4.5 Editorial Material

Ears of the Armadillo: Global Health Research and Neglected Diseases in Texas

Journal

PLOS NEGLECTED TROPICAL DISEASES
Volume 7, Issue 6, Pages -

Publisher

PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pntd.0002021

Keywords

-

Funding

  1. NIAID NIH HHS [R01 AI099483] Funding Source: Medline

Ask authors/readers for more resources

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.5
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Public, Environmental & Occupational Health

Addressing high cervical cancer rates in the Rio Grande Valley along the Texas-Mexico border: a community-based initiative focused on education, patient navigation, and medical provider training/telementoring

M. P. Salcedo, R. Gowen, A. M. Rodriguez, S. Fisher-Hoch, M. Daheri, L. Guerra, P. A. Toscano, M. Gasca, J. Morales, F. E. Reyna-Rodriguez, B. Cavazos, E. Marin, C. Perez, M. Guerra, A. Milbourne, M. L. Varon, B. Reininger, M. E. Fernandez, T. Ogburn, P. E. Castle, J. McCormick, E. Baker, E. Hawk, K. M. Schmeler

Summary: By implementing a comprehensive intervention program, including community education, patient navigation, and training for local providers, a large number of women in the Rio Grande Valley were able to receive diagnosis and treatment for cervical dysplasia. If sustained, these efforts are expected to decrease cervical cancer rates in the region.

PERSPECTIVES IN PUBLIC HEALTH (2023)

Article Public, Environmental & Occupational Health

Diagnosis of Acute Chagas Disease in a Belizean Child with Evidence of a Multiclonal Trypanosoma cruzi Infection

Kristy O. Murray, Miguel A. Saldana, Sarah M. Gunter, Russell Manzanero, Emily Zielinski-Gutierrez, Claudia Herrera, Julie M. Thompson, Adrianna Maliga, Kim Bautista, Allison Lino, Ella Hawes, Shannon E. Ronca, Francis Morey, Rafael Chacon Fuentes, Beatriz Lopez, Eric Dumonteil, Gerhaldine H. Morazan

Summary: In January 2020, acute febrile illness surveillance was conducted in 11 hospitals and clinics across Belize, leading to the diagnosis of the first known case of acute Chagas infection in the country. Molecular analysis revealed a multiclonal Trypanosoma cruzi infection and the presence of Triatoma species vectors in the patient's home. The case was confirmed through seroconversion and successfully treated.

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2022)

Letter Infectious Diseases

Tracking immune correlates of protection for emerging SARS-CoV-2 variants

Eric J. Nilles, Cecilia Then Paulino, Michael de St Aubin, William Duke, Petr Jarolim, Isaac Miguel Sanchez, Kristy O. Murray, Colleen L. Lau, Emily Zielinski Gutierrez, Ronald Skewes Ramm, Marietta Vasquez, Adam Kucharski

LANCET INFECTIOUS DISEASES (2023)

Letter Pediatrics

The Advanced Research Projects Agency-Health (ARPA-H): a new model for research in child health

Brian U. Varisco, Sherin Devaskar, Kristy Murray, Tina Cheng

PEDIATRIC RESEARCH (2023)

Article Public, Environmental & Occupational Health

Prevalence of Trypanosoma cruzi, the Etiologic Agent of Chagas Disease, Infection in Texas Skunks (Mammalia: Mephitidae)

Bonnie E. Gulas-Wroblewski, Rodion Gorchakov, Rebecca B. Kairis, Robert C. Dowler, Kristy O. Murray

Summary: Chagas disease is a neglected tropical disease that affects millions of people in the Americas. This study investigated the prevalence of Trypanosoma cruzi infection in wild skunks in Texas, United States, and found varying infection rates among different skunk species. The results highlight the potential risk of skunks in the transmission of the parasite and provide important baseline data for future surveillance and conservation efforts.

VECTOR-BORNE AND ZOONOTIC DISEASES (2023)

Article Microbiology

Excretory/Secretory Proteome of Females and Males of the Hookworm Ancylostoma ceylanicum

Samuel C. Uzoechi, Bruce A. Rosa, Kumar Sachin Singh, Young-Jun Choi, Bethany K. Bracken, Paul J. Brindley, R. Reid Townsend, Robert Sprung, Bin Zhan, Maria-Elena Bottazzi, John M. Hawdon, Yide Wong, Alex Loukas, Sergej Djuranovic, Makedonka Mitreva

Summary: We used mass spectrometry to analyze and compare the excretory/secretory products (ESPs) of male and female Ancylostoma ceylanicum, a zoonotic hookworm. We identified 795 ESPs with common and sex-specific functions, providing insights into parasite-host interactions and potential targets for drug development.

