Journal
OPHTHALMIC SURGERY LASERS & IMAGING RETINA
Volume 46, Issue 6, Pages 638-641Publisher
SLACK INC
DOI: 10.3928/23258160-20150610-07
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- Research to Prevent Blindness
- Heed Ophthalmic Foundation
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BACKGROUND AND OBJECTIVE: To quantitatively evaluate the change in pigment epithelial detachment (PED) morphology on spectral-domain optical coherence tomography (SD-OCT) 18 months after the transition to intravitreal aflibercept in patients with neovascular age-related macular degeneration (AMD) with PED recalcitrant to monthly intravitreal bevacizumab or ranibizumab. PATIENTS AND METHODS: Retrospective case series examining patients with neovascular AMD who had a persistent fibrovascular or serous PED on SD-OCT. PED volume was calculated by manually outlining the PED on individual OCT slices of the raster scan and multiplying by the pixel dimensions. RESULTS: Eleven eyes of 10 patients who had received an average of 25.7 +/- 20.1 (range: 6 to 70) prior bevacizumab or ranibizumab injections over a period of 26.6 +/- 19.8 months (range: 4 to 63) were included. PED volume decreased with aflibercept from 0.687 +/- 0.837 mm(3) to 0.562 +/- 0.705 mm(3) (P = .02), a decrease of 19% +/- 12.27%. CONCLUSION: After 18 months of aflibercept, recalcitrant PED volumes were reduced by 19% while preserving visual acuity in eyes with neovascular AMD.
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