Drosophila CaV2 channels harboring human migraine mutations cause synapse hyperexcitability that can be suppressed by inhibition of a Ca2+ store release pathway

FDA approves licensing of erenumab-aooe to prevent migraine

(2018) Kate Traynor   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

ARISE: A Phase 3 randomized trial of erenumab for episodic migraine

(2018) David W Dodick et al.   CEPHALALGIA

Clinical spectrum of hemiplegic migraine and chances of finding a pathogenic mutation

(2018) Nadine Pelzer et al.   NEUROLOGY

Triptans and CGRP blockade – impact on the cranial vasculature

(2017) Silvia Benemei et al.   JOURNAL OF HEADACHE AND PAIN

Safety and efficacy of erenumab for preventive treatment of chronic migraine: a randomised, double-blind, placebo-controlled phase 2 trial

(2017) Stewart Tepper et al.   LANCET NEUROLOGY

A Controlled Trial of Erenumab for Episodic Migraine

(2017) Peter J. Goadsby et al.   NEW ENGLAND JOURNAL OF MEDICINE

The role of calcitonin gene–related peptide in peripheral and central pain mechanisms including migraine

(2017) Smriti Iyengar et al.   PAIN

A Presynaptic Glutamate Receptor Subunit Confers Robustness to Neurotransmission and Homeostatic Potentiation

(2017) Beril Kiragasi et al.   Cell Reports

Clinically severe CACNA1A alleles affect synaptic function and neurodegeneration differentially

(2017) Xi Luo et al.   PLoS Genetics

Induction of Migraine-Like Photophobic Behavior in Mice by Both Peripheral and Central CGRP Mechanisms

(2016) Bianca N. Mason et al.   JOURNAL OF NEUROSCIENCE

Maturation of active zone assembly byDrosophilaBruchpilot

(2016) Wernher Fouquet et al.   JOURNAL OF CELL BIOLOGY

Abnormal synaptic Ca2+homeostasis and morphology in cortical neurons of familial hemiplegic migraine type 1 mutant mice

(2015) Katharina Eikermann-Haerter et al.   ANNALS OF NEUROLOGY

Site of effect of LY2951742 for migraine prophylaxis

(2015) Peer Tfelt-Hansen   LANCET NEUROLOGY

Abnormal cortical synaptic transmission in CaV2.1 knockin mice with the S218L missense mutation which causes a severe familial hemiplegic migraine syndrome in humans

(2015) Dania Vecchia et al.   Frontiers in Cellular Neuroscience

A single-cross, RNA interference-based genetic tool for examining the long-term maintenance of homeostatic plasticity

(2015) Douglas J. Brusich et al.   Frontiers in Cellular Neuroscience

Dosage Compensation inDrosophila

(2015) John C. Lucchesi et al.   Cold Spring Harbor Perspectives in Biology

Homeostatic synaptic depression is achieved through a regulated decrease in presynaptic calcium channel abundance

(2015) Michael A Gaviño et al.   eLife

Familial hemiplegic migraine treated by sodium valproate and lamotrigine

(2014) Nadine Pelzer et al.   CEPHALALGIA

Archaerhodopsin Voltage Imaging: Synaptic Calcium and BK Channels Stabilize Action Potential Repolarization at the Drosophila Neuromuscular Junction

(2014) K. J. Ford et al.   JOURNAL OF NEUROSCIENCE

Synaptic Gain-of-Function Effects of Mutant Cav2.1 Channels in a Mouse Model of Familial Hemiplegic Migraine Are Due to Increased Basal [Ca2+]i

(2014) M. N. Di Guilmi et al.   JOURNAL OF NEUROSCIENCE

Safety and efficacy of LY2951742, a monoclonal antibody to calcitonin gene-related peptide, for the prevention of migraine: a phase 2, randomised, double-blind, placebo-controlled study

(2014) David W Dodick et al.   LANCET NEUROLOGY

Mechanism underlying unaltered cortical inhibitory synaptic transmission in contrast with enhanced excitatory transmission in CaV2.1 knockin migraine mice

