RAS Transformation Requires CUX1-Dependent Repair of Oxidative DNA Damage

Ras Effector Mutant Expression Suggest a Negative Regulator Inhibits Lung Tumor Formation

(2014) Guillaume Vandal et al.   PLoS One

CUX1 in leukemia: dosage matters

(2013) J. Boultwood   BLOOD

A Modular Lentiviral and Retroviral Construction System to Rapidly Generate Vectors for Gene Expression and Gene Knockdown In Vitro and In Vivo

(2013) Benjamin Geiling et al.   PLoS One

CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia

(2012) M. E. McNerney et al.   BLOOD

Loss of heterozygosity in 7q myeloid disorders: clinical associations and genomic pathogenesis

(2012) A. Jerez et al.   BLOOD

Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies

(2012) Michael Steckel et al.   CELL RESEARCH

Translation-dependent mechanisms lead to PML upregulation and mediate oncogenic K-RAS-induced cellular senescence

(2012) Pier Paolo Scaglioni et al.   EMBO Molecular Medicine

CUX1 transcription factors: From biochemical activities and cell-based assays to mouse models and human diseases

(2012) Laura Hulea et al.   GENE

Identification ofCUX1as the recurrent chromosomal band 7q22 target gene in human uterine leiomyoma

(2012) Eric F. P. M. Schoenmakers et al.   GENES CHROMOSOMES & CANCER

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

CUX1 transcription factor is required for optimal ATM/ATR-mediated responses to DNA damage

(2012) Charles Vadnais et al.   NUCLEIC ACIDS RESEARCH

Quantitative proteomics profiling of the poly(ADP-ribose)-related response to genotoxic stress

(2012) Jean-Philippe Gagné et al.   NUCLEIC ACIDS RESEARCH

Synthetic lethality: exploiting the addiction of cancer to DNA repair

(2011) M. Shaheen et al.   BLOOD

Genome integrity of myeloproliferative neoplasms in chronic phase and during disease progression

(2011) T. Klampfl et al.   BLOOD

Induction of NAD(P)H-quinone oxidoreductase 1 by antioxidants in female ACI rats is associated with decrease in oxidative DNA damage and inhibition of estrogen-induced breast cancer

(2011) B. Singh et al.   CARCINOGENESIS

A high level of liver-specific expression of oncogenic KrasV12 drives robust liver tumorigenesis in transgenic zebrafish

(2011) A. T. Nguyen et al.   Disease Models & Mechanisms

ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence

(2011) U Weyemi et al.   ONCOGENE

Cut homeobox 1 causes chromosomal instability by promoting bipolar division after cytokinesis failure

(2011) Laurent Sansregret et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A review of PARP inhibitors: from bench to bedside

(2010) C. Underhill et al.   ANNALS OF ONCOLOGY

Prevalence and prognostic impact of allelic imbalances associated with leukemic transformation of Philadelphia chromosome-negative myeloproliferative neoplasms

(2010) N. H. Thoennissen et al.   BLOOD

Ink4a/Arf and Oncogene-Induced Senescence Prevent Tumor Progression during Alternative Colorectal Tumorigenesis

(2010) Moritz Bennecke et al.   CANCER CELL

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

CUX1: target of Akt signalling and mediator of resistance to apoptosis in pancreatic cancer

(2010) S. Ripka et al.   GUT

Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models

(2010) Silvestre Vicent et al.   JOURNAL OF CLINICAL INVESTIGATION

Cux1 and Cux2 Regulate Dendritic Branching, Spine Morphology, and Synapses of the Upper Layer Neurons of the Cortex

(2010) Beatriz Cubelos et al.   NEURON

Enhanced elimination of oxidized guanine nucleotides inhibits oncogenic RAS-induced DNA damage and premature senescence

(2010) P Rai et al.   ONCOGENE

Mouse Mammary Tumor Virus p75 and p110 CUX1 Transgenic Mice Develop Mammary Tumors of Various Histologic Types

(2009) C. Cadieux et al.   CANCER RESEARCH

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

(2009) Ji Luo et al.   CELL

A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene

(2009) Ji Luo et al.   CELL

p110 CUX1 Homeodomain Protein Stimulates Cell Migration and Invasion in Part through a Regulatory Cascade Culminating in the Repression of E-cadherin and Occludin

(2009) Valerie Kedinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53 isoforms Δ133p53 and p53β are endogenous regulators of replicative cellular senescence

(2009) Kaori Fujita et al.   NATURE CELL BIOLOGY

Production, concentration and titration of pseudotyped HIV-1-based lentiviral vectors

(2009) Robert H Kutner et al.   Nature Protocols

Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase

(2009) Michel DuPage et al.   Nature Protocols

Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence

(2009) P. Rai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

The multiple roles of CUX1: Insights from mouse models and cell-based assays

(2008) Laurent Sansregret et al.   GENE

Polycystic Kidneys Caused by Sustained Expression of Cux1 Isoform p75

(2008) Chantal Cadieux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ras oncogenes: split personalities

(2008) Antoine E. Karnoub et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY