Article
Cell Biology
Xing Yang, Rumeng Jia, Fan Hu, Wen Fan, Tongtong Lin, Xiaotao Zhang, Chenjie Xu, Shirong Ruan, Chunyi Jiang, Yan Li, Cailong Pan, Yang Yang, Liang Hu, Qi Chen, Wen-Tao Liu
Summary: This study aimed to illustrate the role of macrophage scavenger receptor A1 (SR-A1) in the clearance of high-mobility group box 1 (HMGB1) and resolution of chemotherapy-induced peripheral neuropathy (CIPN). The results showed that AMP-activated protein kinase (AMPK) activation increased macrophage-mediated HMGB1 engulfment and degradation, leading to the alleviation of CIPN.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Microbiology
Nikeya L. Tisdale, Alan Ashbaugh, Keeley Hendrix, Margaret S. Collins, Alexey P. Porollo, Melanie T. Cushion
Summary: This article discusses the importance of considering sex differences in disease research and suggests the inclusion of females in experimental models.
Article
Immunology
Zhuo-Qian Zhang, Francis Gigliotti, Terry W. Wright
Summary: Pneumocystis is a respiratory fungal pathogen that causes life-threatening pneumonia in immunocompromised hosts. M2 polarized macrophages have been found to be effective against Pneumocystis. The drug sulfasalazine has shown dual benefits in immune reconstitution inflammatory syndrome by suppressing immunopathogenesis and accelerating fungal clearance.
INFECTION AND IMMUNITY
(2023)
Article
Immunology
Huan-Yi Wu, Kuan-Sheng Wu, Yi-Luan Huang, Shr-Hau Dai, Ding-Yu Chang, Shu-Hung Kuo, Shun-Yi Chen, Chih-Chen Chou, Ya-Wei Weng, Yu-Ting Tseng, Jui-Kuang Chen, Cheng-Len Sy, Hung-Chin Tsai, Susan Shin-Jung Lee, Yao-Shen Chen
Summary: Radiological predictors identified through chest CT scans can help differentiate pulmonary coinfections in patients with PCP, which is crucial for improving prognosis. Lack of ground glass opacity and presence of pleural effusion were predictors for bacterial pneumonia, while diffuse consolidation and presence of pleural effusion were predictors for fungal pneumonia.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Immunology
Peng Gu, Ruofan Liu, Qin Yang, Li Xie, Rongjuan Wei, Jiaxin Li, Fengyi Mei, Tao Chen, Zhenhua Zeng, Yan He, Hongwei Zhou, Hongjuan Peng, Kutty Selva Nandakumar, Huikuan Chu, Yong Jiang, Wei Gong, Ye Chen, Bernd Schnabl, Peng Chen
Summary: The level of Candida albicans was decreased in bacterial sepsis patients, and the supernatant of Candida albicans culture showed bactericidal activity and improved sepsis symptoms. Phenylpyruvate (PPA) derived from Candida albicans enhanced the bactericidal activity of macrophages by binding to SIRT2 and increasing ROS production. PPA also correlated with the severity of sepsis in patients, highlighting the role of commensal fungi in bacterial disease modulation.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Oncology
Ian Y. Zhang, Shunan Liu, Leying Zhang, Rongrui Liang, Qingxiao Fang, Jie Zhao, Lyuzhi Ren, Eric F. Medina, Aleksandr Filippov, Kimberley-Jane Bonjoc, Ammar Chaudhry, Mojtaba Dayyani, Andrea H. Bild, Behnam Badie
Summary: Through genetic ablation of RAGE in two murine glioma models, we found that intracellular RAGE ablation suppresses tumor growth and invasion by suppressing AKT and ERK1/2 activities and downregulating MMP9 expression. In addition, RAGE inhibition enhances tumor inflammatory responses and potentiates the efficacy of immune checkpoint blockade therapy.
Article
Immunology
Laura McCulloch, Alison J. Harris, Alexandra Malbon, Michael J. D. Daniels, Mehwish Younas, John R. Grainger, Stuart M. Allan, Craig J. Smith, Barry W. McColl
Summary: Post-stroke infection is a common complication of stroke, and the ablation of B cells and reduction in IgM antibody levels after stroke could increase susceptibility to infection. Treatment with IgM-enriched intravenous immunoglobulin (IgM-IVIg) improves bacterial clearance from the lung and lung pathology after stroke, and induces immunomodulatory effects systemically. IgM-IVIg shows promise as a treatment for post-stroke infection.
