Article
Biochemistry & Molecular Biology
Maja Di Rocco, Eduardo Forleo-Neto, Robert J. Pignolo, Richard Keen, Philippe Orcel, Thomas Funck-Brentano, Christian Roux, Sami Kolta, Annalisa Madeo, Judith S. Bubbear, Jacek Tabarkiewicz, Malgorzata Szczepanek, Javier Bachiller-Corral, Angela M. Cheung, Kathryn M. Dahir, Esmee Botman, Pieter G. Raijmakers, Mona Al Mukaddam, Lianne Tile, Cynthia Portal-Celhay, Neena Sarkar, Peijie Hou, Bret J. Musser, Anita Boyapati, Kusha Mohammadi, Scott J. Mellis, Andrew J. Rankin, Aris N. Economides, Dinko Gonzalez Trotter, Gary A. Herman, Sarah J. O'Meara, Richard Delgizzi, David M. Weinreich, George D. Yancopoulos, E. Marelise W. Eekhoff, Frederick S. Kaplan
Summary: Fibrodysplasia ossificans progressiva (FOP) is a rare disease characterized by abnormal bone formation in connective tissues and painful flare-ups. Garetosmab, an activin A-blocking antibody, can prevent the formation of new lesions but does not significantly impact the activity of pre-existing lesions.
Article
Nutrition & Dietetics
Sakda Arj-Ong Vallibhakara, Katanyuta Nakpalat, Areepan Sophonsritsuk, Chananya Tantitham, Orawin Vallibhakara
Summary: The study suggests that vitamin E (mixed-tocopherol) supplementation may have a preventive effect on bone loss in postmenopausal osteopenic women through anti-resorptive activity.
Article
Nutrition & Dietetics
Briana M. Nosal, Junichi R. Sakaki, Zachary Macdonald, Kyle Mahoney, Kijoon Kim, Matthew Madore, Staci Thornton, Thi Dong Binh Tran, George Weinstock, Elaine Choung-Hee Lee, Ock K. Chun
Summary: This study aimed to examine the dose-dependent effects of blackcurrant supplementation on preventing bone loss in adult women. The results showed that blackcurrant supplementation decreased the loss of whole-body bone mineral density and increased the marker of bone formation, P1NP. Further studies with larger samples and different skeletal conditions are needed to confirm these findings.
Article
Clinical Neurology
Chad Heatwole, Elizabeth Luebbe, Spencer Rosero, Katy Eichinger, William Martens, James Hilbert, Jeanne Dekdebrun, Nuran Dilek, Christine Zizzi, Nicholas Johnson, Araya Puwanant, Rabi Tawil, Giovanni Schifitto, Christopher A. Beck, J. Franklin Richeson, Wojciech Zareba, Charles Thornton, Michael P. McDermott, Richard Moxley
Summary: Mexiletine did not significantly affect 6-minute walk distance in patients with DM1, but did improve hand grip myotonia. Adverse events and cardiac conduction measures were similar between the mexiletine and placebo groups.
Article
Nutrition & Dietetics
Triantafyllos Didangelos, Eleni Karlafti, Evangelia Kotzakioulafi, Eleni Margariti, Parthena Giannoulaki, Georgios Batanis, Solomon Tesfaye, Konstantinos Kantartzis
Summary: Oral methylcobalamin treatment for diabetic neuropathy patients for one year increased plasma B12 levels and improved neurophysiological parameters, sudomotor function, pain score, and quality of life, although it did not significantly affect certain aspects of cardiovascular autonomic reflex tests and neuropathy screening instrument examination.
Article
Oncology
Mrinal M. Gounder, Albiruni Abdul Razak, Neeta Somaiah, Sant Chawla, Javier Martin-Broto, Giovanni Grignani, Scott M. Schuetze, Bruno Vincenzi, Andrew J. Wagner, Bartosz Chmielowski, Robin L. Jones, Richard F. Riedel, Silvia Stacchiotti, Elizabeth T. Loggers, Kristen N. Ganjoo, Axel Le Cesne, Antoine Italiano, Xavier Garcia Del Muro, Melissa Burgess, Sophie Piperno-Neumann, Christopher Ryan, Mary F. Mulcahy, Charles Forscher, Nicolas Penel, Scott Okuno, Anthony Elias, Lee Hartner, Tony Philip, Thierry Alcindor, Bernd Kasper, Peter Reichardt, Lore Lapeire, Jean-Yves Blay, Christine Chevreau, Claudia Maria Valverde Morales, Gary K. Schwartz, James L. Chen, Hari Deshpande, Elizabeth J. Davis, Garth Nicholas, Stefan Groeschel, Helen Hatcher, Florence Duffaud, Antonio Casado Herraez, Roberto Diaz Beveridge, Giuseppe Badalamenti, Mikael Eriksson, Christian Meyer, Margaret von Mehren, Brian A. Van Tine, Katharina Gotze, Filomena Mazzeo, Alexander Yakobson, Aviad Zick, Alexander Lee, Anna Estival Gonzalez, Andrea Napolitano, Mark A. Dickson, Dayana Michel, Changting Meng, Lingling Li, Jianjun Liu, Osnat Ben-Shahar, Dane R. Van Domelen, Christopher J. Walker, Hua Chang, Yosef Landesman, Jatin J. Shah, Sharon Shacham, Michael G. Kauffman, Steven Attia
Summary: The clinical benefit of Selinexor in patients with advanced DD-LPS has been evaluated. The results showed that Selinexor improved PFS and time to next treatment compared to placebo.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Jeroen M. Schuitenmaker, Thijs Kuipers, Renske A. B. Oude Nijhuis, Marlies P. Schijven, Andre J. P. M. Smout, Paul Fockens, Albert J. Bredenoord
Summary: This study evaluated the effects of a novel electronic sleep positional therapy wearable device on sleep position and nocturnal reflux symptoms. The results showed that using the device promoted sleeping in the left lateral decubitus position, reduced time spent sleeping in the right lateral position, and effectively alleviated nocturnal reflux symptoms.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Food Science & Technology
Yajie Zheng, Fang Wu, Ming Zhang, Bing Fang, Liang Zhao, Lijie Dong, Xiaojuan Zhou, Shaoyang Ge
Summary: The study found that camel milk supplement has positive effects in reducing blood glucose, cholesterol, and increasing GLP-1, indicating improvement in adipose tissue and skeletal muscle. Camel milk powder can be used as a functional food to treat type 2 diabetes.
FOOD SCIENCE & NUTRITION
(2021)
Article
Plant Sciences
Ziba Majidi, Mohammad Ansari, Zhila Maghbooli, Afsaneh Ghasemi, Shadi Sadat Seyyed Ebrahimi, Arash Hossein-nezhad, Solaleh Emamgholipour
Summary: This study demonstrated that supplementation with 150 mg/day Oligopin (R) for 12 weeks had beneficial effects on postmenopausal women with osteopenia by improving the antioxidant defense system in plasma and PBMCs, accompanied by an increase in bone turnover markers.
Article
Medicine, Research & Experimental
David S. Perlin, Garry A. Neil, Colleen Anderson, Inbal Zafir-Lavie, Shane Raines, Carl F. Ware, H. Jeffrey Wilkins
Summary: This study demonstrates that the use of CERC-002 treatment in patients with COVID-19-associated ARDS can reduce LIGHT levels and may decrease the risk of respiratory failure and death.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Chemistry, Medicinal
Omid Toupchian, Shima Abdollahi, Amin Salehi-Abargouei, Javad Heshmati, Cain C. T. Clark, Mohammad Hasan Sheikhha, Hossein Fallahzadeh, Hassan Mozaffari-Khosravi
Summary: The study found that resveratrol supplementation significantly increased mRNA expression levels of p53 and p21 genes, as well as reduced serum levels of sCD163/sTWEAK ratio in patients with type 2 diabetes. However, no significant effect on expression levels of PPAR alpha and p16 genes was observed after supplementation. More research is needed to confirm the benefits of resveratrol for diabetic patients.
