Article
Biochemistry & Molecular Biology
Elisabetta Esposito, Laura Calderan, Andrea Galvan, Enrica Cappellozza, Markus Drechsler, Paolo Mariani, Alessia Pepe, Maddalena Sguizzato, Enrico Vigato, Edoardo Dalla Pozza, Manuela Malatesta
Summary: This study investigated the transdermal fate of ethosomes and transethosomes on human skin. The results showed that the vesicle penetration capability was influenced by their physical-chemical features, with different vesicles reaching different levels of the skin. This offers potential for tailored transdermal drug delivery based on specific cutaneous pathologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Kacper Wachol, Tadeusz Morawiec, Anna Nowak-Wachol, Bartlomiej Kubaszek, Teresa Kasprzyk-Kucewicz, Domenico Baldi, Agnieszka Machorowska-Pieniazek, Malgorzata Skucha-Nowak, Armand Cholewka
Summary: This clinical study aimed to analyze the accuracy of computer-guided implant surgery using dynamic implant navigation in patients treated with dental implants after bone augmentation. The results show that this technique has a high success rate, and it can reduce surgical risks and complications.
Article
Chemistry, Multidisciplinary
Dong-Jun Seo, Seong-Yong Moon, Jae-Seek You, Won-Pyo Lee, Ji-Su Oh
Summary: This study aimed to identify a method that can maximize implant primary stability (IPS) and bone density in low-density bones through an ex vivo study. The results showed that the osseodensification technique in the counter-clockwise direction can increase the IPS and bone mineral density of dental implants.
APPLIED SCIENCES-BASEL
(2022)
Article
Multidisciplinary Sciences
Hendricus Nijland, Jinwen Zhu, Thomas C. Kwee, Ding-Jun Hao, Paul C. Jutte
Summary: Bone metastases are becoming more common in cancer patients, and microwave ablation is commonly used for treatment. This study found that in the metaphysis of long bones, MWA may decrease mechanical strength up to 50% after six weeks, but it remains sufficient for patients to engage in direct mobilization.
Article
Anatomy & Morphology
Marilia Ferrari Marsiglia, Ana Lucia Miluzzi Yamada, Fernanda Rodrigues Agreste, Lilian Rose Marques de Sa, Rodrigo Tavares Nieman, Luis Claudio Lopes Correia da Silva
Summary: This study aimed to describe the imaging characteristics of the equine joint surface and subchondral bone in order to improve the detection of injuries or adaptations in racehorses. The findings showed that ultrasound images were most closely related to histological examination in terms of sensitivity, while macroscopic and radiographic examinations differed the most between evaluators. Moreover, the irregularities and modifications observed in the articular cartilage surface and subchondral bone were normal adaptations of trained racehorses' anatomical structures.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2022)
Article
Acoustics
Molly Smallcomb, Julianna C. Simon
Summary: Histotripsy can fractionate most soft tissues, but healthy tendons have shown resistance. However, pre-heating tendons and using dual-frequency histotripsy may successfully fractionate tendons. This study evaluated the efficacy of single- and dual-frequency histotripsy in healthy and tendinopathic bovine tendons, and found that dual-frequency histotripsy can achieve complete fractionation in tendinopathic tendons.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Francesca Ferrara, Mascia Benedusi, Franco Cervellati, Maddalena Sguizzato, Leda Montesi, Agnese Bondi, Markus Drechsler, Walter Pula, Giuseppe Valacchi, Elisabetta Esposito
Summary: In this study, transethosomes were explored as potential delivery systems for dimethyl fumarate. Formulative studies were conducted to investigate the effects of various compositions on the morphology and drug entrapment capacity of vesicles. Results showed that certain formulations were able to effectively improve wound healing and control drug release, indicating their potential application in wound treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Marcio de Carvalho Formiga, Helio Doyle Pereira da Silva, Bruna Ghiraldini, Rafael Shinoske Siroma, Lavinia Cosmina Ardelean, Adriano Piattelli, Jamil Awad Shibli
Summary: Primary stability is crucial for the success of dental implants. Osseodensification (OD) is a new bone site preparation method that increases bone-to-implant contact and primary stability. This study compared the effects of OD on cylindrical and conical implants with conventional instrumentation. The results showed that OD improved implant stability quotient (ISQ), insertion torque (IT), and removal torque (RT) for both types of implants.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
A. Torres, M. Dierickx, W. Coucke, MS. Pedano, P. Lambrechts, R. Jacobs
Summary: This study validates the use of an intraoral scan (IOS) post-operatively compared to the gold standard Cone Beam Computed Tomography (CBCT) in measuring the accuracy of guided endodontics. Clinical data shows high accuracy of guided endodontics with mean apical deviation less than 0.5 mm and mean angular deviation less than 2 degrees. Hence, IOS can be used to assess the accuracy of guided endodontics.
