Serine- and Threonine/Valine-Dependent Activation of PDK and Tor Orthologs Converge on Sch9 to Promote Aging

Acetic acid and acidification accelerate chronological and replicative aging in yeast

(2012) Mario G. Mirisola et al.   CELL CYCLE

Mitochondrial Respiratory Thresholds Regulate Yeast Chronological Life Span and its Extension by Caloric Restriction

(2012) Alejandro Ocampo et al.   Cell Metabolism

Replicative and Chronological Aging in Saccharomyces cerevisiae

(2012) Valter D. Longo et al.   Cell Metabolism

Down-Regulating Sphingolipid Synthesis Increases Yeast Lifespan

(2012) Xinhe Huang et al.   PLoS Genetics

Amino Acid Signaling in TOR Activation

(2011) Joungmok Kim et al.   Annual Review of Biochemistry

Mechanistic enzymology of serine palmitoyltransferase

(2011) Hiroko Ikushiro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Role of Sch9 in regulating Ras-cAMP signal pathway inSaccharomyces cerevisiae

(2011) Aili Zhang et al.   FEBS LETTERS

Yeast cells can access distinct quiescent states

(2011) M. M. Klosinska et al.   GENES & DEVELOPMENT

Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control

(2011) Robbie Loewith et al.   GENETICS

Yeast 3-Phosphoinositide-dependent Protein Kinase-1 (PDK1) Orthologs Pkh1–3 Differentially Regulate Phosphorylation of Protein Kinase A (PKA) and the Protein Kinase B (PKB)/S6K Ortholog Sch9

(2011) Karin Voordeckers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence for Direct Activation of mTORC2 Kinase Activity by Phosphatidylinositol 3,4,5-Trisphosphate

(2011) Xiaoqing Gan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impact of caloric and dietary restriction regimens on markers of health and longevity in humans and animals: a summary of available findings

(2011) John F Trepanowski et al.   Nutrition Journal

A Split-Ubiquitin Two-Hybrid Screen for Proteins Physically Interacting with the Yeast Amino Acid Transceptor Gap1 and Ammonium Transceptor Mep2

(2011) Griet Van Zeebroeck et al.   PLoS One

Molecular mechanisms involved in the adaptation to amino acid limitation in mammals

(2010) Cédric Chaveroux et al.   BIOCHIMIE

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

A molecular mechanism of chronological aging in yeast

(2010) Christopher R. Burtner et al.   CELL CYCLE

The JmjC domain of Gis1 is dispensable for transcriptional activation

(2010) Yao Yu et al.   FEMS YEAST RESEARCH

The Rapamycin-sensitive Phosphoproteome Reveals That TOR Controls Protein Kinase A Toward Some But Not All Substrates

(2010) Alexandre Soulard et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

(2010) Shomit Sengupta et al.   MOLECULAR CELL

Localization to, and Effects of Pbp1, Pbp4, Lsm12, Dhh1, and Pab1 on Stress Granules in Saccharomyces cerevisiae

(2010) Kylie D. Swisher et al.   PLoS One

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Calorie restriction and cancer prevention: metabolic and molecular mechanisms

(2010) Valter D. Longo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Amino acids as regulators of gene expression in mammals: Molecular mechanisms

(2009) Alain Bruhat et al.   BIOFACTORS

mTOR and the control of whole body metabolism

(2009) Pazit Polak et al.   CURRENT OPINION IN CELL BIOLOGY

Saccharomyces cerevisiae plasma membrane nutrient sensors and their role in PKA signaling

(2009) Marta Rubio-Texeira et al.   FEMS YEAST RESEARCH

Metabolic Adaptations to Interrupted Glycosaminoglycan Recycling

(2009) Josh C. Woloszynek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila

(2009) Richard C. Grandison et al.   NATURE

Excess omega-3 fatty acid consumption by mothers during pregnancy and lactation caused shorter life span and abnormal ABRs in old adult offspring

(2009) M.W. Church et al.   NEUROTOXICOLOGY AND TERATOLOGY

Tor1/Sch9-Regulated Carbon Source Substitution Is as Effective as Calorie Restriction in Life Span Extension

(2009) Min Wei et al.   PLoS Genetics

Dietary composition specifies consumption, obesity, and lifespan inDrosophila melanogaster

(2008) Danielle A. Skorupa et al.   AGING CELL

Amino acid regulation of TOR complex 1

(2008) Joseph Avruch et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

HowSaccharomycesResponds to Nutrients

(2008) Shadia Zaman et al.   Annual Review of Genetics

Life Span Extension by Calorie Restriction Depends on Rim15 and Transcription Factors Downstream of Ras/PKA, Tor, and Sch9

(2008) Min Wei et al.   PLoS Genetics

Influence of genotype and nutrition on survival and metabolism of starving yeast

(2008) V. M. Boer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE

Posttranscriptional regulation ofFLO11upon amino acid starvation inSaccharomyces cerevisiae

(2007) Claudia Fischer et al.   FEMS YEAST RESEARCH

Amino acid transport through the Saccharomyces cerevisiae Gap1 permease is controlled by the Ras/cAMP pathway

(2007) Jinnie M. Garrett   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY