Article
Entomology
Xingtao Qie, Yaxin Ren, Xueting Chen, Yuzhe Du, Ke Dong, Zhaonong Hu
Summary: This study found that Drosophila sodium channel 1 (DSC1) plays a crucial regulatory role in the insecticidal activity of Haedoxan A (HA). Knockout of DSC1 gene reduced the sensitivity of Drosophila to HA, and HA exerted its effects on Drosophila through modulating neuronal excitability. These findings provide valuable information for understanding the regulatory mechanism of DSC1 in the neural system of insects and the action mechanism of HA.
Article
Neurosciences
Florencia Fernandez-Chiappe, Lia Frenkel, Carina Celeste Colque, Ana Ricciuti, Bryan Hahm, Karina Cerredo, Nara Ines Muraro, Maria Fernanda Ceriani
Summary: Research on Drosophila has revealed that the electrical properties of clock neurons play a crucial role in the temporal coordination of circadian behaviors, with the Ih channel being essential for communication between neurons and behavioral effects.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Cell Biology
Minwoo Baek, Wijeong Jang, Changsoo Kim
Summary: This study identifies dual oxidase (duox) as a source of neuronal oxidative stress associated with animal lifespan. The research found that reducing oxidative stress in neurons extends the lifespan of Drosophila melanogaster, with duox playing a crucial role in this process.
Article
Multidisciplinary Sciences
Xi Liu, Zhi Qiao, Yuming Chai, Zhi Zhu, Kaijie Wu, Wenliang Ji, Daguang Li, Yujie Xiao, Lanqun Mao, Chao Chang, Quan Wen, Bo Song, Yousheng Shu
Summary: Midinfrared stimulation (MIRS) is a potential neuromodulation approach that exerts nonthermal, long-distance, and reversible modulatory effects on ion channel activity, neuronal signaling, and sensorimotor behavior. This method provides gain control over spiking activities and modulates startle responses, making it suitable for clinical application.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemical Research Methods
Reza Ghaemi, Meryl Acker, Ana Stosic, Roger Jacobs, Ponnambalam Ravi Selvaganapathy
Summary: A simple microfluidic device has been demonstrated for single neuronal imaging of a fully intact Drosophila larva. The device can immobilize the brain and CNS of the larva, allowing for clear imaging of single neurons.
Article
Cell Biology
Judit Carrasco, Fernando Mateos, Valerie Hilgers
Summary: Cell-type-specific gene regulatory programs are critical for cell differentiation and function. In fruit flies, the ELAV protein family plays an essential role in generating unique transcript isoforms during neuronal differentiation. The study also reveals that the establishment of a subset of neuronal transcript isoforms by ELAV at the onset of neuronal differentiation is a developmental bottleneck that cannot be overcome by the activation of a paralog gene later in neurons. Loss of ELAV function outside of this critical time window leads to neurological defects.
Article
Biology
Matthew P. Bostock, Anadika R. Prasad, Alicia Donoghue, Vilaiwan M. Fernandes
Summary: This study reveals that the Hh pathway activity is gradiently distributed along the distal-proximal axis of lamina columns, which is determined by the gradient of Hh ligand. Manipulating the activity of the Hh pathway in lamina precursors and photoreceptors showed that different levels of activity specify unique cell identities, with more proximal cell types specified in response to lower Hh levels. These findings establish the role of Hh as a morphogen in patterning the lamina, and demonstrate a remarkable similarity with the pattern formation of the vertebrate neural tube.
Article
Biochemistry & Molecular Biology
Binod Aryal, Subash Dhakal, Bhanu Shrestha, Youngseok Lee
Summary: This study reveals the mechanism of amino acid sensing in Drosophila, which involves the activation of sweet and bitter taste receptors as well as ion receptors in different types of sensilla to stimulate sensory neurons and mediate attraction or aversion behaviors.
