Review
Hematology
Gabor Forgo, Evy Micieli, Walter Ageno, Lana A. Castellucci, Gabriela Cesarman-Maus, Henry Ddungu, Erich Vinicius De Paula, Mert Dumantepe, Maria Cecilia Guillermo Esposito, Stavros V. Konstantinides, Nils Kucher, Claire McLintock, Fionnuala Ni Ainle, Alex C. Spyropoulos, Tetsumei Urano, Beverley J. Hunt, Stefano Barco
Summary: The use of thromboprophylaxis among hospitalized medically ill patients globally is still unsatisfactory, with Europe having the highest usage rate.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Medicine, Research & Experimental
Srinivas Abbina, Chanel C. La, Sreeparna Vappala, Manu Thomas Kalathottukaren, Usama Abbasi, Arshdeep Gill, Stephanie A. Smith, Charles A. Haynes, James H. Morrissey, Jayachandran N. Kizhakkedathu
Summary: Designing polyP inhibitors with good biocompatibility is a major challenge, but by modifying the steric shield design, highly biocompatible inhibitors can be achieved.
MOLECULAR PHARMACEUTICS
(2022)
Article
Hematology
Santiago Grillo Perez, Paula Ruiz-Talero, Oscar Mauricio Munoz Velandia
Summary: This study found that high BMI, active cancer, leukocytosis, and ICU requirement are associated with failed thromboprophylaxis. Future research should evaluate the potential benefits of adjusting thromboprophylaxis schemes in patients with one or more of these factors.
THROMBOSIS JOURNAL
(2023)
Review
Hematology
Philippe Debourdeau, Anne Lamblin, Theodore Debourdeau, Pierre Yves Marcy, Lea Vazquez
Summary: Symptomatic catheter related thrombosis (CRT) occurs in 4%-8% of cancer patients, with a mean incidence of 12-14% detected by echography or Doppler. No validated thromboprophylaxis has been identified, but pharmacological prophylaxis with vitamin K antagonists or low molecular weight heparins can reduce CRT incidence by 55%-60% without increasing major bleeding risk. This prophylaxis should be started before catheter insertion at prophylactic doses and continued thereafter at subtherapeutic doses.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Medicine, Research & Experimental
Oscar A. Marcos-Contreras, Jacob W. Myerson, Jia Nong, Jacob Samuel Brenner, Vladimir R. Muzykantov, Patrick M. Glassman
Summary: This study demonstrates that albumin-linked anticoagulants can serve as injectable, long-circulating, and safe thromboprophylactic agents, providing durable protection against thrombotic insults without adversely affecting hemostasis.
MOLECULAR PHARMACEUTICS
(2023)
Editorial Material
Clinical Neurology
Laura Esteban-Lucia, Soraya de la Fuente Batista, Andrea Maria Kallmeyer Mayor, Marcelino Cortes Garcia
Summary: This article provides supplemental digital content for reference.
Article
Oncology
V Leclerc, L. Karlin, C. Herledan, L. Marchal, A. Baudouin, A. Gouraud, A. G. Caffin, V Larbre, A. Lazareth, E. Bachy, G. Salles, H. Ghesquieres, C. Rioufol, F. Ranchon
Summary: This study aimed to evaluate the implementation of international guidelines regarding thromboprophylaxis strategy in myeloma patients treated with immunomodulatory drugs. The results showed that thromboprophylaxis was commonly performed in these patients, but the choice of anticoagulant or anti-platelet agent remained debatable, with variable adherence to existing guidelines.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Oncology
Christa L. LiBrizzi, Amil R. Agarwal, Anthony K. Chiu, Carol D. Morris, Savyasachi C. Thakkar, Adam S. Levin
Summary: This study found that patients undergoing lower extremity primary bone or soft tissue sarcoma resection had higher odds of developing DVT and PE when prescribed DOACs compared to LMWH, but there was no difference in the odds of bleeding complications.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Review
Medicine, General & Internal
Emerito Carlos Rodriguez-Merchan
Summary: This narrative review examined the literature related to the risk of deep vein thrombosis (DVT) in people with hemophilia (PWH) after orthopedic surgery. It concluded that pharmacological thromboprophylaxis is generally not necessary for PWH, except in cases of major orthopedic surgery with additional VTE risk factors. Limited evidence suggests the use of low molecular weight heparins or direct oral anticoagulants in some PWH with risk factors for VTE.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jingxuan Jiang, Jianyong Wei, Yueqi Zhu, Liming Wei, Xiaoer Wei, Hao Tian, Lei Zhang, Tianle Wang, Yue Cheng, Qianqian Zhao, Zheng Sun, Haiyan Du, Yu Huang, Hui Liu, Yuehua Li
Summary: The study aims to develop a clot-based radiomics model using CT imaging radiomic features and machine learning to identify cardioembolic (CE) stroke before mechanical thrombectomy (MTB) in patients with acute ischemic stroke (AIS). The results show that the radiomics model performs better than the routine radiological method in predicting CE stroke.
