Article
Chemistry, Organic
Kaixia Jian, Bingnan Li, Shuxian Zhu, Qingqing Xuan, Qiuling Song
Summary: In this study, a catalyst-free and efficient method using H3N•BH3 for the chemoselective reduction of α,β-unsaturated cycloketones and acyclic α,β-unsaturated ketones is described. The method is expedient, green, and applicable.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Physical
Fei Fang, Jiarui Chang, Jie Zhang, Xuenian Chen
Summary: An efficient solvent-free catalyst system for hydrosilylation of aldehydes and ketones, based on iron pre-catalyst Fe-2(CO)(9)/C6H4-o-(NCH2PPh2)(2)BH, showed good tolerance towards many functional groups, with corresponding alcohols obtained in high yields following basic hydrolysis of the reaction products. The reaction is likely catalyzed by an in situ generated pincer ligated iron hydride complex.
Article
Chemistry, Multidisciplinary
Budaganaboyina Prasad, Mandalaparthi Phanindrudu, Jagadeesh Babu Nanubolu, Ahmed Kamal, Dharmendra Kumar Tiwari
Summary: In this study, a novel stereoselective synthesis of 2H-isoindolin-1,3-ylidenes from 2-(formylphenyl)acrylates and phenacylazide in the presence of piperidine was successfully demonstrated. The one-pot tandem reaction provides a simple and efficient method to access highly functionalized ethyl (Z)-2-((Z)-3-(2-oxo-2-arylethylidene)-2,3-dihydro-1H-benzo[e]isoindol-1-ylidene)-acetates in good to excellent yields (up to 91%), and is compatible with a wide variety of functional groups.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Muneer-Ul-Shafi Bhat, Majid Ahmad Ganie, Bhahwal Ali Shah
Summary: A metal-free approach for tunable 1,2-difunctionalization of terminal alkynes, involving tandem installation of C-C and C-S bonds, has been developed. The key factor enabling this approach is the use of acetic acid as an acyl source to synthesize beta-substituted alpha,beta-unsaturated ketones. The reaction at different temperatures results in regioselective acylation at the terminal carbon and the more substituted carbon of the alkynes respectively.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Organic
Ravinder Kumar, Jai Parkash, Raj Kamal, Vipan Kumar, Sangeeta Saini
Summary: This study investigates and validates oxidative 1,2-aryl C-C migration in variegated alpha,beta-unsaturated diaryl ketones, leading to the synthesis of alpha-aryl-beta,beta-ditosylm ketones. The mechanism and generality of this migration were supported by computational studies, demonstrating a novel strategy for regioselective synthesis of various aryl compounds.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Qing-Wen Gui, Bin-Bin Wang, Sha Zhu, Fu-Long Li, Meng-Xue Zhu, Min Yi, Jia-Ling Yu, Zhi-Lin Wu, Wei-Min He
Summary: This study efficiently synthesized various 3-aminomethylated imidazoheterocycles in one step using green ethanol as the sole solvent, under metal-free, oxidant-free, and mild conditions with cheap and commercially available reactants.
Article
Chemistry, Multidisciplinary
Silvia Roscales, Aurelio G. Csaky
Summary: The method reported in the study utilizes nitrosobenzene as a reagent to activate boronic acid and aldehyde C-H bond simultaneously, triggering the synthesis of ketones through intramolecular migration. This practical and scalable method provides a straightforward approach for ketone synthesis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Spectroscopy
Wantao Zhao, Fuyan Xiao, Guofan Jin, Binxian Li
Summary: A series of novel phenylenediamine-fluoroboron pyrrole fluorescent derivatives were prepared, showing distinct fluorescence properties in different solvents and hydrogen ion concentration conditions. The compounds demonstrated unique fluorescence in acidic environment and have great potential as acidic probes in cell imaging research.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Multidisciplinary
Jiangfei Chen, Yan-Ping Zhu, Jin-Heng Li, Qiu-An Wang
Summary: This new method involves a copper-catalyzed two-component amino-benzoyloxylation of unactivated alkenes using O-benzoylhydroxylamines as benzoyloxy sources. The chemoselectivity of the reaction depends on the position of the tethered olefins, providing a way for external-oxidant-free alkene difunctionalization. It directly utilizes O-benzoylhydroxylamines as benzoyloxy radical precursors and internal oxidants for synthesizing cyclic nitrones and isoxazolines.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Chanhyun Jung, Siyuan Li, Kwanghee Lee, Mayavan Viji, Heesoon Lee, Soonsil Hyun, Kiho Lee, Young Kee Kang, Chhabi Lal Chaudhary, Jae-Kyung Jung
Summary: In this study, solvent-directed intramolecular hydrofunctionalization of readily available o-alkynoylphenols was successfully achieved under reagent-free conditions. The strategy is remarkable for its regioselectivity, atom economy, and efficiency in terms of atom, carbon, and reaction mass.
