Article
Ophthalmology
Luca Ventre, Matteo Fallico, Antonio Longo, Guglielmo Parisi, Andrea Russo, Vincenza Bonfiglio, Paola Marolo, Paolo Caselgrandi, Teresio Avitabile, Enrico Borrelli, Michele Reibaldi
Summary: This study compared the efficacy of conventional internal limiting membrane peeling with inverted flap technique in treating small-to-medium idiopathic macular hole. The results showed that conventional ILM peeling group had better final macular sensitivity, but there were no significant differences between the two groups in terms of visual acuity improvement, hole closure, and optical coherence tomography findings.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Article
Ophthalmology
Lingzi Liu, Zengyi Wang, Yanping Yu, Xiaohan Yang, Biying Qi, Ke Zhang, Wu Liu
Summary: This study aimed to compare the prognosis of surgically closed large idiopathic macular holes (MH) with internal limiting membrane (ILM) peeling or ILM insertion. The results showed that ILM insertion had a higher initial closure rate compared to ILM peeling. However, ILM peeling resulted in better visual and macular microstructure recovery after surgery.
Article
Multidisciplinary Sciences
Bowen Zhang, Xingmei Dong, Yi Sun
Summary: The necessity of internal limiting membrane (ILM) peeling for patients with idiopathic epiretinal membrane (iERM) was further evaluated. The study found that ILM peeling did not significantly improve the best-corrected visual acuity (BCVA), central macular thickness (CMT), but it did reduce the recurrence rate.
Article
Ophthalmology
Aman Kumar, Bruttendu Moharana, Deeksha Katoch, Ramandeep Singh
Summary: The study compared the outcomes of papillomacular bundle (PMB) sparing internal limiting membrane (ILM) peeling (group LP) and conventional ILM peeling (group CP) for idiopathic macular hole (MH) treatment of <= 400 mu m. The results showed that both groups achieved successful closure of the macular hole with comparable visual improvement. Postoperatively, the retinal nerve fiber layer (RNFL) was significantly thinner in the temporal quadrant in the CP group. The ganglion cell-inner plexiform layer (GC-IPL) was significantly thinner in the temporal quadrants in the LP group, while it was comparable in the CP group. The study concluded that PMB sparing ILM peeling is comparable to conventional ILM peeling in terms of closure rate and visual gain, with the advantage of less retinal damage at 3 months.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Nurullah Kocak, Volkan Yeter, Hakki Birinci
Summary: The study compares the outcomes of conventional ILM peeling and temporal inverted ILM flap technique for large full-thickness macular holes. The results suggest that the temporal inverted ILM flap technique is more effective in terms of hole closure rate, BCVA improvement, and restoration of the outer retinal layers.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Yen-Chih Chen, San-Ni Chen
Summary: The study reported a rare complication related to fovea-sparing internal limiting membrane peeling technique, termed as isolated central epiretinal membrane. Among five patients, one had high myopia with foveoschisis, while others had vitreomacular traction or proliferative diabetic retinopathy.
JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Medicine, General & Internal
Hui Qi, Hongtao Yan, Yan Cheng, Ling Zuo
Summary: Terson's syndrome with spontaneous inner limiting membrane (ILM) peeling off combined with macular hole is rare. Patients may have poor visual outcomes due to the extensive ILM peeling off, despite successful closure of the macular hole after surgery.
Article
Ophthalmology
Xiao Yu, Lingyao Wu, Ziqing Mao, Huimin Fan, Wenjia Dong, Zhipeng You
Summary: This study aimed to investigate the effectiveness of Pars Plana Vitrectomy (PPV) with Internal Limiting Membrane (ILM) peeling and intravitreal injection mouse Nerve Growth Factor (mNGF) in treating Idiopathic Macular Hole (IMH) using Optical Coherence Tomography Angiography (OCTA) and microperimetry. A retrospective study was conducted on 44 adult patients with IMH who underwent surgical treatment. The results showed that PPV combined with ILM peeling and intravitreal mNGF might be more effective for initial IMH, improving blood flow and promoting the recovery of visual function.
Article
Ophthalmology
Kiyoung Kim, Kyungwoo Yoon, Jong Beom Park, Min Seok Kang, Eung Suk Kim, Seung-Young Yu
Summary: This study aimed to evaluate the perifoveal microvascular changes following pars plana vitrectomy with internal limiting membrane (ILM) peeling for epiretinal membrane (ERM) and macular hole (MH) patients. The results showed that there was a significant reduction in perifoveal vessel density (pfVD) in specific sectors after surgery, especially in patients with macular hole.
Article
Medicine, General & Internal
Zhigao Liu, Shuya Wang, Yu Wang, Aihua Ma, Bojun Zhao
Summary: This study reported a case of successful surgical closure of a macular hole following a ruptured retinal arterial macroaneurysm, with improvement of the patient's visual acuity.
