Article
Microbiology
Brian F. Niemeyer, Bridget Sanford, Joy E. Gibson, Jennifer N. Berger, Lauren M. Oko, Eva Medina, Eric T. Clambey, Linda F. van Dyk
Summary: Research has shown that the viral cyclin plays a critical role in promoting the transition of gammaherpesviruses from latency to active infection by affecting the frequency of LANA gene expression. Disruption of the viral cyclin significantly reduces the expression frequency of the LANA gene, without affecting the distribution of infected cells, but is crucial for reactivation.
Article
Virology
Brandon Cieniewicz, Varvara Kirillov, Isabel Daher, Xiaofan Li, Darby G. Oldenburg, Qiwen Dong, Julie A. Bettke, Kenneth B. Marcu, Laurie T. Krug
Summary: The noncanonical NF-kappa B signaling pathway plays a critical role in the establishment of latency in secondary lymphoid organs of mice infected with the murine gammaherpesvirus pathogen MHV68, particularly in relation to BAFF-R. Blocking this pathway in infected cells showed reduced latency in mice in a route- and cell type-dependent manner.
JOURNAL OF VIROLOGY
(2022)
Article
Microbiology
C. N. Jondle, K. E. Johnson, C. Aurubin, P. Sylvester, G. Xin, W. Cui, A. R. Huppler, V. L. Tarakanova
Summary: Gammaherpesviruses establish lifelong infections and are associated with B cell lymphomas. This study reveals a novel proviral role of host interleukin 17A (IL-17A) in the establishment of chronic gammaherpesvirus infection and gammaherpesvirus-driven germinal center response. IL-17A signaling promotes viral infection following mucosal route, lytic replication, and reactivation from latency.
Article
Virology
C. N. Jondle, V. L. Tarakanova
Summary: This study reveals that T cell-intrinsic IL-17RA signaling plays a crucial role in promoting the MHV68-driven germinal center response by supporting CD4(+) T follicular helper cell expansion. It also contributes to the systemic proviral role of IL-17RA signaling, highlighting the multifaceted function of IL-17RA signaling during MHV68 infection.
JOURNAL OF VIROLOGY
(2022)
Article
Microbiology
Tiffany R. Frey, Ibukun A. Akinyemi, Eric M. Burton, Sumita Bhaduri-McIntosh, Michael T. McIntosh
Summary: Research has shown a potential link between the expression of human endogenous retroviruses (HERVs) and the lytic activation of human gammaherpesviruses, with the HERV-W envelope protein Syncytin-1 playing a role in lytic activation and contributing to cell cycle progression. This suggests that EBV and KSHV have adapted a dependency on Syncytin-1 to facilitate lytic replication activation from latency, while also promoting viral persistence by contributing to B cell proliferation.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Ana Citlali Marquez, Carys Croft, Iryna Shanina, Marc Steven Horwitz
Summary: Epstein-Barr virus has been found to trigger multiple sclerosis-like disease in mice, and B cells from infected mice play an important role in this process. However, type I IFN signaling does not directly affect the enhancement of the disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
P. A. Sylvester, C. N. Jondle, D. L. Schmalzriedt, B. N. Dittel, V. L. Tarakanova
Summary: Interferons are crucial for controlling viral infections, and STAT1 plays a critical role in IFN responses. However, T cell-specific STAT1 expression has an unexpected proviral effect during gammaherpesvirus infection.
Article
Multidisciplinary Sciences
Hui-Chen Chang Foreman, Varvara Kirillov, Gabrielle Paniccia, Demetra Catalano, Trevor Andrunik, Swati Gupta, Laurie T. Krug, Yue Zhang
Summary: The study investigates the editing of murine gammaherpesvirus using the Cas9-gRNA CRISPR system, resulting in mutations corresponding to the target regions in cell culture. Cells stably expressing Cas9 and gRNAs show resistance to viral replication, while reactivation of the virus is reduced by 50% in cells expressing gRNAs. The findings suggest that Cas9-gRNA editing of the murine gammaherpesvirus genome has a deleterious impact on productive replication.
