Article
Microbiology
Juan Wu, Zhidong Hu, Shui-Hua Lu, Xiao-Yong Fan
Summary: This study examined the ability of a DNA vaccine expressing a fusion of antigens Rv2299c and Ag85A to boost BCG immunity and protection against tuberculosis. The results showed that the DNA boost significantly amplified Th1-type cell-mediated immunity and reduced bacterial loads and histological damage in the lung.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Yan Liang, Lei Cui, Li Xiao, Xiao Liu, Yourong Yang, Yanbo Ling, Tong Wang, Lan Wang, Jie Wang, Xueqiong Wu
Summary: This study demonstrates that the MTB ag85a/b chimeric DNA vaccine can induce a Th1-type cellular immune response, and DNA immunization by EP can enhance the immunogenicity of the DNA vaccine, reduce the dose, and result in good immunotherapeutic effects.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tamara Z. Ishwarlall, Victoria T. Adeleke, Leah Maharaj, Moses Okpeku, Adebayo A. Adeniyi, Matthew A. Adeleke
Summary: This study aimed to identify T-cell and B-cell epitopes from the mycobacterial membrane protein large (MmpL) proteins of M. ulcerans and construct multi-epitope vaccines. Through analysis of the epitope properties and structural analysis of the constructs, the potential of these epitopes and the stability of the constructs were demonstrated. However, experimental validation is still required.
Article
Immunology
Tamara Z. Ishwarlall, Victoria T. Adeleke, Leah Maharaj, Moses Okpeku, Adebayo A. Adeniyi, Matthew A. Adeleke
Summary: This study generates a multi-epitope vaccine against Mycobacterium ulcerans using immunoinformatics approach. The vaccine candidates show antigenicity, immunogenicity, non-allergenicity, and non-toxicity, with the potential to provide broad population coverage. Further analysis and laboratory validation are needed.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Nan Wang, Yan Liang, Qianqian Ma, Jie Mi, Yong Xue, Yourong Yang, Lan Wang, Xueqiong Wu
Summary: Our research developed a novel TB DNA vaccine that showed therapeutic effects on a mouse TB model, but the mechanisms between intramuscular injection and electroporation remain unclear.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Immunology
Taylor W. Foreman, Christine E. Nelson, Michelle A. Sallin, Keith D. Kauffman, Shunsuke Sakai, Francisco Otaizo-Carrasquero, Timothy G. Myers, Daniel L. Barber
Summary: CD30 is highly expressed on granuloma T cells in macaques infected with Mtb. In mice, CD30 is essential for T cell differentiation and survival during Mtb infection, indicating that CD30-dependent co-stimulation is necessary for T cell immune responses against Mtb.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Immunology
Yanzhi Lu, Huanhuan Ning, Jian Kang, Guangchun Bai, Lei Zhou, Yali Kang, Zhengfeng Wu, Maolin Tian, Junhao Zhao, Yueyun Ma, Yinlan Bai
Summary: Many antigens from Mycobacterium tuberculosis have strong immunogenicity and potential as vaccine candidate antigens. In this study, the researchers explored the immunogenicity and immune responses induced by the bacterial second messenger Cyclic di-AMP (c-di-AMP) phosphodiesterase (CnpB) in mice. They found that CnpB had strong immunogenicity and induced high levels of humoral response and lung mucosal immunity after M. tuberculosis infection. CnpB also interfered with host innate and adaptive immune responses and conferred protection against M. tuberculosis respiratory infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Wenping Gong, Yan Liang, Jie Mi, Zaixing Jia, Yong Xue, Jie Wang, Lan Wang, Yusen Zhou, Shihui Sun, Xueqiong Wu
Summary: The study developed a novel tuberculosis vaccine MP3RT based on peptides, which showed promising protective efficacy in humanized mice by significantly reducing pathogen load and inflammatory cell count, as well as inducing high levels of IFN-γ and CD3(+)IFN-γ(+) T lymphocytes. These findings provide a foundation for the development of peptide-based vaccines against TB.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Laura Liebscher, Christine Weissenborn, Stefanie Langwisch, Bjoern-Oliver Gohlke, Robert Preissner, Gabriel A. Rabinovich, Nina Christiansen, Holger Christiansen, Ana Claudia Zenclussen, Stefan Fest
Summary: Gal-1 negatively regulates CD8+ T cells in NB, while vaccination with DNA plasmids encoding Gal-1 epitopes enhances immunity and effectively suppresses NB tumor growth.
Review
Immunology
Abu Salim Mustafa
Summary: ESAT6 is an important immunogenic protein of Mycobacterium tuberculosis, with potential applications in tuberculosis diagnosis and vaccine development. Proteins encoded by specific RD regions of M. tuberculosis have shown promise as vaccine components to replace or supplement BCG, with some demonstrating efficacy in clinical trials.
