Editorial Material
Infectious Diseases
Fang Huang, Li Zhang, Zhi-Gui Xia
Summary: This article highlights China's practices and experience in targeting vivax malaria control and elimination, including radical cure strategies, comprehensive but adaptive strategies, mass drug administration, and case-/focus-centered surveillance and response systems. After nearly 70 years of effort, China was certified as a malaria-free country in June 2021.
INFECTIOUS DISEASES OF POVERTY
(2023)
Review
Microbiology
Carola Schafer, Gigliola Zanghi, Ashley M. Vaughan, Stefan H. I. Kappe
Summary: Plasmodium vivax, the most widespread human malaria parasite, can form latent liver stages known as hypnozoites which can activate weeks, months, or even years after the primary infection, causing relapses of blood stage infection. Eliminating hypnozoites is a major obstacle for malaria treatment and eradication as they are undetectable and unaffected by most antimalarial drugs.
ANNUAL REVIEW OF MICROBIOLOGY, VOL 75, 2021
(2021)
Editorial Material
Multidisciplinary Sciences
Jui A. Shah
Summary: This commentary reviews the success factors for Thailand to achieve zero malaria, focusing on effective surveillance, and discusses other measures needed to reach the goal on time.
NATURE COMMUNICATIONS
(2022)
Article
Public, Environmental & Occupational Health
Colleen M. Leonard, Hussein Mohammed, Mekonnen Tadesse, Jessica N. McCaffery, Doug Nace, Eric S. Halsey, Samuel Girma, Ashenafi Assefa, Jimee Hwang, Eric Rogier
Summary: This study investigated whether mixed infections were missed by microscopy in a therapeutic efficacy study in Ethiopia. The results showed that even with multiple trained readers, microscopy can miss P. falciparum/P. vivax mixed infections.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Microbiology
Ipsita Pal Bhowmick, Tulika Nirmolia, Apoorva Pandey, Sarala K. Subbarao, Aatreyee Nath, Susmita Senapati, Debabrata Tripathy, Rocky Pebam, Suman Nag, Rajashree Roy, Dipanjan Dasgupta, Jayanta Debnath, Kongkona Gogoi, Karuna Gogoi, Lakhyajit Borah, Rajdeep Chanda, Arup Borgohain, Chelapro Mog, Ujjwal Sarkar, Phiroz Gogoi, Bishal Debnath, Jyotish Debbarma, Dibya Ranjan Bhattacharya, Pyare Lal Joshi, Harpreet Kaur, Kanwar Narain
Summary: A study in Tripura, India found a significant burden of P. vivax malaria cases and mixed infections with P. vivax and P. falciparum during mass surveillance in dry winter months. Molecular diagnostic techniques detected a high proportion of asymptomatic infections, emphasizing the importance of screening for malarial reservoirs in pre-Jhum months.
Review
Parasitology
Nikhat Khan, Gauri Awasthi, Aparup Das
Summary: Malaria is a significant health hazard in tropical and subtropical areas, with the goal of elimination by 2030. Despite a decrease in incidence, countries like India continue to report cases regularly. The unique epidemiology of malaria in India, including specific parasite and vector characteristics, conducive ecoepidemiological situations, and vulnerable populations in rural and forested areas, poses challenges to public health efforts. However, targeted elimination is still achievable through planned programmatic approaches.
TRENDS IN PARASITOLOGY
(2023)
Review
Infectious Diseases
Loick P. Kojom Foko, Aditi Arya, Amit Sharma, Vineeta Singh
Summary: This study conducted a systematic review and meta-analysis of Indian literature on severe vivax malaria, providing evidence for P. vivax as the etiologic agent of severe malaria leading to deaths in some cases. Further research is needed on SVM in pregnancy, SVM in drug resistance, and correlations with cytoadherence in disease severity due to P. vivax.