Article
Multidisciplinary Sciences
Zhe Huang, Seung Goo Kang, Yunqiao Li, Jaroslav Zak, Namir Shaabani, Kaiyuan Deng, Jovan Shepherd, Raag Bhargava, John R. Teijaro, Changchun Xiao
Summary: Inhibition of IFN-I signaling in NK cells enhances the responses of CD4 and CD8 T cells, promotes humoral immune responses, and thereby facilitates the control of persistent virus infection.
Article
Microbiology
Claudia Gandolfo, Chiara Terrosi, Shibily Prathyumnan, Gabriele Anichini, Gianni Gori Savellini, Giuseppe Morgante, Maria Grazia Cusi
Summary: This study utilized HUVECs as an in vitro model to investigate ZIKV infection, revealing that HUVECs are an optimal reservoir for viral replication and can sustain infection for up to two weeks without causing cytopathic effects. The presence of immune system components such as PMNs was found to play a crucial role in altering endothelial cell junctions, suggesting that these components may promote the spread of ZIKV in vivo in the bloodstream.
Article
Biochemistry & Molecular Biology
Yang Xu, Guoli Hou, Qizhi Liu, Qiushi Zhang, Chun Li, Liang Hu, Xiaoying Chen, Rui Chen, Chengming Ding, Deliang Li, Junhua Li
Summary: This study reveals a helicase-independent effector-like function of RIG-I against murine gamma herpesviruses 68, which involves blocking the nuclear trafficking of viral proteins and suppressing viral transcription and replication.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Microbiology
Yiping Wang, Scott A. Tibbetts, Laurie T. Krug
Summary: Gammaherpesviruses have evolved specifically to infect their respective hosts, with human gammaherpesviruses not naturally infecting nonhuman primates or rodents. Research into gammaherpesvirus pathogenesis, host control, and immune evasion is crucial for understanding infection and virus-associated cancers. Recent advancements in understanding how gammaherpesviruses colonize hosts and drive disease provide insights for interventions against infections and cancers associated with these viruses.
ANNUAL REVIEW OF VIROLOGY, VOL 8
(2021)
Article
Virology
C. N. Jondle, K. E. Johnson, W. P. Mboko, V. L. Tarakanova
Summary: This study demonstrates that the global expression of the antiviral and tumor suppressor interferon regulatory factor 1 (IRF-1) attenuates the murine gammaherpesvirus 68 (MHV68)-driven germinal center response and restricts the expansion of the latent viral reservoir. T cell-intrinsic IRF-1 expression also replicates aspects of the antiviral state during chronic MHV68 infection. Additionally, IRF-1 is identified as a negative regulator of IL-17-driven immune responses in chronic gammaherpesvirus infection.
JOURNAL OF VIROLOGY
(2021)
Article
Immunology
Ziang Zhu, Tong Li, Jinya Chen, Jai Kumar, Princy Kumar, Jing Qin, Colleen Hadigan, Irini Sereti, Jason V. Baker, Marta Catalfamo
Summary: This study examines the impact of HIV infection on endothelial inflammation and repair by evaluating cell phenotypes and subsets in the blood of HIV-infected individuals. The researchers found that infection-induced phenotypic changes were associated with inflammatory biomarkers, suggesting that HIV infection may affect endothelial inflammation and repair.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Isobel C. Mouat, Zachary J. Morse, Iryna Shanina, Kelly L. Brown, Marc S. Horwitz
Summary: The study found that latent gammaherpesvirus infection enhances clinical arthritis without actively stimulating the immune response. Additionally, age-associated B cells are mechanistically required for viral enhancement of disease and provoke arthritis, although the exact mechanisms are still not well understood.