JOURNAL OF DENTISTRY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Fiona Mankertz, Nadine Bayerl, Ole Gemeinhardt, Norbert Hosten, Marie-Luise Kromrey
Summary: The study investigated the effect of cooling fluid composition on ablation size and carbonisation rate during hepatic laser ablation. Results showed that using a mixture of saline and distilled water as cooling fluid resulted in a larger ablation volume and a lower carbonisation rate. This finding suggests that this combination may improve patient outcomes for hyperthermic ablation.
Article
Engineering, Environmental
Sandra Ballesteros, Josefa Domenech, Antonia Velazquez, Ricard Marcos, Alba Hernandez
Summary: The biomedical applications of graphene-based nanomaterials have seen significant growth in recent years, with important implications for the interaction between GBN and blood cells triggering immune responses. The study used an innovative approach to study the effects of GBN on the secretome and showed potential impacts on cell growth, providing relevant data for biomedical use of GBN in patients.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Hematology
Monica T. Hinds, Azzdine Y. Ammi, Jennifer Johnson, Sanjiv Kaul
Summary: This study examined the effects of ultrasound and microbubbles on thrombosis in an ex vivo physiological model using juvenile baboons. Results showed that high peak rarefactional acoustic pressure amplitudes at 1.05 and 2.20 MHz significantly reduced platelet accumulation on the thrombogenic device.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Chemistry, Physical
Henning Staedt, Diana Heimes, Karl M. Lehmann, Peter Ottl, Monika Bjelopavlovic, Wilfried Wagner, Bilal Al-Nawas, Peer W. Kaemmerer
Summary: The study found that primary stability of dental implants increases with increasing length and the presence of screw threads at the apical end in both hard and soft bone. Undersized drilling preparation in soft bone significantly improves primary stability.
Article
Medicine, General & Internal
Corantin Maurin, Zhiguo He, Marielle Mentek, Paul Verhoeven, Sylvie Pillet, Thomas Bourlet, Francoise Rogues, Jean Loup Pugniet, Thierry Peyragrosse, Marion Barallon, Chantal Perrache, Ines Aouimeur, Sophie Acquart, Sandrine Ninotta, Marc Baud'huin, Bertrand Vabres, Sylvain Poinard, Philippe Gain, Gilles Thuret
Summary: In this study, the capacity of human cornea to be infected by SARS-CoV-2 was assessed, and it was found that corneas can be infected and replicate the virus ex vivo. The risk of corneal contamination by SARS-CoV-2 in donors diagnosed with COVID-19 was also found to be low.
Article
Engineering, Biomedical
Qin Zou, Yuqing Huang, Junling Gao, Bo Zhang, Diya Wang, Mingxi Wan
Summary: A new algorithm was proposed to efficiently reconstruct high-quality 3D ultrasound volumes using sparse 2D ultrasound images. The algorithm has the potential to provide rapid feedback and precise analysis of stereoscopic details in the musculoskeletal system scanning.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Medicine, General & Internal
Frank R. Kloss, Peer W. Kaemmerer, Anita Kloss-Brandstaetter
Summary: This study aimed to identify potential risk factors for complications related to alveolar ridge augmentation using bone blocks. The study found that complications were more frequent with autogenous bone blocks compared to allogeneic bone blocks, but these complications were minor and did not affect the success of dental rehabilitation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Lena Katharina Mueller-Heupt, Nadine Wiesmann-Imilowski, Sofia Schroeder, Jonathan Gross, Pablo Cores Ziskoven, Philipp Bani, Peer Wolfgang Kaemmerer, Eik Schiegnitz, Anja Eckelt, John Eckelt, Ulrike Ritz, Till Opatz, Bilal Al-Nawas, Christopher Synatschke, James Deschner
Summary: Periodontitis is a chronic inflammatory disease that leads to tooth loss and significantly impacts global health. A hyaluronic acid-based dispersion with controlled oxygen delivery shows potential as a treatment for periodontitis. In vitro and in vivo studies demonstrate the biocompatibility, antimicrobial activity against Porphyromonas gingivalis, and angiogenesis enhancement of the developed oxygen-releasing dispersion. This suggests the potential of oxygen-releasing biomaterials for periodontal tissue regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Polymer Science
Anja Kriegel, Eva Langendorf, Valentina Kottmann, Peer W. Kaemmerer, Franz Paul Armbruster, Nadine Wiesmann-Imilowski, Andreas Baranowski, Erol Gercek, Philipp Drees, Pol Maria Rommens, Ulrike Ritz
Summary: Bone fracture healing is a complex process involving early immune reactions, bone formation, and angiogenesis. This study focuses on the effects of bone sialoprotein (BSP) immobilized in a collagen type I gel on angiogenesis. In vitro analyses and a yolk sac membrane assay demonstrate that BSP induces angiogenesis and that collagen type I is the optimal carrier for BSP. This suggests that BSP could be a promising molecule for bone tissue regeneration.
Article
Oncology
Peer W. Kaemmerer, Silke Tribius, Lena Cohrs, Gabriel Engler, Tobias Ettl, Kolja Freier, Bernhard Frerich, Shahram Ghanaati, Martin Gosau, Dominik Haim, Stefan Hartmann, Max Heiland, Manuel Herbst, Sebastian Hoefert, Juergen Hoffmann, Frank Hoelzle, Hans-Peter Howaldt, Kilian Kreutzer, Henry Leonhardt, Rainer Lutz, Maximilian Moergel, Ali Modabber, Andreas Neff, Sebastian Pietzka, Andrea Rau, Torsten E. Reichert, Ralf Smeets, Christoph Sproll, Daniel Steller, Joerg Wiltfang, Klaus-Dietrich Wolff, Kai Kronfeld, Bilal Al-Nawas
Summary: This is the first prospective study using a multicentric approach to investigate the effectiveness of adjuvant radiotherapy in patients with early squamous cell carcinoma of the oral cavity and oropharynx. The study found that adjuvant radiotherapy does not seem to influence overall survival, but it positively affects time to progression. However, irradiated patients report a significantly decreased quality of life up to three years after therapy.
Article
Oncology
Sebastian Blatt, Peer W. Kaemmerer, Maximilian Krueger, Rambabu Surabattula, Daniel G. E. Thiem, Simon T. Dillon, Bilal Al-Nawas, Towia A. Libermann, Detlef Schuppan
Summary: Oral cancer is a life-threatening disease and specific protein biomarkers in the blood can help with early tumor detection and individualized therapy. This exploratory study used advanced technology to analyze serum proteome and identified novel biomarkers for oral cancer. The study showed significant differences in serum protein levels between oral cancer patients and controls, as well as before and after curative surgery.
Article
Biochemistry & Molecular Biology
Nadja Engel, Michael Dau, Vivien Engel, Denise Franz, Fabian Klemmstein, Christiane Thanisch, Juergen F. Kolb, Marcus Frank, Armin Springer, Ruediger Koehling, Rainer Bader, Bernhard Frerich, Nadine Wiesmann, Diana Heimes, Peer W. Kaemmerer
Summary: By combining electrical stimulation of a commercial titanium implant with real-time impedance sensing, osteogenesis progress can be monitored and electrical stimulation can be adjusted accordingly for individual fracture healing.
Review
Dentistry, Oral Surgery & Medicine
Peer W. Kaemmerer, Shengchi Fan, Carlos Aparicio, Edmond Bedrossian, Ruben Davo, Dean Morton, Gerry M. M. Raghoebar, Sepehr Zarrine, Bilal Al-Nawas
Summary: This study assessed the outcome and complications of zygomatic implant placement using the original surgical technique (OST) and an Anatomy-Guided approach (AGA) in patients with severely atrophic maxillae. Based on the systematic review, placing ZI with OST and AGA is associated with a high implant survival rate and a higher risk of surgical complications, including sinusitis and soft tissue infection around the implant, during a minimum of 6 months follow-up.
