Article
Neurosciences
Guela Sokhadze, Peter W. Campbell, Naomi Charalambakis, Gubbi Govindaiah, William Guido, Aaron W. McGee
Summary: Researchers characterized three Cre driver lines targeting the nuclei of the dorsal thalamus in mice, each showing unique expression patterns specifically in TC neurons. These Cre driver lines are useful for developmental studies and investigating sensory TC circuitry. Optogenetic activation of TC afferents in the primary visual cortex proved to be effective in measuring frequency-dependent depression.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Article
Neurosciences
Rachana D. Somaiya, Natalie A. Huebschman, Lata Chaunsali, Ubadah Sabbagh, Gabriela L. Carrillo, Bhanu P. Tewari, Michael A. Fox
Summary: The study investigated the transcriptional identity and development of astrocytes in the mouse visual thalamus, revealing that these cells have acquired adult-like morphology and functional characteristics before eye-opening. The results also showed that thalamic astrocytes ensheathe retinogeniculate synapses and are capable of efficient uptake of glutamate by eye-opening.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Article
Neurosciences
Christa Mueller-Axt, Cornelius Eichner, Henriette Rusch, Louise Kauffmann, Pierre-Louis Bazin, Alfred Anwander, Markus Morawski, Katharina von Kriegstein
Summary: This study demonstrates that quantitative MRI methods can be used to assess the microstructural features of the human lateral geniculate nucleus (LGN) and its subdivisions, providing insights into the functional and structural characteristics of the LGN in humans.
Article
Neurosciences
Norihiro Takakuwa, Kaoru Isa, Hirotaka Onoe, Jun Takahashi, Tadashi Isa
Summary: Blindsight is a phenomenon where some patients can respond to visual stimuli in their lesion-affected visual field even after damage to the primary visual cortex (V1). The study used pharmacological inactivation of the pulvinar and LGN to clarify their roles in a simple visually guided saccades task, finding that both regions play key roles in performing the task after V1 lesioning.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biology
Natalia Lozovaya, Sanaz Eftekhari, Constance Hammond
Summary: Electrophysiological recordings show that early excitatory cholinergic-GABAergic microcircuits are crucial for the maturation of GABAergic inhibition in the mouse striatum. Cholinergic interneurons in the striatum activate local GABAergic inhibitory microcircuits, which play a role in action selection and associative learning. The study focuses on dual cholinergic/GABAergic interneurons (CGINs) and finds that their morphological and electrophysiological properties rapidly develop during the first post-natal week.
COMMUNICATIONS BIOLOGY
(2023)
Article
Neurosciences
Gubbi Govindaiah, Michael A. Fox, William Guido
Summary: The ventral lateral geniculate nucleus (vLGN) is involved in complex visual behaviors, and the external subdivision (vLGNe) and internal subdivision (vLGNi) have different characteristics. This study found that neurons in vLGNe receive convergent input from the retina and cortical layer V, while neurons in vLGNi only respond to cortical layer V input.
Article
Materials Science, Multidisciplinary
Meng-Horng Lee, Gabriella C. Russo, Yohan Suryo Rahmanto, Wenxuan Du, Ashleigh J. Crawford, Pei-Hsun Wu, Daniele Gilkes, Ashley Kiemen, Tsutomu Miyamoto, Yu Yu, Mehran Habibi, Ie-Ming Shih, Tian-Li Wang, Denis Wirtz
Summary: A new high-throughput technology for generating uniform, small-volume, multi-compartment tumor models has been developed. These models can mimic the tumor microenvironment and assess the characteristics and drug responsiveness of cancer cells in a single platform. This method is of great significance for studying tumor progression and drug screening.
Article
Neurosciences
Hiroki Oishi, Hiromasa Takemura, Kaoru Amano
Summary: This article presents a method for identifying subdivisions of the lateral geniculate nucleus (LGN) using structural magnetic resonance imaging. The validity of the method was confirmed by comparing it with histological data and functional magnetic resonance imaging measurements, as well as analyzing test-retest reliability. The findings suggest that this method is promising for evaluating tissue properties of LGN subdivisions in living humans, enabling further research in neuroscience and clinical applications.
Article
Multidisciplinary Sciences
Long Li, Romain Durand-de Cuttoli, Antonio V. Aubry, C. Joseph Burnett, Flurin Cathomas, Lyonna F. Parise, Kenny L. Chan, Carole Morel, Chongzhen Yuan, Yusuke Shimo, Hsiao-yun Lin, Jun Wang, Scott J. Russo
Summary: Research shows that following chronic social defeat stress, a subset of male and female mice tend to avoid social interaction with non-aggressive, same-sex juvenile C57BL/6J mice and do not exhibit context-dependent social reward after encounters. This avoidance behavior seems to be linked to the activation of specific stress-responsive neurons in the lateral septum, which interferes with social reward processing.
Article
Multidisciplinary Sciences
Long Li, Romain Durand-de Cuttoli, Antonio V. Aubry, C. Joseph Burnett, Flurin Cathomas, Lyonna F. Parise, Kenny L. Chan, Carole Morel, Chongzhen Yuan, Yusuke Shimo, Hsiao-yun Lin, Jun Wang, Scott J. Russo
Summary: Traumatic social experiences in humans can lead to psychiatric disorders. In rodents, little is known about the impact of social trauma on social reward. A study on the chronic social defeat stress (CSDS) model in mice suggests that previously rewarding social targets are perceived as threats in susceptible mice.