Article
Virology
Lisa M. Williams, Brian F. Niemeyer, David S. Franklin, Eric T. Clambey, Linda F. van Dyk
JOURNAL OF VIROLOGY
(2015)
Article
Immunology
X. Zhou, H. Loomis-King, S. J. Gurczynski, C. A. Wilke, K. E. Konopka, C. Ptaschinski, S. M. Coomes, Y. Iwakura, L. F. van Dyk, N. W. Lukacs, B. B. Moore
MUCOSAL IMMUNOLOGY
(2016)
Article
Microbiology
Kevin W. Diebel, Lauren M. Oko, Eva M. Medina, Brian F. Niemeyer, Cody J. Warren, David J. Claypool, Scott A. Tibbetts, Carlyne D. Cool, Eric T. Clambey, Linda F. van Dyk
Article
Microbiology
Emily R. Feldman, Mehmet Kara, Lauren M. Oko, Katrina R. Grau, Brian J. Krueger, Junjie Zhang, Pinghui Feng, Linda F. van Dyk, Rolf Renne, Scott A. Tibbetts
Article
Immunology
Andrew Getahun, Scott M. Wemlinger, Pratyaydipta Rudra, Mario L. Santiago, Linda F. van Dyk, John C. Cambier
JOURNAL OF EXPERIMENTAL MEDICINE
(2017)
Article
Immunology
Abigail K. Kimball, Lauren M. Oko, Bonnie L. Bullock, Raphael A. Nemenoff, Linda F. van Dyk, Eric T. Clambey
JOURNAL OF IMMUNOLOGY
(2018)
Article
Virology
Brian F. Niemeyer, Lauren M. Oko, Eva M. Medina, Darby G. Oldenburg, Douglas W. White, Carlyne D. Cool, Eric T. Clambey, Linda F. van Dyk
JOURNAL OF VIROLOGY
(2018)
Article
Physiology
Shanna L. Ashley, Yangjin Jegal, Thomas A. Moore, Linda F. van Dyk, Yasmina Laouar, Bethany B. Moore
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2014)
Article
Genetics & Heredity
Kevin W. Diebel, David J. Claypool, Linda F. van Dyk
Article
Immunology
Michael L. Freeman, Claire E. Burkum, Tres Cookenham, Alan D. Roberts, Kathleen G. Lanzer, Gail E. Huston, Meghan K. Jensen, John Sidney, Bjoern Peters, Jacob E. Kohlmeier, David L. Woodland, Linda F. van Dyk, Alessandro Sette, Marcia A. Blackman
JOURNAL OF IMMUNOLOGY
(2014)
Article
Multidisciplinary Sciences
Qun Wu, Di Jiang, Chunjian Huang, Linda F. van Dyk, Liwu Li, Hong Wei Chu
Article
Multidisciplinary Sciences
Kira Rubtsova, Anatoly V. Rubtsov, Linda F. van Dyk, John W. Kappler, Philippa Marrack
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2013)
Article
Microbiology
Emily R. Feldman, Mehmet Kara, Carrie B. Coleman, Katrina R. Grau, Lauren M. Oko, Brian J. Krueger, Rolf Renne, Linda F. van Dyk, Scott A. Tibbetts
Article
Microbiology
Lauren M. Oko, Abigail K. Kimball, Rachael E. Kaspar, Ashley N. Knox, Carrie B. Coleman, Rosemary Rochford, Tim Chang, Benjamin Alderete, Linda F. van Dyk, Eric T. Clambey
Article
Virology
Ashley N. Knox, Alice Mueller, Eva M. Medina, Eric T. Clambey, Linda F. van Dyk
Summary: This study investigated the regulation of pol III promoters and transcripts during gammaherpesvirus infection, revealing that lytic infection with gamma HV68 increased transcription from multiple host and viral pol III promoters. Additionally, induction of endogenous pol III-derived ncRNAs correlated tightly with viral gene expression, demonstrating how lytic gammaherpesvirus infection alters the transcriptional landscape of host cells to enhance host and viral noncoding RNA expression.
JOURNAL OF VIROLOGY
(2021)