Article
Immunology
Shuai Zhang, Lumen Chao, Lemuge She, Humujile Sui, Huaxin Niu, Zeliang Chen, Xiangyang Li, Jingbo Zhai
Summary: Brucella is a globally distributed zoonotic disease that can cause abortion and immune function changes. This study developed an attenuated oral Brucella vaccine using Antigen 85A as a carrier, which effectively reduced toxicity residue, induced better immunogenic response, and downregulated the expression levels of inflammatory factors.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Infectious Diseases
Eamonn Gormley, Deirdre Ni Bhuachalla, Tara Fitzsimons, James O'Keeffe, Guy McGrath, Jamie M. Madden, Naomi Fogarty, Kevin Kenny, Locksley L. Mc Messam, Denise Murphy, Leigh A. L. Corner
Summary: Vaccination of badgers with Mycobacterium bovis Bacille Calmette-Guerin (BCG) has been shown to protect badgers against tuberculosis in experimental trials. The study results suggest that BCG vaccination could indirectly protect unvaccinated badgers, leading to a high level of population immunity against tuberculosis. This indicates that BCG vaccination could be an effective method for reducing tuberculosis incidence in badger populations.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Immunology
Jialu Zhang, Qian He, Chaoqiang An, Qunying Mao, Fan Gao, Lianlian Bian, Xing Wu, Qian Wang, Pei Liu, Lifang Song, Yaqian Huo, Siyuan Liu, Xujia Yan, Jinghuan Yang, Bopei Cui, Changgui Li, Junzhi Wang, Zhenglun Liang, Miao Xu
Summary: The study found significant differences in humoral and cellular immune responses induced by different vaccine platforms when administered individually in a mouse model. Boosting with recombinant subunit, adenovirus vectored or mRNA vaccine after two doses of inactivated vaccine improved immune responses compared to a third dose of inactivated vaccine. This provides new ideas for prophylactic vaccination strategy against SARS-CoV-2.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Immunology
Mayank Khanna, Hamada Rady, Guixiang Dai, Alistair J. Ramsay
Summary: This study found that intranasal delivery of MVA-AE can enhance the immune response induced by BCG vaccine, reduce the replication of Mycobacterium tuberculosis in the lungs, and improve the protective efficacy of neonatally-administered BCG against TB infection.
Article
Immunology
Lok R. Joshi, David Knudsen, Pablo Pineyro, Santosh Dhakal, Gourapura J. Renukaradhya, Diego G. Diel
Summary: The study developed two recombinant orf viruses expressing the HA gene or the HA and NP genes of IAV-S, which induced robust virus neutralizing antibody responses in pigs. The immunization with the HA-NP virus resulted in a Th1-biased immune response and provided incremental protection against challenge infection compared to the HA group.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Hermann Giresse Tima, Juma'a Raheem Al Dulayymi, Olivier Denis, Pauline Lehebel, Klarah Sherzad Baols, Mohsin Omar Mohammed, Laurent L'Homme, Mohaned Mohammed Sahb, Georges Potemberg, Sylvie Legrand, Roland Lang, Rudi Beyaert, Jacques Piette, Mark Stephen Baird, Kris Huygen, Marta Romano
JOURNAL OF INNATE IMMUNITY
(2017)
Article
Mycology
Muriel Vincent, Marta Romano, Francis Corazza, Kris Huygen, Olivier Michel, Olivier Denis
Article
Chemistry, Organic
G. Rotthier, D. Cappoen, Quang Trung Nguyen, Tuyet Anh Dang Thi, V. Mathys, Van Tuyen Nguyen, K. Huygen, L. Maes, P. Cos, K. Abbaspour Tehrani
ORGANIC & BIOMOLECULAR CHEMISTRY
(2016)
Article
Immunology
Ha Thi Thu Hoang, Elke Leuridan, Kirsten Maertens, Trung Dac Nguyen, Niel Hens, Ngoc Ha Vu, Raissa Nadege Cabore, Hong Thi Duong, Kris Huygen, Pierre Van Damme, Anh Duc Dang
Article
Immunology
Kirsten Maertens, Raissa Nadege Cabore, Kris Huygen, Sandra Vermeiren, Niel Hens, Pierre Van Damme, Elke Leuridan
Article
Immunology
Kirsten Maertens, Raissa Nadege Cabore, Kris Huygen, Niel Hens, Pierre Van Damme, Elke Leuridan
Editorial Material
Immunology
Kris Huygen
Article
Medicine, General & Internal
Sophie Duterme, Raymond Vanhoof, Jean Vanderpas, Denis Pierard, Kris Huygen
ACTA CLINICA BELGICA
(2016)
Article
Public, Environmental & Occupational Health
H. Martini, C. Rodeghiero, C. Van Den Poel, M. Vincent, D. Pierard, K. Huygen
EPIDEMIOLOGY AND INFECTION
(2017)
Article
Construction & Building Technology
M. Vincent, P. Percier, S. De Prins, K. Huygen, G. Potemberg, E. Muraille, M. Romano, O. Michel, O. Denis
Article
Immunology
Kathy Dernivoix, Virginie Roupie, Sarah Welby, Sophie Roelandt, Sophie Viart, Jean-Jacques Letesson, Ruddy Wattiez, Kris Huygen, Marc Govaerts
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2017)
Article
Veterinary Sciences
K. Soetaert, C. Vluggen, L. Duytschaever, J. Denoel, V. Roupie, F. Smeets, N. Bruffaerts, K. Huygen, D. Fretin, M. Diels, L. Rigouts, C. Saegerman, V. Mathys
Article
Immunology
Raissa Nadege Cabore, Kirsten Maertens, Alexandre Dobly, Elke Leuridan, Pierre Van Damme, Kris Huygen
Article
Multidisciplinary Sciences
Toon Braeye, Jan Verheagen, Annick Mignon, Wim Flipse, Denis Pierard, Kris Huygen, Carole Schirvel, Niel Hens
Article
Multidisciplinary Sciences
Nicolas Bruffaerts, Christelle Vluggen, Virginie Roupie, Lucille Duytschaever, Christophe Van den Poel, Joseph Denoel, Ruddy Wattiez, Jean-Jacques Letesson, David Fretin, Leen Rigouts, Ophelie Chapeira, Vanessa Mathys, Claude Saegerman, Kris Huygen