Review
Critical Care Medicine
Geoffroy Hariri, Lucie Collet, Lucie Duarte, Guillaume L. Martin, Matthieu Resche-Rigon, Guillaume Lebreton, Adrien Bougle, Agnes Dechartres
Summary: This study assessed the effectiveness of non-pharmacological interventions in reducing the incidence of cardiac surgery-associated acute kidney injury (CSA-AKI). The results showed that goal-directed perfusion and remote ischemic preconditioning may be effective in reducing CSA-AKI incidence, while the application of pulsatile flow during cardiopulmonary bypass may also be beneficial but with lower quality of evidence.
Review
Medicine, Research & Experimental
Ying Yu, Chenning Li, Shuainan Zhu, Lin Jin, Yan Hu, Xiaomin Ling, Changhong Miao, Kefang Guo
Summary: Acute kidney injury (AKI) is a common and serious complication of cardiac surgery, causing increased mortality, morbidity, and economic burden. The pathogenesis of cardiac surgery-associated acute kidney injury (CSA-AKI) is complex and multifactorial, and biomarker exploration and validation are important for diagnosis. Prevention is key, with strategies such as maintaining renal perfusion, individualized blood pressure targets, balanced fluid management, goal-directed oxygen delivery, and avoiding nephrotoxins. This article reviews the pathogenesis, diagnosis, and prevention strategies for AKI in cardiac surgical patients.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Review
Medicine, General & Internal
Christina Massoth, Alexander Zarbock
Summary: Acute kidney injury after cardiac surgery presents specific patterns of damage and recovery, which are crucial for management and outcomes. The KDIGO classification only partially covers the conceptual framework and is insufficient for a comprehensive diagnosis. This review discusses the strengths and limitations of recent criteria for CSA-AKI and provides an overview of biomarkers. The evolving understanding of CSA-AKI as a time-sensitive condition has led to an increased demand for enhancing diagnostic criteria and implementing biomarkers in clinical practice.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Critical Care Medicine
Mira Kuellmar, Khaschayar Saadat-Gilani, Raphael Weiss, Christina Massoth, Anas Lagan, Manuel Nunez Cortes, Joachim Gerss, Lakhmir S. Chawla, Danilo Fliser, Melanie Meersch, Alexander Zarbock
Summary: Elevated renin concentrations are associated with cardiovascular instability and increased AKI after cardiac surgery. Elevated renin concentrations could be used to identify high-risk patients for cardiovascular instability and AKI who would benefit from timely intervention that could improve their outcomes.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Bing-qi Fu, Xue-biao Wei, Zedazhong Su, Ying-wen Lin, Zu-hui Ke, Tong Tan, Ji-yan Chen, Shou-hong Wang, Dan-qing Yu
Summary: The study found that preoperative statin treatment did not significantly affect the risk of acute kidney injury (AKI) among elderly patients undergoing valve replacement surgery, as well as in-hospital death and 1-year mortality rates.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Transplantation
Gregory L. Hundemer, Anand Srivastava, Kirolos A. Jacob, Neeraja Krishnasamudram, Salman Ahmed, Emily Boerger, Shreyak Sharma, Kapil K. Pokharel, Sameer A. Hirji, Marc Pelletier, Kassem Safa, Win Kulvichit, John A. Kellum, Leonardo Riella, David E. Leaf
Summary: Renal transplant recipients have a higher risk of acute kidney injury following cardiac surgery compared to non-RTRs, especially those with deceased donor status and higher preoperative calcineurin inhibitor trough levels.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Anesthesiology
Yu Tian, Xiuyuan Li, Yuefu Wang, Wei Zhao, Chunrong Wang, Yuchen Gao, Sudena Wang, Jia Liu
Summary: This retrospective observational study aimed to investigate the association between preoperative statin exposure and postoperative cardiac surgery-associated acute kidney injury (CSA-AKI). The results showed that preoperative statin exposure was associated with a decreased risk of all stages of postoperative CSA-AKI and stage 3 CSA-AKI.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2022)
Article
Cardiac & Cardiovascular Systems
Jin Sun Cho, Jae-Kwang Shim, Sak Lee, Jong-Wook Song, Nakcheol Choi, Sugeun Lee, Young-Lan Kwak
Summary: The study revealed that postoperative AKI in valvular heart surgery patients increases the risk of AKD and CKD development, with persistent AKI further escalating this risk. Additionally, heart failure and high right ventricular pressure postoperatively were identified as independent risk factors for CKD.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Anesthesiology
Lisa Verwijmeren, Madeleen Bosma, Lisette M. Vernooij, Esther M. Linde, Ineke M. Dijkstra, Edgar J. Daeter, Eric P. A. Van Dongen, Wilton A. Van Klei, Peter G. Noordzij
Summary: Preoperative cardiac, inflammatory, renal, and metabolic biomarkers are associated with CSA-AKI and may improve identification of patients at risk. The use of a biomarker panel may enhance the identification of patients with CSA-AKI compared to using only clinical risk factors.