Article
Materials Science, Multidisciplinary
Grandprix T. M. Kadja, Mutiara D. Rukmana, Rino R. Mukti, M. Haris Mahyuddin, Adhitya G. Saputro, Triati D. K. Wungu
Summary: In this study, solvent-free synthesis of ZSM-5 zeolites assisted by NMP was reported. The characterization techniques confirmed the formation of highly crystalline ZSM-5 with the presence of NMP molecules. NMR spectroscopy and DFT calculations provided insights into the structure and stability of NMP within ZSM-5.
Article
Chemistry, Organic
Serena Traboni, Emiliano Bedini, Alba Silipo, Giulia Vessella, Alfonso Iadonisi
Summary: The novel glycosylation method reported in this study, based on the direct activation of per-O-acylated donors using methanesulfonic acid as a catalyst in the absence of solvents, offers a sustainable and environmentally friendly approach for the synthesis of carbohydrates and their derivatives. The method not only avoids the use of toxic and polluting organic solvents, but also shows high stereoselectivity and efficiency in obtaining desired glycosides.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Qiangwen Fan, Honglei Zhang, Huijun Ren, Yanling He, Yuhang Gu, Guorong Wu, Haibo Zhu, Zongbo Xie, Zhanggao Le
Summary: Here, a photocatalyst-free, facile and eco-friendly method was reported for the selective conversion of alcohols to aldehydes or ketones under mild conditions. The method showed excellent tolerance towards both electron-donating and electron-withdrawing groups, and yielded a range of aldehydes or ketones in considerable yields. The plausible mechanism was investigated through control experiments and DFT calculations. The readily accessible, atomic economy, and green reaction conditions of this method make it a promising application in chemical synthesis.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Chemistry, Physical
Ahmed Elabd, Jiheon Kim, Daniel Sethio, Sangho Kang, Taemin Kang, Jang Wook Choi, Ali Coskun
Summary: Electrolyte engineering is a promising strategy for improving sulfur utilization and cycle life in lithium-sulfur batteries. By introducing a dual functional high donor electrolyte, 3-FPN, high polysulfide solubility and compatibility with lithium metal are achieved, resulting in high specific capacity and robust cycling performance.
ACS ENERGY LETTERS
(2022)
Article
Chemistry, Organic
Shuang-Gui Lei, You Zhou, Li-Sheng Wang, Zhi-Cheng Yu, Ting Chen, Yan-Dong Wu, Meng Gao, An-Xin Wu
Summary: A novel multicomponent cascade cyclization reaction has been developed for the synthesis of pyrido[3,2-a]phenoxazin-5-ones using simple o-aminophenols, paraformaldehyde, and enaminones. The o-aminophenol serves as a bis-nucleophile and an iminoquinone precursor, facilitating the formation of aminophenoxazinones for the first time through the Povarov reaction, resulting in high-efficiency synthesis of pyrido[3,2-a]phenoxazin-5-ones. These compounds exhibit polarity sensitivity and aggregation-induced emission (AIE) characteristics, making them promising for bioimaging and theranostic applications.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Ashruba B. Danne, Mukund Deshpande, Jaiprakash N. Sangshetti, Vijay M. Khedkar, Bapurao B. Shingate
Summary: This study describes the design of a small library of new 1,2,3-triazole-appended bis-pyrazoles using a molecular hybridization approach, which show broad-spectrum antifungal activity with excellent minimum inhibitory concentration values against various fungal strains. Additionally, the compounds also exhibit promising antioxidant activity.
