Article
Biochemistry & Molecular Biology
Luke B. Allen, Karoly Mirnics
Summary: De novo sterol synthesis plays a critical role in maintaining brain homeostasis. However, certain medications, including beta-blockers, can inhibit this process and potentially harm brain health. This study found that two commonly used beta-blockers, metoprolol and nebivolol, significantly increased the production of the highly oxidizable cholesterol precursor 7-dehydrocholesterol in vitro. Follow-up experiments in mice also showed elevated levels of 7-dehydrocholesterol in the brain and other organs of the offspring when the mother was exposed to metoprolol during pregnancy. These findings suggest that the use of metoprolol during pregnancy may have detrimental effects on the development of offspring, and alternative beta-blockers should be considered.
Article
Chemistry, Physical
Agata Kowalczyk, Bozena Zgardzinska, Karol Osipiuk, Katarzyna Jedruchniewicz, Katarzyna Tyszczuk-Rotko, Magdalena Gozdziuk, Haitao Wang, Bozena Czech
Summary: Water is essential for life on Earth, but the increasing global population has led to higher water consumption and increased production of wastewater. Current wastewater treatment techniques are not efficient enough to remove pharmaceuticals, highlighting the need for innovative approaches. This study investigates the photocatalytic oxidation of beta-blockers using modified TiO2 photocatalysts. The results show that solely relying on pollutant concentration reduction is insufficient for determining treatment method safety and additional ecotoxicity testing is necessary.
Article
Medicine, General & Internal
Ze-Liang Zhao, Chao Liu, Qi-Zhang Wang, Wen-Bo Zhang, Lu Shao, Hai-Wei Wu, Jia-Wei Zheng
Summary: An internal survey was conducted among Chinese clinicians regarding the dosage, dose regimen, and dose escalation methods of oral propranolol and oral atenolol for the treatment of infantile hemangiomas (IH). The survey found that doctors from tertiary hospitals tended to use higher doses, while those from private hospitals preferred lower doses. Oral atenolol has become an additional medication intervention option for IH in mainland China.
Article
Polymer Science
Phodiso Prudence Mashile, Philiswa Nosizo Nomngongo
Summary: The study introduced a recyclable magnetic cellulose-chitosan nanocomposite for simultaneous removal of beta-blockers and an anticonvulsant from contaminated water. The nanocomposite showed mesoporous structure with promising adsorption efficiency for the removal of pharmaceuticals. The adsorption equilibrium and kinetics of the nanocomposite were analyzed, showing high efficiency in removing the target pollutants.
Article
Otorhinolaryngology
Yi Ji, Siyuan Chen, Kaiying Yang, Xuepeng Zhang, Jiangyuan Zhou, Lizhi Li, Bo Xiang, Tong Qiu, Shiyi Dai, Xian Jiang, Guoyan Lu, Liqing Qiu, Feiteng Kong, Yongbo Zhang
Summary: Comparing the efficacy and safety of propranolol vs atenolol in infants with problematic IHs, this study found that atenolol had similar efficacy but fewer adverse events compared to propranolol. This suggests that oral atenolol could be considered as an alternative treatment option for IH patients requiring systemic therapy.
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2021)
Article
Chemistry, Multidisciplinary
Brahim Samir, Nabil Bouazizi, Patrick Nkuigue Fotsing, Julie Cosme, Veronique Marquis, Guilherme Luiz Dotto, Franck Le Derf, Julien Vieillard
Summary: In this research, the removal of pharmaceutical contaminants AT and PR using modified activated carbon in a liquid solution was studied. Both adsorption and photodegradation methods were used, with 92% and 94% removal rates achieved, respectively. The modified AC-OH showed good stability and recyclability, making it suitable for industrial wastewater treatment. The results recommend adsorption as a promising and eco-friendly method.
