Article
Microbiology
Krisztina M. Papp-Wallace, Adam B. Shapiro, Scott A. Becka, Elise T. Zeiser, John J. LiPuma, Douglas J. Lane, Rekha G. Panchal, John P. Mueller, John P. O'Donnell, Alita A. Miller
Summary: Burkholderia genus, including pathogens causing Melioidosis and Glanders, are hard to treat, but the combination of sulbactam-durlobactam (SUL-DUR) shows potential for treating these infections by inhibiting bacterial growth and reducing beta-lactamase activity.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Microbiology
Julianna Siciliano de Araujo, Raiza Brandao Peres, Patricia Bernardino da Silva, Marcos Meuser Batista, Geert Jan Sterk, Louis Maes, Guy Caljon, Rob Leurs, Harry P. de Koning, Titilola D. Kalejaiye, Maria de Nazare Correia Soeiro
Summary: NPD-008 showed activity against different forms and strains of Trypanosoma cruzi, and displayed synergistic interaction when combined with benznidazole. It also exhibited moderate activity against intracellular amastigotes of Leishmania amazonensis and Leishmania infantum, indicating its potential as an antitrypanosomatid drug candidate.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Agriculture, Multidisciplinary
Daniel Kruzselyi, Jozsef Bakonyi, Peter G. Ott, Andras Darcsi, Peter Csontos, Gertrud E. Morlock, Agnes M. Moricz
Summary: The root extracts of three goldenrods were found to contain antimicrobial compounds, including matricaria esters, dehydromatricaria esters, and benzyl 2-hydroxy-6-methoxybenzoate, which showed strong antifungal effects against pathogenic fungi.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Cell Biology
Lei Peng, Zhenhao Fang, Paul A. Renauer, Andrew McNamara, Jonathan J. Park, Qianqian Lin, Xiaoyu Zhou, Matthew B. Dong, Biqing Zhu, Hongyu Zhao, Craig B. Wilen, Sidi Chen
Summary: This study develops a multi-species coronavirus vaccine using lipid nanoparticle-mRNA technology and tests its effectiveness in animal models. The vaccine induces specific antibody responses against different coronaviruses and provides insights into the immune profiles of vaccinated animals. Sequential vaccination shows stronger antibody responses compared to simultaneous vaccination.
Article
Microbiology
Yi Sun, Lihua Tan, Zhaoqian Yao, Lujuan Gao, Ji Yang, Tongxiang Zeng
Summary: In this study, the interactions between TOR inhibitor AZD8055 and azoles against various pathogenic fungi were investigated. The results showed that AZD8055 exhibited synergistic effects with itraconazole, voriconazole, posaconazole, and fluconazole, enhancing the antifungal efficacy of these azoles. This combination therapy may help overcome azole resistance and improve antifungal susceptibilities. The in vivo assays in Galleria mellonella model confirmed the efficacy of the AZD8055-azole combinations. Overall, this study highlights the potential of combining AZD8055 with azoles for the treatment of fungal infections.
MICROBIOLOGY SPECTRUM
(2022)
Article
Engineering, Environmental
Na Sun, Abdul Haseeb, Panpan Sun, Hua Zhang, Jia Zhong, Wei Yin, Kuohai Fan, Huizhen Yang, Zhenbiao Zhang, Yaogui Sun, Panpan Hu, Hongquan Li
Summary: Scutellarin exerts anti-apoptotic effects on ZEA-induced mouse ovarian granulosa cells (GCs) by targeting Wnt5a.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Microbiology
Ingrid Richter, Silvia Radosa, Zoltan Cseresnyes, Iuliia Ferling, Hannah Buettner, Sarah P. Niehs, Ruman Gerst, Kirstin Scherlach, Marc Thilo Figge, Falk Hillmann, Christian Hertweck
Summary: The soil community is a complex system characterized by predator-prey interactions. Fungi have developed effective strategies to defend themselves against predators, such as forming a symbiotic relationship with bacteria to produce toxins.
