Vestigialization of an Allosteric Switch: Genetic and Structural Mechanisms for the Evolution of Constitutive Activity in a Steroid Hormone Receptor

Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors

(2013) M. J. Harms et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epistasis Among Adaptive Mutations in Deer Mouse Hemoglobin

(2013) C. Natarajan et al.   SCIENCE

The spatial architecture of protein function and adaptation

(2012) Richard N. McLaughlin Jr et al.   NATURE

The Impact of Point Mutations in the Human Androgen Receptor: Classification of Mutations on the Basis of Transcriptional Activity

(2012) Colin W. Hay et al.   PLoS One

Intramolecular Epistasis and the Evolution of a New Enzymatic Function

(2012) Sajid Noor et al.   PLoS One

Do mollusks use vertebrate sex steroids as reproductive hormones? II. Critical review of the evidence that steroids have biological effects

(2012) Alexander P. Scott   STEROIDS

Reconstruction of Ancestral Metabolic Enzymes Reveals Molecular Mechanisms Underlying Evolutionary Innovation through Gene Duplication

(2012) Karin Voordeckers et al.   PLOS BIOLOGY

Evolution of Minimal Specificity and Promiscuity in Steroid Hormone Receptors

(2012) Geeta N. Eick et al.   PLoS Genetics

Determinants of Homodimerization Specificity in Histidine Kinases

(2011) Orr Ashenberg et al.   JOURNAL OF MOLECULAR BIOLOGY

Regulatory evolution through divergence of a phosphoswitch in the transcription factor CEBPB

(2011) Vincent J. Lynch et al.   NATURE

Slow protein evolutionary rates are dictated by surface-core association

(2011) A. Toth-Petroczy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms for the Evolution of a Derived Function in the Ancestral Glucocorticoid Receptor

(2011) Sean Michael Carroll et al.   PLoS Genetics

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Analyzing protein structure and function using ancestral gene reconstruction

(2010) Michael J Harms et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Evolution of steroid receptors from an estrogen-sensitive ancestral receptor

(2010) Geeta N. Eick et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Protein Evolution by Molecular Tinkering: Diversification of the Nuclear Receptor Superfamily from a Ligand-Dependent Ancestor

(2010) Jamie T. Bridgham et al.   PLOS BIOLOGY

Structural Determinants of Protein Evolution Are Context-Sensitive at the Residue Level

(2009) E. A. Franzosa et al.   MOLECULAR BIOLOGY AND EVOLUTION

An epistatic ratchet constrains the direction of glucocorticoid receptor evolution

(2009) Jamie T. Bridgham et al.   NATURE

Evolution: Convergent Eye Losses in Fishy Circumstances

(2008) Jeremy E. Niven   CURRENT BIOLOGY

Hormone-Activated Estrogen Receptors in Annelid Invertebrates: Implications for Evolution and Endocrine Disruption

(2008) June Keay et al.   ENDOCRINOLOGY

Elucidation of phenotypic adaptations: Molecular analyses of dim-light vision proteins in vertebrates

(2008) S. Yokoyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution of a New Function by Degenerative Mutation in Cephalochordate Steroid Receptors

(2008) Jamie T. Bridgham et al.   PLoS Genetics