PATHOGENS (2023)

Article Immunology

Autoantibodies neutralizing type I IFNs underlie West Nile virus encephalitis in & SIM;40% of patients

Adrian Gervais, Francesca Rovida, Maria Antonietta Avanzini, Stefania Croce, Astrid Marchal, Shih-Ching Lin, Alessandro Ferrari, Christian W. Thorball, Orianne Constant, Tom Le Voyer, Quentin Philippot, Jeremie Rosain, Micol Angelini, Malena Perez Lorenzo, Lucy Bizien, Cristian Achille, Francesca Trespidi, Elisa Burdino, Irene Cassaniti, Daniele Lilleri, Chiara Fornara, Jose Camilla Sammartino, Danilo Cereda, Chiara Marrocu, Antonio Piralla, Chiara Valsecchi, Stefano Ricagno, Paola Cogo, Olaf Neth, Ines Marin-Cruz, Monia Pacenti, Alessandro Sinigaglia, Marta Trevisan, Andrea Volpe, Antonio Marzollo, Francesca Conti, Tiziana Lazzarotto, Andrea Pession, Pierluigi Viale, Jacques Fellay, Stefano Ghirardello, Melodie Aubart, Valeria Ghisetti, Alessandro Aiuti, Emmanuelle Jouanguy, Paul Bastard, Elena Percivalle, Fausto Baldanti, Anne Puel, Margaret R. MacDonald, Charles M. Rice, Giada Rossini, Kristy O. Murray, Yannick Simonin, Anna Nagy, Luisa Barzon, Laurent Abel, Michael S. Diamond, Aurelie Cobat, Shen-Ying Zhang, Jean-Laurent Casanova, Alessandro Borghesi

Summary: Gervais et al. found that auto-antibodies neutralizing type I interferons (IFNs) and pre-existing infection are responsible for 40% cases of West Nile virus (WNV) encephalitis. These auto-antibodies can neutralize the protective effect of type I IFNs against WNV in blood and cerebrospinal fluid samples. The prevalence of these auto-antibodies is the highest in patients with encephalitis (around 40%), while the prevalence in individuals with silent WNV infection is as low as that in the general population. These findings highlight the role of auto-antibodies neutralizing IFN-α and/or IFN-ω in the development of WNV encephalitis.

JOURNAL OF EXPERIMENTAL MEDICINE (2023)

Article Immunology

Infectious profiles in pediatric anti-N-methyl-D-aspartate receptor encephalitis

Alexander J. Sandweiss, Timothy A. Erickson, Yike Jiang, Varun Kannan, Jonathan M. Yarimi, Jesse M. Levine, Kristen Fisher, Eyal Muscal, Gail Demmler-Harrison, Kristy O. Murray, Shannon E. Ronca

Summary: This study found that Anti-N-methyl-D-aspartate receptor autoimmune encephalitis (NMDAR AE) may be caused by post-herpes simplex virus-1 meningoencephalitis (HSV ME) and ovarian teratomas. HSV ME was more common in the experimental group than in the control group with idiopathic intracranial hypertension. Recent Epstein-Barr virus infection was also observed more in experimental patients, providing evidence for a genuine measure of effect.

JOURNAL OF NEUROIMMUNOLOGY (2023)

Review Virology

Interleukins, Chemokines, and Tumor Necrosis Factor Superfamily Ligands in the Pathogenesis of West Nile Virus Infection

Emna Benzarti, Kristy O. Murray, Shannon E. Ronca

Summary: This article provides an up-to-date review of cytokine expression patterns in human and experimental animal models of West Nile virus (WNV) infections. Cytokines play a critical role in inflammation and immunity during and after WNV infection, with some offering protection and assisting with viral clearance, while others contributing to neuropathogenesis and immune-mediated tissue damage.

VIRUSES-BASEL (2023)

Article Infectious Diseases

Human Schistosomiasis Vaccines as Next Generation Control Tools

Peter J. J. Hotez, Maria Elena Bottazzi

TROPICAL MEDICINE AND INFECTIOUS DISEASE (2023)

Article Medicine, Research & Experimental

Challenges and strategies for recruitment of minorities to clinical research and trials

Susan P. Fisher-Hoch, Jennifer E. Below, Kari E. North, Joseph B. McCormick

Summary: Minority populations have been underrepresented in clinical research trials, leading to increasing burdens of cancer and chronic disease. Challenges to recruiting minorities in the United States include issues of trust. Successful recruitment strategies involve addressing community concerns and training staff from the same community. In one case study, a team was recruited and trained from a local community in Texas, enrolling over five thousand Mexican Americans in a cohort study on chronic diseases and acquiring advanced skills and health information.

JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE (2023)

Article Pediatrics

Impact of the COVID-19 pandemic on pediatric faculty: a report from nine academic institutions

Teresia M. O'Connor, Milenka Cuevas Guaman, Kimberly A. Randell, Heather T. Keenan, Jessica Snowden, Jennifer W. Mack, Elizabeth A. Camp, Oriana Perez, Michael L. Chang, Angela L. Myers, Lise E. Nigrovic, Jennifer O'Toole, Jennifer L. Reed, Jennifer Reese, Abby R. Rosenberg, Anne C. Slater, Susan H. Wootton, Sonja I. Ziniel, H. Joseph Yost, Kristy O. Murray, Lara Shekerdemian, Corrie E. Chumpitazi

Summary: The COVID-19 pandemic had a negative impact on the work productivity of pediatric faculty, especially those with caregiving responsibilities. Mitigation strategies are needed to minimize the long-term impacts on academic pediatric career pathways.

PEDIATRIC RESEARCH (2023)

Article Immunology

A Recombinant Protein XBB.1.5 RBD/Alum/CpG Vaccine Elicits High Neutralizing Antibody Titers against Omicron Subvariants of SARS-CoV-2

Syamala Rani Thimmiraju, Rakesh Adhikari, Maria Jose Villar, Jungsoon Lee, Zhuyun Liu, Rakhi Kundu, Yi-Lin Chen, Suman Sharma, Karm Ghei, Brian Keegan, Leroy Versteeg, Portia M. Gillespie, Allan Ciciriello, Nelufa Y. Islam, Cristina Poveda, Nestor Uzcategui, Wen-Hsiang Chen, Jason T. Kimata, Bin Zhan, Ulrich Strych, Maria Elena Bottazzi, Peter J. Hotez, Jeroen Pollet

Summary: The study describes the development and characterization of a next-generation SARS-CoV-2 vaccine adapted to the XBB variants. The XBB.1.5 RBD/CpG/alum vaccine elicited a robust antibody response in mice and demonstrated potent neutralization against several Omicron pseudoviruses. These findings highlight the potential for an updated vaccine formulation utilizing the XBB.1.5 RBD antigen.

VACCINES (2023)

Article Immunology

Monitoring Temporal Changes in SARS-CoV-2 Spike Antibody Levels and Variant-Specific Risk for Infection, Dominican Republic, March 2021-August 2022

Eric J. Nilles, Michael de St Aubin, Devan Dumas, William Duke, Marie Caroline Etienne, Gabriela Abdalla, Petr Jarolim, Timothy Oasan, Salome Garnier, Naomi Iihoshi, Beatriz Lopez, Lucia de la Cruz, Yosanly Cornelio Puello, Margaret Baldwin, Kathryn W. Roberts, Farah Pena, Kara Durski, Isaac Miguel Sanchez, Sarah M. Gunter, Alexander R. Kneubehl, Kristy O. Murray, Allison Lino, Sarah Strobel, Amado Alejandro Baez, Colleen L. Lau, Adam Kucharski, Emily Zielinski Gutierrez, Ronald Skewes-Ramm, Marietta Vasquez, Cecilia Then Paulino

Summary: To assess the changes in SARS-CoV-2 spike binding antibody prevalence and its implications for immunologic protection against variants of concern, a prospective study was conducted in the Dominican Republic from March 2021 to August 2022, involving 2,300 patients with undifferentiated febrile illnesses. Serum samples were tested for spike antibodies and nasopharyngeal samples were tested for acute SARS-CoV-2 infection. The study found that geometric mean spike antibody titers significantly increased over time, and higher antibody levels were associated with reduced odds of acute infection, regardless of the viral strain. The combination of serologic and virologic screening could help monitor population immunologic markers and their impact on emerging variant transmission.

EMERGING INFECTIOUS DISEASES (2023)

Article Public, Environmental & Occupational Health

A Chronic Care Management Framework Bridging Clinic, Home, and Community Care in a Mexican American Population

Maria Zolezzi, Juliana Lopez, Lisa Mitchell-Bennet, Lisa Y. Payne, Joseph B. McCormick, Belinda Reininger

Summary: This study presents an Innovative Care for Chronic Conditions framework for Mexican Americans with Type 2 diabetes mellitus, focusing on the role of community health workers in delivering community-based services. The framework has shown promising results and has potential for replication in diverse settings.

HEALTH PROMOTION PRACTICE (2022)

No Data Available