Article
Allergy
Fahad H. Alahmadi, Brian Keevil, Lynn Elsey, Kate George, Robert Niven, Stephen J. Fowler
Summary: LC-MS/MS can reliably detect commonly used ICSs in the blood at least 8 hours after dosing, providing a measure of adherence in severe asthma patients. Lower blood levels were associated with higher exacerbation rates and poorer lung function.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Respiratory System
Heath Heatley, Trung N. Tran, Arnaud Bourdin, Andrew Menzies-Gow, David Joshua Jackson, Ekaterina Maslova, Jatin Chapaneri, Derek Skinner, Victoria Carter, Jeffrey Shi Kai Chan, Con Ariti, John Haughney, David B. Price
Summary: Intermittent oral corticosteroid (OCS) use for asthma is associated with increased risks of adverse outcomes. More frequent prescribing patterns of OCS are associated with higher risks of adverse outcomes, particularly pneumonia and sleep apnea. Mitigation strategies are needed to minimize intermittent OCS prescription in primary care.
Article
Health Care Sciences & Services
Chelsea Richwine, Jordan Everson
Summary: This study provides national-level estimates on the use of prescription drug monitoring programs (PDMPs) among office-based physicians in the USA and examines the associated benefits. The findings suggest that both frequency and ease of use of PDMPs are positively correlated with PDMP integration status. Efforts to make PDMPs easier to access and use have contributed to informed clinical decision-making and may provide additional benefits beyond reducing prescribing.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Review
Respiratory System
Raja Dhar, Chin Kook Rhee, Diahn-Warng Perng, Koichi Fukunaga, Mary Sau-Man Ip, Siwasak Juthong, Mariko Siyue Koh, Jing Li, Shubham Sharma, Wiwien Heru Wiyono
Summary: Most patients with asthma can manage their condition effectively with inhaled medications. However, those with severe or uncontrolled asthma may require systemic corticosteroids, which can have long-term adverse health outcomes. Studies suggest that there is an overuse of systemic corticosteroids in asthma management globally, including Asia, and coordinated changes are needed to reduce this burden.
Article
Allergy
Britt Overgaard Hedegaard, Kjell Erik Julius Hakansson, Frodi Fridason Jensen, Charlotte Suppli Ulrik, Ulla Moller Weinreich
Summary: This study aimed to evaluate the reliability of using the Foster score to assess adherence to inhaled corticosteroids in adults with asthma. The study found that self-reported adherence scores were higher than objective measures of adherence, indicating some discrepancy between the Foster score and medication possession ratio.
JOURNAL OF ASTHMA AND ALLERGY
(2022)
Article
Medicine, General & Internal
Tongluk Teerasarntipan, Yingluk Sritunyarat, Parinda Prathyajuta, Palada Pitakkitnukun, Chonlada Phathong, Darlene Ariyaskul, Kittipat Kulkraisri, Pisit Tangkijvanich, Sombat Treeprasertsuk, Rungsun Rerknimitr, Roongruedee Chaiteerakij
Summary: HCC surveillance rates are suboptimal, and there are barriers from both physician's and patient's perspectives. Lack of knowledge and resource limitations are primary barriers for physicians, while the lack of doctor's prescription is a major barrier from patient's perspectives. Brief education via social networks shows effectiveness at increasing physicians' knowledge of HCC surveillance.
Article
Allergy
Marianne Eijkemans, Monique Mommers, Carel Thijs
Summary: This study compares parent reported physician diagnosed asthma with general practitioner recorded childhood asthma and finds only moderate agreement between the two. The labeling of early transient wheeze as asthma diagnosis may influence the agreement. Therefore, combining parent reported physician diagnosed asthma with additional questions is important for obtaining reliable information in epidemiological research.