(2014) Dania Vecchia et al.   NEUROBIOLOGY OF DISEASE

Krüppel Mediates the Selective Rebalancing of Ion Channel Expression

(2014) Jay Z. Parrish et al.   NEURON

Pharmacological Correction of Gating Defects in the Voltage-Gated Ca v 2.1 Ca 2+ Channel due to a Familial Hemiplegic Migraine Mutation

(2014) Akira Inagaki et al.   NEURON

A TRPV Channel in Drosophila Motor Neurons Regulates Presynaptic Resting Ca2+ Levels, Synapse Growth, and Synaptic Transmission

(2014) Ching-On Wong et al.   NEURON

A hyperexcitability phenotype in mouse trigeminal sensory neurons expressing the R192Q Cacna1a missense mutation of familial hemiplegic migraine type-1

(2014) S.K. Hullugundi et al.   NEUROSCIENCE

How voltage-gated calcium channels gate forms of homeostatic synaptic plasticity

(2014) C. Andrew Frank   Frontiers in Cellular Neuroscience

Episodic Neurologic Disorders: Syndromes, Genes, and Mechanisms

(2013) Jonathan F. Russell et al.   Annual Review of Neuroscience

RNA expression profiling in brains of familial hemiplegic migraine type 1 knock-in mice

(2013) Boukje de Vries et al.   CEPHALALGIA

Distinct roles ofDrosophila cacophonyandDmca1DCa2+channels in synaptic homeostasis: Genetic interactions withslowpokeCa2+-activated BK channels in presynaptic excitability and postsynaptic response

(2013) Jihye Lee et al.   Developmental Neurobiology

Spontaneous and Evoked Release Are Independently Regulated at Individual Active Zones

(2013) J. E. Melom et al.   JOURNAL OF NEUROSCIENCE

Differential triggering of spontaneous glutamate release by P/Q-, N- and R-type Ca2+ channels

(2013) Yaroslav S Ermolyuk et al.   NATURE NEUROSCIENCE

Differential trigeminovascular nociceptive responses in the thalamus in the familial hemiplegic migraine 1 knock-in mouse: A Fos protein study

(2013) JungWook Park et al.   NEUROBIOLOGY OF DISEASE

CGRP and migraine: Could PACAP play a role too?

(2013) Eric A. Kaiser et al.   NEUROPEPTIDES

Homeostatic plasticity at the Drosophila neuromuscular junction

(2013) C. Andrew Frank   NEUROPHARMACOLOGY

Pathophysiology of Migraine

(2012) Daniela Pietrobon et al.   Annual Review of Physiology

Dynamic clustering of IP3receptors by IP3

(2012) Taufiq Rahman   BIOCHEMICAL SOCIETY TRANSACTIONS

Calcium channels and migraine

(2012) Daniela Pietrobon   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Familial and Sporadic Hemiplegic Migraine: Diagnosis and Treatment

(2012) Nadine Pelzer et al.   Current Treatment Options in Neurology

Safety and efficacy of flunarizine in childhood migraine: 11 years’ experience, with emphasis on its effect in hemiplegic migraine

(2012) BASHEER PEER MOHAMED et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Presynaptic CaV2.1 calcium channels carrying familial hemiplegic migraine mutation R192Q allow faster recovery from synaptic depression in mouse calyx of Held

(2012) Carlota González Inchauspe et al.   JOURNAL OF NEUROPHYSIOLOGY

Cerebellar Ataxia by Enhanced CaV2.1 Currents Is Alleviated by Ca2+-Dependent K+-Channel Activators in Cacna1aS218L Mutant Mice

(2012) Z. Gao et al.   JOURNAL OF NEUROSCIENCE

Miniature IPSCs in Hippocampal Granule Cells Are Triggered by Voltage-Gated Ca2+ Channels via Microdomain Coupling

