Review
Pharmacology & Pharmacy
Alessandra T. Zizzari, Dimanthi Pliatsika, Flavio M. Gall, Thomas Fischer, Rainer Riedl
Summary: Peptides, due to their structural diversity, are considered a unique source of innovative active ingredients, but face challenges in development due to their disadvantageous pharmacokinetic properties. Recent efforts have focused on improving the oral bioavailability of peptide drugs, with the latest findings expected to influence future approaches in developing more efficient and safer orally delivered peptides by pharmaceutical companies.
DRUG DISCOVERY TODAY
(2021)
Review
Biochemistry & Molecular Biology
S. Spoorthi Shetty, Praveen Halagali, Asha P. Johnson, K. M. Asha Spandana, H. V. Gangadharappa
Summary: Diabetes Mellitus is a condition characterized by high blood sugar levels that can be caused by the destruction of beta cells or insulin resistance. Insulin is a hormone that regulates the metabolism of carbohydrates, proteins, and fats. Type 1 Diabetes Mellitus requires insulin for management, but invasive methods of administration may reduce patient adherence. This article discusses the potential of oral insulin as a non-invasive alternative with advantages such as patient compliance and cost reduction, as well as strategies to overcome gastrointestinal barriers.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Medicinal
Shaimaa S. Ibrahim
Summary: The aim of this study was to develop nanostructured lipid carriers (NLC) to improve the therapeutic outcome of prednisolone acetate (PA) by altering its pharmacokinetic profile and/or allowing preferential targeting to inflammatory tissues. Optimized PA-loaded NLCs showed superior anti-inflammatory activity and good stability.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Aun Raza, Jared A. Miles, Fekade Bruck Sime, Benjamin P. Ross, Jason A. Roberts, Amirali Popat, Tushar Kumeria, James R. Falconer
Summary: A novel multi-material delivery system based on gamma-CD and PLGA was developed to enhance the solubility and stability of MER, while maintaining its antibacterial activity.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Pharmacology & Pharmacy
Yousuf Mohammed, Amy Holmes, Philip Chi Lip Kwok, Tushar Kumeria, Sarika Namjoshi, Mohammad Imran, Lana Matteucci, Masood Ali, Waiting Tai, Heather A. E. Benson, Michael S. Roberts
Summary: Epithelial surfaces play a crucial role in protecting the body from foreign materials and can be utilized for drug delivery. The permeability of different epithelia varies based on their exposure and function. Advancements in epithelial drug delivery systems have been driven by quality-by-design approach and the growth of generic products.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Pharmacology & Pharmacy
Rahman Md Moshikur, Rebecca L. Carrier, Muhammad Moniruzzaman, Masahiro Goto
Summary: The development of effective drug formulations and delivery systems is challenging. Ionic liquids (ILs) can address the challenges associated with traditional organic solvents. However, many ILs are non-biodegradable and toxic. The development of biocompatible ILs for drug formulations and delivery systems is important.
Article
Chemistry, Physical
Kei-Xian Tan, Ling-Ling Evelyn Ng, Say Chye Joachim Loo
Summary: Curcumin has been a focus of research in the food and biopharmaceutical industries due to its various health benefits. Researchers are developing an ideal delivery system to enhance curcumin's solubility, bioavailability, and bioactivity. The use of MCT oil and k-carrageenan as a carrier has shown promise in improving oral delivery of curcumin.
