Journal
JOURNAL OF GINSENG RESEARCH
Volume 37, Issue 3, Pages 283-292Publisher
KOREAN SOC GINSENG
DOI: 10.5142/jgr.2013.37.283
Keywords
Panax ginseng; Ginsenoside-Re; Cardiac injury; Hemodynamics; Myocardial preservation
Funding
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [2012R1A1A4A01011658]
- National Research Foundation of Korea [2012R1A1A4A01011658] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Ginsenosides are divided into two groups based on the types of the panaxadiol group (e.g., ginsenoside-Rb1 and -Rc) and the panaxatriol group (e.g., ginsenoside-Rg1 and -Re). Among them, ginsenoside-Re (G-Re) is one of the compounds with the highest content in Panax ginseng and is responsible for pharmacological effects. However, it is not yet well reported if G-Re increases the hemodynamics functions on ischemia (30 min)/reperfusion (120 min) (PR) induction. Therefore, in the present study, we investigated whether treatment of G-Re facilitated the recovery of hemodynamic parameters (heart rate, perfusion pressure, aortic flow, coronary flow, and cardiac output) and left ventricular developed pressure (+/- dp/dt(max)). This research is designed to study the effects of G-Re by studying electrocardiographic changes such as QRS interval, QT interval and R-R interval, and inflammatory marker such as tissue necrosis factor-alpha (TNF-alpha) in heart tissue in PR-induced heart. From the results, PR induction gave a significant increase in QRS interval, QT interval and R-R interval, but showed decrease in all hemodynamic parameters. I/R induction resulted in increased TNF-alpha level. Treatment of G-Re at 30 and 100 mu M doses before I/R induction significantly prevented the decrease in hemodynamic parameters, ameliorated the electrocardiographic abnormality, and inhibited TNF-alpha level. In this study, G-Re at 100 mu M dose exerted more beneficial effects on cardiac function and preservation of myocardium in I/R injury than 30 mu M. Collectively, these results indicate that G-Re has distinct cardioprotectective effects in I/R induced rat heart.
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