Article
Multidisciplinary Sciences
Yoshan Moodley, Andrea Brunelli, Silvia Ghirotto, Andrey Klyubin, Ayas S. Maady, William Tyne, Zilia Y. Munoz-Ramirez, Zhemin Zhou, Andrea Manica, Bodo Linz, Mark Achtman
Summary: The study reveals the coevolutionary history of Helicobacter pylori with humans pre-dating the out-of-Africa diaspora, as well as the genetic relationships between Siberians and Native Americans. The genetic diversity of bacteria across Eurasia and the Americas is structured into three populations, with Siberian bacteria showing both ancient divergence and recent admixture.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Denise Bellotti, Angelica Sinigaglia, Remo Guerrini, Erika Marzola, Magdalena Rowinska-Zyrek, Maurizio Remelli
Summary: The study focused on the role of histidines in metal ion coordination, comparing the binding affinities for Cu(II), Ni(II), and Zn(II), as well as understanding Hpn's ability to form ternary and poly nuclear complexes. The results showed that histidines in position 4 and 8 lead to Cu(II) binuclear complex formation. The ATCUN motif is the most efficient binding site for Cu(II) and Ni(II), while Zn(II) complexes are formed due to the presence of suitable anchoring sites.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Mathematical & Computational Biology
Li Jiao, Junmin Wang, Huan Ma
Summary: Choosing the right treatment plan is crucial, but current triple drug combination therapies for eradicating Helicobacter pylori are not yielding ideal results, and altering drug types and dosages has shown limited success. This study analyzes drug resistance rates of H. pylori, cultivates clinical isolates, determines antibiotic sensitivity, and provides a unique eradication treatment strategy based on experimental analyses and successful treatment plans.
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
(2021)
Review
Immunology
Nina Gorle, Eva Bauwens, Freddy Haesebrouck, Annemieke Smet, Roosmarijn E. Vandenbroucke
Summary: Trillions of symbiotic microbial cells colonize our body, with a larger portion residing in the human gut. Changes in gut microbiota have been linked to various diseases, including neurological disorders. Helicobacter species, particularly H. suis, may play a role in neurological disorders via the microbiome-gut-brain axis, but further research is needed to understand their impact on the brain.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Md Saidur Rahman, Khandkar Shaharina Hossain, Sharnali Das, Sushmita Kundu, Elikanah Olusayo Adegoke, Md Ataur Rahman, Md Abdul Hannan, Md Jamal Uddin, Myung-Geol Pang
Summary: Insulin, a polypeptide hormone secreted mainly by pancreatic beta cells, coordinates with glucagon to regulate blood glucose levels. It induces glucose storage in the liver, muscles, and adipose tissue, leading to overall weight gain. The modulation of physiological processes by insulin is crucial in the onset and progression of various diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Karl Aramouni, Roland K. Assaf, Maria Azar, Karen Jabbour, Abdullah Shaito, Amirhossein Sahebkar, Assaad A. Eid, Manfredi Rizzo, Ali H. Eid
Summary: Atherosclerosis is a major contributor to cardiovascular disease and traditional risk factors explain only half of its etiology. Helicobacter pylori infection, although controversial, may play a potential role in the pathogenesis of atherosclerosis. Further research is needed to establish the association between H. pylori and atherosclerosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Environmental Sciences
Ian W. Tang, Peter H. Langlois, Veronica M. Vieira
Summary: This study found that in Texas, living within the highest tertile of unconventional natural gas development density within 1 km of maternal address was associated with some congenital heart defects and possibly neural tube defects.
ENVIRONMENTAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Megan T. Zangara, Isabel Johnston, Erin E. Johnson, Christine McDonald
Summary: NOD1 and NOD2, in addition to their roles as bacterial sensors, have been implicated in metabolic diseases, showing differential effects in mouse models despite sharing signaling pathway components. These receptors may mediate signaling through cell stressors or metabolic signals in metabolic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Leila Sadeghalbanaei, Farinaz Shirban, Mohammad Bagherniya, Thozhukat Sathyapalan, Amirhossein Sahebkar
Summary: High-density lipoprotein (HDL) is a small and dense lipoprotein with various functions including cardiovascular protection, structural support, anti-inflammatory properties, antioxidant effects, anti-thrombotic effects, transportation of molecules, and induction of signaling pathways. The relationship between HDL concentration and oral health has not been comprehensively studied, but there is a potential significant association between them. This review summarizes the current knowledge and suggests further investigation of the association between HDL and various oral diseases.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Polymer Science
Jan Malecki, Siemowit Muszynski, Bartosz G. Solowiej
Summary: This review article discusses the increasing popularity of proteins in various food products, the sources and roles of proteins, their nutritional value and functional properties, as well as their applications in the food industry and bionanomaterials. The paper also examines the health benefits and risks of consuming high-protein products, current market trends, and consumer preferences in response to the expected increase in demand.
Review
Microbiology
Victor E. Reyes
Summary: Helicobacter pylori infection is a major risk factor for gastric cancer and is associated with chronic inflammation and DNA damage. Understanding the mechanisms of H. pylori-induced carcinogenesis and immune evasion is crucial for preventing gastric cancer and reducing the burden of this disease.
Review
Gastroenterology & Hepatology
Grigorios Leontiadis, George F. Longstreth
Summary: Evolutionary medicine integrates various scientific disciplines to provide explanations for the causes of many diseases, improving physicians' understanding of disease processes, care, and research.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Immunology
Yujiao Lai, Hori Masatoshi, Yanbo Ma, Yuming Guo, Bingkun Zhang
Summary: This review explores the role of vitamin K in intestinal health, including its sources, absorption, and deficiency. It focuses on the effects of vitamin K supplementation on immunity, anti-inflammation, intestinal microbes and their metabolites, antioxidation, coagulation, and epithelial development. The review also highlights the importance of vitamin K-dependent proteins in gastroprotection, anti-inflammation, immunomodulation, and anti-tumorigenesis. Although preliminary studies show the beneficial effects of vitamin K on intestinal health, the specific mechanisms have yet to be fully elucidated.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Agronomy
Alwyn Tan, Mo Salman, Bruce Wagner, Brian McCluskey
Summary: Biosurveillance is the process of gathering, integrating, interpreting, and communicating essential information related to threats or diseases affecting human, animal, or plant health. Animal health surveillance is an important part of biosurveillance systems and can contribute to early detection, situational awareness, and better decision making. This paper explores the components of a biosurveillance system from an animal health perspective and identifies opportunities to enhance biosurveillance in the animal health community.
Article
Nutrition & Dietetics
Man Hung, Wendy C. Birmingham, Monica Ocampo, Amir Mohajeri
Summary: Cardiovascular diseases (CVD) are the leading cause of death in the United States. This study aimed to determine the association between reported CVD and serum 25-hydroxyvitamin D [25(OH)D]. Using data from the National Health and Nutrition Examination Survey, the study found that deficiency and insufficiency of 25(OH)D were associated with CVD, while adequacy of 25(OH)D was not. Healthcare professionals may consider vitamin D supplementation to improve cardiovascular health in adults for CVD prevention.