Review
Biochemistry & Molecular Biology
Anna Paradowska-Stolarz, Mieszko Wieckiewicz, Artur Owczarek, Joanna Wezgowiec
Summary: This review focuses on the recent advances in the use of natural polymers in maintaining or restoring oral health, covering various dental specialties and discussing the comparison between natural and synthetic polymers. It also highlights new perspectives, possible future advancements, and challenges that researchers in the field of dental applications of natural polymers may encounter.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Alireza Ghannad Sabzevari, Hossein Sabahi, Mohsen Nikbakht, Steven J. P. McInnes
Summary: An oral controlled-release formulation of epigallocatechin-3-gallate (EGCG) was developed by intercalating EGCG into mucoadhesive montmorillonite (Mt) nanolayers. The EGCG-loaded Mt showed sustained release of EGCG in a pH-dependent manner, making it a potential nanocarrier for oral administration of EGCG. The study provided valuable insights into the release mechanism and application of EGCG in oral drug delivery.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Carolini Mendes, Anand Thirupathi, Maria E. A. B. Correa, Yaodong Gu, Paulo C. L. Silveira
Summary: This paper explores the application of metallic nanoparticles in the treatment of chronic wounds, highlighting their advantages in drug delivery, antimicrobial activity, and healing acceleration, as well as the safety and applicability of metallic nanoparticles produced through green synthesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Polymer Science
Siphokazi B. K. Dludla, Leshasha T. Mashabela, Brian Ng'andwe, Pedzisai A. Makoni, Bwalya A. Witika
Summary: The application of nanotechnology in ophthalmic drug delivery systems shows great potential to overcome barriers faced by traditional ophthalmic formulations. Stimuli-responsive nano drug carriers have attracted significant attention due to their unique functionalities and therapeutic efficacy, playing a crucial role in the treatment and alleviation of ocular diseases.
Review
Engineering, Biomedical
Sarah J. Shepherd, David Issadore, Michael J. Mitchell
Summary: Nanomedicine has advanced significantly in clinical applications, with microfluidic devices showing potential for generating reproducible nanoparticle formulations. These formulations enhance biomedical applications with controlled physical properties, pointing towards future production scale-independent formulations through parallelization and multi-step reactions.
Article
Biochemistry & Molecular Biology
Silvia Pisani, Enrica Chiesa, Ida Genta, Rossella Dorati, Marilena Gregorini, Maria Antonietta Grignano, Marina Ramus, Gabriele Ceccarelli, Stefania Croce, Chiara Valsecchi, Manuela Monti, Teresa Rampino, Bice Conti
Summary: This study focuses on formulating liposomes for use in hypothermic isolated kidney dynamic machine perfusion as drug delivery systems to improve organ preservation. Microfluidic techniques are found to be superior for obtaining reproducible spherical liposomes with size below 200 nm. Protein encapsulation efficiency is affected by molecular weight and isoelectric point. Lowering incubation temperature slows down protein release. Liposomes are taken up by epithelial tubular renal cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Jie Lou, Hongli Duan, Qin Qin, Zhipeng Teng, Fengxu Gan, Xiaofang Zhou, Xing Zhou
Summary: The oral route is preferred for drug delivery but faces challenges due to the harsh gastrointestinal environment. Innovative approaches including nanoparticulate formulations, biomimetic drug formulations, and microfabricated devices have been explored for improved targeting and bioavailability. This review discusses anatomical, biochemical, and physiological factors influencing oral drug delivery and highlights recent advances in conventional and novel approaches. The challenges and opportunities of oral drug delivery systems are also addressed.
Review
Pharmacology & Pharmacy
Pauric Bannigan, Matteo Aldeghi, Zeqing Bao, Florian Hase, Alan Aspuru-Guzik, Christine Allen
Summary: Machine learning has made significant advances in the healthcare and pharmaceutical sectors, especially in drug formulation development. Traditional approaches to drug formulation development are time-consuming and limited, while machine learning can help accelerate drug formulation development, improve the bioavailability and targeted delivery of new drugs.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Environmental Sciences
Olga Di Fede, Federica Canepa, Vera Panzarella, Rodolfo Mauceri, Carmine Del Gaizo, Alberto Bedogni, Vittorio Fusco, Pietro Tozzo, Giuseppe Pizzo, Giuseppina Campisi, Antonio Galvano
Summary: The study found that compared to aggressive surgery alone, combined conservative surgery showed a statistically significant difference in the 6-month improvement rate. However, there was no significant difference in the 6-month total resolution rate between the two groups. Additionally, combining conservative surgery with various adjuvant non-invasive procedures was found to achieve partial or complete healing at all stages, with improved results and amelioration of many variables.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Environmental Sciences
Vera Panzarella, Alessia Bartolone, Rita Coniglio, Vito Rodolico, Laura Maniscalco, Giorgia Capocasale, Martina Iurato Carbone, Giuseppina Campisi
Summary: The study validated the reliability of specific Optical Coherence Tomography patterns in the early diagnosis of immune-mediated gingivitis, with high accuracy in diagnosing oral Lichen Planus, Pemphigus Vulgaris, and Mucous Membrane Pemphigoid.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Review
Oncology
Vera Panzarella, Giuseppina Campisi, Ylenia Giardina, Laura Maniscalco, Giuseppina Capra, Vito Rodolico, Olga Di Fede, Rodolfo Mauceri
Summary: The study found a low frequency of HPV infection in oral squamous cell carcinoma, suggesting no significant role of HPV in oral carcinogenesis.