Article
Dermatology
T. Nakamura, S. Haider, S. Fontanella, C. S. Murray, A. Simpson, A. Custovic
Summary: This study aimed to identify longitudinal trajectories of atopic dermatitis (AD) in childhood using different data sources and definitions, finding variations in AD categories and associations with risk factors under different definitions of AD.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Sport Sciences
Nikolai Stenfors, Tommie Irewall, Anne Lindberg
Summary: Longitudinal studies are needed to understand the natural history of asthma in athletes. A survey was conducted on 666 Swedish elite endurance athletes to estimate the incidence, remission, and relapse of self-reported asthma. The results showed that elite endurance athletes have a higher incidence of physician-diagnosed asthma, while the remission and relapse of asthma medication usage are similar to the general population.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Economics
Solomos Solomou, Ryland Thomas
Summary: This article brings together some of the improvements to GDP estimates from the income side since the publication of Charles Feinstein's 1972 volume National income, expenditure and output of the United Kingdom, 1855-1965. The focus is on reconstructing income-based estimates for the period 1841-1920 and using the new data to analyze the trend and cyclical path of the late nineteenth-century UK economy.
ECONOMIC HISTORY REVIEW
(2023)
Article
Medicine, Research & Experimental
Peter Daley-Yates, Dave Singh, Juan M. Igea, Luigi Macchia, Manish Verma, Norbert Berend, Maximilian Plank
Summary: This article reviews the efficacy and systemic activity profiles of fluticasone furoate (FF)-containing and budesonide (BUD)-containing asthma therapies in clinical trials and real-world studies. The results indicate that regular daily FF or FF/vilanterol (VI) dosing provides more prolonged bronchoprotection and fewer systemic effects compared to daily BUD, daily BUD/formoterol (FOR), or BUD/FOR maintenance and reliever therapy (MART) dosing, especially in low adherence scenarios.
ADVANCES IN THERAPY
(2023)
Article
Allergy
Katsunori Masaki, Jun Miyata, Takashi Kamatani, Takae Tanosaki, Takao Mochimaru, Hiroki Kabata, Yusuke Suzuki, Koichiro Asano, Tomoko Betsuyaku, Koichi Fukunaga
Summary: This study investigated the characteristics of patients with moderate to severe asthma who showed poor adherence to inhaled corticosteroid therapy in order to identify barriers to optimal treatment. The study found that age at diagnosis is an independent risk factor for predicting poor adherence among adults with moderate to severe asthma.
ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Brendan Hallam, Irene Petersen, Claudia Cooper, Christina Avgerinou, Kate Walters
Summary: This study investigates the incidence of memory concerns and cognitive decline in primary care patients in the UK. The findings suggest that a minority of individuals experiencing memory loss consult their GP, but those who do report concerns are at higher risk of developing dementia, particularly women, older adults, and those in more deprived areas.
CLINICAL EPIDEMIOLOGY
(2022)
Article
Medicine, General & Internal
Eyayaw Ashete Belachew, Adeladlew Kassie Netere, Ashenafi Kibret Sendekie
Summary: This study examines the level of adherence to inhaled corticosteroids (ICS) treatment among adult patients with asthma in Northwest Ethiopia and finds low levels of adherence. Some participants only use ICS before exercise, while others use it when they need it or when they feel breathless. Non-adherence to ICS treatment is significantly associated with poor asthma control. Patients who have access to free healthcare services exhibit better adherence to ICS.
PATIENT PREFERENCE AND ADHERENCE
(2022)
Article
Medicine, General & Internal
Sonal Ghura Mansukhani, Elizabeth A. MacLean, Laura L. Manzey, Carl J. Possidente, Joseph C. Cappelleri, Linda S. Deal
Summary: This research aimed to develop a tool for identifying non-adherent individuals by exploring patient concerns regarding their treatments. The most common concerns were medication-related side effects and fear of bleeding for atrial fibrillation patients, and short-term stomach problems and long-term kidney and liver side effects for osteoarthritis patients. The Concerns Influencing Medication Adherence instrument was developed based on these concerns and is intended for use in patient care in the United States.
PATIENT PREFERENCE AND ADHERENCE
(2021)
Article
Allergy
Qingqing Cai, Ling Ye, Robert Horne, Xiaofen Ye, Qing Xu, Meiling Jin, Xiaoyu Li, Qianzhou Lyu
Summary: This study found a significant relationship between illness perceptions, medication beliefs, and self-reported medication adherence in adult Chinese patients with asthma. Medication adherence was negatively correlated with illness identity, emotional response, and concerns about medication. Beliefs about medication necessity and emotional response to the illness were significantly associated with medication adherence, even after adjusting for illness perceptions, medication beliefs, and demographics.