APPLIED SCIENCES-BASEL
(2023)
Article
Engineering, Environmental
Xiaoping Yu, Wenlei Qin, Xiangjuan Yuan, Lei Sun, Fei Pan, Dongsheng Xia
Summary: The present study systematically investigated the degradation of atenolol (ATL) in an integrated UV/Ozone (O-3)/peroxymonosulfate (PMS) process, focusing on synergistic mechanisms, reaction kinetics, pollutant degradation pathways, and antibacterial activities. Results showed that the integrated UV/O-3/PMS process demonstrated significant advantages in ATL degradation compared to other treatment systems, with the impacts of operating parameters comprehensively explored. The study established a kinetic model to predict the relative contributions of reactive oxidants for ATL elimination in the process and identified the main transformation products and degradation pathways of ATL. Moreover, the UV/O-3/PMS process effectively reduced the antibacterial activity of ATL and its intermediates.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Ammara Zamir, Muhammad Fawad Rasool, Imran Imran, Hamid Saeed, Sundus Khalid, Abdul Majeed, Anees Ur Rehman, Tanveer Ahmad, Fawaz Alasmari, Faleh Alqahtani
Summary: This study developed and evaluated physiologically based pharmacokinetic (PBPK) models to assess the PK of metoprolol in populations with healthy, chronic kidney disease (CKD), and acute myocardial infarction (AMI) conditions. The models were evaluated using visual predictive checks and observed/predicted ratios, and were used to determine the influence of diseases on metoprolol exposure and suggest dosage reductions in CKD. The developed PBPK models successfully elucidated the PK changes of metoprolol in different patient populations, which may aid in dose optimization for diseased patients.
Article
Chemistry, Physical
Arastou Raoufi, Mahmoud Ebrahimi, Mohammad Reza Bozorgmehr
Summary: The interaction of atenolol and metoprolol with human serum albumin was studied using UV-Vis spectroscopy and molecular modeling. The results showed different binding affinities and absorption changes between the two drugs when complexed with the albumin. Molecular dynamics simulations revealed differences in the number of interactive residues between metoprolol and protein compared to atenolol and protein.
RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY A
(2021)
Article
Chemistry, Physical
Krisztina Kovacs, Adam Simon, Tunde Toth, Laszlo Wojnarovits
Summary: The free radical chemistry of atenolol and propranolol in aqueous solutions was studied using pulse- and gamma-radiolysis. Propranolol showed higher reactivity towards free radicals compared to atenolol. The reactions mainly occurred on the aromatic rings, and the end-products of propranolol exhibited toxicity.
RADIATION PHYSICS AND CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Vanessa de Oliveira Marques Cavalcanti, Rayany Magali da Rocha Santana, Fernanda Sobreira Silva, Alex Leandro Andrade de Lucena, Victor Estolano Lima, Antonio Acacio de Melo Neto, Graziele Elisandra do Nascimento, Daniella Carla Napoleao
Summary: This study investigates the efficiency of the treatment of a mixture of drugs using magnetite as a catalyst in a heterogeneous photo-Fenton process. The results show that the drugs can be degraded at the natural pH of the solution, and specific catalyst and hydrogen peroxide concentrations can achieve high degradation efficiency.
Article
Chemistry, Multidisciplinary
Mohammad Saquib, Mohammad Faheem Khan, Jaya Singh, Bhuttu Khan, Priti, Promod Kumar, Mohd Kamil Hussain
Summary: This study reports an efficient and sustainable synthesis method for the production of various aryloxy propanolamines using glycerol as a solvent and promoter. The method offers a broad substrate range, short reaction times, good yields, and environmentally friendly characteristics.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2022)
Article
Cardiac & Cardiovascular Systems
Puck J. Peltenburg, Dania Kallas, Johan M. Bos, Krystien V. V. Lieve, Sonia Franciosi, Thomas M. Roston, Isabelle Denjoy, Katrina B. Sorensen, Seiko Ohno, Ferran Roses-Noguer, Takeshi Aiba, Alice Maltret, Martin J. LaPage, Joseph Atallah, John R. Giudicessi, Sally-Ann B. Clur, Nico A. Blom, Michael Tanck, Fabrice Extramiana, Koichi Kato, Julien Barc, Martin Borggrefe, Elijah R. Behr, Georgia Sarquella-Brugada, Jacob Tfelt-Hansen, Esther Zorio, Heikki Swan, Janneke A. E. Kammeraad, Andrew D. Krahn, Andrew Davis, Frederic Sacher, Peter J. Schwartz, Jason D. Roberts, Jonathan R. Skinner, Maarten P. van den Berg, Prince J. Kannankeril, Fabrizio Drago, Tomas Robyns, Kristina Haugaa, Terezia Tavacova, Christopher Semsarian, Jan Till, Vincent Probst, Ramon Brugada, Wataru Shimizu, Minoru Horie, Antoine Leenhardt, Michael J. Ackerman, Shubhayan Sanatani, Christian van der Werf, Arthur A. M. Wilde
Summary: Selective beta-blockers are associated with a higher risk of arrhythmic events in symptomatic children with CPVT compared to nonselective beta-blockers, especially nadolol. Nadolol, or propranolol if nadolol is unavailable, should be the preferred beta-blocker for treating symptomatic children with CPVT.
