1,25Dihydroxy vitamin D3 improves titanium implant osseointegration in osteoporotic rats

Objective. This study aimed to investigate the effects of 1,25(OH)(2)D-3 on implant osseointegration in osteoporotic rats. Study Design. Twelve weeks after bilateral ovariectomy, each rat had 2 titanium screws implanted in the proximal tibiae. All animals were then randomly divided into 2 groups: control (10 rats) and 1,25(OH)(2)D-3 (10 rats). 1,25(OH)(2)D-3 was administered through oral gavage at 0.1 mu g/kg/d, and control animals were given vehicle. Eight weeks later, tibiae with screws were harvested for mu CT, histologic, and biomechanical analysis. Results. Compared with control, 1,25(OH)(2)D-3 increased percent bone volume by 96.0%, percent osseointegration by 94.4%, mean trabecular number by 112.5%, mean trabecular thickness by 51.8%, trabecular connective density by 38.0%, and decreased trabecular separation by 39.3% in mu CT analysis. The 1,25(OH)(2)D-3 increased bone area density by 1.2-fold and bone-to-implant contact by 1.5-fold in histomorphometry, and increased the maximal push-out force by 2.0-fold in biomechanical test. Conclusions. The 1,25(OH)(2)D-3 improves implant osseointegration in osteoporotic rats. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;114(suppl 5):S174-S178)