ANESTHESIA AND ANALGESIA
(2021)
Article
Medical Laboratory Technology
Hang Zhang, Hong Lang, Mengqing Ma, Min Yu, Hao Chai, Yuntao Hu, Wen Chen, Xin Chen
Summary: The study found that decreased preoperative uromodulin levels are independently associated with an increased risk of acute kidney injury (AKI) and perioperative kidney dysfunction after cardiac surgery.
CLINICA CHIMICA ACTA
(2022)
Article
Health Care Sciences & Services
Xiao-Qin Luo, Yi-Xin Kang, Shao-Bin Duan, Ping Yan, Guo-Bao Song, Ning-Ya Zhang, Shi-Kun Yang, Jing-Xin Li, Hui Zhang
Summary: This study aimed to develop and validate machine learning models for predicting the occurrence of cardiac surgery-associated acute kidney injury (CSA-AKI) in the pediatric population. The study found that combining preoperative and intraoperative data and using the XGBoost model significantly improved preventive and therapeutic strategies during the perioperative periods. The top five predictors of CSA-AKI were baseline serum creatinine level, perfusion time, body length, operation time, and intraoperative blood loss.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Anesthesiology
W. Brenton French, Pranav R. Shah, Yahya I. Fatani, Megan M. Rashid, Spencer T. Liebman, Brian J. Cocchiola, Kenneth F. Potter, Salem Rustom, Michael J. Scott
Summary: The study found that postoperative AKI is associated with increased length of hospital stay, higher surgical hospitalization costs, in-hospital mortality, and 1-year mortality, indicating that even patients with mild AKI are at higher risk for complications in both short and long term.
JOURNAL OF CLINICAL ANESTHESIA
(2022)
Article
Medicine, General & Internal
Suk Hyung Choe, Hyeyeon Cho, Jinyoung Bae, Sang-Hwan Ji, Hyun-Kyu Yoon, Ho-Jin Lee, Ji-Hyun Lee, Jin-Tae Kim, Won Ho Kim
Summary: The study aimed to evaluate the association between the duration and stage of acute kidney injury (AKI) and the occurrence of chronic kidney disease (CKD) in patients undergoing cardiac or thoracic aortic surgery. Results showed a significant and graded association between AKI stages and the development of new-onset CKD during three years after surgery, with higher duration and severity of AKI providing stronger predictive value for CKD development.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Matthias Thielmann, David Corteville, Gabor Szabo, Madhav Swaminathan, Andre Lamy, Lukas J. Lehner, Craig D. Brown, Nicolas Noiseux, Mohamed G. Atta, Elizabeth C. Squiers, Shai Erlich, Daniel Rothenstein, Bruce Molitoris, C. David Mazer
Summary: In high-risk patients undergoing cardiac surgery, a single 10 mg/kg dose of teprasiran significantly reduced the incidence, severity, and duration of early AKI compared to placebo.
Article
Medicine, General & Internal
Charat Thongprayoon, Pattharawin Pattharanitima, Andrea G. Kattah, Michael A. Mao, Mira T. Keddis, John J. Dillon, Wisit Kaewput, Supawit Tangpanithandee, Pajaree Krisanapan, Fawad Qureshi, Wisit Cheungpasitporn
Summary: This study aimed to develop and validate an automated machine learning (autoML) prediction model for cardiac surgery-associated acute kidney injury (CSA-AKI). Comparing different models, the autoML model showed the highest predictive performance and had comparable performance to the random forest model, outperforming other models. The autoML model also demonstrated good calibration. This study suggests that the high-performing autoML CSA-AKI prediction model can guide individualized medical plans for cardiac surgery.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Puneet Dhamija, Dipika Bansal, Anand Srinivasan, Ashish Bhalla, Debasish Hota, Amitava Chakrabarti
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2013)
Article
Biochemistry & Molecular Biology
Rohitash Yadav, Mohammed Imran, Puneet Dhamija, Kapil Suchal, Shailendra Handu
Summary: This study utilized virtual screening, molecular modeling, and docking techniques to identify three potential drugs targeting the N protein of SARS-CoV-2 from Asinex and PubChem databases. These drugs showed promising efficacy at Site 3, with Zidovudine demonstrating stable interaction with the virus, paving the way for further biological validation as a potential treatment.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Review
Cell Biology
Rohitash Yadav, Jitendra Kumar Chaudhary, Neeraj Jain, Pankaj Kumar Chaudhary, Supriya Khanra, Puneet Dhamija, Ambika Sharma, Ashish Kumar, Shailendra Handu
Summary: Coronavirus, including SARS-CoV-2, has a high sequence similarity with bat-related coronaviruses and has a greater affinity for host cell receptors, leading to pathogenic processes. The translation of viral RNA into proteins and the assembly of functional components play a crucial role in the virus's replication and infection mechanism.