Article
Food Science & Technology
Carlos Enrique Ochoa-Velasco, Julio Cesar Perez-Perez, Jose Mauricio Varillas-Torres, Addi Rhode Navarro-Cruz, Paola Hernandez-Carranza, Ricardo Munguia-Perez, Teresa Soledad Cid-Perez, Raul Avila-Sosa
Summary: This study evaluated the effectiveness of thymol and carvacrol against Colletotrichum gloeosporioides in edible films and coatings. In vitro evaluation showed MIC values of the compounds at different pH levels, with additive effects observed in binary mixtures. In vivo evaluation on mango and papaya demonstrated delayed fruit ripening and reduced disease symptoms, indicating the potential of thymol and carvacrol in controlling anthracnose.
Article
Chemistry, Medicinal
Solida Long, Denise Duarte, Carla Carvalho, Rafael Oliveira, Nuno Santarem, Andreia Palmeira, Diana I. S. P. Resende, Artur M. S. Silva, Rui Moreira, Anake Kijjoa, Anabela Cordeiro da Silva, Fatima Nogueira, Emilia Sousa, Madalena M. M. Pinto
Summary: The study explored the antiparasitic potential of pyrazino [2,1-6] quinazoline-3,6-diones containing indole alkaloids against Plasmodium falciparum, Trypanosoma brucei, and Leishmania infantum. Promising hit compounds with species-specific or broad antiparasitic activity were identified, and structure-activity relationships were observed. In silico studies predicted these compounds as possible inhibitors for prolyl-tRNA synthetase both from Plasmodium and Leishmania, indicating their potential for the development of novel and affordable antiparasitic drugs.
ACS MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Microbiology
Nicholas P. Clayton, Akash Jain, Stephanie A. Halasohoris, Lisa M. Pysz, Sanae Lembirik, Steven D. Zumbrun, Christopher D. Kane, Michael J. Hackett, Denise Pfefferle, M. Autumn Smiley, Michael S. Anderson, Henry Heine, Gabriel T. Meister, Michael J. Pucci
Summary: Tebipenem showed activity against a variety of biothreat pathogens in vitro and demonstrated good in vivo efficacy in a murine model, suggesting its potential for treating biothreat pathogens.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Food Science & Technology
Gloria Stephanie Villa-Jaimes, Fabio Alejandro Aguilar-Mora, Herson Antonio Gonzalez-Ponce, Francisco Javier Avelar-Gonzalez, Ma Consolacion Martinez Saldana, Manon Buist-Homan, Han Moshage
Summary: The study found that Opuntia spp-extracts can effectively protect against liver toxicity induced by diclofenac, reducing oxidative stress and inhibiting P53 to protect the liver.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Parasitology
Jennifer Keiser, Cecile Haeberli
Summary: This study identified levamisole as a potential backup drug for strongyloidiasis using a drug repurposing approach, and it should be evaluated in exploratory clinical trials for further assessment. Levamisole showed promising in vivo activity with a median effective dose (ED50) of 1.1 mg/kg, curing all rats in the study.
PARASITES & VECTORS
(2021)
Article
Biochemistry & Molecular Biology
Jun Gu, Shuaifeng Zhang, Xuefeng Xia, Xuehan Zhang, Baochao Fan, Junming Zhou, Haodan Zhu, Wei Wang, Xianghui Qi, Li Li, Bin Li
Summary: An edible cellulose-based antibacterial material was prepared by cross-linking cellulose and kanamycin sulfate, showing excellent inhibitory effects on both Gram-positive and Gram-negative bacteria with low cytotoxicity. This material has the potential to be a stable, inexpensive, and effective carrier for drugs, proteins, or vaccines.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Microbiology
Fabienne Hilgers, Samer S. Habash, Anita Loeschcke, Yannic Sebastian Ackermann, Stefan Neumann, Achim Heck, Oliver Klaus, Jennifer Hage-Huelsmann, Florian M. W. Grundler, Karl-Erich Jaeger, A. Sylvia S. Schleker, Thomas Drepper
Summary: Terpenoids are a diverse group of secondary metabolites with potential commercial applications in biotechnology, pharmaceuticals, and agriculture. This study successfully implemented the plant sesquiterpenoid pathway in the heterologous host Rhodobacter capsulatus to produce beta-caryophyllene, which showed promising anti-fungal bioactivity. The compounds inhibited the growth of certain plant pathogenic fungi, suggesting they could be used for fungal management in agricultural crop production.
Article
Pharmacology & Pharmacy
Analu Barros de Oliveira, Tulio Morandin Ferrisse, Sarah Raquel de Annunzio, Maria Gleiziane Araujo Franca, Maria Goretti de Vasconcelos Silva, Alberto Jose Cavalheiro, Carla Raquel Fontana, Fernanda Lourencao Brighenti
Summary: This study evaluated three plant extracts (Senna splendida, Senna alata, and Senna macranthera) as photosensitizers for antimicrobial photodynamic therapy (aPDT). The results showed that these extracts exhibited high efficacy in killing microorganisms of medical and dental interest in both planktonic and biofilm forms.
Article
Biochemistry & Molecular Biology
Andrea A. E. Mendez, Liliana B. Pena, Lucrecia M. Curto, Marisa M. Fernandez, Emilio L. Malchiodi, Sara M. Garza-Aguilar, Jorge M. Vazquez-Ramos, Susana M. Gallego
Article
Immunology
Andres Sanchez Alberti, Augusto E. Bivona, Marina N. Matos, Natacha Cerny, Kai Schulze, Sebastian Weissmann, Thomas Ebensen, German Gonzalez, Celina Morales, Alejandro C. Cardoso, Silvia Cazorla, Carlos A. Guzman, Emilio L. Malchiodi
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Orlando G. Elso, Augusto E. Bivona, Andres Sanchez Alberti, Natacha Cerny, Lucas Fabian, Celina Morales, Cesar A. N. Catalan, Emilio L. Malchiodi, Silvia Cazorla, Valeria P. Sulsen
Article
Immunology
Natacha Cerny, Augusto Ernesto Bivona, Andres Sanchez Alberti, Sebastian Nicolas Trinitario, Celina Morales, Alejandro Cardoso Landaburu, Silvia Ines Cazorla, Emilio Luis Malchiodi
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
Maria Jose Martinez Monteros, Carolina Maldonado Galdeano, Maria Florencia Balcells, Ricardo Weill, Juan Andres De Paula, Gabriela Perdigon, Silvia Ines Cazorla
Summary: Probiotic supplementation can reduce symptoms of NSAID-induced inflammation in the small intestine, increase antimicrobial activity in the intestines, and promote changes in the gut microbiota to maintain intestinal homeostasis.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
B. Layus, M. A. Gomez, S. Cazorla, A. Rodriguez
Summary: The study showed that the cell-free supernatant of Lactiplantibacillus plantarum CRL759 can reduce inflammatory parameters and clinical signs of ocular inflammation, both in vitro and in vivo. This promising strategy may provide a safe and effective alternative for those refractory to conventional therapies for ocular inflammation.
BENEFICIAL MICROBES
(2021)
Article
Immunology
Jose Maria Lemme-Dumit, Silvia Ines Cazorla, Gabriela Del Valle Perdigon, Carolina Maldonado-Galdeano
Summary: The study shows that oral administration of probiotics or their sub-cellular fraction can reduce bacterial burden in the spleen and liver after Salmonella challenge. The beneficial effects of probiotic-derived CW after challenge are attributed to Th1-type cell-mediated immunity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Nutrition & Dietetics
Florencia Balcells, Maria Jose Martinez Monteros, Alba Lorena Gomez, Silvia Ines Cazorla, Gabriela Perdigon, Carolina Maldonado-Galdeano
Summary: This study found that supplementation with Lactobacillus casei CRL 431 and/or its cell wall improved body weight, intestinal microbiota, and thymus structure and function in obese and aging mice, leading to a better immune system and quality of life.
Article
Medicine, General & Internal
Rodrigo Hernan Tomas-Grau, Diego Ploper, Cesar Luis avila, Esteban Vera Pingitore, Carolina Maldonado Galdeano, Silvina Chaves, Sergio Benjamin Socias, Agustin Stagnetto, Silvia Adriana Navarro, Rossana Elena Chahla, Monica Aguilar Lopez, Conrado Juan Llapur, Patricia Aznar, Maria Elena Alcorta, Dardo Costas, Isolina Flores, Dar Heinze, Gabriela Apfelbaum, Raul Mostoslavsky, Gustavo Mostoslavsky, Silvia Ines Cazorla, Gabriela del Valle Perdigon, Rosana Chehin
Summary: The COVID-19 pandemic has prompted the need for rapid development of diagnostic strategies. Research has shown that a proportion of individuals infected with COVID-19 develop antibodies, but only a small percentage have sufficient antibody levels to be considered as plasma donors.