PHYTOTHERAPY RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Andrew Fagan, Edith A. Gavis, Mary Leslie Gallagher, Travis Mousel, Brian Davis, Puneet Puri, Richard K. Sterling, Velimir A. Luketic, Hannah Lee, Scott C. Matherly, Arun J. Sanyal, R. Todd Stravitz, Vaishali Patel, Mohammad S. Siddiqui, Amon Asgharpour, Michael Fuchs, Leroy Thacker, Jasmohan S. Bajaj
Summary: This double-blind, placebo-controlled trial aimed to improve cognitive function and psychosocial well-being in patients with chronic liver cirrhosis and minimal hepatic encephalopathy (MHE) by administering albumin infusions. The results showed that the albumin group demonstrated improved cognitive function and psychosocial well-being.
JOURNAL OF HEPATOLOGY
(2023)
Article
Cell Biology
Riccardo Pofi, Elisa Giannetta, Tiziana Feola, Nicola Galea, Federica Barbagallo, Federica Campolo, Roberto Badagliacca, Biagio Barbano, Federica Ciolina, Giuseppe Defeudis, Tiziana Filardi, Franz Sesti, Marianna Minnetti, Carmine D. Vizza, Patrizio Pasqualetti, Pierluigi Caboni, Iacopo Carbone, Marco Francone, Carlo Catalano, Paolo Pozzilli, Andrea Lenzi, Mary Anna Venneri, Daniele Gianfrilli, Andrea M. Isidori
Summary: This study found that PDE5 inhibitors can improve cardiac remodeling in male patients with diabetic cardiomyopathy, but not in female patients. Additionally, the use of this inhibitor also improves cardiovascular, metabolic, immune, and renal function in both sexes. However, further research is still needed to confirm whether Klotho and hsa-miR-199-5p are markers for T2DM complications.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Dalong Zhu, Xiaoying Li, Jianhua Ma, Jiao'e Zeng, Shenglian Gan, Xiaolin Dong, Jing Yang, Xiaohong Lin, Hanqing Cai, Weihong Song, Xuefeng Li, Keqin Zhang, Qiu Zhang, Yibing Lu, Ruifang Bu, Huige Shao, Guixia Wang, Guoyue Yuan, Xingwu Ran, Lin Liao, Wenjuan Zhao, Ping Li, Li Sun, Lixin Shi, Zhaoshun Jiang, Yaoming Xue, Hongwei Jiang, Quanmin Li, Zongbao Li, Maoxiong Fu, Zerong Liang, Lian Guo, Ming Liu, Chun Xu, Wenhui Li, Xuefeng Yu, Guijun Qin, Zhou Yang, Benli Su, Longyi Zeng, Houfa Geng, Yongquan Shi, Yu Zhao, Yi Zhang, Wenying Yang, Li Chen
Summary: Dorzagliatin is a drug that improves insulin secretion and glycemic control in drug-naive patients with type 2 diabetes, showing good efficacy and safety.
Article
Agriculture, Multidisciplinary
Xiaotong Kuang, Xianfeng Shao, Huiying Li, Dongmei Jiang, Tianlin Gao, Jie Yang, Kelei Li, Duo Li
Summary: This study found that blue mussel lipid extract improved glycemic traits, inflammatory cytokines, and lipid profile in Chinese patients with type 2 diabetes.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Review
Nutrition & Dietetics
Fabio Bioletto, Chiara D'Eusebio, Fabio Dario Merlo, Umberto Aimasso, Marta Ossola, Marianna Pellegrini, Valentina Ponzo, Alessia Chiarotto, Antonella De Francesco, Ezio Ghigo, Simona Bo
Summary: Teduglutide is an effective treatment for reducing parenteral support in patients with short bowel syndrome. Our meta-analysis provides pooled estimates of response and weaning rates over time and identifies intestinal anatomy as a significant predictor of these outcomes.