Review
Cell Biology
Jitendra Kumar Chaudhary, Rohitash Yadav, Pankaj Kumar Chaudhary, Anurag Maurya, Rakesh Roshan, Faizul Azam, Jyoti Mehta, Shailendra Handu, Ramasare Prasad, Neeraj Jain, Avaneesh Kumar Pandey, Puneet Dhamija
Summary: COVID-19 caused by the novel coronavirus mainly infects humans and other mammals by interacting with the host cell receptor ACE2. The structural and non-structural proteins of the virus play a crucial role in determining the clinical outcomes following infection, suggesting that targeting these key factors in treatment may be prudent.
Article
Psychiatry
Rishi Sharma, Sai Krishna Tikka, Arun Kumar Yadav, Ashish Ramesh Bhute, Puneet Dhamija, Binaya Kumar Bastia
Summary: The meta-analysis revealed lower levels of CSF neurotransmitter metabolites in suicide attempters, particularly 5-HIAA, compared to psychiatric controls, with a significant association between 5-HIAA and violent suicide attempters. However, the findings for HVA and MHPG were inconsistent.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Orthopedics
Tarun Goyal, Puneet Dhamija, Gyan Vardhan, Pratima Gupta, Vivek Trikha
Summary: This study investigated the elution characteristics and antimicrobial activity of piperacillin and tazobactam from bone cement, as well as their combination with gentamicin. The results showed successful elution of piperacillin and tazobactam from bone cement, with sustained antimicrobial activity. Gentamicin improved the elution of piperacillin and tazobactam and enhanced their antimicrobial effects.
ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH
(2022)
Review
Cell Biology
Jitendra Kumar Chaudhary, Rohitash Yadav, Pankaj Kumar Chaudhary, Anurag Maurya, Nimita Kant, Osamah Al Rugaie, Hoineiting Rebecca Haokip, Deepika Yadav, Rakesh Roshan, Ramasare Prasad, Apurva Chatrath, Dharmendra Singh, Neeraj Jain, Puneet Dhamija
Summary: The first quarter of the 21st century has been marked by numerous outbreaks of infectious viral diseases, notably the ongoing COVID-19 pandemic caused by SARS-CoV-2. Efforts have been focused on developing vaccines, with the Spike glycoprotein identified as a promising candidate for eliciting immune responses. Multiple vaccines have received approval and many more are in various stages of development to achieve the goal of herd immunity and control the pandemic.
Article
Medicine, General & Internal
Arkapal Bandyopadhyay, Sarika Palepu, Puneet Dhamija, Uttam Kumar Nath, Rituparna Chetia, Anamika Bakliwal, Sudeep Vaniyath, Debranjani Chattopadhyay, Shailendra Handu
Summary: The study aimed to compare the early molecular response (EMR) rates at 3 months of imatinib therapy with and without vitamin D3 supplementation in patients newly diagnosed with chronic-phase chronic myeloid leukaemia (CML-CP). The results showed that vitamin D3 supplementation with imatinib therapy did not have a significant effect on EMR or CHR in these patients.
Article
Pharmacology & Pharmacy
Pramod Kumar Sharma, Arup Kumar Misra, Ajay Gupta, Surjit Singh, Puneet Dhamija, Puneet Pareek
INDIAN JOURNAL OF PHARMACOLOGY
(2018)
Article
Immunology
Aman Goyal, Harmanjit Singh, Vijay Kumar Sehgal, C. R. Jayanthi, Renuka Munshi, K. Laxminarayana Bairy, Rakesh Kumar, Sandeep Kaushal, Ashish Kumar Kakkar, Sneha Ambwani, Chhaya Goyal, Goutameswar Mazumdar, Anjan Adhikari, Nina Das, Divya John Stephy, Pugazhenthan Thangaraju, D. C. Dhasmana, Shakil U. Rehman, Amit Chakrabarti, Basavaraj Bhandare, Dinesh Kumar Badyal, Inderpal Kaur, K. Chandrashekar, Jagjit Singh, Puneet Dhamija, Sudhir Chandra Sarangi, Yogendra Kumar Gupta
INDIAN JOURNAL OF MEDICAL RESEARCH
(2017)
Article
Gastroenterology & Hepatology
Puneet Dhamija, Debasish Hota, Rakesh Kochhar, Atul Sachdev, Amitava Chakrabarti
INDIAN JOURNAL OF GASTROENTEROLOGY
(2014)
Letter
Biochemistry & Molecular Biology
Kirtimaan Syal, Dibyajyoti Banerjee, Anand Srinivasan
INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY
(2013)