ALS-Associated FUS Mutations Result in Compromised FUS Alternative Splicing and Autoregulation
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Title
ALS-Associated FUS Mutations Result in Compromised FUS Alternative Splicing and Autoregulation
Authors
Keywords
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Journal
PLoS Genetics
Volume 9, Issue 10, Pages e1003895
Publisher
Public Library of Science (PLoS)
Online
2013-11-01
DOI
10.1371/journal.pgen.1003895
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- (2013) Edward Y Chen et al. BMC BIOINFORMATICS
- ALS mutant FUS disrupts nuclear localization and sequesters wild-type FUS within cytoplasmic stress granules
- (2013) Caroline Vance et al. HUMAN MOLECULAR GENETICS
- The changing scene of amyotrophic lateral sclerosis
- (2013) Wim Robberecht et al. NATURE REVIEWS NEUROSCIENCE
- Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis
- (2013) Shuo-Chien Ling et al. NEURON
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- (2013) T. Nakaya et al. RNA
- Overexpression of human wild-type FUS causes progressive motor neuron degeneration in an age- and dose-dependent fashion
- (2012) Jacqueline C. Mitchell et al. ACTA NEUROPATHOLOGICA
- Splice Modulating Therapies for Human Disease
- (2012) Pietro Spitali et al. CELL
- Truncating mutations inFUS/TLSgive rise to a more aggressive ALS-phenotype than missense mutations: a clinico-genetic study in Germany
- (2012) S. Waibel et al. EUROPEAN JOURNAL OF NEUROLOGY
- fus/TLS orchestrates splicing of developmental regulators during gastrulation
- (2012) D. S. Dichmann et al. GENES & DEVELOPMENT
- TDP-43 and FUS RNA-binding Proteins Bind Distinct Sets of Cytoplasmic Messenger RNAs and Differently Regulate Their Post-transcriptional Fate in Motoneuron-like Cells
- (2012) Claudia Colombrita et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- FUS/TLS-immunoreactive Neuronal and Glial Cell Inclusions Increase With Disease Duration in Familial Amyotrophic Lateral Sclerosis With an R521CFUS/TLSMutation
- (2012) Naoki Suzuki et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs
- (2012) Clotilde Lagier-Tourenne et al. NATURE NEUROSCIENCE
- Knockdown of the Drosophila Fused in Sarcoma (FUS) Homologue Causes Deficient Locomotive Behavior and Shortening of Motoneuron Terminal Branches
- (2012) Hiroshi Sasayama et al. PLoS One
- Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptions
- (2012) Shinsuke Ishigaki et al. Scientific Reports
- Widespread binding of FUS along nascent RNA regulates alternative splicing in the brain
- (2012) Boris Rogelj et al. Scientific Reports
- Pathological heterogeneity in amyotrophic lateral sclerosis with FUS mutations: two distinct patterns correlating with disease severity and mutation
- (2011) Ian R. A. Mackenzie et al. ACTA NEUROPATHOLOGICA
- A fraction of the transcription factor TAF15 participates in interactions with a subset of the spliceosomal U1 snRNP complex
- (2011) Michael Leichter et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Understanding the role of TDP-43 and FUS/TLS in ALS and beyond
- (2011) Sandrine Da Cruz et al. CURRENT OPINION IN NEUROBIOLOGY
- mRNA and protein levels of FUS, EWSR1, and TAF15 are upregulated in liposarcoma
- (2011) Jessica I. Spitzer et al. GENES CHROMOSOMES & CANCER
- ALS mutations in FUS cause neuronal dysfunction and death in Caenorhabditis elegans by a dominant gain-of-function mechanism
- (2011) Tetsuro Murakami et al. HUMAN MOLECULAR GENETICS
- PSF Suppresses Tau Exon 10 Inclusion by Interacting with a Stem-Loop Structure Downstream of Exon 10
- (2011) Payal Ray et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Deep proteome and transcriptome mapping of a human cancer cell line
- (2011) N. Nagaraj et al. Molecular Systems Biology
- Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
- (2011) Magdalini Polymenidou et al. NATURE NEUROSCIENCE
- Clinical genetics of amyotrophic lateral sclerosis: what do we really know?