EUROPEAN RADIOLOGY
(2023)
Article
Clinical Neurology
Maria Diaz, Jasmin Jo, Mark Smolkin, Sarah Jane Ratcliffe, David Schiff
Summary: The study found that patients with lower-grade gliomas have a higher VTE risk, which is decreased in the presence of an IDH mutation. The incidence of VTE in glioblastoma patients is not affected by MGMT promoter methylation status.
Article
Hematology
Lara N. Roberts, Virginia Hernandez-Gea, Maria Magnusson, Simon Stanworth, Jecko Thachil, Armando Tripodi, Ton Lisman
Summary: Hospital-associated venous thromboembolism is a significant cause of morbidity and mortality in patients with cirrhosis. The use of thromboprophylaxis in these patients is challenging due to the uncertain balance between thrombosis and bleeding risk. This guidance document provides pragmatic recommendations on VTE prevention for hospitalized patients with cirrhosis, including drug selection and timing.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Oncology
Alexandra Zabeida, Rochelle Winikoff, Marie-Claude Pelland-Marcotte, Janie Charlebois, Christine Sabapathy
Summary: This study aimed to investigate the changes in hemostatic parameters and associated clinical outcomes, such as thrombosis and bleeding, in children with COVID-19 and assess the use of thromboprophylaxis. The study found that D-dimers and fibrinogen levels were elevated in children with SARS-CoV-2 infection, and a minority of patients received anticoagulant thromboprophylaxis. One thrombotic event and one major bleed were observed.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Clinical Neurology
Angela Genchi, Aurora Semerano, Giorgia Serena Gullotta, Davide Strambo, Ghil Schwarz, Andrea Bergamaschi, Pietro Panni, Franco Simionato, Francesco Scomazzoni, Caterina Michelozzi, Mattia Pozzato, Norma Maugeri, Giancarlo Comi, Andrea Falini, Luisa Roveri, Massimo Filippi, Gianvito Martino, Marco Bacigaluppi
Summary: Neutrophils and NETs were heterogeneously distributed within cerebral thrombi of diverse etiology. NET content was significantly higher in cardioembolic thrombi compared to large artery atherosclerosis thrombi. There was a correlation between NET content in the thrombus and in the plasma.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Surgery
Ashlee Kimball, Edward Gibson, Linda Quinn, Rebecca Cooksey, Darren Molony, Michelle Lodge, Bernard Carney, Amy Jeeves
Summary: This retrospective cohort study examines the incidence of thrombotic events in major paediatric burns and identifies risk factors, such as large % total body surface area and central venous catheters. The study suggests that screening and targeted thromboprophylaxis may be necessary for these patients.
ANZ JOURNAL OF SURGERY
(2023)
Article
Veterinary Sciences
J. Novo Matos, J. Silva, S. Regada, S. Rizzo, M. Serena Beato, C. Basso
Summary: This article describes a case of hypertrophic cardiomyopathy (HCM) in a dog, where the diagnosis of HCM was reached by excluding other similar conditions.
JOURNAL OF VETERINARY CARDIOLOGY
(2024)