Article
Virology
Anna Papadopoulou, Paraskevi C. Fragkou, Eirini Maratou, Dimitra Dimopoulou, Antonis Kominakis, Ioanna Kokkinopoulou, Christos Kroupis, Athina Nikolaidou, Georgios Antonakos, Vasiliki Papaevangelou, Apostolos Armaganidis, Argirios Tsantes, Eftychia Polyzogopoulou, Sotirios Tsiodras, Anastasia Antoniadou, Paraskevi Moutsatsou
Summary: Accumulated data suggests a role of the renin-angiotensin system in COVID-19 pathogenesis, with the ACE insertion/deletion polymorphism potentially increasing the risk for severe disease. A retrospective study found that COVID-19 patients with the DD genotype and D allele carriers had a higher risk of developing severe disease, associated with lower ACE activity. This highlights the need for further research on ACE genotype-based therapies in COVID-19 patients.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sergej Nadalin, Sanja Devic Pavlic, Vjekoslav Peitl, Dalibor Karlovic, Lena Zatkovic, Smiljana Ristic, Alena Buretic-Tomljanovic, Hrvoje Jakovac
Summary: We investigated the impact of a functional insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme (ACE) on antipsychotic treatment. The results showed that the ACE-I/D polymorphism was significantly associated with changes in PANSS psychopathology, with a weak gender-specific effect and no association with metabolic-syndrome-related parameters.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Jianhui Du, Jianhua Lan, Hai Yang, Qiao Ying, Guohua Huang, Jian Mou, Jia Long, Zhenghua Qiao, Qiyi Hu
Summary: This meta-analysis reveals that the ACE I/D locus polymorphism is associated with the risk of prostate cancer. The D allele, DD+DI genotype, and DD at the ACE I/D locus are found to increase susceptibility to prostate cancer, suggesting their potential as diagnostic and screening molecular markers for prostate cancer patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Genetics & Heredity
Arezoo Faridzadeh, Mahmoud Mahmoudi, Sara Ghaffarpour, Mohammad Saber Zamani, Akram Hoseinzadeh, Mohammad Mehdi Naghizadeh, Tooba Ghazanfari
Summary: This study aimed to evaluate the association of ACE1 and ACE2 gene polymorphisms with the severity of COVID-19. The findings suggest that the ACE1 DD genotype is inversely correlated with intubation risk and mortality in COVID-19 patients. Additionally, the ACE2 rs1978124 CT and TT genotypes have a positive role in susceptibility to COVID-19 in females, but a protective effect against the severity of the disease.
FRONTIERS IN GENETICS
(2022)
Article
Genetics & Heredity
Mitra Rezaei, Hadiseh Mohammadpour, Mahya Eftekhari, Mihan Pourabdollah, Farinaz Nasr Azadani, Payam Tabarsi, Majid Marjani, Seyed Ali Ziai
Summary: This study aimed to investigate the correlation between angiotensin I converting enzyme (ACE) insertion/deletion polymorphism and the severity of symptoms in COVID-19 patients. The study found that the ACE D allele was associated with an increased risk of disease severity.
FRONTIERS IN GENETICS
(2022)
Review
Medicine, Research & Experimental
Hamid Tanzadehpanah, Elham Lotfian, Amir Avan, Sahar Saki, Sima Nobari, Roghaye Mahmoodian, Mohsen Sheykhhasan, Mohamad Hosein Shafiee Froutagh, Farzaneh Ghotbani, Raoufeh Jamshidi, Hanie Mahaki
Summary: The novel coronavirus SARS-CoV-2 presents a global challenge due to its high infectivity and rapid transmission. It can invade epithelial cells and may worsen the condition of patients with pre-existing vascular diseases by causing endothelial damage and intravascular thrombosis. ACE2, the enzyme involved in the renin-angiotensin aldosterone system, is used by SARS-CoV-2 as a receptor for viral entry. Understanding the mechanism of SARS-CoV-2 infection and its impact on the vascular system is crucial for effective management in patients with vascular diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Clinical Neurology
Malik Nassan, Iyas Daghlas, Ignazio S. Piras, Emily Rogalski, Lianne M. Reus, Yolande Pijnenburg, Leah K. Cuddy, Richa Saxena, M-Marsel Mesulam, Matt Huentelman
Summary: This study used genetic approaches to find that angiotensin-converting enzyme (ACE) inhibition is associated with Alzheimer's disease and frontotemporal dementia, but not with Lewy body dementia or vascular dementia. These results provide evidence for further research on the neurocognitive effects of ACE inhibition.
