HIV-1 Polymerase Inhibition by Nucleoside Analogs: Cellular- and Kinetic Parameters of Efficacy, Susceptibility and Resistance Selection

Natural Substrate Concentrations Can Modulate the Prophylactic Efficacy of Nucleotide HIV Reverse Transcriptase Inhibitors

(2011) J. G. Garcia-Lerma et al.   JOURNAL OF VIROLOGY

Fitness Ranking of Individual Mutants Drives Patterns of Epistatic Interactions in HIV-1

(2011) Javier P. Martínez et al.   PLoS One

HIV Quasispecies Dynamics during Pro-Active Treatment Switching: Impact on Multi-Drug Resistance and Resistance Archiving in Latent Reservoirs

(2011) Max von Kleist et al.   PLoS One

A Critical Subset Model Provides a Conceptual Basis for the High Antiviral Activity of Major HIV Drugs

(2011) L. Shen et al.   Science Translational Medicine

Crystal Structure of HIV-1 Reverse Transcriptase Bound to a Non-Nucleoside Inhibitor with a Novel Mechanism of Action

(2010) Séverine Freisz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pre-Steady-State Kinetic Analysis of the Incorporation of Anti-HIV Nucleotide Analogs Catalyzed by Human X- and Y-Family DNA Polymerases

(2010) Jessica A. Brown et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Simple genomes, complex interactions: Epistasis in RNA virus

(2010) Santiago F. Elena et al.   CHAOS

Pharmacological considerations for tenofovir and emtricitabine to prevent HIV infection

(2010) P. L. Anderson et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Development of a stochastic model for the efficacy of NRTIs using known mechanisms of action

(2010) Samira Khalili et al.   JOURNAL OF THEORETICAL BIOLOGY

HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects

(2010) Maria J Buzón et al.   NATURE MEDICINE

Initiation complex dynamics direct the transitions between distinct phases of early HIV reverse transcription

(2010) Shixin Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of HIV-1 resistance to AZT by excision

(2010) Xiongying Tu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Drug-Class Specific Impact of Antivirals on the Reproductive Capacity of HIV

(2010) Max von Kleist et al.   PLoS Computational Biology

Clinical and Genetic Determinants of Intracellular Tenofovir Diphosphate Concentrations in HIV-Infected Patients

(2009) Jennifer J Kiser et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Discovery of Chiral Cyclopropyl Dihydro-Alkylthio-Benzyl-Oxopyrimidine (S-DABO) Derivatives as Potent HIV-1 Reverse Transcriptase Inhibitors with High Activity Against Clinically Relevant Mutants

(2009) Marco Radi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Analysis of Human Immunodeficiency Virus Type 1 Viremia and Provirus in Resting CD4+ T Cells Reveals a Novel Source of Residual Viremia in Patients on Antiretroviral Therapy

(2009) T. P. Brennan et al.   JOURNAL OF VIROLOGY

Pharmacokinetic–pharmacodynamic relationship of NRTIs and its connection to viral escape: An example based on zidovudine

(2008) Max von Kleist et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Restoration of the antiviral activity of 3'-azido-3'-deoxythymidine (AZT) against AZT-resistant human immunodeficiency virus by delivery of engineered thymidylate kinase to T cells

(2008) A. Lavie et al.   JOURNAL OF GENERAL VIROLOGY

Dose-response curve slope sets class-specific limits on inhibitory potential of anti-HIV drugs

(2008) Lin Shen et al.   NATURE MEDICINE

Slide into Action: Dynamic Shuttling of HIV Reverse Transcriptase on Nucleic Acid Substrates

(2008) S. Liu et al.   SCIENCE

Mechanisms of inhibition of HIV replication by non-nucleoside reverse transcriptase inhibitors

(2008) Nicolas Sluis-Cremer et al.   VIRUS RESEARCH

Mechanisms of resistance to nucleoside analogue inhibitors of HIV-1 reverse transcriptase

(2008) Luis Menéndez-Arias   VIRUS RESEARCH

HIV-1 reverse transcriptase inhibitor resistance mutations and fitness: A view from the clinic and ex vivo

(2008) Javier Martinez-Picado et al.   VIRUS RESEARCH