Article
Pharmacology & Pharmacy
Martin Kruse, Rayne J. Whitten
Summary: Phosphoinositides, despite being a minor component of cell lipids, play essential roles in regulating neuronal activities. Activation of neurotransmitter receptors can rapidly deplete phosphoinositide levels, significantly impacting neuronal behavior. A comprehensive model has been developed to study the connection between muscarinic acetylcholine signaling, phosphoinositide metabolism, and action potential firing in sympathetic neurons.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Wangchao Xu, Justin Rustenhoven, Christopher A. Nelson, Taitea Dykstra, Aura Ferreiro, Zachary Papadopoulos, Carey-Ann D. Burnham, Gautam Dantas, Daved H. Fremont, Jonathan Kipnis
Summary: This study finds that IM33 and SLPI are upregulated in old flies and old mice, respectively, suggesting their key roles in aging. Knockdown of IM33 in glia leads to increased gut ROS levels and altered gut microbiota composition, resulting in a shortened lifespan. Dysbiosis also induces sleep fragmentation through the activation of insulin-producing cells in the brain. Identifying molecular mediators of these processes could contribute to the development of innovative strategies for extending lifespan.
Article
Multidisciplinary Sciences
Takashi Koyama, Selim Terhzaz, Muhammad T. Naseem, Stanislav Nagy, Kim Rewitz, Julian A. T. Dow, Shireen A. Davies, Kenneth Halberg
Summary: Neurosecretory cells in Drosophila release Capa hormones in response to nutrient levels, activating the Capa receptor in peripheral tissues to regulate energy homeostasis. Disruption of Capa/CapaR signaling leads to intestinal hypomotility and impaired nutrient absorption, depleting internal nutrient stores. Additionally, Capa/CapaR inhibits the release of a hormone that mobilizes energy from adipose tissue to prevent harmful hyperglycemia.
NATURE COMMUNICATIONS
(2021)
Review
Neurosciences
Pablo Gimenez-Gomez, Timmy Le, Gilles E. Martin
Summary: Drug use is a serious threat to global health systems, with alcohol being the most consumed substance leading to 3 million deaths (5.3% of all deaths) and 132.6 million disability-adjusted life years. This review provides an updated summary of the global impact of binge alcohol drinking on brain health and cognitive function development, as well as the preclinical models used to study its effects on brain neurobiology. It also discusses the current understanding of the molecular and cellular mechanisms underlying the effects of binge drinking on neuronal excitability and synaptic plasticity, with a focus on the meso-cortico limbic neurocircuitry.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Mikiko Oka, Emiko Suzuki, Akiko Asada, Taro Saito, Koichi M. Iijima, Kanae Ando
Summary: Brain neurons play a significant role in organismal aging, with decreased ATP concentration, glucose content, and mitochondrial quality found in aged flies. By increasing neuronal glucose uptake, ATP levels can be maintained, locomotor deficits can be suppressed, and life span can be extended, especially during dietary restriction.
Article
Multidisciplinary Sciences
Bryce T. Bajar, Nguyen T. Phi, Jesse Isaacman-Beck, Jun Reichl, Harpreet Randhawa, Orkun Akin
Summary: Research has found that patterned neural activity during the development of the fruit fly's central nervous system is coordinated by a small population of neurons expressing the Trp gamma gene. This activity is essential for the formation of synaptic connections and the assembly of the brain. The study establishes the fruit fly's brain as a useful model system for investigating how neural activity contributes to the formation of synapses and circuits.
