Significantly Improved HIV Inhibitor Efficacy Prediction Employing Proteochemometric Models Generated From Antivirogram Data

HIV Therapy Simulator: a graphical user interface for comparing the effectiveness of novel therapy regimens

(2011) Huat Chye Lim et al.   BIOINFORMATICS

Cross-validated stepwise regression for identification of novel non-nucleoside reverse transcriptase inhibitor resistance associated mutations

(2011) Koen Van der Borght et al.   BMC BIOINFORMATICS

Which Compound to Select in Lead Optimization? Prospectively Validated Proteochemometric Models Guide Preclinical Development

(2011) Gerard J. P. van Westen et al.   PLoS One

Extended-Connectivity Fingerprints

(2010) David Rogers et al.   Journal of Chemical Information and Modeling

Proteochemometric Modeling of the Susceptibility of Mutated Variants of the HIV-1 Virus to Reverse Transcriptase Inhibitors

(2010) Muhammad Junaid et al.   PLoS One

Proteochemometric modeling as a tool to design selective compounds and for extrapolating to novel targets

(2010) Gerard J. P. van Westen et al.   MedChemComm

Proteochemometrics mapping of the interaction space for retroviral proteases and their substrates

(2009) Aleksejs Kontijevskis et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Proteochemometric Modeling of Drug Resistance over the Mutational Space for Multiple HIV Protease Variants and Multiple Protease Inhibitors

(2009) Maris Lapins et al.   Journal of Chemical Information and Modeling

How Similar Are Similarity Searching Methods? A Principal Component Analysis of Molecular Descriptor Space

(2009) Andreas Bender et al.   Journal of Chemical Information and Modeling

Predicting the Response to Combination Antiretroviral Therapy: Retrospective Validation of geno2pheno‐THEO on a Large Clinical Database

(2009) André Altmann et al.   JOURNAL OF INFECTIOUS DISEASES

A comparison of HIV-1 drug susceptibility as provided by conventional phenotyping and by a phenotype prediction tool based on viral genotype

(2009) Margriet Van Houtte et al.   JOURNAL OF MEDICAL VIROLOGY

Proteochemometric modeling of HIV protease susceptibility

(2008) Maris Lapins et al.   BMC BIOINFORMATICS