Article
Engineering, Chemical
Seyede Elaheh Ghafouri, Seyed Rasoul Mousavi, Maliheh Khakestani, Shahla Mozaffari, Narges Ajami, Hossein Ali Khonakdar
Summary: This study investigates the release of levetiracetam using poly(lactic acid), poly(epsilon-caprolactone), and their blend electrospun nanofibers as novel systems. Scanning electron microscopy confirms the smooth and beads-free morphology of the samples. With increasing levetiracetam content, the average diameters of the nanofibers also increase. FTIR spectroscopy is used for structural confirmation and observation of functional groups. X-ray diffraction reveals a decrease in crystallinity and different drug release kinetics are evaluated using various models.
POLYMER ENGINEERING AND SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Alena Opalkova Siskova, Maria Buckova, Zuzana Kronekova, Angela Kleinova, Stefan Nagy, Joanna Rydz, Andrej Opalek, Monika Slavikova, Anita Eckstein Andicsova
Summary: Nanofiber mats loaded with Diclofenac sodium salt on the base of poly(epsilon-caprolactone) were studied for their biocompatibility and ability to inhibit bacterial infections. The mats demonstrated good viability with human cells culture and showed significant activity against cancer cells. A minimal concentration of 12.5% was found to effectively eradicate both Gram-negative and Gram-positive bacteria.
Article
Chemistry, Applied
Mahdi Abasalta, Azadeh Asefnejad, Mohammad Taghi Khorasani, Ahmad Ramazani Saadatabadi
Summary: The research developed coaxial electrospinning for producing core-shell nanofibers to control drug release. Extended release and controlled release were achieved under physiological pH against breast cancer cells.
CARBOHYDRATE POLYMERS
(2021)
Article
Polymer Science
Wei Chen, Ping Zhu, Yating Chen, Yage Liu, Liping Du, Chunsheng Wu
Summary: This study successfully synthesized iodine-immobilized UiO-66-NH2 metal-organic framework (MOF) and used it as an antibacterial additive for poly(epsilon-caprolactone) (PCL). UiO-66-NH2 nanoparticles have a high iodine loading capacity, and adding them to PCL reduces the static water angle and exhibits strong antibacterial activities.
Article
Pharmacology & Pharmacy
Eduardo Galdon, Monica Millan-Jimenez, Gloria Mora-Castano, Antxon Martinez de Ilarduya, Isidoro Caraballo
Summary: A biodegradable copolyester, poly(butylene succinate-co-epsilon-caprolactone) (PBS_CL), was successfully utilized as an excipient for pharmaceutical dosage forms using hot processing techniques such as ultrasound-assisted compression (USAC) and hot melt extrusion (HME). Controlled release of the drug was achieved with varying amounts of PBS_CL, with a percolation threshold around 23% v/v estimated.
Article
Biochemistry & Molecular Biology
Amlika Rungrod, Apichaya Kapanya, Winita Punyodom, Robert Molloy, Jomkhwan Meerak, Runglawan Somsunan
Summary: This study developed a new type of hydrogel wound dressing with high swelling capacity and good water vapor transmission rate, which can be controlled by adjusting the concentration of PCLDA. The hydrogel showed no cytotoxicity at the cellular level, and exhibited antibacterial activity against both Gram-positive and Gram-negative bacteria.
Article
Materials Science, Paper & Wood
C. R. Reshmi, P. Sagitha, Sheeja, A. Sujith
Summary: A novel nanostarch-loaded composite nanofibrous membrane of PCL has been developed for wound dressing, showing enhanced hydrophilicity, antibacterial potency, and potential as a pH-responsive transdermal drug delivery material.
Article
Materials Science, Multidisciplinary
Mohammed Bello, Faizuan Abdullah, Abdull Rahim Mohd Yusoff, Wan Mohd Asyraf Wan Mahmood, Tan Yong Chee, Nik Ahmad Nizam Nik Malek, Khairunnadwa Binti Jemon, Palanivel Sathishkumar
Summary: The present study successfully fabricated a natural drug-incorporated nano-based wound-dressing material with high biocompatibility and enhanced antibacterial efficacy, which can promote rapid wound healing.
