Journal
JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES
Volume 7, Issue 1, Pages -Publisher
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S1793545813500296
Keywords
Photoacoustic imaging; nanoparticle; indocyanine green; phospholipid-polyethylene glycol
Funding
- National Basic Research Program of China [2011CB910402, 2010CB732602]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT0829]
- National Natural Science Foundation of China [81127004, 11104087]
- Foundation for Distinguished Young Talents in Higher Education of Guangdong, China [LYM10061]
- Specialized Research Fund for the Doctoral Program of Higher Education [20114407120001]
- Science and Technology Project of Guangzhou, China [2012J4100114]
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Contrast agents are attracting a great deal of attention in photoacoustic imaging. Here we introduce an exogenous contrast agent that provides high photoacoustic signal amplitude at the near-infrared wavelength. Our agents consist of Indocyanine green (ICG) and phospholipid-polyethylene glycol (PL-PEG), entitled ICG-PL-PEG nanoparticles. These nanoparticles have overcome numerous limitations of ICG, such as poor aqueous stability, concentration-dependent aggregation and lack of target specificity. ICG-PL-PEG nanoparticles are biocompatible and relatively nontoxic. All the components of ICG-PL-PEG nanoparticles have been approved for human use. Upon pulsed laser irradiation, the nanoparticles are more efficient in producing photoacoustic waves than ICG alone. The results showed that ICG-PL-PEG nanoparticles act as good contrast agents for photoacoustic imaging. These unique ICG-PL-PEG nanoparticles have great potential in clinical applications.
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