Cofactor-Independent Phosphoglycerate Mutase from Nematodes Has Limited Druggability, as Revealed by Two High-Throughput Screens

Structural role of the active-site metal in the conformation of Trypanosoma brucei phosphoglycerate mutase

(2012) Gustavo F. Mercaldi et al.   FEBS Journal

Molecular modeling, dynamics, and an insight into the structural inhibition of cofactor independent phosphoglycerate mutase isoform 1 fromWuchereria bancroftiusing cheminformatics and mutational studies

(2012) Om Prakash Sharma et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Aggregating Behavior of Phenolic Compounds — A Source of False Bioassay Results?

(2012) Leena Pohjala et al.   MOLECULES

High-throughput Screening and Sensitized Bacteria Identify an M. tuberculosis Dihydrofolate Reductase Inhibitor with Whole Cell Activity

(2012) Anuradha Kumar et al.   PLoS One

A Research Agenda for Helminth Diseases of Humans: The Problem of Helminthiases

(2012) Sara Lustigman et al.   PLoS Neglected Tropical Diseases

Molecular Motions as a Drug Target: Mechanistic Simulations of Anthrax Toxin Edema Factor Function Led to the Discovery of Novel Allosteric Inhibitors

(2012) Élodie Laine et al.   Toxins

Allosteric Inhibitor Development Targeting HIV-1 Integrase

(2011) Laith Q. Al-Mawsawi et al.   ChemMedChem

Filariasis in Africa—treatment challenges and prospects

(2011) A. Hoerauf et al.   CLINICAL MICROBIOLOGY AND INFECTION

Rapid Analysis of Pharmacology for Infectious Diseases

(2011) Andrew L. Hopkins et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Allosteric inhibition of the hepatitis C virus NS5B polymerase:in silicostrategies for drug discovery and development

(2011) Maria Letizia Barreca et al.   Future Medicinal Chemistry

PubChem's BioAssay Database

(2011) Y. Wang et al.   NUCLEIC ACIDS RESEARCH

Innovative Partnerships for Drug Discovery against Neglected Diseases

(2011) Palle H. Jakobsen et al.   PLoS Neglected Tropical Diseases

Structural models in the assessment of protein druggability based on HTS data

(2009) Anvita Gupta et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

A Mapping of Drug Space from the Viewpoint of Small Molecule Metabolism

(2009) James Corey Adams et al.   PLoS Computational Biology

Advancing Drug Innovation for Neglected Diseases—Criteria for Lead Progression

(2009) Solomon Nwaka et al.   PLoS Neglected Tropical Diseases

‘Metabolite-likeness’ as a criterion in the design and selection of pharmaceutical drug libraries

(2008) Paul D. Dobson et al.   DRUG DISCOVERY TODAY

Identification and Characterization of Small Molecule Inhibitors ofPlasmodium falciparumDihydroorotate Dehydrogenase

(2008) Vishal Patel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prior killing of intracellular bacteria Wolbachia reduces inflammatory reactions and improves antifilarial efficacy of diethylcarbamazine in rodent model of Brugia malayi

(2008) Shilpy Shakya et al.   PARASITOLOGY RESEARCH