Article
Pharmacology & Pharmacy
Giulia Di Prima, Giuseppe Angellotti, Amalia Giulia Scarpaci, Denise Murgia, Fabio D'agostino, Giuseppina Campisi, Viviana De Caro
Summary: The study evaluated the transmucosal behavior of resveratrol through the porcine sublingual mucosa and prepared fast-disintegrating sublingual mini-tablets using chemical permeation enhancers.
Review
Medicine, General & Internal
Vera Panzarella, Alessia Bartolone, Vito Rodolico, Giorgia Capocasale, Laura Maniscalco, Domenica Matranga, Olga Di Fede, Giuseppina Campisi
Summary: This systematic review identified specific OCT patterns that can aid in the diagnosis of desquamative gingivitis caused by pemphigus vulgaris and mucous membrane pemphigoid, but not by oral lichen planus. These patterns could potentially provide a helpful diagnostic framework for clinicians in assessing and monitoring these complex pathological conditions.
Article
Biochemistry & Molecular Biology
Fernanda Visioli, Julia Silveira Nunes, Maria Carmela Pedicillo, Rosalia Leonardi, Angela Santoro, Gian Franco Zannoni, Gabriella Aquino, Margherita Cerrone, Monica Cantile, Nunzia Simona Losito, Vito Rodolico, Giuseppina Campisi, Giuseppe Colella, Ilenia Sara De Stefano, Maria Antonietta Ramunno, Cristina Pizzulli, Marco Visconti, Lorenzo Lo Muzio, Giuseppe Pannone
Summary: This study investigates the expression of TLR4 in the epithelium surrounding oral squamous cell carcinomas (OSCC) and finds that TLR4 is significantly upregulated in lichenoid epithelium, which is associated with the inflammatory environment.
Article
Pharmacology & Pharmacy
Giuseppe Angellotti, Giulia Di Prima, Amalia Giulia Scarpaci, Fabio D'Agostino, Giuseppina Campisi, Viviana De Caro
Summary: Cytisine (CYT) is proposed for buccal administration to overcome its unfavorable pharmacokinetic properties. The spray-drying method is used to obtain uniform CYT-loaded pharmaceutical powders, which are compressed to create buccal delivery systems (BDSs). The BDSs enhance CYT permeation and have the potential to achieve therapeutic effects based on in vitro and mathematical evaluations.