FRONTIERS IN MEDICINE
(2021)
Article
Ophthalmology
Yuan Zong, Kaicheng Wu, Jian Yu, Changbo Zhou, Chunhui Jiang
Summary: This study evaluated the efficacy of internal limiting membrane (ILM) peeling and flap inversion in the treatment of large idiopathic macular hole (MH), showing that performing ILM flap inversion under air can improve the functional and anatomical outcomes of the surgery, leading to significant visual acuity improvement in most patients.
JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Yue Qi, Pengyou Yan, Wenying Fan, Ningli Wang, An Li Duan
Summary: A retrospective study was conducted to compare the outcomes of vitrectomy with and without fovea-sparing internal limiting membrane (ILM) peeling for highly myopic eyes with retinoschisis and foveal detachment. The results showed that fovea-sparing ILM peeling had better anatomical outcomes in resolving foveoschisis and foveal detachment compared to non-ILM peeling, while both procedures had similar visual functional outcomes.
Article
Ophthalmology
Vishal Agrawal, Khushbu Jindal, Yogendra Dhakad, Priyanka Rathore, Kamlesh Khilnani
Summary: The multilayered inverted internal limiting membrane flap technique (ML-IILM) had significantly higher anatomical closure and better visual outcome compared to standard internal limiting membrane peeling in vitrectomy for large macular holes.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Jin Liu, Zi-Zhong Hu, Xin-Hua Zheng, Yuan-Long Li, Jun-Long Huang, Er-Bing Cao, Song-Tao Yuan, Ping Xie, Qing-Huai Liu
Summary: Retinal displacement towards the optic disc was observed after successful macular hole surgery. Different internal limiting membrane peeling patterns showed similar visual outcomes and retinal displacement, indicating that the direction of ILM peeling is not a significant factor in postoperative retinal displacement.
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Medicine, General & Internal
Gaku Terauchi, Kei Shinoda, Kazuma Yagura, Makoto Kawashima, Soiti Celso Matsumoto, Atsushi Mizota, Yozo Miyake
Summary: This study aimed to determine the effect of brilliant blue G (BBG) staining on macular function. The results showed that intravitreal injection of BBG did not alter the physiology of the macula, indicating that it is safe. Additionally, iFMERGs can be used to monitor macular function during intraocular surgery.
JOURNAL OF CLINICAL MEDICINE
(2022)
Meeting Abstract
Ophthalmology
Hirotaka Yokouchi, Toshiyuki Oshitari
ACTA OPHTHALMOLOGICA
(2021)
Article
Biotechnology & Applied Microbiology
Tomoaki Tatsumi, Toshiyuki Oshitari, Takayuki Baba, Yoko Takatsuna, Shuichi Yamamoto
BIOMED RESEARCH INTERNATIONAL
(2020)
Article
Endocrinology & Metabolism
Yuko Hayashi, Tomoaki Tatsumi, Toshiyuki Oshitari, Tomomi Kaiho, Yoko Takatsuna, Miyuki Arai, Takayuki Baba, Shuichi Yamamoto
Summary: The study compared the efficacy of one initial intravitreal injection of aflibercept followed by a pro re nata (PRN; 1+PRN) regimen to those of three consecutive monthly injections followed by the PRN (3+PRN) regimen for diabetic macular edema. The results showed that despite the 3+PRN regimen requiring more injections than the 1+PRN regimen, it led to better visual outcomes at 12 months.
JOURNAL OF DIABETES RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Toshiyuki Oshitari
Summary: Diabetic retinopathy, a major retinal disease and top cause of blindness worldwide, involves neurovascular unit disturbances leading to neuronal and vascular abnormalities, particularly neuronal cell death and axon degeneration, directly impacting vision reduction in diabetic patients. Establishing neuroprotective and regenerative therapies for diabetic neuropathy in the retina is crucial in preventing blindness.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Ophthalmology
Norihiro Shimizu, Toshiyuki Oshitari, Jiro Yotsukura, Hirotaka Yokouchi, Takayuki Baba, Shuichi Yamamoto
Summary: The study aimed to determine the epidemiology of tumors of the ocular adnexa and orbit in Japan. Malignant lymphoma was found to be the major malignant tumor in the study, and proactive pathological biopsies should be conducted to prevent missing IgG4-positive MALT lymphomas.
Editorial Material
Cell Biology
Toshiyuki Oshitari
NEURAL REGENERATION RESEARCH
(2022)
Article
Biology
Tomoaki Tatsumi, Toshiyuki Oshitari, Yoko Takatsuna, Ryoichi Ishibashi, Masaya Koshizaka, Yuki Shiko, Takayuki Baba, Koutaro Yokote, Shuichi Yamamoto
Summary: This study found that systemic SGLT2i can reduce DMEs, suggesting that SGLT2i may be an additional treatment option to anti-VEGF treatments for eyes with DMEs.
