Mutations in or near the Transmembrane Domain Alter PMEL Amyloid Formation from Functional to Pathogenic

Amyloids: Friend or Foe?

(2017) Neal D. Hammer et al.   JOURNAL OF ALZHEIMERS DISEASE

Proprotein Convertases Process Pmel17 during Secretion

(2011) Ralf M. Leonhardt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inactivation of Pmel Alters Melanosome Shape But Has Only a Subtle Effect on Visible Pigmentation

(2011) Anders R. Hellström et al.   PLoS Genetics

Modulation of the Oligomerization of Myelin Proteolipid Protein by Transmembrane Helix Interaction Motifs

(2010) Derek P. Ng et al.   BIOCHEMISTRY

Biology of Amyloid: Structure, Function, and Regulation

(2010) Jason Greenwald et al.   STRUCTURE

A mutation within the transmembrane domain of melanosomal protein Silver (Pmel17) changes lumenal fragment interactions

(2009) Regina Kuliawat et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

N-terminal Domains Elicit Formation of Functional Pmel17 Amyloid Fibrils

(2009) Brenda Watt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The repeat domain of the melanosome fibril protein Pmel17 forms the amyloid core promoting melanin synthesis

(2009) R. P. McGlinchey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules

(2009) S. K. Maji et al.   SCIENCE

Protein inheritance (prions) based on parallel in-register β-sheet amyloid structures

(2008) Reed B. Wickner et al.   BIOESSAYS

Formation of Pmel17 Amyloid Is Regulated by Juxtamembrane Metalloproteinase Cleavage, and the Resulting C-terminal Fragment Is a Substrate for γ-Secretase

(2008) Markus P. Kummer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell-specific ATP7A transport sustains copper-dependent tyrosinase activity in melanosomes

(2008) Subba Rao Gangi Setty et al.   NATURE

Electron tomography of early melanosomes: Implications for melanogenesis and the generation of fibrillar amyloid sheets

(2008) I. Hurbain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA