Journal
JOURNAL OF FLOW CHEMISTRY
Volume 3, Issue 4, Pages 127-131Publisher
SPRINGER
DOI: 10.1556/JFC-D-13-00024
Keywords
microreactor; heterogeneous acid catalysis; catalytic monolayer; Friedlander synthesis; deacetalization
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Funding
- Netherlands Organization for Scientific Research (NWO) [ECHO.09.TD.024]
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The inner walls of a glass microreactor were functionalized in a one-step procedure with a single layer of a strong perfluoroalkylsulfonic acid. The applicability of the catalytic device was demonstrated in the successful hydrolysis of benzaldehyde dimethyl acetal in acetonitrile, achieving quantitative conversion within a residence time of only 60 s. Furthermore, the catalytic system showed high conversion for the Friedlander quinoline synthesis between 2-aminobenzophenone and ethyl acetoacetate. The cyclization of pseudoionone in methylcyclohexane proved the wide applicability of the acid-functionalized microreactor also for reactions carried out in apolar media. The platform showed activity for 6 h to 2 days, depending on the solvent, and was reactivated by simple treatment with the catalyst precursor.
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