Structural and Functional Insights into the HIV-1 Maturation Inhibitor Binding Pocket

Context Surrounding Processing Sites Is Crucial in Determining Cleavage Rate of a Subset of Processing Sites in HIV-1 Gag and Gag-Pro-Pol Polyprotein Precursors by Viral Protease

(2012) Sook-Kyung Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the immature retroviral capsid at 8 Å resolution by cryo-electron microscopy

(2012) Tanmay A. M. Bharat et al.   NATURE

A Single Polymorphism in HIV-1 Subtype C SP1 Is Sufficient To Confer Natural Resistance to the Maturation Inhibitor Bevirimat

(2011) Wuxun Lu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

On the Role of the SP1 Domain in HIV-1 Particle Assembly: a Molecular Switch?

(2011) S. A. K. Datta et al.   JOURNAL OF VIROLOGY

The prototype HIV-1 maturation inhibitor, bevirimat, binds to the CA-SP1 cleavage site in immature Gag particles

(2011) Albert T Nguyen et al.   Retrovirology

High prevalence of natural polymorphisms in Gag (CA-SP1) associated with reduced response to Bevirimat, an HIV-1 maturation inhibitor

(2010) Eduardo Seclén et al.   AIDS

NMR Relaxation Studies of an RNA-Binding Segment of the Rous Sarcoma Virus Gag Polyprotein in Free and Bound States: A Model for Autoinhibition of Assembly

(2010) Gwen M. Taylor et al.   BIOCHEMISTRY

HIV-1 Maturation Inhibitor Bevirimat Stabilizes the Immature Gag Lattice

(2010) P. W. Keller et al.   JOURNAL OF VIROLOGY

Polymorphisms in Gag spacer peptide 1 confer varying levels of resistance to the HIV-1 maturation inhibitor bevirimat

(2010) Catherine S. Adamson et al.   Retrovirology

Susceptibility of Human Immunodeficiency Virus Type 1 to the Maturation Inhibitor Bevirimat Is Modulated by Baseline Polymorphisms in Gag Spacer Peptide 1

(2009) K. Van Baelen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

New Small-Molecule Inhibitor Class Targeting Human Immunodeficiency Virus Type 1 Virion Maturation

(2009) W. S. Blair et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Novel approaches to inhibiting HIV-1 replication

(2009) Catherine S. Adamson et al.   ANTIVIRAL RESEARCH

X-Ray Structures of the Hexameric Building Block of the HIV Capsid

(2009) Owen Pornillos et al.   CELL

Virus maturation as a new HIV-1 therapeutic target

(2009) Catherine S Adamson et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Impact of Human Immunodeficiency Virus Type 1 Resistance to Protease Inhibitors on Evolution of Resistance to the Maturation Inhibitor Bevirimat (PA-457)

(2009) C. S. Adamson et al.   JOURNAL OF VIROLOGY

The structural biology of HIV assembly

(2008) Barbie K Ganser-Pornillos et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Critical Role of Conserved Hydrophobic Residues within the Major Homology Region in Mature Retroviral Capsid Assembly

(2008) J. G. Purdy et al.   JOURNAL OF VIROLOGY