Article
Pharmacology & Pharmacy
Sachin B. Gholve, Jaiprakash N. Sangshetti, Omprakash G. Bhusnure, Ram S. Sakhare, Pratap H. Bhosale, Md Ismail Mouzam
Summary: A rapid and specific RP-HPLC method was developed for the determination of Lansoprazole impurities. The method was validated according to ICH guidelines, confirming its sensitivity and accuracy in detecting impurities in the drug substance.
JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL
(2021)
Article
Chemistry, Medicinal
Vaibhav V. V. Raut, Shashikant V. V. Bhandari, Shital M. M. Patil, Aniket P. P. Sarkate
Summary: Novel oxadiazole-isatin pharmacophore-containing molecules were designed and their structural requirements related to anticancer activity were explored using molecular modeling studies. Docking studies revealed promising results, showing that Compound 5 had the best fit to the active site pocket of the enzyme. The newly designed compounds showed drug-like pharmacokinetic properties.
LETTERS IN DRUG DESIGN & DISCOVERY
(2023)
Article
Materials Science, Biomaterials
Kanchan M. Joshi, Amruta Shelar, Umesh Kasabe, Latesh K. Nikam, Ramdas A. Pawar, Jaiprakash Sangshetti, Bharat B. Kale, Ajay Vikram Singh, Rajendra Patil, Manohar G. Chaskar
Summary: The present study demonstrates the synthesis of different forms of zinc oxide nanoparticles using lignin, fragments of lignin, and oxidized fragmented lignin as templates, and investigates their inhibitory effects on the growth and virulence of Candida albicans. Hierarchical FL-ZnO NPs show the highest inhibition, and they exhibit biocompatibility and non-toxicity in vitro and in vivo toxicity tests.
BIOMATERIALS ADVANCES
(2022)
Article
Chemistry, Organic
Ramesh Shingare, Yogesh Patil, Jaiprakash Sangshetti, Rajesh Patil, Dhanji Rajani, Balaji Madje
Summary: A series of novel benzene sulfonamide pyrazole oxadiazole derivatives were synthesized and evaluated for their antimicrobial and antitubercular activity. Compound 5d showed good antibacterial activity against several bacterial strains and also exhibited antitubercular activity against Mycobacterium tuberculosis.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Chemistry, Multidisciplinary
Madiha M. Siddiqui, Amol A. Nagargoje, Satish Akolkar, Jaiprakash N. Sangshetti, Vijay M. Khedkar, Parshuram M. Pisal, Bapurao B. Shingate
Summary: A simple and efficient method has been developed for synthesizing new compounds, which have been found to have potential antioxidant and medicinal properties.
RESEARCH ON CHEMICAL INTERMEDIATES
(2022)
Article
Chemistry, Organic
Ashishkumar P. Katariya, Maya V. Katariya, Jaiprakash Sangshetti, Satish U. Deshmukh
Summary: A green, efficient, and clean route for synthesizing biologically potent pyrano[2,3-c]pyrazole derivatives has been developed. The method utilizes a biodegradable ionic liquid [(EMIM)Ac] as a catalyst and involves a one-pot four-component condensation reaction in ethanol.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Chemistry, Multidisciplinary
Ashishkumar P. Katariya, Ashok R. Yadav, Omprakash B. Pawar, Parshuram M. Pisal, Jaiprakash N. Sangshetti, Maya Katariya, Satish U. Deshmukh
Summary: This study reports an efficient, expedient, clean, and environmentally friendly synthesis of twenty derivatives of tetrahydrobenzo[b]pyran via a one-pot three component condensation reaction. Various benzaldehydes, dimedone, and malononitrile were used as reactants, with an ionic liquid [(EMIM)Ac] used as a catalyst in ethanol at ambient temperature. The advantages of this reaction include the principles of green chemistry, such as simplicity in operation, shorter reaction time, mild reaction conditions, and high yield (78-98%) products.