Article
Health Care Sciences & Services
Alyssa M. Pandolfo, Robert Horne, Yogini Jani, Tom W. Reader, Natalie Bidad, David Brealey, Virve Enne, David M. Livermore, Vanya Gant, Stephen J. Brett
Summary: ICU clinicians' antibiotic decisions are influenced by their judgement of necessity for prescribing/not prescribing and their concerns about potential adverse consequences. Beliefs and perceptions strongly influence clinicians' views on antibiotic necessity, with clinicians often erring on the side of caution in uncertain situations.
BMJ QUALITY & SAFETY
(2022)
Article
Public, Environmental & Occupational Health
Kathryn King, Rob Horne, Vanessa Cooper, Elizabeth Glendinning, Susan Michie, Trudie Chalder
Summary: This article describes a theory-based intervention aimed at improving uptake and adherence to ART in HIV positive patients, using cognitive behavioral and motivational interviewing techniques. The intervention was developed following MRC guidance and informed by NICE guidelines, empirical evidence, and focus groups. Behavior change techniques were tailored to address perceptual and practical barriers identified in previous research, and the intervention materials underwent iterative development through feedback from focus groups.
TRANSLATIONAL BEHAVIORAL MEDICINE
(2022)
Review
Pediatrics
Christina J. Pearce, Amy H. Y. Chan, Tracy Jackson, Louise Fleming, Holly Foot, Andy Bush, Rob Horne
Summary: Adherence interventions in children with asthma vary in effectiveness. Effective intervention studies are more likely to be of high quality, tailored to individual perceptual and practical adherence barriers, and utilize multiple behavior change techniques.
PEDIATRIC PULMONOLOGY
(2022)
Review
Pharmacology & Pharmacy
Usman Talat, Kelly Ann Schmidtke, Saval Khanal, Amy Chan, Alice Turner, Robert Horne, Tim Chadborn, Natalie Gold, Anna Sallis, Ivo Vlaev
Summary: This systematic literature review examines 15 studies describing nudge interventions to optimize medication prescribing. The review finds that 80% of the interventions were effective, with prompts and defaults being the most commonly applied behavior change techniques. However, only a small number of interventions applied a sufficient array of techniques to influence all identified behavioral determinants.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Dora Arnold-Forster, Robert Horne, Will Nutland, Sonali Wayal, Michael Rayment, Caroline Rae, Monica Desai, Amanda Clarke, Ann Sullivan, Sheena McCormack, Mitzy Gafos
Summary: Using the perceptions and practicalities approach (PAPA) can help identify factors that influence PrEP adherence and tailor adherence support in PrEP programs.
Article
Health Care Sciences & Services
Andrew Farmer, Louise Jones, Nikki Newhouse, Cassandra Kenning, Nicola Williams, Yuan Chi, Y. Kiera Bartlett, Catrin Plumpton, Jenny McSharry, Rachel Cholerton, Emily Holmes, Stephanie Robinson, Julie Allen, Bernard Gudgin, Carmelo Velardo, Heather Rutter, Rob Horne, Lionel Tarassenko, Veronika Williams, Louise Locock, Rustam Rea, Ly-Mee Yu, Dyfrig Hughes, Peter Bower, David French
Summary: This study aims to test the effectiveness and cost-effectiveness of a mobile phone-based SMS text message intervention for reducing cardiovascular risk in patients with type 2 diabetes. The trial is currently in the follow-up phase and the results are expected to be published in 2024.
JMIR RESEARCH PROTOCOLS
(2022)
Article
Psychiatry
Nadia E. Crellin, Stefan Priebe, Nicola Morant, Glyn Lewis, Nick Freemantle, Sonia Johnson, Rob Horne, Vanessa Pinfold, Lyn Kent, Ruth Smith, Katherine Darton, Ruth E. Cooper, Maria Long, Jemima Thompson, Lisa Gruenwald, Robert Freudenthal, Jacki L. Stansfeld, Joanna Moncrieff
Summary: This study reveals that patients are commonly dissatisfied with the idea of taking antipsychotic medication on a long-term or life-long basis. The desire to reduce or stop medication is primarily motivated by adverse effects and health concerns. Patients value professional support in achieving reduction or discontinuation.
