Article
Parasitology
Soudah Boma, Sena Herve Vitouley, Martin Bienvenu Somda, Zakaria Bengaly, Isidore Houaga, Yao Lombo, Eyaba Tchamdja, Guiguigbaza-Kossigan Dayo
Summary: This study found that T. vivax in different villages of Togo exhibited resistance to two main trypanocidal drugs, highlighting the need for extended surveillance strategies and providing guidance for veterinarians or herdsmen in choosing treatment strategies.
VETERINARY PARASITOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lauren Carruthers, Jane C. Munday, Godwin U. Ebiloma, Pieter Steketee, Siddharth Jayaraman, Gustavo D. Campagnaro, Marzuq A. Ungogo, Leandro Lemgruber, Anne-Marie Donachie, Tim G. Rowan, Rose Peter, Liam J. Morrison, Michael P. Barrett, Harry P. De Koning
Summary: Trypanosoma congolense is a major pathogen causing livestock trypanosomiasis in Africa, with only diminazene and isometamidium commonly used for treatment. Resistance is widespread but poorly understood. Research showed that resistance to diminazene in T. congolense strain IL3000 was induced in vitro and was associated with inhibited accumulation of DB75 due to folate.
MOLECULAR MICROBIOLOGY
(2021)
Article
Parasitology
Ivy Okello, Eliakunda Mafie, Jahashi Nzalawahe, Gillian Eastwood, Leonard E. G. Mboera, Jean Nepomuscene Hakizimana, Kennedy Ogola
Summary: The study aimed to detect drug-resistant Trypanosoma congolense in Lambwe, Kenya and assess the reliability of a molecular test backed with mice tests in detecting drug sensitivity. The results showed the existence of T. congolense associated with homidium and diminazene resistance in Lambwe. Polymorphisms were found in Lambwe strains and the TcoAde2 gene was found to be unrelated to drug sensitivity. The study concluded that the combination of molecular and mice tests is a reliable method for testing drug sensitivity.
ACTA PARASITOLOGICA
(2023)
Review
Parasitology
Shauna Richards, Liam J. Morrison, Steve J. Torr, Michael P. Barrett, Oliver Manangwa, Furaha Mramba, Harriet Auty
Summary: Trypanocides are crucial in controlling African animal trypanosomiasis in tsetse-infested areas, but issues such as inappropriate use, drug quality problems, and treatment failure have been highlighted by recent research. There are gaps in knowledge and investment in inexpensive AAT diagnostics, understanding of drug resistance, and effective use of trypanocides, making it difficult to develop best practices and policies for existing drugs or inform the development and use of new drugs. Understanding the drivers and behavioral practices around trypanocide use is important for sustainable solutions needed for effective control of AAT.
TRENDS IN PARASITOLOGY
(2021)
Article
Multidisciplinary Sciences
Raymond E. Mdachi, Kennedy O. Ogolla, Joanna E. Auma, Florence N. Wamwiri, Richard K. Kurgat, Kennedy B. Wanjala, Lawrence G. Mugunieri, Phylis M. Alusi, Judith K. Chemuliti, Phoebe W. Mukiria, Sylvance O. Okoth
Summary: This study evaluated the sensitivity of Trypanosoma evansi field isolates collected from two counties in Kenya. Drug resistance was found in all study sites with infected camels. Camel management practices were found to influence the prevalence and degree of drug resistance.
Article
Parasitology
Chukwunonso F. Obi, Michael Okpala, Davinson C. Anyogu, Amaechi Onyeabor, Ikenna O. Ezeh, Romanus C. Ezeokonkwo
Summary: This study assessed the comparative pathogenicity of drug-resistant and drug-sensitive Trypanosoma brucei and Trypanosoma congolense infections in dogs. The results showed that multidrug-resistant T. brucei was less pathogenic, while multidrug-resistant and drug-sensitive T. congolense had comparable pathogenicity in dogs.
PARASITOLOGY RESEARCH
(2023)
Article
Multidisciplinary Sciences
Nick Van Reet, Pati Patient Pyana, Sara Dehou, Nicolas Bebronne, Stijn Deborggraeve, Philippe Buscher
Summary: The TBR sequence in Trypanosoma brucei is not as homogenous as previously believed, with various sequences of different lengths and key single nucleotide polymorphisms. The qTBR PCR developed in this study enhances amplification and genotyping of all Trypanozoon strains, making it a promising tool for prevalence studies of African trypanosomiasis.