Article
Immunology
Laura E. Martinez, Valerie P. O'Brien, Christina K. Leverich, B. Sue E. Knoblaugh, Nina R. Salama
INFECTION AND IMMUNITY
(2019)
Article
Microbiology
Desiree C. Yang, Kris M. Blair, Jennifer A. Taylor, Timothy W. Petersen, Tate Sessler, Christina M. Tull, Christina K. Leverich, Amanda L. Collar, Timna J. Wyckoff, Jacob Biboy, Waldemar Vollmer, Nina R. Salama
JOURNAL OF BACTERIOLOGY
(2019)
Review
Microbiology
Jennifer A. Taylor, Sophie R. Sichel, Nina R. Salama
ANNUAL REVIEW OF MICROBIOLOGY, VOL 73
(2019)
Article
Biology
Jennifer A. Taylor, Benjamin P. Bratton, Sophie R. Sichel, Kris M. Blair, Holly M. Jacobs, Kristen E. DeMeester, Erkin Kuru, Joe Gray, Jacob Biboy, Michael S. VanNieuwenhze, Waldemar Vollmer, Catherine L. Grimes, Joshua W. Shaevitz, Nina R. Salama
Review
Microbiology
Nina R. Salama
CURRENT OPINION IN MICROBIOLOGY
(2020)
Editorial Material
Biochemistry & Molecular Biology
Sophie R. Sichel, Nina R. Salama
Article
Multidisciplinary Sciences
Michael Bauer, Zuzana Nascakova, Anca-Irina Mihai, Phil F. Cheng, Mitchell P. Levesque, Simon Lampart, Robert Hurwitz, Lennart Pfannkuch, Jana Dobrovolna, Melanie Jacobs, Sina Bartfeld, Anders Dohlman, Xiling Shen, Alevtina A. Gall, Nina R. Salama, Antonia Toepfer, Achim Weber, Thomas F. Meyer, Pavel Janscak, Anne Mueller
NATURE COMMUNICATIONS
(2020)
Article
Microbiology
Laura K. Jackson, Barney Potter, Sean Schneider, Matthew Fitzgibbon, Kris Blair, Hajirah Farah, Uma Krishna, Trevor Bedford, Richard M. Peek, Nina R. Salama
Article
Biology
Valerie P. O'Brien, Amanda L. Koehne, Julien Dubrulle, Armando E. Rodriguez, Christina K. Leverich, V. Paul Kong, Jean S. Campbell, Robert H. Pierce, James R. Goldenring, Eunyoung Choi, Nina R. Salama
Summary: This study reveals the significant impact of Hp infection on the progression of gastric precancerous lesions, using transgenic mice with active KRAS expression to mimic the process induced by Hp infection. Hp infection can exacerbate T-cell infiltration and macrophage polarization, leading to more metaplastic and dysplastic glands.
LIFE SCIENCE ALLIANCE
(2021)
Article
Biology
Sophie R. Sichel, Benjamin P. Bratton, Nina R. Salama
Summary: The helical shape of Helicobacter pylori cells is determined by a protein complex involving the bactofilin CcmA, peptidoglycan-hydrolase Csd1, and transmembrane proteins Csd5 and Csd7. CcmA's bactofilin domain and N-terminal region are necessary for helical cell shape, and its bactofilin domain is capable of polymerization and interacting with Csd5 and Csd7. CcmA helps organize cell-shape-determining proteins and promotes proper cell wall modification and synthesis.
Article
Microbiology
V. P. O'Brien, L. K. Jackson, J. P. Frick, A. E. Rodriguez Martinez, D. S. Jones, C. D. Johnston, N. R. Salama
Summary: Chronic infection with Helicobacter pylori is the primary risk factor for developing stomach cancer. In a transgenic mouse gastric metaplasia model, H. pylori strains from unrelated individuals differed in their ability to infect the stomach and colonize metaplastic glands. Genetic variation in a cell surface adhesin gene called sabB was associated with the ability to colonize the diseased stomach environment.
Meeting Abstract
Oncology
Dornell Pete, Amanda I. Phipps, Nina R. Salama, Johanna W. Lampe, Michael C. Wu
Meeting Abstract
Oncology
Dornell Pete, Amanda I. Phipps, Nina R. Salama, Johanna W. Lampe, Michael C. Wu
Meeting Abstract
Oncology
Valerie Phoebe O'Brien, William C. Young, Greg Finak, Raphael Gottardo, Nina R. Salama
Meeting Abstract
Biophysics
Benjamin P. Bratton, Jennifer A. Taylor, Nicholas R. Martin, Edith S. Blackman, Nina R. Salama, Zemer Gitai, Joshua W. Shaevitz
BIOPHYSICAL JOURNAL
(2020)