-Tian Che, Ying Ding, Ge Li, Yuan-Shan Zeng
Summary: For millennia, adult mammals have been unable to recover function lost after severe spinal cord injury due to a failure of brain-derived nerve fiber regeneration across the lesion. Various potential approaches rely on neuronal relays to reconnect the segregated neural networks of the spinal cord, including the use of stem cell-derived neuronal relays and functional electrical stimulation.
Article
Clinical Neurology
Samineh Mesbah, Tyler Ball, Claudia Angeli, Enrico Rejc, Nicholas Dietz, Beatrice Ugiliweneza, Susan Harkema, Maxwell Boakye
Summary: The study found that in individuals with clinically motor complete spinal cord injury, the extent of recovery of lower limb voluntary movements with scES is significantly influenced by the percentage of lumbosacral enlargement coverage by the electrode array and the position of the electrode relative to the lumbosacral enlargement and conus tip.
Article
Clinical Neurology
Mohamed Macki, Mohamed Fakih, Ilan Rubinfeld, Victor Chang, Beverly C. Walters
Review
Clinical Neurology
Christopher D. Shank, Jacob R. Lepard, Beverly C. Walters, Mark N. Hadley
Editorial Material
Clinical Neurology
Beverly C. Walters
Article
Clinical Neurology
Nicholas J. Erickson, Philip G. R. Schmalz, Bonita S. Agee, Matthew Fort, Beverly C. Walters, Benjamin M. McGrew, Winfield S. Fisher
Article
Clinical Neurology
Galal A. Elsayed, Esther B. Dupepe, Matthew S. Erwood, Matthew C. Davis, Samuel G. McClugage, Paul Szerlip, Beverly C. Walters, Mark N. Hadley
JOURNAL OF NEUROSURGERY-SPINE
(2019)
Article
Clinical Neurology
Galal Elsayed, Samuel G. McClugage, Matthew S. Erwood, Matthew C. Davis, Esther B. Dupepe, Paul Szerlip, Beverly C. Walters, Mark N. Hadley
JOURNAL OF NEUROSURGERY-SPINE
(2019)
Article
Clinical Neurology
Kimberly P. Kicielinski, Esther B. Dupepe, Amber S. Gordon, Nancy E. Mayo, Beverly C. Walters
Letter
Clinical Neurology
Mark N. Hadley, Christopher D. Shank, Curtis J. Rozzelle, Beverly C. Walters
Article
Clinical Neurology
Esther B. Dupepe, Kimberly P. Kicielinski, Amber S. Gordon, Beverly C. Walters
Article
Clinical Neurology
Christopher D. Shank, Nicholas J. Erickson, David W. Miller, Brittany F. Lindsey, Beverly C. Walters
Article
Clinical Neurology
Christopher D. Shank, Elizabeth N. Kuhn, Mark N. Hadley, Beverly C. Walters
Letter
Clinical Neurology
Beverly C. Walters, Mark N. Hadley
Review
Clinical Neurology
Thomas Zervos, Beverly C. Walters
WORLD NEUROSURGERY
(2019)
Editorial Material
Clinical Neurology
Sameah A. Haider, Christopher D. Shank, Beverly C. Walters
Review
Medicine, General & Internal
Galal A. Elsayed, Joshua Y. Menendez, Borna E. Tabibian, Gustavo Chagoya, Nidal B. Omar, Evan Zeiger, Beverly C. Walters, Harrison Walker, Barton L. Guthrie
CUREUS JOURNAL OF MEDICAL SCIENCE
(2019)