Article
Immunology
Joel M. Palefsky, Shelly Y. Lensing, Marvin Belzer, Jeannette Lee, Aditya H. Gaur, Kenneth Mayer, Donna Futterman, Elizabeth A. Stier, Mary E. Paul, Elizabeth Y. Chiao, Daniel Reirden, Stephen E. Goldstone, Maribel Tirado, Edward R. Cachay, Luis F. Barroso, Maria Da Costa, Teresa M. Darragh, Bret J. Rudy, Craig M. Wilson, Jessic A. Kahn
Summary: This study aimed to evaluate the safety and efficacy of quadrivalent HPV vaccine on young MSM with HIV. The results showed that vaccination did not provide protection against vaccine-type HPV infection and related lesions. Therefore, it is recommended to vaccinate MSM before initiating sexual activity to prevent HPV-related diseases.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Infectious Diseases
Yiguo Zhou, Yi-Fan Lin, Lei Gao, Jianghong Dai, Ganfeng Luo, Lanying Li, Tanwei Yuan, Peiyang Li, Yuewei Zhan, Yanxiao Gao, Huachun Zou
Summary: HPV infection is common among men who have sex with men in China, with higher prevalence at the anus. HPV genotypes 6, 11, 16, 18, 52, and 58 are predominant. The prevalence of high-risk and low-risk HPV varies between northern and southern regions. Prior sexual behavior is associated with higher HPV prevalence among MSM.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Article
Immunology
Jean-Damien Combes, Jean-Michel Didelot, Sylvie Radenne, Olivia Zaegel-Faucher, Anne-Carole Lesage, Laurent Siproudhis, Lionel Piroth, Lucie Marchand, Isabelle Heard, Nadia Hoyeau, Sebastien Henno, Teresa M. Darragh, Catharina J. Alberts, Gary M. Clifford, Isabelle Etienney
Summary: This study assessed the detection and determinants of anal high-grade squamous intraepithelial lesions (HSILs) in men who have sex with men living with HIV. The study found that baseline positivity for human papillomavirus 16 and p16/Ki67 were the strongest determinants of HSILs. Annual cytology and high-resolution anoscopy improved HSIL detection but couldn't compensate for between-center heterogeneity.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Virology
Cremildo Maueia, Alltalents Murahwa, Alice Manjate, Soren Andersson, Jahit Sacarlal, Darlene Kenga, Tufaria Mussa, Anna-Lise Williamson
Summary: This study demonstrates a high prevalence of HPV infection in women from Maputo, Mozambique, with HIV-positive women having the highest HPV prevalence and being more susceptible to multiple HPV types. High-risk genotypes were the most commonly found.
Article
Medicine, General & Internal
Giulia Ciccarese, Astrid Herzum, Gaetano Serviddio, Corrado Occella, Aurora Parodi, Francesco Drago
Summary: HPV vaccines may have a therapeutic role in addition to standard treatments for anogenital warts and oral warts, especially for persistent lesions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Yuxin Liu, Swati Bhardwaj, Keith Sigel, John Winters, Joseph Terlizzi, Michael M. Gaisa
Summary: This study investigated the prevalence and severity of anal HPV disease among MSM LWH under the age of 35, finding a high prevalence of HPV infection and precancer but no cases of invasive anal cancer. This supports the adoption of age-based anal cancer screening for this population.
INTERNATIONAL JOURNAL OF CANCER
(2024)
Article
Infectious Diseases
Shuting Yu, Yingying Zhu, Huijing He, Yaoda Hu, Xiaoli Zhu, Wenwen Diao, Shuguang Li, Guangliang Shan, Xingming Chen
Summary: The overall prevalence of oral HPV infection among healthy adults aged above 20 in northern China was 4.08%. The most prevalent HPV type detected was HPV-81 (1.35%), followed by HPV-16 (0.64%). Oral HPV infection exhibited a bimodal pattern with respect to age in both male and female participants. The prevalence of oral HPV infection was significantly higher in males than females (5.0% versus 3.6%, P = 0.041). Current smokers (OR = 1.59; P = 0.039) and current drinkers (OR = 1.60; P = 0.023) had a higher prevalence of oral HPV infection. Current alcohol consumption was independently associated with oral HPV infection (OR = 1.74; P = 0.010).
BMC INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Joseph Niyibizi, Marie-Helene Mayrand, Francois Audibert, Patricia Monnier, Paul Brassard, Louise Laporte, Julie Lacaille, Monica Zahreddine, Marie-Josee Bedard, Isabelle Girard, Diane Francoeur, Ana Maria Carceller, Jacques Lacroix, William Fraser, Francois Coutlee, Helen Trottier
Summary: The study found that persistent HPV-16/18 infection is associated with an increased risk of preterm birth, even in women without a history of cervical treatment. Future research should investigate the impact of HPV vaccination and vaccination programs on the risk of preterm birth.