Article
Cell Biology
Hongjian Hou, Gabriel Komla Adzika, Qi Wu, Tongtong Ma, Yanhong Ma, Juan Geng, Mingjin Shi, Lu Fu, Ruqayya Rizvi, Zheng Gong, Hong Sun
Summary: Postmenopausal women are predisposed to chronic stress-induced cardiomyopathy, and estrogen plays a protective role by modulating the phenotypes of cardiomyocytes and macrophages, enhancing cardiac reparative functions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Critical Care Medicine
Feng Ruan, Jing Chen, Jianxin Yang, Guirong Wang
Summary: Mild traumatic brain injury attenuates pneumonia-induced acute lung injury through the modulation of alveolar macrophage bactericidal capacity and M1 polarization in a bacterial pneumonia model.
Article
Biotechnology & Applied Microbiology
Juin-Hong Cherng, Shu-Jen Chang, Yaw-Kwan Chiu, Yu-Hsiang Chiu, Tong-Jing Fang, Hsiang-Cheng Chen
Summary: In this study, a low molecular weight sericin was extracted and its biological effects on macrophages and human adipose stem cells were investigated, showing good biocompatibility and potential in promoting wound healing. The findings provide valuable insights into the application of LMW-sericin as a biomaterial for wound management.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Microbiology
Wu Song, Li Wang, Yinghua Zhao, Gongga Lanzi, Xingye Wang, Chi Zhang, Jiyu Guan, Wei Wang, Xuerui Guo, Ying Meng, Bingmei Wang, Yicheng Zhao
Summary: We identified hibifolin as a sortase A (SrtA) inhibitor that attenuated the pathogenicity of Staphylococcus aureus. Hibifolin directly targeted SrtA, reducing adhesion and biofilm formation in the bacteria. It improved survival rates in mice infected with MRSA and showed synergistic antibacterial effects with cefotaxime.
MICROBIOLOGY SPECTRUM
(2022)
Article
Multidisciplinary Sciences
Satoshi Fukuda, Yosuke Niimi, Yasutaka Hirasawa, Ennert R. Manyeza, C. Edwin Garner, Garry Southan, Andrew L. Salzman, Donald S. Prough, Perenlei Enkhbaatar
Summary: The novel compound R-107 effectively reduced microvascular hyperpermeability and improved multi-organ function in an ovine sepsis model by modulating oxidative/nitrosative stress. Treatment with R-107 significantly lowered fluid requirements, net fluid balance, and water content in organs, while also reducing lung injury scores, arterial lactate levels, and inflammatory markers in plasma.
SCIENTIFIC REPORTS
(2021)
Article
Infectious Diseases
Takahiro Nunokawa, Naofumi Chinen, Kota Shimada, Makiko Kimura, Mutsuto Tateishi, Fang Yi Chen, Keigo Setoguchi, Makoto Sugihara
Summary: This study found that sulfasalazine has a preventive effect against Pneumocystis pneumonia (PCP) in patients with rheumatoid arthritis (RA) through a self-controlled case series method.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2023)
Article
Immunology
Dan Ma, Qian-Yu Zhang, Heng-Mo Rong, Kan Zhai, Zhao-Hui Tong
Summary: This study investigated exosomes derived from B lymphocytes in response to Pneumocystis pneumonia (PCP) using quantitative proteomics. The results showed that these exosomes play a role in immune response and transcription regulation, and have a proinflammatory effect on CD4(+) T cell response in PCP.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Immunology
Jessica Amanda Marques Souza, Isabella Luisa da Silva Gurgel, Nathalia Luisa Sousa de Oliveira Malacco, Flavia Rayssa Braga Martins, Celso Martins Queiroz-Junior, Mauro Martins Teixeira, Frederico Marianetti Soriani
Summary: This study investigates the potential of Aspergillus fumigatus extracellular vesicles (EVs) as an immunization tool. The findings show that pre-exposure to EVs can induce specific antibody production, reduce inflammation, improve lung tissue damage, and enhance fungus clearance. Immunization with EVs combined with Amphotericin B treatment can rescue mice from lethal fungal pneumonia.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)