Journal
JOURNAL OF GINSENG RESEARCH
Volume 35, Issue 3, Pages 375-383Publisher
KOREAN SOC GINSENG
DOI: 10.5142/jgr.2011.35.3.375
Keywords
Panax ginseng; Caenorhabditis elegans; Ginsenoside metabolites; Ginsenoside epimers; Growth
Funding
- National Research Foundation of Korea (NRF) [2011-0021144]
- Ministry of Education, Science and Technology [2009-0093824]
- BK21
- National Research Foundation of Korea [2011-0021144] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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In the previous report, we have demonstrated that ginsenoside Re, one of major ginsenosides, is a major component for the restoration for normal growth of worms in cholesterol-deprived medium. In the present study, we further investigated the roles of minor ginsenosides, such as ginsenoside Rh(1) and Rh(2), ginsenoside metabolites such as compound K (CK), protopanaxadiol (PPD), and protopanaxatriol (PPT) and ginsenoside epimers such as 20(R)- and 20(S)-ginsenoside Rg(3) in cholesterol-deprived medium. We found that ginsenoside Rh; almost restored normal growth of worms in cholesterol-deprived medium in H generation. However, supplement of ginsenoside Rh, caused a suppression of worm growths in cholesterol-deprived medium. In addition, CK and PPD also slightly restored normal growth of worms in cholesterol-deprived medium but PPT not. In experiments using ginsenoside epimers, supplement of 20(5)- but not 20(R)-ginsenoside Rg(3) in cholesterol-deprived medium also almost restored worm growth. These results indicate that the absence or presence of carbohydrate component at backbone of ginsenoside, the number of carbohydrate attached at carbon-3, and the position of hydroxyl group at carbon-20 of ginsenoside might plays important roles in restoration of worm growth in cholesterol-deprived medium.
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