Article
Engineering, Biomedical
Wenbin Zhu, Fang Liu, Biao Yu, Jingwei He
Summary: Incorporating BTTMA into acrylic bone cement improved some properties such as flexural modulus and compressive strength, but also decreased setting time and certain mechanical properties. Additionally, bone cement with 15 wt% of BTTMA showed antibacterial activity against Staphylococcus aureus.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
M. Mohammadzadeh Rad, S. Saber-Samandari, D. Olegovich Bokov, Wanich Suksatan, Mh Malekipour Esfahani, M. Y. P. M. Yusof, A. S. El-Shafay
Summary: In this study, nanocrystalline-Hydroxyapatite (n-HA) was combined with Polymethyl Methacrylate (PMMA) bone cement-Elastin (ELN) to produce a bone cement for orthopedic applications. The adaptability, weight loss, and pH change of the bone cement were evaluated using simulated body fluid (SBF) and phosphate-buffered saline (PBS). The morphology and microchemical analysis of the bone cement materials were examined using Field Emission Scanning Electron Microscopy (FE-SEM) and Energy-dispersive X-ray Spectroscopy (EDX). The mechanical properties, such as elastic modulus and impact strength, were measured using tensile test and Charpy impact test. The study found that the bone cement had low water absorption and porosity, and exhibited proper mechanical performance. This research is significant for the development of bone application materials.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Polymer Science
Jianjun Chu, Chuang Li, Jing Guo, Yang Xu, Yao Fu
Summary: This study reports a new bio-based antibacterial bone cement p(NFMA-co-MMA) by modifying PMMA bone cement, with enhanced antibacterial activity.
Article
Engineering, Biomedical
Hang Li, Jianguo Liao, Yanru Zhang, Yue Yang, Jing Wen, Tingting Ma, Yijia Guan
Summary: This study developed a bioactive material by combining strontium hydroxyapatite (Sr-HAp) with magnesium oxychloride cement (MOC), which exhibited good osteogenic activity and degradability. The incorporation of 10 wt.% Sr-HAp densified the structure of MOC and enhanced its water resistance. Sr-HAp/MOC continuously released Sr2+ during the degradation process and promoted the growth of bone-like component hydroxyapatite crystals on MOC's surface. Implantation of Sr-HAp/MOC in rat femur defect demonstrated its better osteogenic activity. MOC containing 10 wt.% Sr-HAp can provide strong support for bone defects and has the potential to promote bone regeneration.
BIOMEDICAL MATERIALS
(2023)
Article
Geochemistry & Geophysics
Hamid Ait Said, Hassan Noukrati, Hicham Ben Youcef, Ayoub Bayoussef, Hassane Oudadesse, Allal Barroug
Summary: Three-dimensional HA-CS composites were prepared using solid-liquid technique and freeze-drying. The mechanical strength of the composites was influenced by factors such as solid/liquid ratio, polymer content, and molecular weight. Both polymer and apatite worked together to provide cohesive and mechanically stable composites, showing potential for bone repair applications in orthopedics.
Article
Engineering, Biomedical
Feipeng Wu, Hongxia Zhao, Jiahui Shi, Lang Long, Zhiqiang Yang, Hua Jin, Xuedan Hou
Summary: Curcumin is an active ingredient with multiple pharmacological effects. An injectable curcumin loaded chitosan/hydroxyapatite bone cement was prepared, demonstrating improved solubility and drug release properties. The material showed significant inhibitory effects on MG63 cells.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2021)
Review
Multidisciplinary Sciences
Tsion Amsalu Fode, Yusufu Abeid Chande Jande, Thomas Kivevele
Summary: Ordinary Portland cement is widely used in the world, but its production has negative impacts on energy consumption, resource consumption, and environmental pollution. Researchers have explored the use of different supplementary cementitious materials (SCMs) to reduce these impacts. This study reviewed the effects of natural and artificial SCMs on the durability and mechanical properties of cement composites, finding that many SCMs meet replacement standards and that adding 5-20% of certain SCMs can improve the properties of cement composites. However, more research is needed on the effects of silica fume on water absorption and acidic attack resistance.
