Article
Multidisciplinary Sciences
Sangjoon Park, Gwanghyun Kim, Yujin Oh, Joon Beom Seo, Sang Min Lee, Jin Hwan Kim, Sungjun Moon, Jae-Kwang Lim, Chang Min Park, Jong Chul Ye
Summary: In this study, a framework called DISTL is proposed to improve the performance of vision transformer through self-supervision and self-training. The DISTL model shows gradually improved performance in diagnosing tuberculosis, pneumothorax, and COVID-19, even better than fully supervised models with the same amount of labeled data. The model obtained with DISTL is also shown to be robust to real-world nuisances, making it more applicable in a clinical setting.
NATURE COMMUNICATIONS
(2022)
Article
Critical Care Medicine
Maroussia Roelens, Giovanni Battista Migliori, Liudmila Rozanova, Janne Estill, Jonathon R. Campbell, J. Peter Cegielski, Simon Tiberi, Domingo Palmero, Greg J. Fox, Lorenzo Guglielmetti, Giovanni Sotgiu, James C. M. Brust, Didi Bang, Christian Lienhardt, Christoph Lange, Dick Menzies, Olivia Keiser, Mario Raviglione
Summary: The study supports a new definition of XDR-TB as MDR-TB with additional resistance to FQ plus bedaquiline and/or linezolid, which helps assess the adequacy of this definition for surveillance and treatment choice.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Infectious Diseases
Wubshet Assefa, Tewodros Eshete, Yoseph Solomon, Bersabeh Kassaye
Summary: This study analyzed the clinical, epidemiological, and laboratory characteristics of tuberculous lymphadenitis (TBL) in a specialized hospital in northwest Ethiopia. The results showed that TBL typically presents as a fluctuant neck mass, predominantly in young adults. Most patients do not have constitutional symptoms or cough, and HIV infection or chronic medical illnesses are uncommon. An increased erythrocyte sedimentation rate is a consistent finding.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Patricia Comella-del-Barrio, Jose Luis Izquierdo-Garcia, Jacqueline Gautier, Mariette Jean Coute Doresca, Ramon Campos-Olivas, Clara M. Santiveri, Beatriz Muriel-Moreno, Cristina Prat-Aymerich, Rosa Abellana, Tomas M. Perez-Porcuna, Luis E. Cuevas, Jesus Ruiz-Cabello, Jose Dominguez
Summary: In this study, differences in metabolic response in children with different diagnostic certainty of TB were identified using urine nuclear magnetic resonance-based metabolomics. This could help improve the accuracy of TB diagnosis and prediction in pediatric populations.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Peng Cheng, Liang Wang, Wenping Gong
Summary: In this study, a novel polypeptide molecule (PPM) was constructed with acceptable antigenicity, immunogenicity, stability, and the ability to induce robust immune responses, providing a new diagnostic biomarker or peptides-based vaccine for the diagnosis and prevention of LTBI.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Nathella Pavan Kumar, Syed Hissar, Kannan Thiruvengadam, Velayuthum V. Banurekha, N. Suresh, Janani Shankar, S. Elilarasi, N. S. Gomathi, S. Kalpana, J. Ganesh, M. A. Aravind, Dhanaraj Baskaran, Srikanth Tripathy, Soumya Swaminathan, Subash Babu
Summary: The study identified IFN-γ, TNF-α, IL-2, and IL-17A as potential biomarkers for pediatric tuberculosis. Following anti-tuberculosis treatment, cytokine levels decreased significantly, and combiROC models showed high sensitivity and specificity, providing an accurate diagnostic method.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Junseong Kim, Heechul Park, Sung-Bae Park, Eun Ju Lee, Min-A Je, Eunsol Ahn, Bora Sim, Jiyoung Lee, Hyunwoo Jin, Kyung Eun Lee, Sang-Nae Cho, Young Ae Kang, Hyejon Lee, Sunghyun Kim, Jungho Kim
Summary: Early diagnosis of active tuberculosis is important for successful treatment and reduced mortality. This study found that certain miRNAs, including miR-199a-3p and miR-6886-3p, can distinguish between active tuberculosis and latent tuberculosis infection. Additionally, anti-TB treatment helps restore the levels of certain miRNAs. The predicted target genes are involved in various biological processes.