FRONTIERS IN MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Andres Sanchez Alberti, Maria F. Beer, Natacha Cerny, Augusto E. Bivona, Lucas Fabian, Celina Morales, Albertina Moglioni, Emilio L. Malchiodi, Osvaldo J. Donadel, Valeria P. Sulsen
Summary: The study demonstrated that cumanin diacetate showed promising activity and selectivity against Trypanosoma cruzi, especially in inhibiting parasite replication in amastigote forms. This compound could be a potential candidate for further studies in the development of new therapies against Chagas disease.
Article
Chemistry, Physical
Eliana Rita Solorzano, Paolo Pastore, Alessandro Dolmella, Silvia Cazorla, Maria Lucrecia Arias Cassara, Sankaran Venkatachalam Sankaran, Subbiah Thamotharan, Diego M. Gil
Summary: A detailed experimental and theoretical investigation was conducted on a chalcone derivative, DHMC, isolated from Argentinean type-Zuccagnia propolis. The compound was characterized using various spectroscopic techniques and its crystal structure was determined by X-ray diffraction. Theoretical investigations showed good agreement with experimental results in terms of molecular geometry and vibrational frequencies. The compound exhibited anti-leishmanial activity and molecular docking simulations predicted its binding potential to six different leishmanial protein targets.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Review
Food Science & Technology
Sofia Noli Truant, Daniela Maria Redolfi, Maria Belen Sarratea, Emilio Luis Malchiodi, Marisa Mariel Fernandez
Summary: Staphylococcal enterotoxins are a diverse family of bacterial exotoxins that can activate a large proportion of the host T cells. However, these toxins exhibit significant heterogeneity in their structure and homology. The mechanisms underlying their production are not fully understood. Nonetheless, studying these superantigens is crucial for understanding their functions, pathogenicity, and potential for immunotherapeutic interventions.
Article
Pharmacology & Pharmacy
Jimena Borgo, Orlando G. Elso, Jessica Gomez, Mauro Coll, Cesar A. N. Catalan, Juan Mucci, Guzman Alvarez, Lia M. Randall, Patricia Barrera, Emilio L. Malchiodi, Augusto E. Bivona, Maria Florencia Martini, Valeria P. Suelsen
Summary: Stevia species, particularly S. satureiifolia var. satureiifolia and S. alpina, are rich in terpenoid compounds with antiprotozoal activity. Two sesquiterpene lactones, santhemoidin C and 2-oxo-8-deoxyligustrin, were isolated and evaluated for their trypanocidal activity against Trypanosoma cruzi. Santhemoidin C showed promising inhibitory activity against the parasite's different stages and the Tc80 protein, making it a potential candidate for the development of trypanocidal drugs.
Article
Cell Biology
Rodrigo Hernan Tomas-Grau, Carolina Maldonado-Galdeano, Monica Aguilar Lopez, Esteban Vera Pingitore, Patricia Aznar, Maria Elena Alcorta, Eva Maria del Mar Velez, Agustin Stagnetto, Silvana Estefania Soliz-Santander, Cesar Luis Avila, Sergio Benjamin Socias, Dardo Costas, Rossana Elena Chahla, Gabriela Perdigon, Rosana Nieves Chehin, Diego Ploper, Silvia Ines Cazorla
Summary: The early development of vaccines against SARS-CoV-2 has been successful, but age-related immunosenescence remains a challenge. Analysis of the humoral immune response in elderly volunteers who received Gam-COVID-Vac vaccine revealed that at least two doses were necessary to elicit a robust immune response, especially in individuals without previous infection. Antibody titers reached their highest levels at 28 days post-vaccination and remained stable at 60 days, but started to decline at 180 days. Gender did not significantly affect the specific humoral immune responses at early time points, but at 60 days post-vaccination, females had more persistent antibody titers.