Article
Soil Science
Chao Lv, Zhengtao Shen, Qing Cheng, Chao-Sheng Tang, Yue Wang, Kai Gu
Summary: By adding biochar and polypropylene fibre to the cement-solidified sludge system, it was found that biochar can promote cement hydration, while fibre can improve the ductility of the samples. The moisture regulation effect by biochar and the 'bridge' effect by fibre are key mechanisms to enhance mechanical properties.
SOIL USE AND MANAGEMENT
(2022)
Article
Materials Science, Biomaterials
Jinjin Zhu, Shuhui Yang, Yute Yang, Teng Yao, Gang Liu, Shunwu Fan, He Zhao, Fuzhai Cui, Xiumei Wang, Guoqiang Jiang, Xiangqian Fang
Summary: This study aimed to modify PMMA bone cement with mineralized collagen (MC) and compare its efficacy in treating KD with traditional PMMA bone cement. Results showed that MC-modified PMMA could achieve similar clinical effects as PMMA and provide better long-term restoration of vertebral height.
REGENERATIVE BIOMATERIALS
(2021)
Article
Construction & Building Technology
Qing Liu, Xing Ming, Jianyu Xu, Dongshuai Hou, Guoxing Sun, Zongjin Li, Guoqing Geng
Summary: A new cement composite with low hydration temperature and high mechanical strength was developed by combining Field's metal with in situ polymerization of acrylic acid and acrylamide. The composite showed increased compressive and flexural strength, reduced hydration temperature, and improved pore structure, offering potential for more robust and sustainable cementitious materials.
CONSTRUCTION AND BUILDING MATERIALS
(2023)
Article
Materials Science, Ceramics
Ruoxi Liu, Lili Ma, He Liu, Baohua Xu, Chengwei Feng, Rujie He
Summary: This study investigated the effects of pore size on mechanical and biological properties of hydroxyapatite (HAp) scaffolds prepared by stereolithographic 3D printing. Results showed that the scaffold with a pore size of 600 µm had the most promising application prospect.
CERAMICS INTERNATIONAL
(2021)
Article
Polymer Science
Naishun Guo, Mengen Zhao, Sijing Li, Jiahui Hao, Zhaoying Wu, Chao Zhang
Summary: This study developed a HA/PLA nanocomposite by surface modification of n-HA, which improved the dispersion of n-HA in the PLLA matrix and formed a stereocomplex crystal at the interface, leading to greatly enhanced mechanical performance. The composite material exhibited excellent mechanical properties and promoted osteogenic differentiation of bone marrow stromal cells.
Article
Biochemistry & Molecular Biology
Zong-Ju Chen, Hui-Hong Shi, Liang Zheng, Hua Zhang, Yu-Ying Cha, Hui-Xian Ruan, Yi Zhang, Xiu-Cheng Zhang
Summary: The composite aerogel with a dual network structure composed of sheet-like silk fibroin and reticular cellulose wrapping nano-hydroxyapatite on the surface showed high mechanical strength and toughness. In vitro cell culture demonstrated that HEK-293T cells had a high ability of adhesion, proliferation and differentiation on the composite aerogels, indicating potential application in bone tissue engineering.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Construction & Building Technology
Ying-hua Bai, Bo Xie, Huawei Li, Ran Tian, Qi-hang Zhang
Summary: This study investigates the influence of carbon black and carbon fiber as wave-absorbing agents on the structural stability and wave-absorbing performance of foam concrete. The results show that nano-carbon black can promote the formation of ettringite and enhance the cell structure, while compound carbon fiber improves the structural stability and wave-absorbing performance.
CONSTRUCTION AND BUILDING MATERIALS
(2022)
Article
Construction & Building Technology
Junjie Pei, Raju Sharma, Jeong Gook Jang
Summary: The study found that using carbonated cement clinker has a positive effect on the strength of mortar. However, excessive carbonation products can reduce the strength of the materials, making relatively smaller carbonated cement clinkers more suitable for achieving high strength in mortar.