Article
Medicine, General & Internal
Enrica Marzola, Giovanni Abbate-Daga, Elena Scumaci, Valentina Ponzo, Ilaria Goitre, Marianna Pellegrini, Chiara D'Eusebio, Andrea Benso, Sara Belcastro, Franco De Michieli, Chiara Crespi, Fabio Broglio, Ezio Ghigo, Simona Bo
Summary: This study examined attrition from weight loss programs for patients with obesity during the SARS-CoV-2 pandemic and its association with patients' affective temperaments, psychopathology, and clinical variables. The findings suggest that male patients with obesity are at higher risk of dropout during the pandemic, while affective temperaments may serve as a useful baseline assessment for predicting attrition risk outside of the pandemic.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Delia Morlino, Maurizio Marra, Iolanda Cioffi, Lidia Santarpia, Pietro De Placido, Mario Giuliano, Carmine De Angelis, Simone Carrano, Annarita Verrazzo, Giuseppe Buono, Marianna Naccarato, Olivia Di Vincenzo, Enza Speranza, Sabino De Placido, Grazia Arpino, Fabrizio Pasanisi
Summary: Sarcopenia is a common finding in female breast cancer patients with a BMI lower than 30 kg/m(2). The prevalence of sarcopenia in breast cancer patients was found to be 13.9%. Sarcopenic breast cancer patients had significantly lower fat-free mass compared to non-sarcopenic breast cancer patients and the control group.
Article
Nutrition & Dietetics
Monica Guglielmetti, Ottavia Eleonora Ferraro, Ilaria Silvia Rossella Gorrasi, Elisabetta Carraro, Simona Bo, Giovanni Abbate-Daga, Anna Tagliabue, Cinzia Ferraris
Summary: This study investigates the risk of orthorexia nervosa (ON) among university students and examines the impact of lifestyle-related factors. The results suggest that the risk factors for ON may vary among students from different academic programs.
Review
Oncology
Delia Morlino, Iolanda Cioffi, Maurizio Marra, Olivia Di Vincenzo, Luca Scalfi, Fabrizio Pasanisi
Summary: This systematic review explores the use of phase angle (PhA) in breast cancer (BC) patients and its relationship with nutritional status and survival. The findings indicate that PhA decreases after chemotherapy in BC patients, but tailored lifestyle interventions can prevent this decrease. High PhA values are associated with better nutritional status, but there is inconsistent data on survival. Further studies are needed to determine the clinical relevance of PhA in BC patients and its association with disease outcomes and survival.
Article
Nutrition & Dietetics
Ilario Ferrocino, Marianna Pellegrini, Chiara D'Eusebio, Ilaria Goitre, Valentina Ponzo, Maurizio Fadda, Rosalba Rosato, Giulio Mengozzi, Guglielmo Beccuti, Fabio Dario Merlo, Farnaz Rahimi, Isabella Comazzi, Luca Cocolin, Ezio Ghigo, Simona Bo
Summary: The metabolic benefits of time-restricted eating (TRE) in humans are statistically significant but not clinically relevant. This study compared the effects of a TRE regimen with a time-unrestricted (TUE) regimen on patients with obesity. The results show that TRE led to a slightly greater weight loss compared to TUE, but there were no significant differences in other variables. The changes in gut microbiota composition induced by TRE were of uncertain clinical significance.
Article
Nutrition & Dietetics
Raffaella Cancello, Federica Rey, Stephana Carelli, Stefania Cattaldo, Jacopo Maria Fontana, Ilaria Goitre, Valentina Ponzo, Fabio Dario Merlo, Gianvincenzo Zuccotti, Simona Bertoli, Paolo Capodaglio, Simona Bo, Amelia Brunani
Summary: This study examined the changes in telomere length (TL) and mitochondrial DNA (mtDNA) copy number in obese patients after a one-year lifestyle intervention. The results showed that patients with lower baseline TL values had significant increases in TL and mtDNA copy number after the intervention, along with weight loss, reduction in fat mass, increase in fat-free mass, and improvement in total antioxidant capacity.
Review
Nutrition & Dietetics
Marianna Pellegrini, Fabio Dario Merlo, Elena Agnello, Taira Monge, Andrea Devecchi, Valentina Casalone, Filippo Montemurro, Ezio Ghigo, Anna Sapino, Simona Bo
Summary: Breast cancer is a common global cancer and chemotherapy, while essential for treatment, often leads to side effects such as taste alterations. Dysgeusia, although underestimated by clinicians, greatly affects the physical and psychological health of cancer patients, with profound impacts on their quality of life. Strategies for managing dysgeusia in breast cancer patients receiving chemotherapy have been proposed, but the literature on this topic is limited and heterogeneous, making it challenging to obtain definitive results and clinical recommendations.
