Journal
JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES
Volume 4, Issue 2, Pages 159-163Publisher
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S179354581100137X
Keywords
Epithelial tissue; multiphoton microscopy; two-photon excited fluorescence; second-harmonic generation
Funding
- National Natural Science Foundation of China [60908043, 30970783]
- Program for New Century Excellent Talents in University [NCET-07-0191]
- Natural Science Funds for Distinguished Young Scholar in Fujian Province [2009J06031]
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Epithelial cancer comprises more than 85% of human cancers. The detection and treatment at the early stage has been demonstrated to apparently improve patient survival. In this review, we summarize our recent research works on the diagnostic application of epithelial tissue based on multiphoton microscopy (MPM), including identification of the layered structures of esophagus, oral cavity, skin and bronchus tissues, establishment of the diagnostic features for distinguishing gastric normal tissue from cancerous tissue, linking collagen alteration and ectocervical epithelial tumor progression for evaluating epithelial tumor progression, and differentiating normal, inflammatory, and dysplastic ectocervical epithelial tissues. These results provide the groundwork for developing MPM into clinical multiphoton endoscopy.
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