Article
Genetics & Heredity
Lei Chen, Haley J. Abel, Indraniel Das, David E. Larson, Liron Ganel, Krishna L. Kanchi, Allison A. Regier, Erica P. Young, Chul Joo Kang, Alexandra J. Scott, Colby Chiang, Xinxin Wang, Shuangjia Lu, Ryan Christ, Susan K. Service, Charleston W. K. Chiang, Aki S. Havulinna, Johanna Kuusisto, Michael Boehnke, Markku Laakso, Aarno Palotie, Samuli Ripatti, Nelson B. Freimer, Adam E. Locke, Nathan O. Stitziel, Ira M. Hall
Summary: This study investigated the genetic association between genome structural variation (SV) and cardiometabolic traits in the Finnish population, identifying 31 genome-wide significant associations at 15 loci. The study revealed two loci with strong phenotypic effects from SVs, shedding light on the impact of SVs on cardiometabolic traits. Integrating SVs in trait-mapping studies is crucial for expanding our understanding of genetic factors underlying disease risk.
AMERICAN JOURNAL OF HUMAN GENETICS
(2021)
Article
Genetics & Heredity
Jiali Xu, Yong Ruan, Jinkui Sun, Pengfei Shi, Jiajin Huang, Lingang Dai, Meimei Xiao, Houqiang Xu
Summary: The study evaluated the growth traits of Xiangsu hybrid pigs through PRKAA2 and MSMB as candidate genes. Sanger sequencing identified three intronic mutation sites in PRKAA2 and six mutation sites (including both exonic and intronic) in MSMB. Association analysis showed different relationship patterns between these mutation sites and various growth traits. The expression of PRKAA2 was highest in the longissimus dorsi muscle, while the expression of MSMB was highest in the spleen. These findings suggest that PRKAA2 and MSMB can be used for marker-assisted selection in improving growth traits of Xiangsu hybrid pigs, contributing to pig molecular breeding.
Article
Genetics & Heredity
Huiyu Wang, Xiaoyi Wang, Mingli Li, Hao Sun, Qiang Chen, Dawei Yan, Xinxing Dong, Yuchun Pan, Shaoxiong Lu
Summary: This study conducted a genome-wide association study using SLAF-seq technology to identify candidate genes and novel QTLs related to growth traits in pigs, revealing the genetic mechanisms underlying pig growth traits and providing a biological basis for improving pig growth and production performance.
Article
Fisheries
Hongyan Liu, Wenping Zhang, Minghua Wang, Siqi Xu, Liqiang Zhong, Wenji Bian, Shiyong Zhang, Xiaohui Chen
Summary: Understanding the genetic basis for growth traits in channel catfish is crucial for the catfish breeding industry. This study investigated the rrp44 gene in channel catfish and found significant associations between this gene and growth traits. The highest expression of rrp44 was observed in the kidneys, while the lowest expression was in the spleen. Several SNPs of the rrp44 gene were associated with body weight, providing new insights for molecular marker-assisted breeding in channel catfish.
AQUACULTURE REPORTS
(2023)
Article
Agriculture, Dairy & Animal Science
Herman Alberto Revelo, Diana Lopez-Alvarez, Yineth Alexandra Palacios, Oscar David Vergara, Moris Bustamante Yanez, Manuel Fernando Ariza, Susan Lorena Castro Molina, Yurany Ortiz Sanchez, Luz angela Alvarez
Summary: This study conducted a genome-wide association study on meat quality traits using GWAS and identified 11 candidate genes associated with water-holding capacity. It provided a baseline for future GWAS research on meat quality traits in Colombian hair sheep.
TROPICAL ANIMAL HEALTH AND PRODUCTION
(2023)
Article
Biotechnology & Applied Microbiology
Xiurong Zhao, Changsheng Nie, Jinxin Zhang, Xinghua Li, Tao Zhu, Zi Guan, Yu Chen, Liang Wang, Xue Ze Lv, Weifang Yang, Yaxiong Jia, Zhonghua Ning, Haiying Li, Changqing Qu, Huie Wang, Lujiang Qu
Summary: This study utilized genome-wide association study to identify 148 SNPs associated with egg number traits and 32 candidate genes related to hormone regulation, follicle development, and reproductive system development. The study also highlighted a genomic region on GGA5 as a potential candidate region underlying egg number traits.
Article
Biotechnology & Applied Microbiology
Aijun Wang, Yuqi Jiang, Xinyue Shu, Zhongping Zha, Desuo Yin, Yao Liu, Danhua Zhang, Deze Xu, Chengzhi Jiao, Xiaomei Jia, Xiaoying Ye, Shuangcheng Li, Qiming Deng, Shiquan Wang, Jun Zhu, Yueyang Liang, Ting Zou, Huainian Liu, Lingxia Wang, Jianqing Zhu, Ping Li, Zaijun Zhang, Aiping Zheng
Summary: In this study, 259 rice accessions were re-sequenced, and GWAS on 13 agronomic traits using 2.8 million SNPs identified 816 significant SNP signals. Candidate genes related to the traits were detected within 200 kb of associated SNP loci, offering important genomic resources for breeding high yielding rice cultivars.