- (2011) Peter M. Andersen et al. Nature Reviews Neurology
- RNA targets of wild-type and mutant FET family proteins
- (2011) Jessica I Hoell et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Integrating diverse databases into an unified analysis framework: a Galaxy approach
- (2011) D. Blankenberg et al. Database-The Journal of Biological Databases and Curation
- Molecular Determinants and Genetic Modifiers of Aggregation and Toxicity for the ALS Disease Protein FUS/TLS
- (2011) Zhihui Sun et al. PLOS BIOLOGY
- FUS and TARDBP but Not SOD1 Interact in Genetic Models of Amyotrophic Lateral Sclerosis
- (2011) Edor Kabashi et al. PLoS Genetics
- FUS Transgenic Rats Develop the Phenotypes of Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration
- (2011) Cao Huang et al. PLoS Genetics
- Expression of human FUS protein in Drosophila leads to progressive neurodegeneration
- (2011) Yanbo Chen et al. Protein & Cell
- Expression of human FUS/TLS in yeast leads to protein aggregation and cytotoxicity, recapitulating key features of FUS proteinopathy
- (2011) Kazuo Fushimi et al. Protein & Cell
- Aberrant RNA processing events in neurological disorders
- (2010) Karen Anthony et al. BRAIN RESEARCH
- TDP-43 regulates its mRNA levels through a negative feedback loop
- (2010) Youhna M Ayala et al. EMBO JOURNAL
- ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import
- (2010) Dorothee Dormann et al. EMBO JOURNAL
- Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model
- (2010) Y. Hua et al. GENES & DEVELOPMENT
- Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules
- (2010) Daryl A. Bosco et al. HUMAN MOLECULAR GENETICS
- TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration
- (2010) C. Lagier-Tourenne et al. HUMAN MOLECULAR GENETICS
- Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities
- (2010) Sven Heinz et al. MOLECULAR CELL
- Intracellular localization and splicing regulation of FUS/TLS are variably affected by amyotrophic lateral sclerosis-linked mutations
- (2010) Yoshihiro Kino et al. NUCLEIC ACIDS RESEARCH
- The UCSC Genome Browser database: update 2011
- (2010) P. A. Fujita et al. NUCLEIC ACIDS RESEARCH
- A new subtype of frontotemporal lobar degeneration with FUS pathology
- (2009) M. Neumann et al. BRAIN
- Rethinking ALS: The FUS about TDP-43
- (2009) Clotilde Lagier-Tourenne et al. CELL
- Sporadic ALS has compartment-specific aberrant exon splicing and altered cell–matrix adhesion biology
- (2009) Stuart J. Rabin et al. HUMAN MOLECULAR GENETICS
- Auto- and Cross-Regulation of the hnRNP L Proteins by Alternative Splicing
- (2009) O. Rossbach et al. MOLECULAR AND CELLULAR BIOLOGY
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- (2009) Yuanchao Xue et al. MOLECULAR CELL
- Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
- (2009) Da Wei Huang et al. Nature Protocols
- An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells
- (2009) Gene W Yeo et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Increasing the relative expression of endogenous non-coding Steroid Receptor RNA Activator (SRA) in human breast cancer cells using modified oligonucleotides
- (2009) Charlton Cooper et al. NUCLEIC ACIDS RESEARCH
- Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6
- (2009) C. Vance et al. SCIENCE
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- (2009) T. J. Kwiatkowski et al. SCIENCE
- The TET Family of Proteins: Functions and Roles in Disease
- (2009) A. Y. Tan et al. Journal of Molecular Cell Biology
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- HITS-CLIP yields genome-wide insights into brain alternative RNA processing
- (2008) Donny D. Licatalosi et al. NATURE
- An integrated software system for analyzing ChIP-chip and ChIP-seq data
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