CONSTRUCTION AND BUILDING MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Esen Sayin, Erkan Turker Baran, Ahmed Elsheikh, Vivek Mudera, Umber Cheema, Vasif Hasirci
Summary: It was found that the 3D culture of MSCs in collagen/silk fibroin scaffolds could significantly enhance the expressions of OSX and VEGFA, and result in improved tensile mechanical properties compared to 2D culture, with different effects observed under different oxygen environments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nanoscience & Nanotechnology
Dilara Goksu Tamay, Seyda Gokyer, Jurgen Schmidt, Alina Vladescu, Pinar Yilgor Huri, Vasif Hasirci, Nesrin Hasirci
Summary: The study focused on modifying magnesium-calcium alloys with calcium phosphate or doped with zinc and gallium to enhance their biocompatibility and corrosion resistance. The modified alloys showed decreased corrosivity and increased cell affinity, making them novel candidates for biodegradable metallic implants in orthopedic applications.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Applied
Deniz Atila, Ching-Yun Chen, Chun-Pin Lin, Yuan-Ling Lee, Vasif Hasirci, Aysen Tezcaner, Feng-Huei Lin
Summary: This study developed an injectable hydrogel system that utilizes Tideglusib and Rg1 to induce differentiation of dental pulp stem cells and vascularization of pulp. Gene expression analysis showed that this hydrogel system has the potential to improve strategies for vital pulp regeneration.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Tugba Dursun Usal, Metin Yesiltepe, Deniz Yucel, Yildirim Sara, Vasif Hasirci
Summary: In this study, a 3D-printed PCL nerve guide using an aligned gelatin-poly(3-hydroxybutyrate-co-3-hydroxyvalerate) electrospun mat was produced, showing significant potential for assisting the regeneration of injured peripheral nerves. Functional recovery and improved nerve conduction velocities were observed in animal experiments using the nerve guides, with the highest new tissue organization observed when the guides contained the electrospun mat and seeded cells.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Chemistry, Analytical
Menekse Ermis, Ezgi Antmen, Ozgur Kuren, Utkan Demirci, Vasif Hasirci
Summary: Microfabrication technologies have been widely used in cell biology and cancer research. In this study, a transparent cell culture chip was developed to monitor the behavior of breast cancer cells. The chip proved to be advantageous in analyzing live cells and studying breast cancer cell-substrate interactions.
Article
Pharmacology & Pharmacy
Gulhan Isik, Aysel Kiziltay, Nesrin Hasirci, Aysen Tezcaner
Summary: In this study, micelles composed of mPEG-b-PCL with ionically conjugated LCA and pH responsive release of LCA were prepared and investigated as drug carrier devices for cancer therapy. The results demonstrated that these micelles effectively internalized into breast cancer cells, inhibited cell migration, induced apoptosis, decreased lipogenic activity, and suppressed angiogenesis ability.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Engineering, Biomedical
Deniz Atila, Vasif Hasirci, Aysen Tezcaner
Summary: This study optimized the electrospinning process of core/shell poly(methyl methacrylate)/silk fibroin fibers to mimic the extracellular matrix and induce tissue regeneration. By adjusting the morphology and chemical properties of the fibers, the water contact angle and porosity of the mats could be altered. The core/shell fibers exhibited intermediate mechanical properties, porous structure, and fine morphology. These fibers promoted the attachment and proliferation of dental pulp stem cells.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Materials Science, Ceramics
Senem Buyuksungur, Pinar Yilgor Huri, Juergen Schmidt, Iulian Pana, Mihaela Dinu, Catalin Vitelaru, Adrian E. Kiss, Dilara Goksu Tamay, Vasif Hasirci, Alina Vladescu, Nesrin Hasirci
Summary: Ti6Al4V alloy has been widely used as implant material in dental and orthopedic surgeries for its superior compatibility, low density, and corrosion resistance compared to other metals. Surface modification of the alloy is necessary to improve material-tissue interaction and bone integration. In this study, Ti6Al4V alloy surfaces were modified by RF magnetron sputtering and coated with zinc-doped hydroxyapatite. The resulting coating exhibited high stability, crystalline structure, enhanced corrosion resistance, osteointegration, and antimicrobial effectiveness against Escherichia coli (E. coli) bacteria.