Article
Reproductive Biology
Rongrong Ding, Yibin Qiu, Zhanwei Zhuang, Donglin Ruan, Jie Wu, Shenping Zhou, Jian Ye, Lu Cao, Linjun Hong, Zheng Xu, Enqin Zheng, Zicong Li, Zhenfang Wu, Jie Yang
Summary: This study aimed to investigate the genetic basis of litter traits in pigs, identifying valuable genes and genetic markers for pig breeding. Through a genome-wide association study, 76 significantly related SNPs and 10 potential candidate genes were detected, including 13 pleiotropic SNPs that affected multiple litter traits. Functional enrichment analysis indicated that significant pathways were associated with hormone secretion and embryo and organ development, providing new insights into improving litter quality in pigs.
Article
Agriculture, Dairy & Animal Science
Dan Wang, Jun Teng, Chao Ning, Wenwen Wang, Shuai Liu, Qin Zhang, Hui Tang
Summary: This study reveals the significant effect of mitochondrial DNA single-nucleotide polymorphisms (SNPs) on body measurement traits of chickens. Specifically, the SNP mt11086 T/C in the ND3 gene was found to significantly affect chest depth, highlighting its genetic impact on chicken body size and growth. However, no significant association was found between mitochondrial haplotypes or haplogroups and body measurement traits.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Agronomy
Yanfei Li, Ying-hui Li, Huilong Hong, Yansong Ma, Yongzhe Gu, Zhangxiong Liu, Scott A. Jackson, Li-juan Qiu
Summary: The study identified the genetic basis and correlations of growth period traits in soybean, revealing 28 SNPs associated with different growth periods. The results provide candidate SNP markers and genes for further molecular marker-assisted breeding.
GENETIC RESOURCES AND CROP EVOLUTION
(2022)
Article
Agriculture, Dairy & Animal Science
Worrarak Norseeda, Guisheng Liu, Tawatchai Teltathum, Pantaporn Supakankul, Korawan Sringarm, Watcharapong Naraballobh, Trisadee Khamlor, Siriwadee Chomdej, Korakot Nganvongpanit, Patcharin Krutmuang, Supamit Mekchay
Summary: The IL-4 and IL-4R cytokine genes play a role in the immune and reproductive systems of pigs, and their polymorphisms have been found to be associated with litter size traits. These genetic markers could potentially be used to improve the reproductive traits of pigs in the breeding industry.
Article
Plant Sciences
Kafilat Abiodun Odesola, Odunayo Joseph Olawuyi, Rajneesh Paliwal, Olaniyi Ajewole Oyatomi, Michael T. T. Abberton
Summary: This study reveals the associations between sequencing-based diversity array technology (DArTseq) and phenotypic character as well as differing indices related to drought tolerance in 100 accessions of Bambara groundnut. The genome wide association study predicts drought tolerance in Bambara accessions and identifies quantitative trait loci (QTLs) that could be useful in marker-assisted selection in drought molecular breeding programs. The selected drought-tolerant accessions could be used for hybridization breeding.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Mudasir Nazar, Ismail Mohamed Abdalla, Zhi Chen, Numan Ullah, Yan Liang, Shuangfeng Chu, Tianle Xu, Yongjiang Mao, Zhangping Yang, Xubin Lu
Summary: Udder conformation traits are economically important for dairy animals, and understanding their genetic architecture is crucial for genetic improvement and long-term selection in Holstein Friesian cattle. By conducting a GWAS on udder traits in Chinese Holstein cattle, several significant SNPs and candidate genes associated with udder structure traits were identified. These findings provide valuable information for improving the genetic information, health, longevity, and production of dairy cattle.
Article
Plant Sciences
Guanglian Liao, Min Zhong, Zhiqiang Jiang, Junjie Tao, Dongfeng Jia, Xueyan Qu, Chunhui Huang, Qing Liu, Xiaobiao Xu
Summary: The study revealed the complex biological characteristics of kiwifruit flowers and leaves through GWAS, identifying key genes associated with these traits. An analysis of 946,337 SNP markers also uncovered the genetic structure of A. eriantha and drew conclusions from it.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Fisheries
Hanhan Yao, Fuzhen Ren, Yongbo Bao, Yinghui Dong, Zhihua Lin
Summary: In this study, the LAP3 gene of Tegillarca granosa was characterized, showing a highly conserved genomic structure with two functional domains. Differential expression of Tg-LAP3 was observed in embryos/larvae and adult tissues, with no significant differences in growth traits among different genotypes. This study provides valuable information for molecular marker-assisted selection (MAS) of the blood clam.