Article
Infectious Diseases
Ausra Lukosiute-Urboniene, Inga Dekeryte, Kamile Donielaite-Anise, Arturas Kilda, Vidmantas Barauskas
Summary: Abdominal tuberculosis is a rare form of extrapulmonary TB that can affect children without comorbidities. The diagnosis of abdominal TB remains challenging due to its unspecific clinical features and unclear recommendations regarding the best diagnostic tools.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Medical Laboratory Technology
Ximeng Chen, Jianan Wang, Jinyang Wang, Jingyun Ye, Ping Di, Chang Dong, Hong Lei, Chengbin Wang
Summary: This study utilized proteomics to analyze serum proteins and identify potential biomarkers for the diagnosis of osteoarticular tuberculosis. ITIH2, CFHR2, CFHR3, and CFHR5 were found to be potential biomarkers, with CFHR2 and CFHR3 showing good diagnostic efficacy when combined in a diagnostic model.
CLINICA CHIMICA ACTA
(2023)
Article
Gastroenterology & Hepatology
James Buxbaum, Bashar Qumseya, Sachin Wani
Summary: Despite the lack of consensus criteria for the diagnosis of cholangitis, the BILE criteria appears to be a promising approach in identifying high-risk patients. Further validation studies are needed to confirm its diagnostic performance and ability to prevent unnecessary ERCP.
GASTROINTESTINAL ENDOSCOPY
(2021)
Review
Biochemistry & Molecular Biology
Nagarajan Usharani, Swarna Vinodh Kanth, Natarajan Saravanan
Summary: Tuberculosis is a deadly disease caused by Mycobacterium tuberculosis, with high morbidity and mortality rates each year. The development of anti-TB drugs holds promise for controlling and treating TB. However, the response to drugs varies depending on the bacterial load and host immune profiles. Poor adherence to treatment and acquired drug resistance are common due to the long treatment regimen and high pill burden. Nanotechnology offers targeted strategies to enhance therapeutic recovery with minimum treatment duration and better drug adherence. This review provides insights into nano-delivery systems for pulmonary tuberculosis treatment, including carrier selection, optimized processes, metabolic actions, and excretion processes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Multidisciplinary Sciences
Sabira Tahseen, Atiqa Ambreen, Sheeba Ishtiaq, Faisal M. Khanzada, Nauman Safdar, Lisbet Sviland, Tehmina Mustafa
Summary: This study assessed the value of histological examination in diagnosing tuberculous lymphadenitis (LNTB) and found that combining histology with Xpert can improve the diagnostic rate of LNTB compared to using Xpert alone.
SCIENTIFIC REPORTS
(2022)
Article
Infectious Diseases
Jesus Ruiz-Cabello, Iker A. Sevilla, Ekine Olaizola, Javier Bezos, Ana B. Miguel-Coello, Marta Munoz-Mendoza, Marta Beraza, Joseba M. Garrido, Jose L. Izquierdo-Garcia
Summary: Plasma metabolic TB profile was identified using high-field nuclear magnetic resonance (NMR) spectroscopy, and this characteristic profile was successfully measured using low-field benchtop (LF) NMR as an affordable molecular technology for TB diagnosis. The study showed that metabolic fingerprinting using HF and LF-NMR could differentiate TB subjects from uninfected animals, and PTB and PTB-vaccinated subjects who may show false positive results for TB.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Multidisciplinary Sciences
Mitiku Dubale, Mulualem Tadesse, Melkamu Berhane, Mekidim Mekonnen, Gemeda Abebe
Summary: This study evaluated the diagnostic performance of Xpert MTB/RIF in diagnosing pulmonary tuberculosis (PTB) from stool specimens in children. The results showed that the sensitivity of Xpert in stool samples was comparable to that in gastric aspirate samples. Therefore, stool samples could be a potential alternative to pulmonary specimens for diagnosing PTB in children using Xpert.