CERAMICS INTERNATIONAL
(2023)
Article
Biophysics
Deniz Atila, Dilek Keskin, Yuan-Ling Lee, Feng-Huei Lin, Vasif Hasirci, Aysen Tezcaner
Summary: Injectable hydrogels have potential in dental pulp regeneration due to their ability to fill non-uniform voids. In this study, gelatin methacrylate/thiolated pectin hydrogels carrying electrospun core/shell fibers were designed for vital pulp regeneration. The release of melatonin and Tideglusib from the fibers induced stem cell proliferation and odontoblastic differentiation. This hydrogel system holds promise for pulp tissue regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Biophysics
Juergen Schmidt, Iulian Pana, Anna Bystrova, Mihaela Dinu, Yuri Dekhtyar, Catalin Vitelaru, Marks Gorohovs, Ioana Maria Marinescu, Pinar Yilgor Huri, Dilara Goksu Tamay, Gabriela Andreea Juravlea, Senem Buyuksungur, Anca Constantina Parau, Vasif Hasirci, Nesrin Hasirci, Alina Vladescu
Summary: The purpose of this study was to investigate the effect of Zn doped CaP coatings prepared by micro-arc oxidation method on MgCa1 alloy degradation. The results showed that the addition of Zn into CaP increased the corrosion resistance of MgCa1 alloy and enhanced the adhesion strength of the coatings. All samples exhibited cytocompatibility and the degradation rate of MgCa1 alloy in simulated body fluids (SBF) or DMEM was decreased by coating with CaP, which was further reduced by adding a small amount of Zn. The samples with CaP coatings and Zn doped CaP coating also demonstrated antibacterial efficacy against E.coli.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Materials Science, Biomaterials
Ezgi Antmen, Menekse Ermis, Ozgur Kuren, Kemal Beksac, Cigdem Irkkan, Vasif Hasirci
Summary: In this study, the combination of conventional molecular-level evaluations and in vitro methods on micropatterned biomaterial surfaces was used to assess breast adenocarcinoma patients. The results showed that molecular markers and shape descriptors could distinguish cells from different locations and patients. Cells with the highest metastatic and invasive properties exhibited both the highest deformability and the highest level of metastatic markers. By combining molecular markers with nuclear deformation, the detection and separation of subpopulations in heterogeneous breast cancer specimens at the single-cell level can be improved.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Review
Nanoscience & Nanotechnology
Duygu Ege, Vasif Hasirci
Summary: osteochondral tissue regeneration is difficult due to its complex organization. 3D printing, specifically using extrusion, stereolithography, and inkjet printing approaches, is employed to design complex multilayer structures. Different materials and methods are discussed, along with the potential for improving material properties and the future prospects of 3D printing in osteochondral tissue repair.
ACS APPLIED BIO MATERIALS
(2023)
Article
Biochemical Research Methods
Milan Finn Wesseler, Mathias Norbaek Johansen, Aysel Kiziltay, Kim Mortensen, Niels B. Larsen
Summary: This paper proposes a non-contact 3D mapping method for oxygen tension using commercially available oxygen microsensor beads embedded in confocal phosphorescence lifetime microscopy. The method accurately evaluates oxygen distribution in high cell-density cultures. Its versatility is demonstrated in the design and control of microperfused 3D printed hydrogel culture chips.
Meeting Abstract
Cell & Tissue Engineering
Gozde Ervin Kole, Halime Kenar, Vasif Hasirci, Deniz Yucel
TISSUE ENGINEERING PART A
(2022)