Article
Multidisciplinary Sciences
Walid Al-Qerem, Abdel Qader Al Bawab, Osama Abusara, Nimer Alkhatib, Robert Horne
Summary: The aim of this study was to validate the Arabic versions of the Beliefs about Medication Questionnaire-specific (BMQ-specific) and Medication Adherence Report Scale questionnaire (MARS-5). A total of 485 patients from secondary and tertiary care clinics in Jordan were recruited for a cross-sectional study. The results of exploratory and confirmatory factor analyses showed that the BMQ-specific had a two-factor model and the MARS-5 had a one-factor model. The internal consistency of the questionnaires was also confirmed. This study suggests that the Arabic versions of both BMQ-specific and MARS-5 are valid for the study population.
Review
Multidisciplinary Sciences
Amy Hai Yan Chan, Holly Foot, Christina Joanne Pearce, Rob Horne, Juliet Michelle Foster, Jeff Harrison
Summary: This systematic review and meta-analysis examines the effect of electronic adherence monitoring (EAM) on medication adherence and clinical outcomes across various chronic conditions and patient age groups. The results show that patients receiving EAM intervention had significantly better adherence compared to those who did not receive intervention. However, improved adherence did not consistently translate into clinical benefits. Patient acceptability towards EAM varied. Further research on the effects of EAM on clinical outcomes and patient acceptability is needed.
Article
Psychology, Multidisciplinary
Monika K. Heller, Sarah C. E. Chapman, Rob Horne
Summary: In clinical trials, patients often report more side-effects when receiving placebo, and medication beliefs and other psychological factors can predict the detection and attribution of side-effects.
ANNALS OF BEHAVIORAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Z. Paskins, O. Babatunde, A. Sturrock, L. S. Toh, R. Horne, I. Maidment
Summary: This article conducts a realist review to explore interventions that can improve the optimization of medication use in osteoporosis. The study finds that interventions that support patient-informed decision making and primary care clinician decision making are crucial in optimizing medication use. However, further research is needed to identify a sustainable, integrated, patient-centered, and cost- and clinically effective model of long-term care for osteoporosis patients.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Molebogeng X. Rangaka, Yohhei Hamada, Trinh Duong, Henry Bern, Joanna Calvert, Marie Francis, Amy Louise Clarke, Alex Ghanouni, Charlotte Layton, Vanessa Hack, Ellen Owen-Powell, Julian Surey, Karen Sanders, Helen L. Booth, Angela Crook, Chris Griffiths, Robert Horne, Heinke Kunst, Marc Lipman, Mike Mandelbaum, Peter J. White, Dominik Zenner, Ibrahim Abubakar
Summary: This study aims to evaluate the effect of novel short-course rifapentine-based regimens for TB prevention and additional theory-based treatment support on treatment adherence. The study will recruit participants aged 16 to 65 who are eligible to start TB preventive therapy and will conduct a randomized controlled trial to assess the outcomes.
Article
Nursing
Anas Husam Khalifeh, Fadwa Naji Alhalaiqa, Shaher Hamad Hamaideh, Robert Horne, Ayman Mohammad Hamdan-Mansour
Summary: This study aimed to examine the effect of adherence therapy (AT) on medication adherence, health beliefs, self-efficacy, and depressive symptoms among patients diagnosed with major depressive disorder (MDD). The results showed that AT enhanced positive beliefs towards medication and illness, increased medication adherence self-efficacy, improved medication adherence, and decreased depressive symptoms.
INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
(2023)
Article
Public, Environmental & Occupational Health
Sarah-Jane F. Stewart, Zoe Moon, Rob Horne
Summary: Nonadherence to medicines is a global problem with negative effects on both health and economic outcomes. This article explores the definition, measurement, impact, prevalence, and determinants of nonadherence. It also discusses the importance of a psychosocial perspective in developing interventions to improve adherence and provides recommendations for future research. Effective solutions for nonadherence are difficult to find due to a lack of strong theoretical basis. Tailoring adherence support to individuals' specific perceptions and practicalities can enhance its effectiveness.
PSYCHOLOGY & HEALTH
(2023)
