Review
Immunology
Iara M. M. Backes, David A. A. Leib, Margaret E. E. Ackerman
Summary: The fetal/neonatal period is a critical stage for interventions and also a vulnerable period for viral infections. Maternal transfer of antibodies can reduce the risk of neonatal herpes simplex virus (nHSV) infections. Exploring the combination of antibody-based interventions and antiviral therapy is important for reducing infant mortality and long-term morbidity.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Christine Johnston
Summary: This article discusses the management of genital herpes infection and provides recommendations based on a systematic literature review, serving as a basis for updating the treatment guidelines.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Virology
Richard J. Roller, Tineke Hassman, Alison Haugo-Crooks
Summary: The study found that substituting the HSV-1 UL34 coding sequence with VZV ORF24 resulted in viral defects in growth and spread, despite normal protein interaction and localization. Cell culture evolution showed that the mutated viruses grew and spread more efficiently, revealing the important roles of ICP22 and ICP4 in nuclear lamina disruption and capsid nuclear egress.
JOURNAL OF VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Michael Wainberg, Tain Luquez, David M. Koelle, Ben Readhead, Christine Johnston, Martin Darvas, Cory C. Funk
Summary: Recent studies have reignited interest in the hypothesis that infectious agents, particularly herpesviruses, may contribute to Alzheimer's disease pathogenesis. These studies suggest that many key features of Alzheimer's disease, like amyloid beta production and neuroinflammation, may actually be protective responses to acute infection that become maladaptive in the case of chronic infection.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Zhuoying Feng, Fanghang Zhou, Miaomiao Tan, Tingting Wang, Ying Chen, Wenwen Xu, Bin Li, Xin Wang, Xin Deng, Ming-Liang He
Summary: HSV-1 infection enhances the expression of m6A modification-related genes to facilitate viral replication, while inhibiting m6A modification reduces viral replication and reproduction.
Review
Pharmacology & Pharmacy
Qingqing Shao, Tong Liu, Wenjia Wang, Tianli Liu, Ximing Jin, Zhuo Chen
Summary: Emodin is a versatile anthraquinone derivative with various pharmacological effects including antibacterial, anti-inflammatory, anti-fibrotic, and anticancer activities. Studies have shown that emodin can inhibit the infection and replication of numerous viruses both in vitro and in vivo, making it a potential candidate for antiviral therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nesrine Baatallah, Ahmad Elbahnsi, Benoit Chevalier, Solene Castanier, Jean-Paul Mornon, Iwona Pranke, Aleksander Edelman, Isabelle Sermet-Gaudelus, Isabelle Callebaut, Alexandre Hinzpeter
Summary: A second-site mutation near the CFTR MSD1 groove partially rescued the folding defect caused by cystic fibrosis mutations in MSD1, providing insights into the key features of folding and function of the CFTR protein and type IV ABC transporters in general.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Kerry J. Laing, Werner J. D. Ouwendijk, Victoria L. Campbell, Christopher L. McClurkan, Shahin Mortazavi, Michael Elder Waters, Maxwell P. Krist, Richard Tu, Nhi Nguyen, Krithi Basu, Congrong Miao, D. Scott Schmid, Christine Johnston, Georges M. G. M. Verjans, David M. Koelle
Summary: This study reveals that varicella-zoster virus-specific T cells preferentially persist as tissue-resident-memory T cells in the rash-involved skin after recovery from zoster, indicating their importance in controlling skin infections.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Yuliya Mindarava, Remi Blinder, Valery A. Davydov, Mustapha Zaghrioui, Viatcheslav N. Agafonov, Cecile Autret, Priyadharshini Balasubramanian, Raul Gonzalez Brouwer, Fedor Jelezko
