Functional Genomic Analysis of the let-7 Regulatory Network in Caenorhabditis elegans

Small non-coding RNAs mount a silent revolution in gene expression

(2012) Antti P Aalto et al.   CURRENT OPINION IN CELL BIOLOGY

Contributions of mRNA abundance, ribosome loading, and post- or peri-translational effects to temporal repression of C. elegans heterochronic miRNA targets

(2012) M. Stadler et al.   GENOME RESEARCH

How does Lin28 let-7 control development and disease?

(2012) James E. Thornton et al.   TRENDS IN CELL BIOLOGY

Lin28A and Lin28B Inhibit let-7 MicroRNA Biogenesis by Distinct Mechanisms

(2011) Elena Piskounova et al.   CELL

The Lin28/let-7 Axis Regulates Glucose Metabolism

(2011) Hao Zhu et al.   CELL

The let-7 microRNA interfaces extensively with the translation machinery to regulate cell differentiation

(2011) Xavier C. Ding et al.   CELL CYCLE

Asymmetric Arginine Dimethylation Determines Life Span in C. elegans by Regulating Forkhead Transcription Factor DAF-16

(2011) Yuta Takahashi et al.   Cell Metabolism

Gene silencing by microRNAs: contributions of translational repression and mRNA decay

(2011) Eric Huntzinger et al.   NATURE REVIEWS GENETICS

LIN-28 co-transcriptionally binds primary let-7 to regulate miRNA maturation in Caenorhabditis elegans

(2011) Priscilla M Van Wynsberghe et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genome-wide identification of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs

(2011) Anthony K L Leung et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Experimental strategies for microRNA target identification

(2011) D. W. Thomson et al.   NUCLEIC ACIDS RESEARCH

Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs

(2011) R. J. A. Frost et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP

(2010) Markus Hafner et al.   CELL

Thelet-7microRNA reduces tumor growth in mouse models of lung cancer

(2010) Aurora Esquela-Kerscher et al.   CELL CYCLE

Expanding the MicroRNA Targeting Code: Functional Sites with Centered Pairing

(2010) Chanseok Shin et al.   MOLECULAR CELL

Mammalian microRNAs predominantly act to decrease target mRNA levels

(2010) Huili Guo et al.   NATURE

A quantitative targeted proteomics approach to validate predicted microRNA targets in C. elegans

(2010) Marko Jovanovic et al.   NATURE METHODS

Comprehensive discovery of endogenous Argonaute binding sites in Caenorhabditis elegans

(2010) Dimitrios G Zisoulis et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

New Tricks for Animal MicroRNAs: Targeting of Amino Acid Coding Regions at Conserved and Nonconserved Sites

(2009) I. Rigoutsos   CANCER RESEARCH

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

TUT4 in Concert with Lin28 Suppresses MicroRNA Biogenesis through Pre-MicroRNA Uridylation

(2009) Inha Heo et al.   CELL

An elegant miRror: microRNAs in stem cells, developmental timing and cancer

(2009) Rachael A. Nimmo et al.   CHROMOSOMA

Transcription of the C. elegans let-7 microRNA is temporally regulated by one of its targets, hbl-1

(2009) Sarah F. Roush et al.   DEVELOPMENTAL BIOLOGY

Repression of C. elegans microRNA targets at the initiation level of translation requires GW182 proteins

(2009) Xavier C Ding et al.   EMBO JOURNAL

The role of let-7 in cell differentiation and cancer

(2009) Benjamin Boyerinas et al.   ENDOCRINE-RELATED CANCER

Many roads to maturity: microRNA biogenesis pathways and their regulation

(2009) Julia Winter et al.   NATURE CELL BIOLOGY

Lin28 promotes transformation and is associated with advanced human malignancies

(2009) Srinivas R Viswanathan et al.   NATURE GENETICS

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Biogenesis of small RNAs in animals

(2009) V. Narry Kim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans

(2009) Nicolas J Lehrbach et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

How the Intestinal Peptide Transporter PEPT-1 Contributes to an Obesity Phenotype in Caenorhabditits elegans

(2009) Britta Spanier et al.   PLoS One

A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in Caenorhabditis elegans

(2009) C. M. Hammell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Hormone Receptor Regulation of MicroRNAs Controls Developmental Progression

(2009) Axel Bethke et al.   SCIENCE

Identification of Let-7-Regulated Oncofetal Genes

(2008) B. Boyerinas et al.   CANCER RESEARCH

Genome-scale spatiotemporal analysis of Caenorhabditis elegans microRNA promoter activity

(2008) N. J. Martinez et al.   GENOME RESEARCH

Lin28 Mediates the Terminal Uridylation of let-7 Precursor MicroRNA

(2008) Inha Heo et al.   MOLECULAR CELL

Arginine Methylation of FOXO Transcription Factors Inhibits Their Phosphorylation by Akt

(2008) Kazuyuki Yamagata et al.   MOLECULAR CELL

The impact of microRNAs on protein output

(2008) Daehyun Baek et al.   NATURE

Widespread changes in protein synthesis induced by microRNAs

(2008) Matthias Selbach et al.   NATURE

MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation

(2008) Yvonne Tay et al.   NATURE

A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment

(2008) Agnieszka Rybak et al.   NATURE CELL BIOLOGY

mirWIP: microRNA target prediction based on microRNA-containing ribonucleoprotein–enriched transcripts

(2008) Molly Hammell et al.   NATURE METHODS

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH

Systematic Identification of mRNAs Recruited to Argonaute 2 by Specific microRNAs and Corresponding Changes in Transcript Abundance

(2008) David G. Hendrickson et al.   PLoS One

Suppression of non-small cell lung tumor development by the let-7 microRNA family

(2008) M. S. Kumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing

(2008) M. A. Newman et al.   RNA

Molecular characterization of human Argonaute-containing ribonucleoprotein complexes and their bound target mRNAs

(2008) M. Landthaler et al.   RNA

Selective Blockade of MicroRNA Processing by Lin28

(2008) S. R. Viswanathan et al.   SCIENCE

let-7 microRNAs in development, stem cells and cancer

(2008) Ingo Büssing et al.   TRENDS IN MOLECULAR MEDICINE