Article
Materials Science, Multidisciplinary
Xinghuan Lin, Shanshan Li, Yingfeng Wang, Xiaojian Yang, Joonhoo Jung, Zhiguang Li, Xuehong Ren, Yuyu Sun
Summary: This study developed biodegradable fibrous membranes with antibacterial properties by electrospinning, displaying significant antimicrobial efficacy against specific bacteria after surface treatment. The membranes also exhibited good thrombogenicity and hydrophobicity, suggesting potential for application in biomedical materials.
MATERIALS CHEMISTRY AND PHYSICS
(2021)
Review
Agronomy
Meisam Zargar, Maryam Bayat, Francess Sia Saquee, Simbo Diakite, Nakhaev M. Ramzanovich, Khasukhadzhiev A. S. Akhmadovich
Summary: The number of effective herbicides available to farmers is decreasing due to increasing herbicide resistance. It is important to address weed management challenges by investigating the potential of newly introduced materials, such as biocompatible polymer-based nanoparticles.
Article
Polymer Science
Amlika Rungrod, Apichaya Kapanya, Winita Punyodom, Robert Molloy, Anisa Mahomed, Runglawan Somsunan
Summary: The semi-interpenetrating polymer network (semi-IPN) hydrogel synthesized through free radical UV-photopolymerization technique showed increased elasticity and water absorption capacity, while being non-cytotoxic. Efficient encapsulation of the model drug CIP was achieved, with drug loading capacity enhanced by increasing PCL diol and CIP content. Drug release profiles were influenced by the ratios of Na-AMPS to PCL diol and CIP content, showing diffusion and swelling-controlled release mechanisms. The P(Na-AMPS)/PCL diol semi-IPN hydrogels are promising candidates for drug delivery and controlled release applications in biomedicine.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Materials Science, Multidisciplinary
Thannaphat Jenvoraphot, Boontharika Thapsukhon, Donraporn Daranarong, Robert Molloy, Chayarop Supanchart, Suttichai Krisanaprakornkit, Paul D. Topham, Brian Tighe, Anisa Mahomed, Winita Punyodom
Summary: In this research, a periodontal membrane with nanoporous structure and tetracycline drug loading was designed and fabricated to improve periodontal regeneration and anti-inflammatory effect.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Engineering, Environmental
Hui Ci, Lili Ma, Xiangmei Liu, Yanqin Liang, Yufeng Zheng, Zhaoyang Li, Shengli Zhu, Zhenduo Cui, Shuilin Wu
Summary: In this study, biocompatible nanofibers with antibacterial properties were synthesized using a one-step hydrothermal method and electrospinning. The nanofibers exhibited excellent antibacterial efficacy under visible light due to their photothermal and photocatalytic properties. These nanofibers hold promise for the fabrication of wearable antibacterial fabrics.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Polymer Science
Deniz Albayrak, Hilal Turkoglu Sasmazel
Summary: The aim of this study was to produce three-dimensional fibrous surface patterns on smooth two-dimensional PCL surfaces using electrospinning and to monitor the behavior of cells through the use of a mask/stencil. The results showed that the electrospun scaffold surfaces had a uniform morphology with no beads, while the solvent cast surfaces were smooth and nonporous. The electrospun regions were more hydrophobic than the solvent cast regions. Cell culture studies revealed that the behavior of cells differed on the solvent cast and electrospun patterns.
JOURNAL OF POLYMER RESEARCH
(2022)
Article
Materials Science, Multidisciplinary
Jian Zeng, Qiaolin Ji, Xinxin Liu, Minglong Yuan, Mingwei Yuan, Yuyue Qin
Summary: A controlled-release antibacterial active food packaging film was prepared using electrospinning technique. The film showed improved water vapor barrier performance, UV resistance, and antioxidant activity, while maintaining the antibacterial properties of thymol. The study suggests that the developed film has potential for food active packaging applications.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2022)