Review
Medicine, General & Internal
David A. Montero, Roberto M. Vidal, Juliana Velasco, Sergio George, Yalda Lucero, Leonardo A. Gomez, Leandro J. Carreno, Richard Garcia-Betancourt, Miguel O'Ryan
Summary: This review provides an overview of the causative agent of cholera, Vibrio cholerae, including its evolution, pathogenesis, and the immune response against it. It highlights the adaptability of V. cholerae and its virulence factors, as well as the importance of vaccination in controlling cholera outbreaks. The review also discusses current and future vaccine developments.
FRONTIERS IN MEDICINE
(2023)
Review
Chemistry, Medicinal
Denise Chac, Chelsea N. Dunmire, Jasneet Singh, Ana A. Weil
Summary: This review discusses the host and environmental factors that impact susceptibility to V. cholerae infection and disease severity, emphasizing the ingestion of drinking water contaminated with fecal matter as the primary route of cholera transmission.
ACS INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Stephanie C. Garbern, Tzu-Chun Chu, Phillip Yang, Monique Gainey, Sabiha Nasrin, Samika Kanekar, Kexin Qu, Eric J. Nelson, Daniel T. Leung, Dilruba Ahmed, Christopher H. Schmid, Nur H. Alam, Adam C. Levine
Summary: The study revealed a high prevalence of MDR Vibrio cholerae O1 among patients over five in an urban hospital in Bangladesh. Factors such as prior antibiotic use, longer transport time to hospital, and higher income were associated with MDR.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Microbiology
Bolutife Fakoya, Karthik Hullahalli, Daniel H. F. Rubin, Deborah R. Leitner, Roma Chilengi, David A. Sack, Matthew K. Waldor
Summary: This study created next-generation cholera challenge strains and demonstrated their accuracy and safety in measuring immunity and vaccine effectiveness.
Article
Immunology
Paul Breen, Andrew D. Winters, Kevin R. Theis, Jeffrey H. Withey
Summary: Zebrafish are a popular model organism for studying host-microbe interactions, and Vibrio cholerae infections significantly modulate the zebrafish intestinal microbiome, with the type six secretion system (T6SS) playing a crucial role in inducing mucin secretion and pathogenesis. Different strains of V. cholerae, with or without T6SS, lead to distinct changes in the composition and structure of the intestinal microbiome, highlighting the importance of T6SS in altering host microbial profiles.
INFECTION AND IMMUNITY
(2021)
Article
Multidisciplinary Sciences
Tanzeel Zohra, Aamer Ikram, Muhammad Salman, Afreenish Amir, Asim Saeed, Zurva Ashraf, Abdul Ahad
Summary: The study in Pakistan detected toxigenic V. cholerae in environmental samples, indicating the potential presence of cholera in various regions of the country. There was no clear seasonal pattern in the detection results, but factors like poor sanitation, temperature, and rainfall could influence the frequency and duration of cholera outbreaks across the country.
Article
Infectious Diseases
Naveen Chaudhary, Balvinder Mohan, Harpreet Kaur, Vinay Modgil, Vishal Kant, Alka Bhatia, Neelam Taneja
Summary: Cholera, a disease primarily occurring in developing countries with inadequate sanitation, is caused by Vibrio cholerae which has developed resistance to multiple drugs. In this study, a phage called VMJ710 was isolated from sewage water and shown to effectively kill multidrug-resistant V. cholerae strains. The phage was stable across different environmental conditions and could disrupt bacterial biofilms. It also demonstrated therapeutic and prophylactic potential in animal models. The genetic analysis revealed similarities with a dominant phage found in cholera patients. Overall, the phage VMJ710 could be a promising candidate for combatting MDR V. cholerae infections.
Article
Food Science & Technology
Fabian Rivera-Chavez, Bradley T. Meader, Sinan Akosman, Vuk Koprivica, John J. Mekalanos
Summary: Vibrio cholerae uses its toxin to cause cholera, but a study found that a compound called benzopyrimido-pyrrolo-oxazinedione (BPO-27) can inhibit the toxin-induced symptoms, protecting mice from diarrhea and death. BPO-27 also suppresses the replication and survival of V. cholerae in the gut.
Article
Microbiology
Kaoru Ochi, Tamaki Mizuno, Prosenjit Samanta, Asish K. Mukhopadhyay, Shin-ichi Miyoshi, Daisuke Imamura
Summary: Cholera, caused by pathogenic strains of V. cholerae generated by lysogenization of the filamentous cholera toxin phage CTX Phi, has recently shown alterations in the CTX Phi prophage array, resulting in an inability to replicate the genome. This change suggests a significant shift in the dissemination pattern of the current cholera pandemic.
Article
Microbiology
Haeun Kim, Brianne J. Burkinshaw, Linh G. Lam, Kevin Manera, Tao G. Dong
Summary: This study identified two compounds that effectively target the growth of V. cholerae, potentially providing a new approach to control cholera infections.
MICROBIOLOGY SPECTRUM
(2021)
Article
Immunology
Pan Lu, Jialiang Chen, Zhenpeng Li, Zhe Li, Jingyun Zhang, Biao Kan, Bo Pang
Summary: In this study, a CARID system was developed for rapid detection of toxigenic V. cholerae serogroups. The system showed rapid, sensitive, economically efficient, and portable features, and was suitable for detecting complex samples.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Dustin A. Farr, Dhrubajyoti Nag, Jeffrey H. Withey
Summary: The study reveals that zebrafish can serve as a natural host model for Vibrio cholerae, exhibiting similar diarrheal symptoms as humans. By assessing various immunological markers, it was found that infection with V. cholerae in zebrafish leads to increased gene expression of T-bet and GATA3, as well as elevated levels of mucosal antibodies.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biophysics
Tanaya Chatterjee, Tultul Saha, Paramita Sarkar, Kazi Mirajul Hoque, Barun K. Chatterjee, Pinak Chakrabarti
Summary: Formation of biofilm by Vibrio cholerae is crucial in cholera pathogenesis and transmission. Gold nanoparticles show potential as an effective alternative to antibiotics in targeting biofilms and virulence factors. Among the different sizes and shapes of AuNPs tested, AuNS100 appears to be the most effective in inhibiting biofilm formation and destruction, as well as disrupting the production and function of cholera toxin.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Immunology
Paul Breen, Andrew D. Winters, Kevin R. Theis, Jeffrey H. Withey
Summary: Zebrafish provide an attractive model for studying host-microbe interactions, with the core intestinal microbiome primarily consisting of Proteobacteria. Vibrio cholerae can significantly alter the zebrafish intestinal microbiome, with different strains inducing varying changes. Specific microbes targeted by V. cholerae for colonization in zebrafish hosts depend on the genotype of the V. cholerae strain.
INFECTION AND IMMUNITY
(2021)
Review
Immunology
X. Renee Bina, James E. Bina
Summary: Resistance Nodulation Division (RND) efflux systems are widespread in gram-negative bacteria and play a critical role in protecting against antimicrobial agents and promoting survival in various environments. Vibrio cholerae is a dual lifestyle enteric pathogen that colonizes the intestines and causes cholera diarrhea in humans. Understanding the physiological functions of RND efflux systems and their interactions with the regulation of virulence factor production in V. cholerae can provide insights into the mechanisms of bacterial survival and pathogenesis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)