(2012) S. P. Goswami et al.   JOURNAL OF NEUROSCIENCE

mRNA expression of 5-hydroxytryptamine 1B, 1D, and 1F receptors and their role in controlling the release of calcitonin gene–related peptide in the rat trigeminovascular system

(2012) Dipak V. Amrutkar et al.   PAIN

MiMIC: a highly versatile transposon insertion resource for engineering Drosophila melanogaster genes

(2011) Koen J T Venken et al.   NATURE METHODS

Neurological Channelopathies

(2010) Dimitri M. Kullmann   Annual Review of Neuroscience

Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura

(2010) Jakob Møller Hansen et al.   CEPHALALGIA

Severe and Progressive Neurotransmitter Release Aberrations in Familial Hemiplegic Migraine Type 1 Cacna1a S218L Knock-in Mice

(2010) Simon Kaja et al.   JOURNAL OF NEUROPHYSIOLOGY

Gain of Function in FHM-1 Cav2.1 Knock-In Mice Is Related to the Shape of the Action Potential

(2010) Carlota González Inchauspe et al.   JOURNAL OF NEUROPHYSIOLOGY

Role of G-Proteins in Odor-Sensing and CO2-Sensing Neurons in Drosophila

(2010) C. A. Yao et al.   JOURNAL OF NEUROSCIENCE

Dilation by CGRP of middle meningeal artery and reversal by sumatriptan in normal volunteers

(2010) M. S. Asghar et al.   NEUROLOGY

Drosophila Pacemaker Neurons Require G Protein Signaling and GABAergic Inputs to Generate Twenty-Four Hour Behavioral Rhythms

(2010) David Dahdal et al.   NEURON

Episodic Neurological Channelopathies

(2010) Devon P. Ryan et al.   NEURON

A Hierarchy of Cell Intrinsic and Target-Derived Homeostatic Signaling

(2010) Sharon Bergquist et al.   NEURON

Flunarizine blocks voltage-gated Na+ and Ca2+ currents in cultured rat cortical neurons: A possible locus of action in the prevention of migraine

(2010) Qing Ye et al.   NEUROSCIENCE LETTERS

Contribution of calcium-dependent facilitation to synaptic plasticity revealed by migraine mutations in the P/Q-type calcium channel

(2010) P. J. Adams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activity-induced large amplitude postsynaptic mPSPs at soma-soma synapses between Lymnaea neurons

(2010) T.W. Dunn et al.   SYNAPSE

High cortical spreading depression susceptibility and migraine-associated symptoms in Cav2.1 S218L mice

(2009) Arn M. J. M. van den Maagdenberg et al.   ANNALS OF NEUROLOGY

Enhanced Excitatory Transmission at Cortical Synapses as the Basis for Facilitated Spreading Depression in CaV2.1 Knockin Migraine Mice

(2009) Angelita Tottene et al.   NEURON

A Presynaptic Homeostatic Signaling System Composed of the Eph Receptor, Ephexin, Cdc42, and CaV2.1 Calcium Channels

(2009) C. Andrew Frank et al.   NEURON

Calcitonin gene-related peptide (CGRP) triggers Ca2+responses in cultured astrocytes and in Bergmann glial cells from cerebellar slices

(2008) Stefano Morara et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Dantrolene: Mechanisms of Neuroprotection and Possible Clinical Applications in the Neurointensive Care Unit

(2008) Susanne Muehlschlegel et al.   Neurocritical Care

Calcitonin gene-related peptide does not cause the familial hemiplegic migraine phenotype

(2008) J. M. Hansen et al.   NEUROLOGY

A Presynaptic Giant Ankyrin Stabilizes the NMJ through Regulation of Presynaptic Microtubules and Transsynaptic Cell Adhesion

(2008) Jan Pielage et al.   NEURON

Pre- and post-synaptic mechanisms of synaptic strength homeostasis revealed by slowpoke and shaker K+ channel mutations in Drosophila

(2008) J. Lee et al.   NEUROSCIENCE