Article
Immunology
Rachel L. Winer, John Lin, Troy D. Querec, Elizabeth R. Unger, Joshua E. Stern, Jessica M. Rudd, Matthew R. Golden, Fred Swanson, Lauri E. Markowitz, Elissa Meites
Summary: A study found that among men who have sex with men, those who reported receiving the HPV vaccine before the age of 18 had a lower prevalence of penile HPV infection. This suggests that HPV vaccination is effective in preventing penile HPV infections in young men who have sex with men.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Shuang Li, Junping Zhu, Bin Su, Huanhuan Wei, Fei Chen, Hongshan Liu, Jiaqi Wei, Xiaodong Yang, Qiuyue Zhang, Wei Xia, Hao Wu, Qiushui He, Tong Zhang
Summary: Despite antiretroviral therapy, HIV-related oral disease remains common for PLWH. Impairment of immune function in HIV infection may lead to changes in oral microbiome. The study found decreased microbiome diversity in patients with HIV infections and changes in microbial compositions after ART.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Virology
Xiangyang Yao, Zhenzhen Xu, Chen Duan, Yangjun Zhang, Xiaoliang Wu, Huahui Wu, Kai Liu, Xiongmin Mao, Bo Li, Yang Gao, Hua Xu, Xinghuan Wang
Summary: This study systematically reviews the relationship between HPV-associated viruses and bladder cancer, aiming to elucidate the role of these viruses in the onset and progression of the disease. It also assesses potential strategies for treating virus-induced bladder cancer and introduces the rapid development of oncolytic viruses as a novel treatment option.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Multidisciplinary Sciences
Lara K. Marquez, Patrick Ingiliz, Christoph Boesecke, Ivanka Krznaric, Knud Schewe, Thomas Lutz, Stefan Mauss, Stefan Christensen, Jurgen K. Rockstroh, Sonia Jain, Feng He, Joel O. Wertheim, Natasha K. Martin
Summary: This study evaluated the progress of HCV elimination among MSM living with HIV in Germany using a transmission model. The results showed that by expanding the use of direct-acting antivirals (DAAs), the WHO incidence target can be achieved, indicating the importance of scaling up DAA treatment.
Article
Immunology
Zhuochen Li, Rachel L. Winer, Selly Ba, Marie Pierre Sy, John Lin, Qinghua Feng, Geoffrey S. Gottlieb, Papa Salif Sow, Nancy B. Kiviat, Stephen E. Hawes
Summary: In Senegalese women, HIV-positive women had a lower likelihood of clearing incident HPV infections compared to HIV-negative women, while HIV-2-infected or dually infected women were more likely to clear incident HPV infections than HIV-1-infected women.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Endocrinology & Metabolism
Kirsten N. Redman, Katie E. O'Brien, Francieli S. Ruiz, Dale E. Rae, F. Xavier Gomez-Olive, Malcolm von Schantz, Karine Scheuermaier
Summary: People living with HIV have poorer sleep quality, shorter sleep duration, and earlier sleep phase, which has significant implications for their health and well-being.
JOURNAL OF PINEAL RESEARCH
(2023)
Article
Immunology
Yuxin Liu, Kevin Weiss, Andres Ramirez Zamudio, Monica Prasad Hayes, Mona Saleh, Michael M. Gaisa, Keith Sigel
Summary: Anal HPV disease was highly prevalent in this primary screening cohort of WWH, and genital screening results predicted anal disease. Universal anal cancer screening is recommended for this population.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Virology
James Riddell Iv, Andrew F. Brouwer, Heather M. Walline, Lora P. Campredon, Rafael Meza, Marisa C. Eisenberg, Emily C. Andrus, Rachel L. Delinger, Monica L. Yost, Jodi K. McCloskey, Trey B. Thomas, Suiyuan Huang, Robert L. Ferris, Dong Moon Shin, Carole Fakhry, Thomas Ow, Daniel Li, Ashley Berlot, Thomas E. Carey, Nicolas F. Schlecht
Summary: This study evaluated the risk of oral HPV infection in HIV infected patients compared with HIV-negative controls. The results showed that HIV-positive individuals had a significantly higher prevalence of oral HPV infection and persistence compared to HIV-negative individuals. Male participants had a higher oral HPV prevalence than female participants.
TUMOUR VIRUS RESEARCH
(2022)
Article
Oncology
Walid A. Al-Soneidar, Sam Harper, Sreenath A. Madathil, Nicolas F. Schlecht, Belinda Nicolau
Summary: Alpha-HPV, especially HPV16, increases the risk for head and neck cancers, while there is little evidence for an effect of Beta-HPV and Gamma-HPV. Beta-HPV may have a preventive effect, while Gamma-HPV may increase the risk of head and neck cancers, although to a lesser extent than Alpha-HPV. Results for cutaneous HPV were imprecise and less conclusive.