Article
Biology
Manoj G. Damale, Rajesh Patil, Siddique Akber Ansari, Hamad M. Alkahtani, Sarfaraz Ahmed, Mohammad Nur-e-Alam, Rohidas Arote, Jaiprakash Sangshetti
Summary: This study explores new potential compounds against Pseudomonas aeruginosa specific LpxK through computer-aided drug design, providing possibilities for controlling Pseudomonas aeruginosa infections.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Chemistry, Physical
Pramod D. JawalePatil, Keerti Bhamidipati, Manoj G. Damale, Jaiprakash N. Sangshetti, Nagaprasad Puvvada, Rajesh S. Bhosale, Rajita D. Ingle, Rajendra P. Pawar, Sidhanath Bhosale, Sheshanath Bhosale
Summary: In this study, the synthesis and characterization of 1-16 new naphthalimide derivatives were reported. Compounds 2, 6 and 14 exhibited significant cytotoxic activity and showed potential as lead compounds in drug discovery.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Review
Chemistry, Organic
Shashikant Vasantarao Bhandari, Pranali Kuthe, Shital Manoj Patil, Om Nagras, Aniket Pardip Sarkate
Summary: Cancer is a major global cause of death and can be treated with naturally occurring Curcumin nuclei that have anti-inflammatory and anti-cancer properties. However, Curcumin has limitations such as instability at physiological pH and weak pharmacokinetic profile due to the β-diketone moiety present in it. To overcome this, researchers have focused on mono-ketone moieties in curcumin, known as mono-carbonyl curcumin.
CURRENT ORGANIC SYNTHESIS
(2023)
Article
Chemistry, Multidisciplinary
Tejshri R. Deshmukh, Vijay M. Khedkar, Jaiprakash N. Sangshetti, Bapurao B. Shingate
Summary: This study screened a library of bis-1,2,3-triazolyl-N-phenylacetamides for their antioxidant activity and investigated their binding affinity with myeloperoxidase. The results provided insights into the potential of these compounds as modulators of pro-oxidative tissue injury. The study also contributed significantly to the discovery of potent antioxidants for future research.
RESEARCH ON CHEMICAL INTERMEDIATES
(2023)
Article
Biochemistry & Molecular Biology
Shashikant V. Bhandari, Pranali V. Kuthe, Shital M. Patil, Om G. Nagras, Aniket P. Sarkate, Somdatta Y. Chaudhari, Sandip V. Surve
Summary: This study aimed to design new mono-carbonyl curcumin derivatives and analyze their drug likeness properties. Through research on three distinct EGFR crystal structures, it was found that NME 1 and NME 2 had better binding affinity to wild-type EGFR, while NME 3 showed comparable binding and more stability against the L858R/T790M/C797S mutated protein structure.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Chemistry, Multidisciplinary
Boomin Choi, Min-Hye Ahn, Seojin Hong, Ellane Eda Barcelon, Jaiprakash Sangshetti, Rohidas B. Arote, Sung Joong Lee
Summary: Recent advancements in personalized medicine and gene delivery have opened up exciting possibilities for treating central nervous system disorders. A novel microglia-targeting polyester amine carrier has been developed for successful delivery of genes specifically to microglia in the spinal cord and brain, offering a promising therapeutic strategy for CNS disorders.
Article
Chemistry, Multidisciplinary
Tejshri R. Deshmukh, Vijay M. Khedkar, Rohit G. Jadhav, Aniket P. Sarkate, Jaiprakash N. Sangshetti, Shailee Tiwari, Bapurao B. Shingate
Summary: The study involved the design and synthesis of a library of compounds, which were screened for their antifungal activity and enzymatic inhibition potential. Some of the synthesized compounds showed promising antifungal properties and potential as inhibitors of the 14 alpha-demethylase enzyme.
NEW JOURNAL OF CHEMISTRY
(2021)