Article
Pharmacology & Pharmacy
Satoshi Koyama
Summary: This study introduced flow modeling using hybrid automata to address the logical inconsistency in traditional pharmacokinetic modeling. Through preliminary applications to several examples, it demonstrated the high versatility of hybrid automata in pharmacokinetic analysis. The simulation results indicated that the flow modeling using hybrid automata could avoid the issues associated with traditional pharmacokinetic modeling.
DRUG METABOLISM AND DISPOSITION
(2021)
Article
Pharmacology & Pharmacy
Bruno Lorusso, Giuseppe Cerasoli, Angela Falco, Caterina Frati, Gallia Graiani, Denise Madeddu, Antonella Nogara, Emilia Corradini, Giovanni Roti, Elisa Cerretani, Andrea Gherli, Mariafrancesca Caputi, Letizia Gnetti, Francesco Paolo Pilato, Federico Quaini, Costanza Lagrasta
Summary: β blockers induce autophagy in infantile hemangioma-derived endothelial cells.
VASCULAR PHARMACOLOGY
(2022)
Article
Behavioral Sciences
Pravinkumar Bhutada, Yogita Mundhada, Kuldeep Bansod, Santosh Tawari, Shaktipal Patil, Pankaj Dixit, Sudhir Umathe, Dharmendra Mundhada
BEHAVIOURAL BRAIN RESEARCH
(2011)
Article
Behavioral Sciences
Pravinkumar Satyanarayan Bhutada, Yogita R. Mundhada, Kuldeep U. Bansod, Sudhir N. Umathe, Vivek P. Kahale, Pankaj V. Dixit, Dharmendra R. Mundhada
BEHAVIOURAL PHARMACOLOGY
(2010)
Article
Behavioral Sciences
Pravinkumar S. Bhutada, Yogita R. Mundhada, Yogesh R. Ghodki, Parag Chaware, Pankaj V. Dixit, Kishor S. Jain, Sudhir N. Umathe
BEHAVIOURAL PHARMACOLOGY
(2012)
Article
Behavioral Sciences
Pankaj V. Dixit, Gaurav Parihar, Dinesh K. Jain, Pooja Jaiswal
BEHAVIOURAL PHARMACOLOGY
(2012)
Article
Behavioral Sciences
Pravinkumar Bhutada, Yogita Mundhada, Kuldeep Bansod, Pankaj Dixit, Sudhir Umathe, Dharmendra Mundhada
EPILEPSY & BEHAVIOR
(2010)
Article
Pharmacology & Pharmacy
Pankaj Dixit, Dinesh Kumar Jain, Jaypal Singh Rajpoot
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
(2012)
Article
Clinical Neurology
Pravinkumar Bhutada, Yogita Mundhada, Yogesh Ghodki, Pankaj Dixit, Sudhir Umathe, Kishor Jain
JOURNAL OF PSYCHOPHARMACOLOGY
(2012)
Article
Medicine, Research & Experimental
Pravinkumar Bhutada, Pankaj Dixit, Kapil Thakur, Prashant Deshmukh, Shyam Kaulaskar
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2013)
Article
Behavioral Sciences
Pravinkumar Bhutada, Yogita Mundhada, Kuldeep Bansod, Chetan Bhutada, Santosh Tawari, Pankaj Dixit, Dharmendra Mundhada
NEUROBIOLOGY OF LEARNING AND MEMORY
(2010)
Article
Behavioral Sciences
Pravinkumar S. Bhutada, Yogita R. Mundhada, Kuldeep U. Bansod, Pankaj V. Dixit, Sudhir N. Umathe, Dharmendra R. Mundhada
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2010)
Article
Chemistry, Medicinal
Pravinkumar Bhutada, Yogita Mundhada, Kuldeep Bansod, Rahul Hiware, Sumit Rathod, Pankaj Dixit, Dharmendra Mundhada
PHYTOTHERAPY RESEARCH
(2011)
Review
Clinical Neurology
Pravinkumar Bhutada, Yogita Mundhada, Kuldeep Bansod, Sumit Rathod, Rahul Hiware, Pankaj Dixit, Sudhir Umathe, Dharmendra Mundhada
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2010)
Review
Pharmacology & Pharmacy
Pankaj Vinod Dixit, Rohit Sahu, Dinesh Kumar Mishra
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
(2020)
Meeting Abstract
Pharmacology & Pharmacy
Pankaj V. Dixit, Dinesh Kumar Jain, Pankaj Mangroliya, Shubhi Pandey
INDIAN JOURNAL OF PHARMACOLOGY
(2013)