CANCER EPIDEMIOLOGY
(2022)
Article
Oncology
Jason Y. K. Chan, Man Kit Cheung, Linlin Lan, Cherrie Ng, Eric H. L. Lau, Zenon W. C. Yeung, Eddy W. Y. Wong, Leanne Leung, Xinyu Qu, Liuyang Cai, Hengyan Zhu, Siaw Shi Boon, Robert D. Burk, Paul K. S. Chan, Zigui Chen
Summary: This study investigated the interplay among the oral microbiota, HPV infection, traditional risk factors, and patient outcomes in head and neck squamous cell carcinoma (HNSCC). The results showed that dysbiosis of the oral microbiota is closely associated with HNSCC pathogenesis, and the presence of Fusobacterium is linked to improved outcomes in OSCC patients.
Article
Microbiology
Man Kit Cheung, Sylvia L. Y. Tong, Martin C. S. Wong, Jason Y. K. Chan, Margaret Ip, Mamie Hui, Christopher K. C. Lai, Rita W. Y. Ng, Wendy C. S. Ho, Apple C. M. Yeung, Paul K. S. Chan, Zigui Chen
Summary: This study characterized the bacterial and fungal microbiomes in oral and stool samples from healthy Chinese adults. The results showed limited transmission of microbiota between the oral cavity and gut in healthy individuals, with only a few shared bacterial and fungal variants. The sharing of potentially transmissible fungal variants was associated with host factors.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Christopher K. C. Lai, Man Kit Cheung, Grace C. Y. Lui, Lowell Ling, Jason Y. K. Chan, Rita W. Y. Ng, Hiu Ching Chan, Apple C. M. Yeung, Wendy C. S. Ho, Siaw Shi Boon, Paul K. S. Chan, Zigui Chen
Summary: Dysbiosis in the naso- and/or oro-pharyngeal microbiota is observed in COVID-19 patients compared to healthy individuals. However, this study found that the microbial communities in COVID-19 and non-COVID-19 hospitalized patients did not differ significantly. Alloprevotella and Solobacterium were enriched in COVID-19 patients, while Mogibacterium and Lactococcus were decreased. Alloprevotella was positively correlated with the inflammation biomarker CRP.
MICROBIOLOGY SPECTRUM
(2022)
Article
Medicine, General & Internal
Rita W. Y. Ng, Siaw S. Boon, Zigui Chen, Wendy C. S. Ho, Kitty S. C. Fung, Barry K. C. Wong, Apple C. M. Yeung, Martin C. S. Wong, Paul K. S. Chan
Summary: This prospective cohort study found that individuals infected with SARS-CoV-1 had detectable levels of antibodies that cross-react and cross-neutralize SARS-CoV-2, supporting the development of broadly protective vaccines.
Article
Microbiology
Liping Lyu, Usman Asghar, Jinyu Fu, Yunyi Gao, Xue Zhang, Saleh A. Al-Farraj, Zigui Chen, Feng Gao
Summary: Ciliated protists have both germline micronucleus (MIC) and somatic macronucleus (MAC) within a single cytoplasm. Genomic sequences of ciliates remain largely unknown due to the difficulty in culturing and separating the germline from the somatic genome. Single-cell whole genome amplification techniques such as multiple displacement amplification (MDA) and multiple annealing and looping-based amplification cycles (MALBAC) have been compared in this study to characterize the germline and somatic genomes of ciliates with different genomic architectures.
EUROPEAN JOURNAL OF PROTISTOLOGY
(2023)
Review
Otorhinolaryngology
Haaron S. L. Ting, Zigui Chen, Jason Y. K. Chan
Summary: By systematically analyzing the relationship between head and neck squamous cell carcinoma (HNSCC) and the oral microbiome, similarities and inconsistencies in microbial diversities, microbiome profiles, metagenomic analysis, and host-pathogen interactions were identified. The potential clinical applications of the microbiome in screening and diagnosis of HNSCC were evaluated.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Oncology
Hengyan Zhu, Hon Chi Yip, Man Kit Cheung, Hiu Ching Chan, Cherrie Ng, Eric H. L. Lau, Zenon W. C. Yeung, Eddy W. Y. Wong, Leanne Leung, Xinyu Qu, Daijuanru Wang, Liuyang Cai, Paul K. S. Chan, Jason Y. K. Chan, Zigui Chen
Summary: By sequencing the microbial communities in samples from patients with primary esophageal squamous cell carcinoma (ESCC) and oral cavity squamous cell carcinoma (OSCC), this study found that these two cancers displayed similar patterns of dysbiosis in their upper aerodigestive microbiota. Certain bacterial genera were commonly enriched or depleted in both types of cancer, suggesting a potential role in the pathogenesis of malignancies.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Public, Environmental & Occupational Health
Man Kit Cheung, Rita W. Y. Ng, Christopher K. C. Lai, Chendi Zhu, Eva T. K. Au, Jennifer W. K. Yau, Carmen Li, Ho Cheong Wong, Bonnie C. K. Wong, Kin On Kwok, Zigui Chen, Paul K. S. Chan, Grace C. Y. Lui, Margaret Ip
Summary: International travel increases the risk of acquiring antibiotic-resistant bacteria and antibiotic resistance genes (ARGs). This study found that traveling to low- or middle-income countries, Africa or Southeast Asia, a long travel duration, and the use of alcohol-based hand sanitizer or doxycycline as antimalarial prophylaxis are important risk factors for the acquisition/enrichment of ARGs during international travel.