Article
Immunology
Xue Gong, Yunru He, Kaiyu Zhou, Yimin Hua, Yifei Li
Summary: This meta-analysis evaluated the effectiveness of the GeneXpert MTB/RIF assay (Xpert) for diagnosing different types of tuberculosis (TB) using various specimens. The results showed that Xpert had high sensitivity when using sputum and gastric juice for diagnosing pulmonary TB, and it also exhibited high accuracy in detecting bone and joint TB and tuberculosis lymphadenitis. However, the accuracy of Xpert for diagnosing TB meningitis and tuberculous pleuritis was not satisfactory. Therefore, selecting appropriate specimens for Xpert analysis is crucial.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Environmental Sciences
Gopal Krishna, Rabi N. Sahoo, Prafull Singh, Himesh Patra, Vaishangi Bajpai, Bappa Das, Sudhir Kumar, Raju Dhandapani, Chandrapal Vishwakarma, Madan Pal, V. Chinnusamy
Summary: This study investigated the response of different rice genotypes to water deficit stress using thermal imaging, visible imaging, RWC, and CWSI, and identified drought-tolerant and drought-resistant genotypes. Effective relationships between RWC and CWSI, as well as canopy reflectance spectra and CWSI, were established, with 10 optimal wavebands related to water deficit stress identified. This research contributes to the quick detection of water deficit stress in crops and can aid in the development of drought-tolerant rice genotypes in the future.
GEOCARTO INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Shovan Dogra, Madhumangal Pal
Summary: This paper introduces the concept of picture fuzzy subring of a crisp ring and studies some basic results. The properties of picture fuzzy subring under classical ring homomorphism are also investigated.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES INDIA SECTION A-PHYSICAL SCIENCES
(2021)
Letter
Biochemistry & Molecular Biology
Zain Chagla, Madhukar Pai
Letter
Biochemistry & Molecular Biology
C. S. Pramesh, Giridhara R. Babu, Joyeeta Basu, Indu Bhushan, Christopher M. Booth, Girish Chinnaswamy, Randeep Guleria, S. P. Kalantri, Gagandeep Kang, Pavitra Mohan, Nachiket Mor, Madhukar Pai, Manu Prakash, Priscilla Rupali, Priya Sampathkumar, Manju Sengar, Richard Sullivan, Priya Ranganathan
Review
Chemistry, Analytical
Sagnik Das, Subhajit Mojumder, Debdulal Saha, Mrinal Pal
Summary: In this review, the significant effects of various parameters on the sensing behavior of semiconductor metal oxide (SMO) based chemiresistive gas sensors have been discussed in detail. The study systematically reviewed the impact of different material and operating condition aspects on the gas sensing performance of SMO sensors. The importance of long-term stability and high-throughput synthesis techniques in practical applications was emphasized, and the future prospects of SMO-based sensors in personalized healthcare were briefly outlined.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Physical
Tanushri Das, Subhajit Mojumder, Sonam Chakraborty, Debdulal Saha, Mrinal Pal
Summary: Pure and Sn-doped Bismuth Ferrite (BFO) nanoparticles were synthesized and their gas sensing properties towards formaldehyde were investigated. The Sn-doped BFO nanoparticles showed enhanced formaldehyde sensing performance, with high selectivity and fast response/recovery time. The detection limit of the prepared sensors was low, making them a potential candidate for monitoring formaldehyde in indoor and outdoor air quality.
APPLIED SURFACE SCIENCE
(2022)
Article
Materials Science, Ceramics
Sonam Chakraborty, Nirman Chakraborty, Swastik Mondal, Mrinal Pal
Summary: This study reports the efficient photocatalytic degradation of methyl blue dye using Sn-doped bismuth ferrite nanoparticles under visible light. The 1.5% Sn-doped BFO nanoparticles exhibited the highest photocatalytic activity, degrading 70% of the dye within 10 minutes of visible light irradiation. These nanoparticles also showed potential for degrading another important contaminant, RhB.
