FAK Acts as a Suppressor of RTK-MAP Kinase Signalling in Drosophila melanogaster Epithelia and Human Cancer Cells

Late endosomal and lysosomal trafficking during integrin-mediated cell migration and invasion

(2013) Elena Rainero et al.   BIOESSAYS

Internalization Mechanisms of the Epidermal Growth Factor Receptor after Activation with Different Ligands

(2013) Lasse Henriksen et al.   PLoS One

Disrupting the Scaffold to Improve Focal Adhesion Kinase-Targeted Cancer Therapeutics

(2013) W. G. Cance et al.   Science Signaling

Neuropilin-1-Dependent Regulation of EGF-Receptor Signaling

(2012) S. Rizzolio et al.   CANCER RESEARCH

Src-dependent autophagic degradation of Ret in FAK-signalling-defective cancer cells

(2012) Emma Sandilands et al.   EMBO REPORTS

Diacylglycerol kinase α controls RCP-dependent integrin trafficking to promote invasive migration

(2012) Elena Rainero et al.   JOURNAL OF CELL BIOLOGY

Safety, Pharmacokinetic, and Pharmacodynamic Phase I Dose-Escalation Trial of PF-00562271, an Inhibitor of Focal Adhesion Kinase, in Advanced Solid Tumors

(2012) Jeffrey R. Infante et al.   JOURNAL OF CLINICAL ONCOLOGY

Chemical genetic discovery of targets and anti-targets for cancer polypharmacology

(2012) Arvin C. Dar et al.   NATURE

Paradoxical roles of FAK in tumor cell migration and metastasis

(2011) Yanhua Zheng et al.   CELL CYCLE

Focal Adhesion Kinase (FAK) Binds RET Kinase via Its FERM Domain, Priming a Direct and Reciprocal RET-FAK Transactivation Mechanism

(2011) Iván Plaza-Menacho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling

(2011) Emma Sandilands et al.   NATURE CELL BIOLOGY

Fission of Tubular Endosomes Triggers Endosomal Acidification and Movement

(2011) Kumi Mesaki et al.   PLoS One

Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development

(2010) Xiaofeng Zhao et al.   JOURNAL OF CELL BIOLOGY

Lipid raft localization of EGFR alters the response of cancer cells to the EGFR tyrosine kinase inhibitor gefitinib

(2010) Mary E. Irwin et al.   JOURNAL OF CELLULAR PHYSIOLOGY

SRC-3Δ4 Mediates the Interaction of EGFR with FAK to Promote Cell Migration

(2010) Weiwen Long et al.   MOLECULAR CELL

The FERM domain: organizing the structure and function of FAK

(2010) Margaret C. Frame et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphorylation of focal adhesion kinase on tyrosine 194 by Met leads to its activation through relief of autoinhibition

(2010) T-H Chen et al.   ONCOGENE

Drosophila as a Novel Therapeutic Discovery Tool for Thyroid Cancer

(2010) Tirtha Das et al.   THYROID

Epidermal growth factor receptor as a potential therapeutic target in triple-negative breast cancer

(2009) B. Corkery et al.   ANNALS OF ONCOLOGY

Signal transduction by focal adhesion kinase in cancer

(2009) Jihe Zhao et al.   CANCER AND METASTASIS REVIEWS

The Ret Receptor Tyrosine Kinase Pathway Functionally Interacts with the ER  Pathway in Breast Cancer

(2008) A. Boulay et al.   CANCER RESEARCH

Clathrin-Mediated Internalization Is Essential for Sustained EGFR Signaling but Dispensable for Degradation

(2008) Sara Sigismund et al.   DEVELOPMENTAL CELL

Mutation ofDrosophilafocal adhesion kinase induces bang-sensitive behavior and disrupts glial function, axonal conduction and synaptic transmission

(2008) Atsushi Ueda et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Signaling from endosomes: Location makes a difference

(2008) Lukasz Sadowski et al.   EXPERIMENTAL CELL RESEARCH

Fak56 functions downstream of integrin alphaPS3betanu and suppresses MAPK activation in neuromuscular junction growth

(2008) Pei-I Tsai et al.   Neural Development