Review
Pharmacology & Pharmacy
Siyuan Qin, Zhe Zhang, Zhao Huang, Yinheng Luo, Ningna Weng, Bowen Li, Yongquan Tang, Li Zhou, Jingwen Jiang, Yi Lu, Jichun Shao, Na Xie, Edouard C. Nice, Zhe-Sheng Chen, Jian Zhang, Canhua Huang
Summary: Although the clinical benefit from blocking the P-glycoprotein (P-gp/ABCB1) pathway in multidrug resistance (MDR) in cancers remains inconclusive, our study demonstrates that the combined use of chemotherapy and CCT251545 (CCT) displays a robust synergistic effect against MDR cancer cells and suppresses tumor growth and metastasis in vivo. The synergistic activity of CCT is mainly attributed to enhanced uptake of chemotherapeutic agents and cell phenotype changes. Mechanistically, CCT exerts its chemosensitizing effect through Rac1-dependent macropinocytosis.
DRUG RESISTANCE UPDATES
(2023)
Article
Multidisciplinary Sciences
Mouhamadou M. Dieng, Kiswend-sida M. Dera, Percy Moyaba, Gisele M. S. Ouedraogo, Guler Demirbas-Uzel, Fabian Gstottenmayer, Fernando C. Mulandane, Luis Neves, Sihle Mdluli, Jean-Baptiste Rayaisse, Adrien M. G. Belem, Soumaila Pagabeleguem, Chantel J. de Beer, Andrew G. Parker, Jan Van den Abbeele, Robert L. Mach, Marc J. B. Vreysen, Adly M. M. Abd-Alla
Summary: The sterile insect technique is an effective and sustainable method for managing insect pests. This study examines the interaction between Sodalis bacteria and Trypanosoma infection in tsetse flies. The presence of Sodalis and Trypanosoma varied among different countries and tsetse species. The study also found differences in the prevalence of specific Trypanosoma species in different regions.
SCIENTIFIC REPORTS
(2022)
Article
Microbiology
Keisuke Suganuma, David D. N'Da, Ken-ichi Watanabe, Yusuke Tanaka, Ehab Mossaad, Afraa Elata, Noboru Inoue, Shin-ichiro Kawazu
Summary: This study aimed to evaluate the in vivo efficacy of nitrofurantoin in treating Animal African trypanosomosis (AAT) caused by Trypanosoma congolense. The results showed that oral administration of nitrofurantoin significantly suppressed parasitemia in infected mice, and higher doses led to higher survival rates and cure rates. Oral nitrofurantoin administration has potential trypanocidal efficacy against T. congolense induced AAT.
Article
Microbiology
Nnamdi Ikeogu, Folayemi Olayinka-Adefemi, Chidalu Edechi, Chukwunonso Onyilagha, Ping Jia, Aaron Marshall, Julius Ode, Jude Uzonna
Summary: In this study, the trypanocidal efficacy of Crosspteryx fibrifuga leaf extract (C.f/L-extract) was evaluated. The extract showed a significant decrease in parasite number and an increase in apoptotic markers expression. It was not cytotoxic to murine whole splenocytes and exhibited immune regulatory effects. Treatment of infected mice with the extract led to a decrease in parasite numbers and an increase in mouse survival. The extract also affected the distribution of immune cells and the activity of superoxide dismutase.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Nutrition & Dietetics
Aida Lahmar, Aline Mathey, Virginie Aires, Dorra Elgueder, Anne Vejux, Rihab Khlifi, Fairouz Sioud, Leila Chekir-Ghedira, Dominique Delmas
Summary: The study highlights the potential of Pituranthos chloranthus and Teucrium ramosissimum Desf. essential oils as chemopreventive and chemosensitizing agents against uterine sarcoma cell lines. The combination of these oils with doxorubicin induces synergistic effects that increase cell death in resistant cells and decrease resistance to the chemotherapy drug. This is achieved through modulation of the cell cycle, induction of apoptosis, and a decrease in P-gp expression and activity.
Article
Medicine, Research & Experimental
Sweta Ghosh, Rajbir Singh, Zachary Matthew Vanwinkle, Haixun Guo, Praveen Kumar Vemula, Ajay Goel, Bodduluri Haribabu, Venkatakrishna Rao Jala
Summary: The gut microbial metabolite UroA and its structural analogue UAS03 sensitized 5FUR colon cancers to 5FU chemotherapy by regulating drug transporters and transcription factors.
Article
Food Science & Technology
Carolina Ibarguren, M. Virginia Guitian, Romina M. Lenz, Soria M. Cecilia, M. Carina Audisio
Summary: Listeria monocytogenes is a foodborne pathogen that can survive in harsh food processing environments. The use of bacteriocins as a natural alternative to control this pathogen has been hindered by the emergence of resistant strains. This study compares the properties of susceptible and resistant strains, including growth, antibiotic susceptibility, cell morphology, virulence factor expression, and biofilm formation. The results contribute to the understanding of bacteriocin-resistance development in L. monocytogenes and its implications for the use of these peptides as biopreservatives.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2022)
Article
Immunology
Han Du, Jian Bing, Xiaohong Xu, Qiushi Zheng, Tianren Hu, Yajuan Hao, Shuping Li, Clarissa J. Nobile, Ping Zhan, Guanghua Huang
Summary: We report an outbreak of Candida vulturna among individuals in Shanxi Province, China from 2019 to 2022. The isolates were resistant to multiple antifungal drugs and showed enhanced adhesion and biofilm formation properties.
EMERGING INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Laurence Geebelen, Dieter Van Cauteren, Brecht Devleesschauwer, Sarah Moreels, Katrien Tersago, Herman Van Oyen, Niko Speybroeck, Tinne Lernout
TICKS AND TICK-BORNE DISEASES
(2019)
Article
Infectious Diseases
G. Suzanne A. Smit, Binh Thi Lam Vu, Dung Trung Do, Quan Ha Do, Huy Quang Pham, Niko Speybroeck, Brecht Devleesschauwer, Elizaveta Padalko, Ellen Roets, Pierre Dorny
BMC INFECTIOUS DISEASES
(2019)
Article
Multidisciplinary Sciences
Helen Byomire Ndagije, Leonard Manirakiza, Dan Kajungu, Edward Galiwango, Donna Kusemererwa, Sten Olsson, Anne Spinewine, Niko Speybroeck
Article
Medicine, General & Internal
Thanh Vinh Pham, Hong Van Nguyen, Angel Rosas Aguirre, Van Van Nguyen, Mario A. Cleves, Xa Xuan Nguyen, Thao Thanh Nguyen, Duong Thanh Tran, Hung Xuan Le, Niel Hens, Anna Rosanas-Urgell, Umberto D'Alessandro, Niko Speybroeck, Annette Erhart
Article
Infectious Diseases
Emma C. Hobbs, Kabemba Evans Mwape, Brecht Devleesschauwer, Inge Van Damme, Meryam Krit, Dirk Berkvens, Gideon Zulu, Moses Mambwe, Mwelwa Chembensofu, Chiara Trevisan, Jacoba Baauw, Isaac Khozozo Phiri, Niko Speybroeck, Jennifer Ketzis, Pierre Dorny, Arve Lee Willingham, Sarah Gabriel
PLOS NEGLECTED TROPICAL DISEASES
(2019)
Article
Public, Environmental & Occupational Health
Carine Van Malderen, Agbessi Amouzou, Aluisio J. D. Barros, Bruno Masquelier, Herman Van Oyen, Niko Speybroeck
Article
Public, Environmental & Occupational Health
Francoise Renard, Brecht Devleesschauwer, Niko Speybroeck, Patrick Deboosere
Article
Multidisciplinary Sciences
Elisa Solano-Villarreal, Walter Valdivia, Morgan Pearcy, Catherine Linard, Jose Pasapera-Gonzales, Diamantina Moreno-Gutierrez, Philippe Lejeune, Alejandro Llanos-Cuentas, Niko Speybroeck, Marie-Pierre Hayette, Angel Rosas-Aguirre
SCIENTIFIC REPORTS
(2019)
Article
Infectious Diseases
Helen Byomire Ndagije, Ronald Kiguba, Leonard Manirakiza, Elijah Kirabira, Allan Sserwanga, Leah Nabirye, Jackson Mukonzo, Sten Olsson, Anne Spinewine, William D'Hoore, Niko Speybroeck
Article
Multidisciplinary Sciences
Camille Soudeyns, Niko Speybroeck, Marc Brisson, Joel Mossong, Ardashel Latsuzbaia
Article
Infectious Diseases
Doudou Yobi, Nadine K. Kayiba, Dieudonne M. Mvumbi, Raphael Boreux, Pius Z. Kabututu, Hippolyte N. T. Situakibanza, Joris L. Likwela, Patrick De Mol, Emile W. Okitolonda, Niko Speybroeck, Georges L. Mvumbi, Marie-Pierre Hayette
Article
Infectious Diseases
Diamantina Moreno-Gutierrez, Angel Rosas-Aguirre, Alejandro Llanos-Cuentas, Joke Bilcke, Jose Luis Barboza, Marie-Pierre Hayette, Juan Contreras-Mancilla, Kristhian Aguirre, Dionicia Gamboa, Hugo Rodriguez, Niko Speybroeck, Philippe Beutels
Article
Public, Environmental & Occupational Health
G. S. A. Smit, S. Abrams, P. Dorny, N. Speybroeck, B. Devleesschauwer, V Hutse, H. Jansens, H. Theeten, P. Beutels, N. Hens
EPIDEMIOLOGY AND INFECTION
(2019)
Letter
Cardiac & Cardiovascular Systems
Julie Paul, Joelle Kefer, Marianne Beeckmans, Niko Speybroeck, Benoit Boland
JOURNAL OF GERIATRIC CARDIOLOGY
(2018)
Article
Public, Environmental & Occupational Health
Paul R. Torgerson, Simon Ruegg, Brecht Devleesschauwer, Bernadette Abela-Ridder, Arie H. Havelaar, Alexandra P. M. Shaw, Jonathan Rushton, Niko Speybroeck