Editorial Material
Cardiac & Cardiovascular Systems
Nicolas H. Pope, Robert B. Hawkins, Leora T. Yarboro
Summary: The report presented a patient with recurrent left ventricular assist device thrombosis, who was successfully treated with device conversion and transplantation after being listed as status 2.
ANNALS OF THORACIC SURGERY
(2021)
Article
Medicine, General & Internal
Jia-Lin Chen, Yi-Ting Tsai, Chih-Yuan Lin, Hong-Yan Ke, Yi-Chang Lin, Hsiang-Yu Yang, Chien-Ting Liu, Shih-Ying Sung, Jui-Tsung Chang, Ying-Hsiang Wang, Tso-Chou Lin, Chien-Sung Tsai, Po-Shun Hsu
Summary: Combined ECLS and t-BiVAD could be a salvage treatment for patients with severe cardiogenic shock, especially for those already having prolonged CPR.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Yue Qu, Anton Y. Peleg, David McGiffin
Summary: Ventricular assist device (VAD)-specific infections, particularly driveline infections, are a concerning complication of VAD implantation due to biofilm formation and migration. Despite multiple preventative strategies, driveline infections still have a high prevalence and unsatisfactory treatment outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Kiyonori Kobayashi, Masato Mutsuga, Akihiko Usui
Summary: The study found that the leg extensor muscle strength at discharge is associated with rehospitalization after VAD surgery, with a high strength group more likely to avoid readmission. Patients showed improved grip strength, 6-min walk distance, and peak VO2 at 1 year after discharge, but LEMS did not increase in VAD patients who avoided rehospitalization.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Ying-Hsiang Wang, Chien -Sung Tsai, Jia-Lin Chen, Yi-Ting Tsai, Chih-Yuan Lin, Hsiang-Yu Yang, Po-Shun Hsu
Summary: This study investigated the efficacy of temporary ventricular assist device (VAD) in the extracorporeal cardiopulmonary resuscitation (ECPR) of acute fulminant myocarditis (AFM) patients. The results showed that patients who received VAD support had better hemodynamic improvement, systemic perfusion, and survival rates compared to those who underwent extracorporeal life support (ECLS) alone.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Anubodh S. Varshney, Ersilia M. DeFilippis, Jennifer A. Cowger, Ivan Netuka, Sean P. Pinney, Michael M. Givertz
Summary: With the increasing prevalence of advanced heart failure, treatment options such as heart transplantation and LVAD support have shown to improve quality of life and extend survival. Recent advancements, including the use of HeartMate 3 in clinical practice and revisions to the organ allocation system, have led to better management of LVAD-related complications. Although contemporary LVAD recipients have higher illness severity preoperatively, they have higher survival rates and lower adverse event rates compared to previous eras. However, challenges such as bleeding, infection, neurologic events, and right ventricular failure still limit the wider implementation of LVAD support. Ongoing efforts to optimize management of current LVAD devices and develop next-generation devices are expected to further enhance outcomes for patients with advanced heart failure.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Tanous Aoun, Guillaume Baudry, Gilles Rioufol, Jean Francois Obadia, Matteo Pozzi
Summary: Myocardial recovery in LVAD patients is rare, and surgical explantation is risky. This report highlights the use of a Watchman closure device for deactivation of a HeartMate 3 LVAD.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Tabea Amstad, Jan Taeymans, Lars Englberger, Paul Mohacsi, Dieter Steiner, Markus J. Wilhelm, Matthias Hermann
Summary: The aim of this study was to investigate the effects of cardiac rehabilitation on exercise capacity and quality of life in patients with ventricular assist devices (VADs). The study found that patients with VAD implantation showed significant improvements in exercise capacity and quality of life during cardiac rehabilitation. Patients on destination therapy showed greater benefits from rehabilitation than bridge-to-transplant patients, and patients with left VADs improved more than biventricular VAD patients.
JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Luke A. Ziegler, Sheelagh Pousatis, David J. Kaczorowski, Ronson J. Madathil
Summary: LVAD driveline transection is a serious complication, but can be treated with emergency and durable driveline splicing surgeries, allowing patients to be discharged safely.
ANNALS OF THORACIC SURGERY
(2021)
Article
Emergency Medicine
Moira E. Smith, James H. Moak
Summary: LVADs have improved survival for heart failure patients, but the growing population of LVAD patients often experience complications and visits to the Emergency Department. Patients with LVADs may experience dysrhythmias such as ventricular tachycardia and ventricular fibrillation, yet remain asymptomatic in some cases.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Engineering, Biomedical
Danielle S. Burstein, Michael McBride, Angela Lorts, David Rosenthal, David M. Peng, Jodie Lantz, Hari Tunuguntla, Matthew Zinn, Tracy Curran, Samuel Wittekind
Summary: Despite limited data on exercise testing and cardiac rehabilitation (CR) in children with pediatric ventricular assist devices (VAD), there is interest in implementing standardized CR programs among pediatric VAD centers to improve outcomes pre- and post-transplant.
Article
Infectious Diseases
Sebastian Rojas, Simon Junghans, Henrik Fox, Kanstantsin Lazouski, Rene Schramm, Michiel Morshuis, Jan F. Gummert, Justus Gross
Summary: This case report describes a severe outflow graft infection following LVAD implantation. The patient underwent complex wound management and local bacteriophage therapy, which resulted in a significant decrease in infection.
Article
Cardiac & Cardiovascular Systems
Maryam Ajmal, Aisha Ajmal, Maryam Rizvi, Umar Salim, Lei Huang
Summary: This study aimed to investigate the changes in myocardial gene expression profile after LVAD implantation and their molecular biological significance. The results showed that inflammatory signaling pathway is crucial for the pathophysiology after LVAD implantation and chemokines mediate cardiac inflammatory response and tissue remodeling through GPCR-ligand binding.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Hematology
Kristin Klaeske, Maja-Theresa Dieterlen, Sandra Eifert, Ute Scholz, Jens Garbade, Khalil Jawad, Franz Sieg, Michael A. Borger, Anna L. Meyer
Summary: This study compared platelet receptor expression patterns and oxidative stress levels between LVAD patients with non-surgical bleeding (NSB) and those without coagulation disorders. The findings suggested that changes in three platelet receptors (GPIb alpha, P-selectin, and PECAM-1) and elevated oxidative stress may play a role in bleeding complications following LVAD implantation.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Cardiac & Cardiovascular Systems
Jared P. Beller, J. Hunter Mehaffey, Zachary K. Wegermann, Maria Grau-Sepulveda, Sean M. O'Brien, J. Matthew Brennan, Vinod Thourani, Vinay Badhwar, Francis D. Pagani, Gorav Ailawadi, Leora T. Yarboro, Nicholas R. Teman
Summary: Patients with severe right ventricular failure during durable left ventricular assist device implantation may benefit from the use of RVAD over VA-ECMO. Regardless of the type of support, initiation at the index operation was associated with improved outcomes.
ANNALS OF THORACIC SURGERY
(2022)