Article
Multidisciplinary Sciences
Tomoaki Tatsumi, Yoko Takatsuna, Toshiyuki Oshitari, Tomomi Kaiho, Yohei Kawasaki, Yuki Shiko, Takeshi Sugawara, Takayuki Baba, Shuichi Yamamoto
Summary: This study compared the efficacy and safety of intravitreal aflibercept combined with subthreshold laser therapy to intravitreal aflibercept monotherapy for treating diabetic macular edema. The results showed that the combination therapy did not reduce the number of injections needed and there was no significant difference in treatment outcomes between the two groups.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Toshiyuki Oshitari
Summary: Diabetic retinopathy is a tissue-specific neurovascular impairment in diabetic patients that affects the retina. Advanced glycation end-products (AGEs) are a major pathological factor causing neurovascular coupling impairments. Mechanisms such as AGE-receptor axis, reactive oxygen species, inflammation, and cell death pathways contribute to the impairment of neurovascular units. Neuronal cell death is directly associated with vision reduction in diabetic patients, highlighting the need for neuroprotective therapies targeting AGEs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ophthalmology
Tatsuya Nagai, Hirotaka Yokouchi, Gen Miura, Masaya Koshizaka, Yoshiro Maezawa, Toshiyuki Oshitari, Koutaro Yokote, Takayuki Baba
Summary: This study documented three cases of Werner syndrome patients with thinning of the RNFL, GCC, and choroidal thickness observed using OCT. Visual field tests revealed visual field loss mainly due to glaucoma. These findings highlight the importance of considering Werner syndrome in the differential diagnosis for patients with juvenile cataracts of unknown cause showing abnormal retinal and choroidal thinning in the OCT images.
Review
Biochemistry & Molecular Biology
Guzel Bikbova, Toshiyuki Oshitari, Mukharram Bikbov
Summary: There is a clear connection between diabetes and atherosclerotic cardiovascular disease, necessitating therapeutic approaches that target both diseases. Ongoing clinical trials are examining the roles of obesity, adipose tissue, gut microbiota, and pancreatic beta cell function in diabetes. Inflammation plays a crucial role in diabetes pathophysiology and associated metabolic disorders, leading to increased interest in targeting inflammation for diabetes prevention and control. Diabetic retinopathy, a neurodegenerative and vascular disease that develops after poorly controlled diabetes, is also increasingly linked to inflammation. Molecular pathways such as oxidative stress and advanced glycation end-products contribute to the inflammatory response in diabetes-related complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Toshiyuki Oshitari
Summary: Diabetic retinopathy (DR) is a common complication of diabetes and a prominent cause of blindness globally. Recently, DR has been defined as a neurovascular disease that impairs the retinal neurovascular function in individuals with diabetes. Neurovascular cell death is the primary cause of this impairment, and protecting neurovascular cells offers a potential therapy for preventing DR progression. Various cell death pathways, including apoptosis, necroptosis, ferroptosis, and pyroptosis, are associated with neurovascular cell death in DR, and targeting these regulated cell death mechanisms may serve as therapies to ameliorate DR pathogenesis. This review focuses on these cell death mechanisms and presents potential therapies that protect against neurovascular cell death in the treatment of DR.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Toshiyuki Oshitari
Summary: This review focuses on the pathogenesis of neurovascular impairments in diabetic retinopathy and introduces possible neurovascular protective therapies.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Ophthalmology
Takayuki Baba, Tomoaki Tatsumi, Toshiyuki Oshitari, Shuichi Yamamoto
Summary: This study reported 4 cases of recurrent rhegmatogenous retinal detachment 10-17 years after primary reattachment surgery by pars plana vitrectomy. The new retinal breaks were punched-out shaped without horseshoe tears or atrophic holes, and all cases achieved reattachment with combined vitrectomy and scleral buckling surgery. Best-corrected visual acuity ranged from 20/30 to 20/25 among patients.
CASE REPORTS IN OPHTHALMOLOGY
(2021)
Review
Ophthalmology
Toshiyuki Oshitari
Summary: Adult neurons in the mammalian central nervous system do not regenerate after injury primarily due to reduced intrinsic regenerative pathways and inhibitory glial environment. Research focusing on optic nerve crush models has shed light on the basic knowledge and trends in CNS axonal regeneration. Expert suggest that stabilization of growth cones and multiple strategies are essential for successful optic nerve regeneration.
EXPERT REVIEW OF OPHTHALMOLOGY
(2021)