Effect of ionic strength on the stabilities of ciprofloxacin - Metal complexes

Proton-ligand dissociation constant of 1-cyclopropyl-1,4-dihydro-4-oxo-7-(1-piperazinyl) quinolone-3-carboxylic acid is ciprofloxacin and metal-ligand stability constants of its complexes with some metal ions have been determined potentiometrically in the presence of (0.01, 0.02 and 0.03 mol/dm(3)) NaClO4. The order of the stability constants of the formed complexes increases in the sequence Cu2+, Fe3+, Ni2+ and Zn2+ and decreases with increase in the concentration of ionic strength. (C) 2011 King Saud University. Production and hosting by Elsevier B.V. All rights reserved.