Summary: The article demonstrates the synthesis of core-shell diamond nanoparticles with nitrogen-vacancy centers and naturally abundant C-13 in the core and highly isotopically enriched shell. The particles were formed by overgrowth on previously electron-irradiated nanodiamonds under high-pressure high-temperature conditions. The research showed promising potential for these particles in transferring spin polarization and hyperpolarization of nuclear spins in a fluid environment.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Article
Biochemistry & Molecular Biology
Giorgia Napoletani, Virginia Protto, Maria Elena Marcocci, Lucia Nencioni, Anna Teresa Palamara, Giovanna De Chiara
Summary: This study investigated the impact of recurrent HSV-1 infection on neuronal aging, revealing a significant increase in H4K16ac, Sin3, and HDAC1 levels, which are related to aging markers. There was a significant decrease in H3K56ac specifically linked to viral reactivation, and a complex modulation of HIRA expression and localization in HSV-1 infected mouse brains, suggesting a specific role of this protein in viral latency and reactivation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Yuliya Mindarava, Remi Blinder, Valery A. Davydov, Mustapha Zaghrioui, Viatcheslav N. Agafonov, Cecile Autret, Priyadharshini Balasubramanian, Raul Gonzalez Brouwer, Fedor Jelezko
Summary: This article discusses the synthesis of core-shell diamond nanoparticles with nitrogen-vacancy (NV-) centers and isotopically enriched C-13, formed by overgrowth on previously electron-irradiated nanodiamonds. These particles have potential for hyperpolarizing nuclear spins in fluids.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Article
Immunology
Yasmin Schmitz, Mara Schwerdtfeger, Jaana Westmeier, Elisabeth Littwitz-Salomon, Mira Alt, Leonie Brochhagen, Adalbert Krawczyk, Kathrin Sutter
Summary: Research shows that different subtypes of type I interferons exhibit subtype-specific differences in reducing local viral loads in genital HSV-1 infections. IFN beta has the strongest antiviral efficacy against the virus, while IFN alpha 1, IFN alpha 4, and IFN alpha 11 have no impact on viral loads. The study also reveals subtype-specific modulations of the antiviral immunity during HSV-1 infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Medicine, General & Internal
Fadi Shahoud, Mobeen H. Rathore, Chetan C. Shah, Rana Alissa
Summary: This case series explores the different manifestations of central nervous system (CNS) involvement in neonatal herpes simplex virus (HSV) infection and highlights the challenges in diagnosis and treatment. Neonatal HSV infection is a rare but serious condition with potential neurological consequences. The article presents three cases, each with distinct clinical features and outcomes. While early diagnosis and treatment are important, some cases may still have a poor prognosis.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Virology
Kati Tormanen, Shaohui Wang, Harry H. Matundan, Jack Yu, Ujjaldeep Jaggi, Homayon Ghiasi
Summary: The latency-associated transcript (LAT) of herpes simplex virus 1 (HSV-1) plays a significant role in the establishment of latency and reactivation. This study reveals that LAT contains two small noncoding RNAs (sncRNAs) that control the expression of the herpesvirus entry mediator (HVEM) by activating its promoter. These findings provide insights into the pathogenesis and regulation of latency in HSV-1.
JOURNAL OF VIROLOGY
(2022)
Review
Microbiology
Sajal Deea Shukla, Tibor Valyi-Nagy
Summary: HSV-1 is a human virus that causes lifelong infections and can lead to various diseases, including blindness and central nervous system diseases. Host molecules play important roles in the infection process, including immune response, autophagy, and inflammation. Understanding the interaction between the virus and host molecules is essential for developing effective treatments.