CERAMICS INTERNATIONAL
(2022)
Article
Chemistry, Analytical
Subhajit Mojumder, Tanushri Das, Sagnik Das, Nirman Chakraborty, Debdulal Saha, Mrinal Pal
Summary: This study presents a highly sensitive and selective Al and Y co-doped ZnO nanopowder sensor for detecting trace ethanol in exhaled breath. The sensor exhibits rapid response and recovery time, good repeatability, and long-term stability, as well as excellent selectivity towards ethanol. It has the potential to be used for detecting liver problems and for breathalyzer testing in cases of drunken driving.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Multidisciplinary
Snehasis Mishra, Kaustav Das, Sujan Chatterjee, Panchanan Sahoo, Sudip Kundu, Mrinal Pal, Asim Bhaumik, Chandan Kumar Ghosh
Summary: Carbon dots (CQDs) with tunable fluorescence emission and excitation, high water solubility, good photostability, and biocompatibility are considered promising for tumor theranostics. This study focused on the synthesis and characterization of highly fluorescent CQDs from orange juice. CQD/Ag heterostructures were also synthesized and their photostability and characterization were investigated. Cellular toxicity measurements were conducted to select the superior CQD/Ag heterostructure in the human colorectal carcinoma (HCT 116) cell line, along with the observation of cell death signaling through the ROS-dependent mitochondrial-mediated pathway.
Article
Chemistry, Multidisciplinary
Monalisa Adhikari, Sagnik Das, Dipankar Chattopadhyay, Debdulal Saha, Mrinal Pal
Summary: Recently, there has been significant interest in the precise detection of VOCs, especially acetone, ammonia, and alcohol, due to their importance in industrial safety, environmental monitoring, and human health. This article reports on a chemiresistive sensor based on polypyrrole nanotubes (PPNT) for the selective detection of trace acetone vapor at room temperature. The PPNT sensor demonstrated a high response to trace acetone vapor with a low detection limit and quick response and recovery times.
Article
Chemistry, Multidisciplinary
Sagnik Das, Uttam K. Ghorai, Rajib Dey, Chandan K. Ghosh, Mrinal Pal
Summary: This study reports the achievement of highly reproducible, stable, and intense white phosphorescence from phase-pure zinc oxide nanopowder synthesized by a simple, low temperature process. The white light emission has appreciable quantum yield and cool/near cool correlated color temperature, making it suitable for W-LED applications. The presence of zinc interstitial and oxygen interstitial defects responsible for the white phosphorescence was confirmed, and a defect chemistry-based thermodynamic interpretation was proposed to explain the white emission adequately.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Infectious Diseases
S. Huddart, P. Ingawale, J. Edwin, V. Jondhale, M. Pai, A. Benedetti, D. Shah, S. Vijayan
Summary: The study revealed a moderate treatment phase CFR among PPIA-managed private sector patients, with low rates of post-treatment fatality and recurrence. Factors affecting fatality and recurrence include age, clinical diagnosis, treatment duration, and adherence. Routine monitoring of patient outcomes after treatment is crucial for strengthening PPIAs and informing future interventions.
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
(2021)
Review
Medicine, General & Internal
Jerry S. Zifodya, Jonah S. Kreniske, Ian Schiller, Mikashmi Kohli, Nandini Dendukuri, Samuel G. Schumacher, Eleanor A. Ochodo, Frederick Haraka, Alice A. Zwerling, Madhukar Pai, Karen R. Steingart, David J. Horne
Summary: Xpert Ultra shows higher sensitivity but lower specificity compared to Xpert MTB/RIF for pulmonary tuberculosis, especially in smear-negative individuals and those living with HIV. The trade-off between sensitivity and specificity may vary by setting. Additionally, for rifampicin resistance detection, Xpert Ultra and Xpert MTB/RIF have similar sensitivity and specificity, with Xpert Ultra yielding more trace-positive results.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Sagnik Das, Uttam Kumar Ghorai, Rajib Dey, Chandan Kumar Ghosh, Mrinal Pal
Summary: This paper reports the successful tuning of defect-mediated blue phosphorescence of ZnO nanopowders by annealing at different temperatures, resulting in changes in intensity, shade, and color temperature. Multiple characterization techniques were used to examine the microstructural, compositional, and band-structure details, and optical properties of the samples were studied through PL and tau-PL spectroscopy.
Article
Computer Science, Artificial Intelligence
Sankar Das, Ganesh Ghorai, Madhumangal Pal
Summary: This paper introduces the concept of picture fuzzy competition graphs and its generalizations, as well as investigates the properties of related picture fuzzy graphs. It also presents applications of m-step picture fuzzy competition graphs and picture fuzzy competition hypergraphs in various fields.
ARTIFICIAL INTELLIGENCE REVIEW
(2021)