Article
Nutrition & Dietetics
Olivia Di Vincenzo, Maurizio Marra, Valentina Antognozzi, Rosa Sammarco, Giada Ballarin, Iolanda Ciof, Luca Scalfi, Fabrizio Pasanisi
Summary: The aim of this study was to investigate the variations in bioimpedance analysis (BIA)-derived phase angle (PhA) among individuals with different weight status based on age, sex, and body mass index (BMI). The results showed that PhA was higher in men than in women, and it decreased linearly with age in women, while in men, the decline occurred after the age of 40. However, there were no significant differences in PhA with increasing BMI in either sex, except for potentially lower values when BMI was over 50 kg/m2. This study provides valuable insights into the assessment of PhA in obesity and its implications for prevention and clinical nutrition.
Article
Nutrition & Dietetics
Iolanda Cioffi, Filippo Scialo, Olivia Di Vincenzo, Monica Gelzo, Maurizio Marra, Anna Testa, Fabiana Castiglione, Maria Vitale, Fabrizio Pasanisi, Lidia Santarpia
Summary: This study aimed to assess the relationship between inflammation, malnutrition risk, and nutritional status in patients with Crohn's disease. Asymptomatic or untreated inflammation along with malnutrition can impair clinical outcomes in these patients.
Article
Nutrition & Dietetics
Fabio Dario Merlo, Umberto Aimasso, Marta Ossola, Mirko Ippolito, Leila Cravero, Valentina Ponzo, Simona Bo
Summary: Liraglutide has beneficial effects on fecal output in short bowel syndrome patients after surgical resection. A pilot observational study showed that after 6 months of treatment, the median ostomy/fecal output was significantly reduced in liraglutide-treated patients compared to untreated patients. The main side effect of liraglutide was mild nausea, except in one patient who experienced severe nausea/vomiting.
Review
Nutrition & Dietetics
Samuele Venturi, Mirko Marino, Iolanda Cioffi, Daniela Martini, Cristian Del Bo', Simone Perna, Patrizia Riso, Dorothy Klimis-Zacas, Marisa Porrini
Summary: Metabolic Syndrome (MetS) is a group of dysmetabolic conditions accompanied by oxidative stress, inflammation, and vascular dysfunction. Berries and their bioactives have shown potential in mitigating the risk factors associated with MetS. This systematic review summarizes recent human intervention studies on the effects of berries in subjects with MetS parameters, showing positive effects on lipid profile and inflammation. However, further high-quality trials are needed to fully establish the role of berries in reducing risk factors for MetS.
Article
Nutrition & Dietetics
Fabio Bioletto, Andrea Evangelista, Giovannino Ciccone, Amelia Brunani, Valentina Ponzo, Enrica Migliore, Eva Pagano, Isabella Comazzi, Fabio Dario Merlo, Farnaz Rahimi, Ezio Ghigo, Simona Bo
Summary: Adults with obesity have a higher risk of hospitalization and high hospitalization-related healthcare costs. This study aimed to develop a predictive model for the risk of readmission in patients with severe obesity. The study found that age, BMI, smoking habit, serum creatinine, diabetes, and number of previous admissions were predictive factors for hospital readmission.
Article
Psychiatry
Ilaria Silvia Rossella Gorrasi, Cinzia Ferraris, Raffaella Degan, Giovanni Abbate Daga, Simona Bo, Anna Tagliabue, Monica Guglielmetti, Mattia Roppolo, Giorgio Gilli, Daniela Acquadro Maran, Elisabetta Carraro
Summary: The study compared the results of surveying undergraduate students for eating disorders using web-based survey and paper-based survey, finding higher prevalence and test scores for eating disordered behaviors in the web-based survey group, while higher response rate in the paper-based survey group, and no differences in prevalence and test scores for ON and MD were found.
EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY
(2022)