Article
Neurosciences
Kevin R. Duffy, Nathan A. Crowder, Arnold J. Heynen, Mark F. Bear
Summary: During a critical period after birth, monocular deprivation (MD) reduces the size of neurons in the dorsal lateral geniculate nucleus (dLGN) connected to the deprived eye and shifts cortical ocular dominance in favor of the non-deprived eye. Temporary inactivation of the non-deprived eye, known as monocular inactivation (MI), can promote better recovery from long-term MD effects compared to conventional occlusion therapy. MI has a significant impact on neuron size in the dLGN, especially when applied during the peak of the critical period. Unlike MD, MI induces structural plasticity in both the binocular and monocular segments of the dLGN. The effectiveness of MI decreases with age but still produces significant effects even beyond the critical period, showing double the magnitude and efficacy compared to MD. The effects of MI can be fully remedied with a short period of binocular experience, leading to full recovery of vision in the previously inactivated eye. These findings highlight the potential of MI to modify the visual pathway and its ability to ameliorate visual system disorders like amblyopia.
JOURNAL OF COMPARATIVE NEUROLOGY
(2023)
Review
Clinical Neurology
Bahadar S. Srichawla, Raymond M. Catton, Alexander A. Lichtenberg, Nils Henninger
Summary: This article presents a case report of a 17-year-old female with acute pancreatitis who developed acute onset bilateral painless vision loss due to bilateral infarction of the lateral geniculate bodies (LGB), and a systematic review of relevant literature. The review findings indicate that bilateral LGB infarction is a rare cause of vision loss, predominantly affecting women and often associated with systemic diseases.
NEUROLOGICAL SCIENCES
(2023)
Article
Neurosciences
Irem Yildirim, Keith A. Schneider
Summary: Perception alternates between two different stimuli presented to each eye in binocular rivalry. The study found that activity in the lateral geniculate nucleus (LGN) is correlated with perception during binocular rivalry, suggesting that perception occurs in the LGN and is not limited to a single information channel.
Review
Biochemistry & Molecular Biology
Soju Seki, Yoshihiro Kitaoka, Sou Kawata, Akira Nishiura, Toshihiro Uchihashi, Shin-ichiro Hiraoka, Yusuke Yokota, Emiko Tanaka Isomura, Mikihiko Kogo, Susumu Tanaka
Summary: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the degeneration of motor neurons, with emerging evidence suggesting involvement of sensory neurons. Clinical research has shown sensory symptoms and abnormal nerve conduction in ALS patients, while preclinical research has identified genetic abnormalities in both sensory and motor neurons. This review highlights the potential of targeting sensory neuron abnormalities in ALS for new therapies.
Article
Clinical Neurology
Prayerna Uppal, William P. Madigan, Jonathan Murnick, Jeffrey Strelzik, Dana Harrar
Summary: We present a case of a 13-year-old female with influenza who developed vision loss due to retinal and lateral geniculate nucleus (LGN) infarctions. Her left eye remained with near-total vision loss even after 3.5 years. This case is the second reported instance of bilateral retinal and LGN infarctions associated with influenza. The mechanism of infarction is still unknown, but it is crucial to recognize this condition and provide appropriate counseling to patients as visual recovery may be poor.
PEDIATRIC NEUROLOGY
(2023)
Article
Biophysics
Michele Migliore, Giada De Simone, Rosanna Migliore
BIOPHYSICAL JOURNAL
(2015)
Article
Neurosciences
Francesco Miceli, Maria Virginia Soldovieri, Paolo Ambrosino, Michela De Maria, Michele Migliore, Rosanna Migliore, Maurizio Taglialatela
JOURNAL OF NEUROSCIENCE
(2015)
Article
Multidisciplinary Sciences
Michele Migliore, Francesco Cavarretta, Addolorata Marasco, Eleonora Tulumello, Michael L. Hines, Gordon M. Shepherd
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Neurosciences
Sigita Augustinaite, Paul Heggelund
Article
Neurosciences
Jenny Tigerholm, Michele Migliore, Erik Fransen
Article
Neurosciences
Daniela Bianchi, Pasquale De Michele, Cristina Marchetti, Brunello Tirozzi, Salvatore Cuomo, Helene Marie, Michele Migliore
Article
Neurosciences
Sigita Augustinaite, Bernd Kuhn, Paul Johannes Helm, Paul Heggelund
JOURNAL OF NEUROSCIENCE
(2014)
Article
Neurosciences
Yuguo Yu, Michele Migliore, Michael L. Hines, Gordon M. Shepherd
JOURNAL OF NEUROSCIENCE
(2014)
Article
Multidisciplinary Sciences
Aldo Casaleggio, Michael L. Hines, Michele Migliore
Article
Neurosciences
Francesco Cavarretta, Nicholas T. Carnevale, Domenico Tegolo, Michele Migliore
FRONTIERS IN CELLULAR NEUROSCIENCE
(2014)
Article
Mathematical & Computational Biology
Michele Migliore, Francesco Cavarretta, Michael L. Hines, Gordon M. Shepherd
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
(2014)
Article
Biochemistry & Molecular Biology
Sigita Augustinaite, Bernd Kuhn
Article
Biochemical Research Methods
Sigita Augustinaite, Bernd Kuhn
Summary: ISI is a technique used to map the functional architecture of the cortex based on hemodynamic responses. The protocol described involves using a cranial window with an access port to identify the area of V1 in a head-fixed mouse, followed by targeted viral vector injection for subsequent two-photon imaging of V1 layer 6 corticothalamic neurons. For more details, refer to the paper by Augustinaite and Kuhn (2020b).
Article
Biochemical Research Methods
Sigita Augustinaite, Bernd Kuhn
Meeting Abstract
Behavioral Sciences
Michele Migliore, Francesco Cavarretta, Addolorata Marasco, Michael L. Hines, Gordon M. Shepherd