INTERNATIONAL JOURNAL OF IMPLANT DENTISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Vinay V. Kumar, Sainath Venkat, P. C. Jacob, Gaurav Khemeria
Summary: This 10-year follow-up report discusses the interdisciplinary comprehensive management of an aneurysmal bone cyst in the maxilla of a 24-year-old patient. The treatment involved resection and reconstruction using a vascularized deep circumflex iliac artery-based composite free flap, implant placement, and soft tissue management using denture-guided epithelial regeneration. The patient was followed up for 10 years, with definitive management achieved through implant-supported cast partial dentures.
JOURNAL OF MAXILLOFACIAL & ORAL SURGERY
(2023)
Article
Surgery
Diana Heimes, Peer W. Kaemmerer
Summary: Secondary chronic osteomyelitis (SCO) is a progressive jawbone destruction caused by bacterial infection. Antibiotics are the first-line treatment, but surgery may not provide a cure. Bisphosphonates have shown promising results in SCO patients, similar to their success in primary nonbacterial osteomyelitis.
JOURNAL OF SURGICAL CASE REPORTS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Diana Heimes, Andreas Pabst, Philipp Becker, Amely Hartmann, Frank Kloss, Jochen Tunkel, Ralf Smeets, Peer W. Kaemmerer
Summary: This study analyzed and compared morbidity-related parameters after alveolar ridge augmentation using autogenous and allogeneic bone blocks from patients' perspective. The results showed that the rate of nerve irritations was twice as high in the autologous group, and swelling was significantly higher in patients with autologous bone blocks. However, the overall satisfaction of patients in both groups was very high, with over 8/10 points.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Matthias W. Gielisch, Fabia Siegberg, Daniel G. E. Thiem, Sebastian Blatt, Diana Heimes, Peer W. Kaemmerer
Summary: This study investigated the impact of three different osteosynthesis plate systems on failure rates and complications after mandibular resections. The results suggest that RP3 should be preferred over RP1 and RP2 due to lower failure rates and complications.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2023)
Review
Medicine, General & Internal
Shengchi Fan, Gustavo Saenz-Ravello, Leonardo Diaz, Yiqun Wu, Ruben Davo, Feng Wang, Marko Magic, Bilal Al-Nawas, Peer W. Kaemmerer
Summary: The study aimed to evaluate the accuracy of different approaches for zygomatic implant (ZI) placement in patients with severe maxillary problems. The results showed that dynamic computer-aided surgery (d-CAIS) and modified static computer-aided surgery (s-CAIS) had clinically acceptable outcomes, while the conventional s-CAIS had the highest deviation values. Surgeons should be aware of potential deviations and complications regardless of the selected approach.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Daniel Stephan, Sebastian Blatt, Julian Riedel, Katja Mohnke, Robert Ruemmler, Alexander Ziebart, Bilal Al-Nawas, Peer W. Kaemmerer, Daniel G. E. Thiem
Summary: This study aimed to investigate the impact of ischemia on intra-flap metabolism and electrolyte concentrations during transplantation surgery using a novel animal model. The results showed that even a short ischemic period could induce anaerobic glycolysis and electrolyte displacement, leading to acidosis and tissue damage.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Diana Heimes, Nicolas Alexander Mark, Robert Kuchen, Andreas Pabst, Philipp Becker, Solomiya Kyyak, Daniel G. E. Thiem, Ralf Schulze, Peer W. Kaemmerer
Summary: The study aimed to evaluate the skills of dental students in choosing the correct stage, diagnostics, and treatment option for MRONJ based on clinical and radiographic imaging. The results showed a lack of knowledge among students in staging, diagnostics, and treatment of MRONJ, although CBCT imaging positively affected decision-making. Further teaching in this disease's context and X-ray diagnostics is needed.
MEDICINA-LITHUANIA
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jochen Tunkel, Frederik Hoffmann, Yannik Schmelcher, Anita Kloss-Brandstaetter, Peer W. Kaemmerer
Summary: Compared to the autogenous technique, allogeneic shell augmentation has a shorter surgical time and a similar rate of intra- and postoperative complications as autogenous bone. Together with its promising clinical results, this technique can be recommended.
INTERNATIONAL JOURNAL OF IMPLANT DENTISTRY
(2023)