JOURNAL OF INFECTION
(2021)
Article
Immunology
Yanie Tayipto, Jason Rosado, Dionicia Gamboa, Michael T. T. White, Benson Kiniboro, Julie Healer, D. Herbert Opi, James G. G. Beeson, Eizo Takashima, Takafumi Tsuboi, Matthias Harbers, Leanne Robinson, Ivo Mueller, Rhea J. J. Longley
Summary: A surveillance tool has been developed to detect total IgG as a serological marker of recent Plasmodium vivax exposure. However, its performance is poorer in areas with moderate-high transmission intensity. Study results suggest that shorter-lived antibodies may be better markers in these settings. IgG3 antibody levels were found to be positively associated with increasing age, higher transmission intensity, and multiple P. vivax infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Ying Liu, Tao Zhang, Shen-Bo Chen, Yan-Bing Cui, Shu-Qi Wang, Hong-Wei Zhang, Hai-Mo Shen, Jun-Hu Chen
Summary: This study retrospectively reported the whole-genome sequence variation of 10 Plasmodium vivax isolates from inland China, aiming to investigate the molecular epidemiology during the pre-elimination stage. The results showed that China's inland population was highly structured with a single potential ancestor. Furthermore, selective signatures of drug resistance genes were identified, and an increase in the proportion of wild-type dhps and dhfr-ts after the prohibition of specific drugs was observed.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Infectious Diseases
Barbara Aparecida Chaves, Denise Anete Madureira de Alvarenga, Matheus de Oliveira Costa Pereira, Marcelo Gordo, Emanuelle L. Da Silva, Edson Rodrigues Costa, Aline Souza de Menezes Medeiros, Igor Jose Martins Pedrosa, Daniela Brito, Mauricio Teixeira Lima, Maria Paula Mourao, Wuelton M. Monteiro, Nikos Vasilakis, Cristiana Ferreira Alves de Brito, Gisely C. Melo, Marcus V. G. Lacerda
Summary: The study found natural Plasmodium vivax infection in some Neotropical monkeys, indicating a potential contribution of NHP infection to the transmission of malaria to humans. Discussions on wildlife conservation and management should be included in the agenda for malaria elimination.
Article
Immunology
Fang Huang, Yanwen Cui, Zhuoying Huang, Siqi Wang, Shigang Li, Xiangrui Guo, Xiang Guo, Zhi-Gui Xia
Summary: China declared malaria-free in June 2021. Serological surveillance conducted in Yingjiang County, China, revealed a risk of malaria exposure in the post-elimination setting. The study emphasizes the importance of continued surveillance to evaluate the risk of malaria re-establishment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Parasitology
Yanie Tayipto, Zoe Liu, Ivo Mueller, Rhea J. Longley
Summary: Plasmodium vivax is the most prevalent cause of human malaria worldwide, and despite efforts to control the disease, case reduction rates have decreased in recent years. Surveillance of malaria transmission levels is crucial, with serological tools providing valuable insights especially as transmission declines. Antibodies can remain in the host system for extended periods after parasite clearance, highlighting the importance of understanding antibody longevity and measuring antibodies to multiple antigens for accurate assessment of population exposure and immune status.
PARASITOLOGY INTERNATIONAL
(2022)
Article
Immunology
Suelen Queiroz Diniz, Maria Marta Figueiredo, Pedro Augusto Carvalho Costa, Olindo Assis Martins-Filho, Andrea Teixeira-Carvalho, Dhelio Batista Pereira, Mauro Shugiro Tada, Luis Carlos Crocco Afonso, Markus Kohlhoff, Carlos Leomar Zani, Ricardo Tostes Gazzinelli, Fabiano Oliveira, Lis Ribeiro Antonelli
Summary: This study reveals that monocytes in patients with malaria produce high levels of inflammatory cytokines and also have a regulatory role through specific receptors, suggesting a dual role of monocytes in malaria.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Narimane Nekkab, Raquel Lana, Marcus Lacerda, Thomas Obadia, Andre Siqueira, Wuelton Monteiro, Daniel Villela, Ivo Mueller, Michael White
Summary: The study evaluates the impact of introducing tafenoquine into case management practices on population-level transmission dynamics using a mathematical model of P. vivax transmission. The introduction of tafenoquine is predicted to improve effective hypnozoite clearance among P. vivax cases and reduce population-level transmission over time.
Article
Biology
Tobias Mourier, Denise Anete Madureira de Alvarenga, Abhinav Kaushik, Anielle de Pina-Costa, Olga Douvropoulou, Qingtian Guan, Francisco J. Guzman-Vega, Sarah Forrester, Filipe Vieira Santos de Abreu, Cesare Bianco Junior, Julio Cesar de Souza Junior, Silvia Bahadian Moreira, Zelinda Maria Braga Hirano, Alcides Pissinatti, Maria de Fatima Ferreira-da-Cruz, Ricardo Lourenco de Oliveira, Stefan T. Arold, Daniel C. Jeffares, Patricia Brasil, Cristiana Ferreira Alves de Brito, Richard Culleton, Claudio Tadeu Daniel-Ribeiro, Arnab Pain
Summary: Plasmodium simium, a malaria parasite of non-human primates, likely originated in South America from Plasmodium vivax and has recently acquired the ability to infect humans. Genetic analysis suggests that specific gene deletions in P. simium, especially in the Duffy-binding protein 1 (DBP1), may play a role in its ability to invade human red blood cells, leading to recent zoonotic infections.