Review
Biochemistry & Molecular Biology
Cole Malloy, Maisie Ahern, Lin Lin, Dax A. Hoffman
Summary: The coordinated action of voltage-gated ion channels, often associated with auxiliary subunits, is crucial for controlling neuronal physiology and circuit function in the brain. Dipeptidyl aminopeptidase-like protein 6 (DPP6), an auxiliary subunit expressed in multiple brain regions, interacts with A-type K+ channels to regulate their distribution and gating properties, as well as plays an independent role in synaptic formation and maintenance. Dysfunction of DPP6 is associated with various neurological disorders. Understanding the contribution of DPP6 to these disorders is an active area of research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Alexandria Wise, Luis Tenezaca, Robert W. Fernandez, Emma Schatoff, Julian Flores, Atsushi Ueda, Xiaotian Zhong, Chun-Fang Wu, Anne F. Simon, Tadmiri Venkatesh
JOURNAL OF NEUROGENETICS
(2015)
Article
Neurosciences
Frank D. Rinkevich, Yuzhe Du, Josh Tolinski, Atsushi Ueda, Chun-Fang Wu, Boris S. Zhorov, Ke Dong
Article
Developmental Biology
Jihye Lee, Atsushi Ueda, Chun-Fang Wu
DEVELOPMENTAL NEUROBIOLOGY
(2014)
Article
Biology
Barry Ganetzky, Chun-Fang Wu
JOURNAL OF BIOSCIENCES
(2014)
Article
Genetics & Heredity
Atulya Iyengar, Chun-Fang Wu
JOURNAL OF NEUROGENETICS
(2014)
Article
Multidisciplinary Sciences
Salleh N. Ehaideb, Atulya Iyengar, Atsushi Ueda, Gary J. Iacobucci, Cathryn Cranston, Alexander G. Bassuk, David Gubb, Jeffrey D. Axelrod, Shermali Gunawardena, Chun-Fang Wu, J. Robert Manak
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2014)
Article
Genetics & Heredity
Hiroshi Ishimoto, Zhe Wang, Yi Rao, Chun-Fang Wu, Toshihiro Kitamoto
Article
Biochemistry & Molecular Biology
Wanhao Chi, Atulya S. R. Iyengar, Monique Albersen, Marjolein Bosma, Nanda M. Verhoeven-Duif, Chun-Fang Wu, Xiaoxi Zhuang
HUMAN MOLECULAR GENETICS
(2019)
Editorial Material
Genetics & Heredity
Jeffrey S. Dason, Ina Anreiter, Chun-Fang Wu
JOURNAL OF NEUROGENETICS
(2021)
Article
Neurosciences
Atulya Iyengar, Hongyu Ruan, Chun-Fang Wu
Summary: In this study, different motor circuits in Drosophila were examined, revealing distinct neurophysiological changes during aging. The research focused on the giant fiber circuit and the afferent circuits driving flight motoneuron activities, and identified different aging trajectories in their functional properties. Additionally, it was found that the aging trajectories in flies reared at high temperature were similar to those in flies reared at normal temperature over a compressed time scale. Furthermore, lifespan reduction in mutant flies was accompanied by alterations in motor circuit properties different from those in flies reared at high temperature.
Correction
Biochemistry & Molecular Biology
Wanhao Chi, Atulya S. R. Iyengar, Monique Albersen, Marjolein Bosma, Nanda M. Verhoeven-Duif, Chun-Fang Wu, Xiaoxi Zhuang
HUMAN MOLECULAR GENETICS
(2022)
Article
Multidisciplinary Sciences
Wanhao Chi, Atulya S. R. Iyengar, Wenqin Fu, Wei Liu, Abigayle E. Berg, Chun-Fang Wu, Xiaoxi Zhuang
Summary: This study investigates the phenotypic variations resulting from PNPO mutations and the effects of different alleles and diet interactions. Using Drosophila as a model, the researchers generated knock-in flies with different PNPO alleles and found that they exhibited various phenotypes, including developmental impairments, abnormal locomotor activities, spontaneous seizures, and shortened life span. The severity of these phenotypes varied with the known biochemical severity of the mutations. Diet treatments further diversified the phenotypes, and supplementation with pyridoxal 5'-phosphate (PLP) prevented developmental impairments and seizures in flies. The study also revealed that one of the PNPO alleles had a dominant-negative effect, making heterozygous flies more susceptible to seizures and premature death.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Xiaomin Xing, Chun-Fang Wu
Article
Neurosciences
Garrett A. Kaas, Junko Kasuya, Patrick Lansdon, Atsushi Ueda, Atulya Iyengar, Chun-Fang Wu, Toshihiro Kitamoto