FRONTIERS IN MICROBIOLOGY
(2022)
Editorial Material
Microbiology
Karen L. Mossman, Sandra K. Weller
CELL HOST & MICROBE
(2015)
Review
Virology
Samantha Smith, Sandra K. Weller
Article
Biochemistry & Molecular Biology
Alexandra K. Pozhidaeva, Kareem N. Mohni, Sirano Dhe-Paganon, Cheryl H. Arrowsmith, Sandra K. Weller, Dmitry M. Korzhnev, Irina Bezsonova
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Virology
Anthar S. Darwish, Lorry M. Grady, Ping Bai, Sandra K. Weller
JOURNAL OF VIROLOGY
(2016)
Article
Microbiology
Dianne I. Lou, Eui Tae Kim, Nicholas R. Meyerson, Neha J. Pancholi, Kareem N. Mohni, David Enard, Dmitri A. Petrov, Sandra K. Weller, Matthew D. Weitzman, Sara L. Sawyer
CELL HOST & MICROBE
(2016)
Review
Microbiology
Sandra K. Weller, James A. Sawitzke
ANNUAL REVIEW OF MICROBIOLOGY, VOL 68
(2014)
Article
Virology
Samantha Smith, Nina Reuven, Kareem N. Mohni, April J. Schumacher, Sandra K. Weller
JOURNAL OF VIROLOGY
(2014)
Article
Virology
Brandon S. Albright, Athena Kosinski, Renata Szczepaniak, Elizabeth A. Cook, Nigel D. Stow, James F. Conway, Sandra K. Weller
JOURNAL OF VIROLOGY
(2015)
Article
Multidisciplinary Sciences
Savithri Weerasooriya, Katherine A. DiScipio, Anthar S. Darwish, Ping Bai, Sandra K. Weller
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Virology
Mitali Adlakha, Christine M. Livingston, Irina Bezsonova, Sandra K. Weller
JOURNAL OF VIROLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Willie Taylor, Emily Camilleri, D. Levi Craft, George Korza, Maria Rocha Granados, Jaliyah Peterson, Renata Szczpaniak, Sandra K. Weller, Ralf Moeller, Thierry Douki, Wendy W. K. Mok, Peter Setlow
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2020)
Editorial Material
Biochemistry & Molecular Biology
Sandra K. Weller, Neal A. Deluca
Summary: The dynamic interactions between invading viral pathogens and their hosts, particularly the ability of herpes simplex virus (HSV) to establish life-long infections in humans, are governed by a balance between maintaining a latent state and re-entering the lytic phase during reactivation. This balance is influenced by innate immune signaling, intrinsic cellular antiviral mechanisms, and epigenetic repression of the viral genome. The study by Suzich et al. (2021) provides a comprehensive model that integrates individual observations and sheds light on the mechanisms underlying viral genome repression and latency.
Article
Immunology
Matthew D. Hall, James M. Anderson, Annaliesa Anderson, David Baker, Jay Bradner, Kyle R. Brimacombe, Elizabeth A. Campbell, Kizzmekia S. Corbett, Kara Carter, Sara Cherry, Lillian Chiang, Tomas Cihlar, Emmie de Wit, Mark Denison, Matthew Disney, Courtney Fletcher, Stephanie L. Ford-Scheimer, Matthias Gotte, Abigail C. Grossman, Frederick G. Hayden, Daria J. Hazuda, Charlotte A. Lanteri, Hilary Marston, Andrew D. Mesecar, Stephanie Moore, Jennifer O. Nwankwo, Jules O'Rear, George Painter, Kumar Singh Saikatendu, Celia A. Schiffer, Timothy P. Sheahan, Pei-Yong Shi, Hugh D. Smyth, Michael J. Sofia, Marla Weetall, Sandra K. Weller, Richard Whitley, Anthony S. Fauci, Christopher P. Austin, Francis S. Collins, Anthony J. Conley, Mindy Davis
Summary: The NIH Virtual SARS-CoV-2 Antiviral Summit aimed to provide an overview of the status and challenges in developing antiviral therapeutics for COVID-19, with the goals of reviewing the current science, sharing insights, and identifying opportunities for collaboration.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Microbiology
Katherine A. DiScipio, Savithri Weerasooriya, Renata Szczepaniak, Akram Hazeen, Lee R. Wright, Dennis L. Wright, Sandra K. Weller
Summary: Most drug discovery efforts against herpesviruses have focused on nucleoside analogs, but this study proposes a new strategy targeting two-metal ion-dependent viral enzymes. The results showed weak activity of integrase inhibitors and inhibition of HSV-1 and CMV by 8-hydroxyquinolines. The compounds exhibited antiviral activity through different mechanisms, providing an opportunity for the development of dual-targeting agents against herpesviruses.
Article
Microbiology
Katherine A. DiScipio, Savithri Weerasooriya, Renata Szczepaniak, Akram Hazeen, Lee R. Wright, Dennis L. Wright, Sandra K. Weller
Summary: The research focused on targeting viral enzymes based on two-metal ion-dependent strategy. It was found that integrase inhibitors exhibited weak activity against HSV-1, while 8-hydroxyquinolines could inhibit both HSV-1 and cytomegalovirus, providing an opportunity for the development of dual-targeting agents against herpesviruses.