Article
Health Care Sciences & Services
Gaurav Kumar, Veena Pande, Shweta Pasi, Vijay P. Ojha, Ramesh C. Dhiman
Article
Environmental Sciences
Soma Sarkar, Vinay Gangare, Poonam Singh, Ramesh C. Dhiman
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2019)
Article
Health Care Sciences & Services
Soma Sarkar, Poonam Singh, Mercy Aparna L. Lingala, Preeti Verma, Ramesh C. Dhiman
Article
Multidisciplinary Sciences
Ruchi Singh Parihar, Prasanta Kumar Bal, Vaibhav Kumar, Saroj Kanta Mishra, Sandeep Sahany, Popat Salunke, Sushil Kumar Dash, Ramesh Chand Dhiman
SCIENTIFIC REPORTS
(2019)
Article
Infectious Diseases
Mrigendra Pal Singh, Sunil Kumar Chand, Kalyan Brata Saha, Neetiraj Singh, Ramesh C. Dhiman, Lora L. Sabin
Article
Public, Environmental & Occupational Health
Mercy Aparna L. Lingala, Poonam Singh, Preeti Verma, Ramesh C. Dhiman
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2020)
Article
Public, Environmental & Occupational Health
Malay Pramanik, Poonam Singh, Gaurav Kumar, V. P. Ojha, Ramesh C. Dhiman
Article
Infectious Diseases
Malay Pramanik, Poonam Singh, Ramesh C. Dhiman
Summary: The study aimed to understand the bio-climatic determinants of KFD tick distribution in southern India using the MaxEnt model. The results showed that the most influential variables affecting Haemaphysalis spinigera spatial distribution were related to temperature and precipitation.
BMC INFECTIOUS DISEASES
(2021)
Article
Entomology
Suman Lata, Gaurav Kumar, V. P. Ojha, Ramesh C. Dhiman
Summary: This study found an endemic focus of cutaneous leishmaniasis (CL) coexisting with visceral leishmaniasis (VL) in the Sutlej River Valley in Himachal Pradesh, India. The sand flies Phlebotomus longiductus and Phlebotomus major were identified as possible vectors for CL in the region. Leishmania donovani infection was detected in sand flies collected from CL endemic villages, highlighting the epidemiological significance of the findings for vector control strategies in India.
JOURNAL OF MEDICAL ENTOMOLOGY
(2022)
Article
Environmental Sciences
Syed Shah Areeb Hussain, Ramesh C. Dhiman
Summary: This study used species distribution modeling to predict the current and future distribution of Aedes aegypti and Aedes albopictus vectors in India. The results indicate that Aedes aegypti is prevalent in most parts of southern India, the eastern coastline, northeastern states, and the northern plains, while Aedes albopictus has localized distribution in the eastern and western coastlines, northeastern states, and lower Himalayas. Future scenarios of climate change may lead to the expansion of Aedes aegypti in unsuitable regions and Aedes albopictus in the upper and trans Himalaya regions.
Article
Public, Environmental & Occupational Health
Namita Soni, Ramesh C. Dhiman
PARASITE EPIDEMIOLOGY AND CONTROL
(2020)
Article
Infectious Diseases
S. Haq, Gaurav Kumar, Ramesh C. Dhiman
JOURNAL OF VECTOR BORNE DISEASES
(2019)
Review
Infectious Diseases
Ramesh C. Dhiman, Poonam Singh, Yogesh Yadav, Shweta Saraswat, Gaurav Kumar, R. K. Singh, V. P. Ojha, B. C. Joshi, Pankaj Singh
JOURNAL OF VECTOR BORNE DISEASES
(2019)
Article
Immunology
Ramesh Dhiman, Neena Valecha
INDIAN JOURNAL OF MEDICAL RESEARCH
(2019)
Article
Immunology
Preeti Verma, Soma Sarkar, Poonam Singh, Ramesh C. Dhiman
INDIAN JOURNAL OF MEDICAL RESEARCH
(2017)