JOURNAL OF TRAVEL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Bei Huang, Steven W. H. Chau, Yaping Liu, Joey W. Y. Chan, Jing Wang, Suk Ling Ma, Jihui Zhang, Paul K. S. Chan, Yun Kit Yeoh, Zigui Chen, Li Zhou, Sunny Hei Wong, Vincent C. T. Mok, Ka Fai To, Hei Ming Lai, Simon Ng, Claudia Trenkwalder, Francis K. L. Chan, Yun Kwok Wing
Summary: The study reveals that the gut microbiota compositions are significantly altered in early PD and RBD compared with control and RBD-FDR. The depletion of butyrate-producing bacteria and the enrichment of pro-inflammatory Collinsella have emerged in RBD and RBD-FDR after controlling potential confounders. The study also identifies 12 microbial markers that can effectively distinguish RBD from control.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Siaw Shi Boon, Yin Ching Lee, Ka Lai Yip, Ho Yin Luk, Chuanyun Xiao, Man Kin Yim, Zigui Chen, Paul Kay Sheung Chan
Summary: This study identified Aurora kinase B (AurB) as a novel interacting partner of human papillomavirus E6, and investigated the molecular mechanism of how E6 recruits AurB to induce cell immortalization and proliferation, leading to eventual cancer development. The study also evaluated the efficacy of Aurora kinase inhibitors in halting HPV-mediated carcinogenesis. The findings revealed the potential for specific and selective inhibitors to be developed for the treatment of HPV-related cancers.
Article
Microbiology
Yehao Chen, Yuping Song, Zigui Chen, Jennifer Wing Ki Yau, Kate Ching Ching Chan, Agnes Sze Yin Leung, Oi Man Chan, Apple Chung Man Yeung, Connie Lai Yuk Yuen, Paul Kay Sheung Chan, Wing Hung Tam, Ting Fan Leung
Summary: This study investigated the early-life evolution of the skin microbiome in Chinese children and its association with eczema phenotypes. The results showed that atopic sensitization at 12 months was strongly associated with persistent eczema at 24 months. Children with atopic eczema had reduced alpha diversity at 12 months and transiently higher abundance of the genus Janibacter at 6 months compared to those with non-atopic eczema. These findings suggest that atopic sensitization at 12 months may predict persistent eczema, and atopic eczema is associated with unique skin microbiome profiles at different time points. Non-invasive skin-microbiome profiling may have predictive value for atopic eczema.
Article
Microbiology
Ying Pan, Guihao Li, Lei Su, Pengfei Zheng, Yaping Wang, Zhuo Shen, Zigui Chen, Qiuying Han, Jun Gong
Summary: Seagrass colonization significantly affects the structure and function of belowground microeukaryotes, reducing their diversity and increasing heterotroph biomass. This study also highlights the relationship between eukaryotic parasites hotspot and high productivity in natural ecosystems.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Infectious Diseases
Rita Wai-Yin Ng, Chun-Kwok Wong, Grace Chung-Yan Lui, Eugene Yuk-Keung Tso, Zigui Chen, Owen Tak-Yin Tsang, Siaw Shi Boon, Christopher Koon-Chi Lai, Kitty Sau-Chun Fung, Apple Chung-Man Yeung, Wendy Ching-Sze Ho, David Shu-Cheong Hui, Paul Kay-Sheung Chan, Jacky Man-Chun Chan
Summary: This study assessed viral RNA and cytokine profiles in HIV patients with SARS-CoV-2 infection in Hong Kong. The results showed that HIV patients had similar respiratory viral shedding compared to controls, but had lower levels of IL-10 and NT-proBNP.
JOURNAL OF CLINICAL VIROLOGY PLUS
(2022)