ALZHEIMERS & DEMENTIA
(2023)
Article
Food Science & Technology
Jingjing Dong, Shen Wang, Xiaoyao Yin, Min Fang, Zhiyong Gong, Yongning Wu
Summary: This study investigated the antihypertensive effect of rice peptide (RP) and revealed its mechanism of action. The results demonstrated that RP could effectively reduce systolic blood pressure in hypertensive rats, potentially through regulating the renin-angiotensin system and nitric oxide release.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Biochemistry & Molecular Biology
Fatih Aydin, Vedat Turkoglu, Zehra Bas
Summary: The study successfully purified ACE enzyme from sheep lungs in one step and determined that captopril, a specific ACE inhibitor, has a significant inhibitory effect with a very low IC50 value of 0.51 nM.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Neurosciences
Ankit Goyal, Alvee Saluja, Kallur N. Saraswathy, Priya Bansal, Rajinder K. Dhamija
Summary: The study demonstrates a strong association between ACE insertion/deletion polymorphism and the risk of acute ischemic stroke (AIS), with the DD genotype independently associated with an increased risk. This finding suggests the potential of ACE polymorphism as a genetic risk factor for AIS.
Article
Biochemistry & Molecular Biology
Se Yeong Park, Eun Woo Jeong, Yun Sun Yang, Hyun-Joo Kim, Gwang-woong Go, Hyeon Gyu Lee
Summary: Finger millet ethanol extracts (FEs) exhibit lipid-lowering, antioxidant, renin-angiotensin system-controlling, and vascular remodeling-improving effects in spontaneously hypertensive rats (SHRs), significantly reducing systolic blood pressure.
Article
Pharmacology & Pharmacy
Hichem Bouchenaki, Amandine Bernard, Flavien Bessaguet, Simon Frachet, Laurence Richard, Franck Sturtz, Laurent Magy, Sylvie Bourthoumieu, Claire Demiot, Aurore Danigo
Summary: Ramipril has the potential to prevent paclitaxel-induced peripheral neuropathy, and the neuroprotective role of ramipril in this condition is mediated through the involvement of the AT2 receptor.
Article
Public, Environmental & Occupational Health
Guillaume Butler-Laporte, Tomoko Nakanishi, Vincent Mooser, Alessandra Renieri, Sara Amitrano, Sirui Zhou, Yiheng Chen, Vincenzo Forgetta, J. Brent Richards
Summary: Mendelian randomization using genetic determinants of serum-ACE levels found no association between genetically decreased ACE levels and susceptibility to, or severity of, COVID-19, suggesting that individuals taking ACE inhibitors should not discontinue therapy during the pandemic.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Physiology
Ana Paula Renno Sierra, Bryan Steve Martinez Galan, Cesar Augustus Zocoler de Sousa, Duane Cardoso de Menezes, Jessica Lais de Oliveira Branquinho, Raquel Leao Neves, Julia Galanakis Arata, Clarissa Azevedo Bittencourt, Hermes Vieira Barbeiro, Heraldo Possolo de Souza, Joao Bosco Pesquero, Maria Fernanda Cury-Boaventura
Summary: The study aims to evaluate the role of ACE I/D and BDKRB2 +9/-9 polymorphism on exercise-induced cytokine response. The results showed the association between BDKRB2 genotype and exercise-induced cytokine response related to muscle repair and cardioprotection, while ACE I/D genotype was associated with inflammatory response.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Physiology
Haru Nomura, Sanjaya Kuruppu, Niwanthi W. Rajapakse
Summary: Diabetic nephropathy is a common disease leading to end-stage renal disease. Chronic activation of the RAAS contributes to kidney inflammation and fibrosis, resulting in kidney disease. Targeting the reno-protective arm of the RAAS provides potential therapeutic options for improving kidney inflammation and fibrosis in diabetic nephropathy.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Hematology
Aisha Qayyum, Muzammil Hasan Najmi, Qaisar Mansoor, Muhammad Irfan, Abdul Khaliq Naveed, Andleeb Hanif, Ali Raza Kazmi, Muhammad Ismail
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2018)
Article
Chemistry, Physical
Aqsa Arshad, Javed Iqbal, Qaisar Mansoor
APPLIED SURFACE SCIENCE
(2019)
Review
Biochemistry & Molecular Biology
Ammad Ahmad Farooqi, Qaisar Mansoor, Nada Alaaeddine, Baojun Xu
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Biochemical Research Methods
Shamaila Sajjad, Bushra Uzair, Anum Shaukat, Madiha Jamshed, Sajjad Ahmed Khan Leghari, Muhammad Ismail, Qaiser Mansoor
IET NANOBIOTECHNOLOGY
(2019)
Article
Materials Science, Biomaterials
Javaria Hanif, Nauman Khalid, Rao Sanaullah Khan, Muhammad Faraz Bhatti, Mohammad Qasim Hayat, Muhammad Ismail, Saadia Andleeb, Qaisar Mansoor, Faria Khan, Faheem Amin, Rumeza Hanif, Muhammad Uzair Hashmi, Hussnain Ahmed Janjua
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2019)
Article
Chemistry, Multidisciplinary
Saira Naz, Qaisar Mansoor, Amjad Nisar, Shafqat Karim, Maaz Khan, Ghafar Ali, Ata-ur-Rahman, Mashkoor Ahmad
Article
Immunology
Tariq Jan, Sohail Azmat, Qaisar Mansoor, H. M. Waqas, M. Adil, S. Z. Ilyas, Ishaq Ahmad, Muhammad Ismail
MICROBIAL PATHOGENESIS
(2019)
Article
Biotechnology & Applied Microbiology
M. Atif, Seemab Iqbal, M. Fakhar-E-Alam, M. Ismail, Qaisar Mansoor, Lubna Mughal, Muhammad Hammad Aziz, Atif Hanif, W. A. Farooq
BIOMED RESEARCH INTERNATIONAL
(2019)
Article
Materials Science, Multidisciplinary
Tariq Jan, Sohail Azmat, Qaisar Mansoor, S. Z. Ilyas, Ishaq Ahmad, Hamdullah Khan, M. Ismail
MATERIALS RESEARCH EXPRESS
(2019)
Article
Materials Science, Ceramics
Irum Talat, Aqsa Arshad, Qaisar Mansoor
Summary: This study demonstrates the potential of GNPs/Cr2O3 nanocomposites as innovative nanoantibiotics for pathogen control, showing excellent antibacterial performance against both Gram-positive and Gram-negative bacteria. The synergistic contribution of Cr2O3 nanoflakes and GNPs/Cr2O3 nano-composites plays a key role in bacterial membrane disruption, making them a promising solution for combating drug resistance.
CERAMICS INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Qaisar Mansoor, Muhammad Ismail, Shah Ali Ul Qader
Summary: This study aims to identify the prognostic genetic elements of FTO gene linkage disequilibrium block SNPs rs9940128 and rs9939609 in breast cancer and type II diabetes in the Pakistani population. These genetic markers are closely associated with disease onset and can help understand the underlying disease genetics and identify treatment targets. The study found that these genetic markers are significantly associated with the incidence of breast cancer and type II diabetes.
Article
Biochemistry & Molecular Biology
Samina Asghar Abbasi, Ruqia Mehmood Baig, Mehvish Naseer Ahmed, Muhammad Ismail, Rashida Khan, Humera Mehmood, Qaisar Mansoor
Summary: The study found a strong association of MAP3K1 SNP rs889312 with breast cancer in the Pakistani population, as well as a characteristic association of unique genotypes TC and CC in pre- and post-menopausal breast cancer patients. These findings can serve as a convenient tool for breast cancer marker in south Asian populations.
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2022)
Article
Pharmacology & Pharmacy
Shahid Hussain, Jabar Zaman Khan Khattak, Mohammad Ismail, Qaisar Mansoor, Mohammad Haroon Khan
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2018)
Review
Immunology
Ammad Ahmad Farooqi, Syed Kamran-ul-Hassan Naqvi, Aliye Aras Perk, Onur Yanar, Sobia Tabassum, Muhammad Sheeraz Ahmad, Qaisar Mansoor, Mohamed S. Ashry, Muhammad Ismail, George E. Naoum, Waleed O. Arafat
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
(2018)
Article
Medicine, General & Internal
Amina Nadeem, Sadaf Mumtaz, Wasif Saif, Abdul Khaliq Naveed, Muhammad Aslam, Qaiser Mansoor, Arif Siddiqui, Muhammad Ismail
JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION
(2018)