Article
Medicine, General & Internal
Olga Di Fede, Carmine Del Gaizo, Vera Panzarella, Gaetano La Mantia, Pietro Tozzo, Anna Di Grigoli, Antonio Lo Casto, Rodolfo Mauceri, Giuseppina Campisi
Summary: The study evaluated the efficiency and safety of ozone via oral mucosal infiltrations for cancer patients with MRONJ who are not eligible for surgery. Significant clinical improvement and healing were observed in the patients, suggesting the need for further research on the efficacy of O2O3 mixtures in MRONJ treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Environmental Sciences
Giuseppina Campisi, Fortunato Buttacavoli, Massimo Attanasio, Mirella Milioto, Silvia Radosti, Salvatore Amato, Vera Panzarella
Summary: This exploratory study aimed to investigate the knowledge of sex and gender in clinical medicine among Sicilian physicians. Regarding the knowledge of gender medicine, 71.1% of participants stated that they know it, while 88.5% believe that gender medicine should be included in training programs. 77.6% of participants would like to keep up to date on this topic.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Oncology
Vera Panzarella, Fortunato Buttacavoli, Alessio Gambino, Giorgia Capocasale, Olga Di Fede, Rodolfo Mauceri, Vito Rodolico, Giuseppina Campisi
Summary: Optical Coherence Tomography (OCT) is a promising non-invasive method for oral diagnostics. However, there is a lack of systematic comparisons between clinical/histological and OCT parameters, especially in reference to the anatomical site-codification of the oral mucosa. In this study, suspected OSCCs were evaluated using both in vivo OCT and histological investigations, with the OCT images of the same site-coded healthy mucosa as references. The results revealed site-specific OCT patterns in OSCCs, indicating potential for the reliable use of OCT in oral cancer diagnosis.
Review
Oncology
Rodolfo Mauceri, Martina Coppini, Davide Vacca, Giorgio Bertolazzi, Vera Panzarella, Olga Di Fede, Claudio Tripodo, Giuseppina Campisi
Summary: This study aimed to analyze the composition of salivary microbiota in patients with oral squamous cell carcinoma (OSCC), and found that periodontal pathogens were the most common bacteria in OSCC patients. However, due to the heterogeneity of the studies, it is challenging to identify a specific microbiota pattern associated with OSCC.
Review
Pharmacology & Pharmacy
Giuseppe Angellotti, Giulia Di Prima, Elena Belfiore, Giuseppina Campisi, Viviana De Caro
Summary: Oral squamous cell carcinoma (OSCC) is a prevalent and aggressive cancer, and conventional treatments have limitations. Resveratrol (RSV), a natural compound, has shown potential for treating OSCC due to its antiproliferative, antimetastatic, and proapoptotic effects. RSV also synergizes with chemotherapeutics and overcomes drug resistance. However, there is a lack of specific investigations on RSV's effects in different administration routes and vehicles. RSV-loaded liposomes have demonstrated efficacy against OSCC models, suggesting the development of drug delivery systems as a turning point in oral cancer treatment.
Article
Oncology
Rodolfo Mauceri, Martina Coppini, Davide Vacca, Giorgio Bertolazzi, Valeria Cancila, Claudio Tripodo, Giuseppina Campisi
Summary: This study investigated the salivary microbiota composition in patients with oral squamous cell carcinoma (OSCC) using Oxford Nanopore Technology. Prevotella, Chlamydia, Tissierellia, and other microorganisms were detected as the most abundant in OSCC patients. If the connection between salivary microbiota composition and OSCC onset is confirmed, it could have significant implications for prevention strategies and follow-up visits.
Article
Immunology
Michela Butta, Nicola Serra, Vera Panzarella, Teresa Maria Assunta Fasciana, Giuseppina Campisi, Giuseppina Capra
Summary: Knowledge of the transmission of human papillomavirus from the genital tract to the oral mucosa remains inadequate, with limited and inconsistent literature findings. This retrospective study investigated the simultaneous detection of orogenital HPV, high-risk and low-risk genotypes, and identified prevalent non-vaccine genotypes in 337 samples. The study recommends including HPV51, HPV68, HPV53, and HPV66 in future HPV vaccine formulations.
Article
Medicine, General & Internal
Rodolfo Mauceri, Denise Murgia, Orazio Cicero, Luigi Paterno, Luca Fiorillo, Viviana De Caro, Giuseppina Campisi
Summary: The study investigates the effectiveness of using L-PRF and L-PRF blocks in treating critical-size alveolar bone defects, showing positive outcomes in achieving bone healing and tissue regeneration in selected cases.
MEDICINA-LITHUANIA
(2021)
